LOCUS       NM_001040424            6525 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens PR/SET domain 15 (PRDM15), transcript variant 2, mRNA.
ACCESSION   NM_001040424
VERSION     NM_001040424.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6525)
  AUTHORS   Liu,N., Zhang,J., Chen,W., Ma,W. and Wu,T.
  TITLE     The RNA methyltransferase METTL16 enhances cholangiocarcinoma
            growth through PRDM15-mediated FGFR4 expression
  JOURNAL   J Exp Clin Cancer Res 42 (1), 263 (2023)
   PUBMED   37817227
  REMARK    GeneRIF: The RNA methyltransferase METTL16 enhances
            cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6525)
  AUTHORS   Zhao,L.N., Guccione,E. and Kaldis,P.
  TITLE     Proof-of-Concept Method to Study Uncharacterized Methyltransferases
            Using PRDM15
  JOURNAL   Int J Mol Sci 24 (2), 1327 (2023)
   PUBMED   36674842
  REMARK    GeneRIF: Proof-of-Concept Method to Study Uncharacterized
            Methyltransferases Using PRDM15.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6525)
  AUTHORS   Mann,N., Mzoughi,S., Schneider,R., Kuhl,S.J., Schanze,D.,
            Klambt,V., Lovric,S., Mao,Y., Shi,S., Tan,W., Kuhl,M.,
            Onuchic-Whitford,A.C., Treimer,E., Kitzler,T.M., Kause,F.,
            Schumann,S., Nakayama,M., Buerger,F., Shril,S., van der Ven,A.T.,
            Majmundar,A.J., Holton,K.M., Kolb,A., Braun,D.A., Rao,J.,
            Jobst-Schwan,T., Mildenberger,E., Lennert,T., Kuechler,A.,
            Wieczorek,D., Gross,O., Ermisch-Omran,B., Werberger,A., Skalej,M.,
            Janecke,A.R., Soliman,N.A., Mane,S.M., Lifton,R.P., Kadlec,J.,
            Guccione,E., Schmeisser,M.J., Zenker,M. and Hildebrandt,F.
  TITLE     Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome
  JOURNAL   J Am Soc Nephrol 32 (3), 580-596 (2021)
   PUBMED   33593823
  REMARK    GeneRIF: Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat
            Syndrome.
REFERENCE   4  (bases 1 to 6525)
  AUTHORS   Mzoughi,S., Di Tullio,F., Low,D.H.P., Motofeanu,C.M., Ong,S.L.M.,
            Wollmann,H., Wun,C.M., Kruszka,P., Muenke,M., Hildebrandt,F.,
            Dunn,N.R., Messerschmidt,D.M. and Guccione,E.
  TITLE     PRDM15 loss of function links NOTCH and WNT/PCP signaling to
            patterning defects in holoprosencephaly
  JOURNAL   Sci Adv 6 (2), eaax9852 (2020)
   PUBMED   31950080
  REMARK    GeneRIF: PRDM15 loss of function links NOTCH and WNT/PCP signaling
            to patterning defects in holoprosencephaly.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6525)
  AUTHORS   Hosgood Iii,H.D., Diaz-Pena,R., Blansky,D., Jaime,S., Parra,V.,
            Boekstegers,F., Bermejo,J.L., Garcia-Valero,J., Montes,J.F.,
            Valdivia,G., Miravitlles,M., Agusti,A., Silva,R.S. and
            Olloquequi,J.
  TITLE     PRDM15 Is Associated with Risk of Chronic Obstructive Pulmonary
            Disease in a Rural Population in Chile
  JOURNAL   Respiration 99 (4), 307-315 (2020)
   PUBMED   32222710
  REMARK    GeneRIF: PRDM15 Is Associated with Risk of Chronic Obstructive
            Pulmonary Disease in a Rural Population in Chile.
REFERENCE   6  (bases 1 to 6525)
  AUTHORS   Mzoughi,S., Zhang,J., Hequet,D., Teo,S.X., Fang,H., Xing,Q.R.,
            Bezzi,M., Seah,M.K.Y., Ong,S.L.M., Shin,E.M., Wollmann,H.,
            Wong,E.S.M., Al-Haddawi,M., Stewart,C.L., Tergaonkar,V., Loh,Y.H.,
            Dunn,N.R., Messerschmidt,D.M. and Guccione,E.
  TITLE     PRDM15 safeguards naive pluripotency by transcriptionally
            regulating WNT and MAPK-ERK signaling
  JOURNAL   Nat Genet 49 (9), 1354-1363 (2017)
   PUBMED   28740264
  REMARK    GeneRIF: Findings indicate that PR domain containing 15 protein
            (PRDM15) is important in both mouse and human induced pluripotent
            stem cells (iPSCs) reprogramming.
REFERENCE   7  (bases 1 to 6525)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 6525)
  AUTHORS   Shibuya,K., Kudoh,J., Okui,M. and Shimizu,N.
  TITLE     Identification of a novel zinc finger protein gene (ZNF298) in the
            GAP2 of human chromosome 21q
  JOURNAL   Biochem Biophys Res Commun 332 (2), 557-568 (2005)
   PUBMED   15904895
REFERENCE   9  (bases 1 to 6525)
  AUTHORS   Gardiner,K., Slavov,D., Bechtel,L. and Davisson,M.
  TITLE     Annotation of human chromosome 21 for relevance to Down syndrome:
            gene structure and expression analysis
  JOURNAL   Genomics 79 (6), 833-843 (2002)
   PUBMED   12036298
REFERENCE   10 (bases 1 to 6525)
  AUTHORS   Reymond,A., Camargo,A.A., Deutsch,S., Stevenson,B.J.,
            Parmigiani,R.B., Ucla,C., Bettoni,F., Rossier,C., Lyle,R.,
            Guipponi,M., de Souza,S., Iseli,C., Jongeneel,C.V., Bucher,P.,
            Simpson,A.J. and Antonarakis,S.E.
  TITLE     Nineteen additional unpredicted transcripts from human chromosome
            21
  JOURNAL   Genomics 79 (6), 824-832 (2002)
   PUBMED   12036297
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB051812.1, HY066601.1 and AP002955.1.
            
            On Oct 22, 2019 this sequence version replaced NM_001040424.2.
            
            Transcript Variant: This variant (2) lacks seven alternate in-frame
            exons and differs in the 3' UTR, compared to variant 1. The encoded
            isoform (2) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051812.1, SRR14038196.2841229.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398548.6/ ENSP00000381556.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2309              AB051812.1         130-2438
            2310-2344           HY066601.1         432-466
            2345-3083           AB051812.1         2474-3212
            3084-6525           AP002955.1         25426-28867         c
FEATURES             Location/Qualifiers
     source          1..6525
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..6525
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /note="PR/SET domain 15"
                     /db_xref="GeneID:63977"
                     /db_xref="HGNC:HGNC:13999"
                     /db_xref="MIM:617692"
     exon            1..75
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            76..121
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..3510
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 298; PR domain zinc finger protein 15; PR
                     domain containing 15; PR domain 15"
                     /codon_start=1
                     /product="PR domain zinc finger protein 15 isoform 2"
                     /protein_id="NP_001035514.2"
                     /db_xref="CCDS:CCDS42932.2"
                     /db_xref="GeneID:63977"
                     /db_xref="HGNC:HGNC:13999"
                     /db_xref="MIM:617692"
                     /translation="MAEDGSEEIMFIWCEDCSQYHDSECPELGPVVMVKDSFVLSRAR
                     SSLPPNLEIRRLEDGAEGVFAITQLVKRTQFGPFESRRVAKWEKESAFPLKVFQKDGH
                     PVCFDTSNEDDCNWMMLVRPAAEAEHQNLTAYQHGSDVYFTTSRDIPPGTELRVWYAA
                     FYAKKMDKPMLKQAGSGVHAAGTPENSAPVESEPSQWACKVCSATFLELQLLNEHLLG
                     HLEQAKSLPPGSQSEAAAPEKEQDTPRGEPPAVPESENVATKEQKKKPRRGRKPKVSK
                     AEQPLVIVEDKEPTEQVAEIITEVPPDEPVSATPDERIMELVLGKLATTTTDTSSVPK
                     FTHHQNNTITLKRSLILSSRHGIRRKLIKQLGEHKRVYQCNICSKIFQNSSNLSRHVR
                     SHGDKLFKCEECAKLFSRKESLKQHVSYKHSRNEVDGEYRYRCGTCEKTFRIESALEF
                     HNCRTDDKTFQCEMCFRFFSTNSNLSKHKKKHGDKKFACEVCSKMFYRKDVMLDHQRR
                     HLEGVRRVKREDLEAGGENLVRYKKEPSGCPVCGKVFSCRSNMNKHLLTHGDKKYTCE
                     ICGRKFFRVDVLRDHIHVHFKDIALMDDHQREEFIGKIGISSEENDDNSDESADSEPH
                     KYSCKRCQLTFGRGKEYLKHIMEVHKEKGYGCSICNRRFALKATYHAHMVIHRENLPD
                     PNVQKYIHPCEICGRIFNSIGNLERHKLIHTGVKSHACEQCGKSFARKDMLKEHMRVH
                     DNVREYLCAECGKGMKTKHALRHHMKLHKGIKEYECKECHRRFAQKVNMLKHCKRHTG
                     IKDFMCELCGKTFSERNTMETHKLIHTVGKQWTCSVCDKKYVTEYMLQKHVQLTHDKV
                     EAQSCQLCGTKVSTRASMSRHMRRKHPEVLAVRIDDLDHLPETTTIDASSIGIVQPEL
                     TLEQEDLAEGKHGKAAKRSHKRKQKPEEEAGAPVPEDATFSEYSEKETEFTGSVGDET
                     NSAVQSIQQVVVTLGDPNVTTPSSSVGLTNITVTPITTAAATQFTNLQPVAVGHLTTP
                     ERQLQLDNSILTVTFDTVSGSAMLHNRQNDVQIHPQPEASNPQSVAHFINLTTLVNSI
                     TPLGSQLSDQHPLTWRAVPQTDVLPPSQPQAPPQQAAQPQVQAEQQQQQMYSY"
     exon            122..215
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            216..369
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            370..622
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            623..724
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            725..955
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1085
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1267
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1362
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1450
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1618
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1713
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1845
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1980
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2144
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2224
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2344
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2476
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2560
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2736
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2817
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..3027
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..6525
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6496..6501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /note="hexamer: AATAAA"
     polyA_site      6525
                     /gene="PRDM15"
                     /gene_synonym="C21orf83; PFM15; ZNF298"
                     /note="major polyA site"
ORIGIN      
        1 ggtgctgcgc agtttccgga gcggatcgca acccggagtc cggatccgat cccgctctgc
       61 acattccaaa ggcaggtgtc agagatggct gaagatggga gcgaagagat catgttcatc
      121 tggtgtgaag actgcagcca gtaccacgac tccgaatgtc ccgagctggg cccagtggtc
      181 atggtcaaag actcctttgt gttaagcagg gcaaggtcat cccttcctcc caacttggag
      241 atcagacgac tggaagatgg agccgagggg gtgttcgcca tcactcagct cgtcaagcgg
      301 acacagttcg gtccctttga gtccaggagg gtcgccaaat gggaaaagga gtctgcattt
      361 cccctgaagg tgttccagaa ggacgggcac cccgtgtgct tcgacacctc caacgaggat
      421 gactgcaact ggatgatgct ggtgcggcca gcggcggagg ccgagcacca gaacctgacg
      481 gcctaccagc acggcagcga cgtgtacttc accacctcca gagacatccc cccgggtacc
      541 gagctgcgcg tgtggtatgc ggccttctat gccaagaaga tggacaagcc catgctgaag
      601 caggccggct ctggcgtcca cgctgcaggc accccagaaa acagcgcccc cgtggagtcg
      661 gagcccagcc agtgggcgtg taaagtgtgt tctgccacct tcctggagct gcagctcctc
      721 aatgaacatc tgttgggcca cttagaacaa gccaaaagcc ttcctccagg cagccaaagc
      781 gaggcagcag ctcccgagaa ggagcaggac acaccccggg gggaaccccc tgcagtgccc
      841 gagagcgaga atgttgccac caaagaacag aagaaaaagc ctcgaagggg gagaaaaccc
      901 aaagtgtcca aagctgagca gcctctagtc atcgtggaag acaaggaacc cacagagcaa
      961 gtggcagaga tcattaccga ggtccctccg gatgagcctg tgagtgcaac gccagatgag
     1021 cggatcatgg agctggttct ggggaagctg gccaccacca ccactgacac cagctcggtt
     1081 ccaaagttca cccatcatca gaataacacc atcacgctca agaggagctt aattctctca
     1141 agcagacacg gcatccggcg caagctcatc aaacagctcg gggagcacaa gcgggtttac
     1201 cagtgcaata tctgcagcaa gatcttccag aacagcagca acctgagcag gcacgtgcgc
     1261 tcgcatggtg acaagctgtt taagtgcgaa gagtgtgcaa aattgttcag ccgcaaagag
     1321 agcctaaagc agcacgtttc ctacaagcac agcaggaacg aggtggacgg cgagtacagg
     1381 taccgctgcg gcacttgtga gaagaccttc cgcatcgaga gcgcgctgga gttccacaac
     1441 tgcaggacag atgacaagac gttccaatgt gagatgtgtt tcagattctt ctccaccaac
     1501 agcaacctct ccaagcacaa gaagaagcac ggcgacaaga agtttgcctg tgaggtctgc
     1561 agcaagatgt tctaccgcaa ggacgtcatg ctggaccacc agcgccggca cctggaagga
     1621 gtgcggcgag tgaagcgaga ggacctggag gccggtgggg agaacctggt ccgttacaag
     1681 aaggagcctt ccgggtgccc ggtgtgtggc aaggtgttct cctgccggag caatatgaac
     1741 aagcacctgc tcacccacgg cgacaagaag tacacctgcg agatctgcgg gcgcaagttc
     1801 ttccgcgtgg atgtgctcag ggaccacatc catgtccact tcaaggacat cgcgttgatg
     1861 gatgaccacc agagggaaga gtttatcggc aagatcggga tctcctcgga agaaaacgat
     1921 gacaattctg acgagagcgc agactcggag cctcacaagt acagctgcaa gcggtgccag
     1981 ctcaccttcg gccgggggaa ggagtacctg aagcacatca tggaggtgca caaggagaag
     2041 ggctatggct gcagcatctg caaccggcgc tttgcactga aggccaccta ccacgcccac
     2101 atggtcatcc accgtgaaaa cctgccggac cccaacgtgc agaagtacat ccacccctgc
     2161 gagatctgcg ggcggatctt caacagcatc gggaacctgg agcgccacaa gctcatccac
     2221 acaggtgtga agagccacgc ctgcgagcag tgtgggaagt cctttgccag gaaggacatg
     2281 ctgaaggagc acatgcgtgt gcacgacaat gtccgcgagt acctgtgtgc cgagtgtggg
     2341 aaaggcatga agaccaagca cgcgctgcgc caccacatga agctgcacaa gggcatcaag
     2401 gagtacgagt gcaaggagtg ccaccgcagg ttcgcgcaga aggtcaacat gctcaagcac
     2461 tgcaagcggc acacggggat taaagatttc atgtgtgaat tgtgtgggaa gacattcagc
     2521 gagaggaaca ccatggagac ccacaagctc atccacacag tgggcaagca gtggacgtgc
     2581 tccgtgtgcg acaagaagta cgtgaccgag tacatgctgc agaagcacgt tcagctcaca
     2641 cacgacaagg tggaggcgca gagctgccag ctgtgcggga ccaaggtgtc caccagggcc
     2701 tccatgagcc gacacatgcg gcgcaagcac cccgaggtgc tcgcggtgag gatcgatgac
     2761 ctggaccacc tcccggagac caccaccatc gacgcctcct ccattggcat cgtccagcct
     2821 gagctgactc tggagcagga ggatttggcc gaagggaagc acgggaaagc tgccaagcga
     2881 agtcacaaga gaaagcagaa gccagaagag gaggcgggtg ctccggtgcc cgaggacgcc
     2941 accttcagcg aatactcaga gaaagagacg gagttcacag gcagtgtagg cgacgagacc
     3001 aattccgcag tacagagcat tcagcaggta gtggtgaccc tgggtgaccc aaatgtgacc
     3061 acaccatcga gctcagtcgg cttaaccaac atcaccgtga cccccatcac cactgcggcc
     3121 gcgactcagt ttaccaatct ccagccggtg gccgtggggc accttaccac ccctgaacgc
     3181 cagttacagc tggacaactc aatcctgacc gtgacctttg ataccgtcag cggctctgcc
     3241 atgttgcaca accgccaaaa tgacgtccag atccaccccc agccggaagc ctcgaaccca
     3301 cagtctgtgg cccatttcat caacctgacg accctggtca actccatcac gcccctgggg
     3361 agccagctta gtgaccagca cccgctcacg tggcgggcag tgccccagac tgacgtcttg
     3421 ccaccctcgc agccgcaggc acccccacag caggcggccc agccccaggt gcaggcggag
     3481 cagcagcagc agcagatgta cagctactga gctgcgttcc gggagactcg gggcaagaac
     3541 tgcagaggga tgtttgggat ttgtttagat gtgtttgctg gataccaaac aaacaaaaag
     3601 tcatacattg caatgtaagg ttgacttagc tttgcagagt atctccagat cccccgccag
     3661 caaccattac ggtctgtcag cttaactcta gaagggacct ctggcaggcc agagttttaa
     3721 actggatggg gctccacacc atgccttacc aaggcagtaa gtcctgggcc ggggccgcat
     3781 ctgcctcccc ttacagaacc agtgttcgcc cgacacaggg ttcgggaaag tgaagctgag
     3841 agagaagcag gattttaaga ggcaggagat aagttattag gaacacaaat ggttcatttt
     3901 cttttttctt ttagagctcg gttcctatga gaacacagac agtattcaca ggtggcagca
     3961 ggcagcaggg aacattttct cctcacttct ggattttttt gcaagcgagc acatagaagt
     4021 taaagtaacg tgtattctct ttgaactagg agtggagtcg gttcttatac aactatgggc
     4081 tgaaaccatg aggcgtgctg agccgcacct gatcctgcaa ccttcgaggt catcacggtc
     4141 atcatgtgca aggggtcacg tgaggtcact gactccagct caaaacgcat cttagtaata
     4201 tccatgaatc gatttccaat agagtttttt tccttttttt tttttaactt tatttcaaac
     4261 atacattatg tgttcaagac tgttatggcc aatattgtgt tttagtttta tgttaacatg
     4321 ataaagtcat gtgcactgta ggaccatctg tccctgtcca cccttcacag ctgcccagat
     4381 gcagagggtc gcgcggctgt gtgtgaggag tgagcctccc tgctgccccc aggggctcct
     4441 ccgggttgtc tcaggattct ctgcaatcca aatgtatcca ttctggctga agcccagcca
     4501 gaatcccgag tggaagaaac gggggaaaag tcatattttc cttctgttta aacttcaatt
     4561 ccaaaggttg gtgtatttca tgaccagttt tctataaaaa tattgaatga gtttggctct
     4621 ttacaatgga aaagtgtagg tatttctgaa acacagagaa aatgctattt cctgccaggt
     4681 ggtaatgaaa gcagagaggt tagttcacta atagaagcat taattgcccc taaaactgaa
     4741 tgtgcggtga acagccaggt ctgcgtgtgc ggggacacgt gctgtcacgt ctgtgtacca
     4801 gtttcggggg caggggccag ggttggggga ggcacccagc cctcctgctg cccacgacaa
     4861 gaaacactga gaggtgtggg gagaagtttg ctcttaactt tcctggtact ctgtttgtgg
     4921 ccacagtgag aggacaaacc tgccttaagg tgtcctgctt tgccagttat cccagatcct
     4981 gcactcactg ggagtccatc ttgaggaaac actggcatgg ctgagtaatt gatcaggagc
     5041 agtcctgatg ttgccagcag aacaaaggat gattgtgttt ttcaaaacgc aactttctca
     5101 gcacttcact ccaaacagca gacttttgag gacagggctg gaatttgttt tgtgcaatat
     5161 atgccttcat gaactaagga atgttcatcc ccaggcagca tgcaggaggg tctgtggggc
     5221 tcacctcctc accttaccca ccatcactcg cgcctagctc tcacctctca gttgaatgaa
     5281 tagtgggaga tcatttgact tttaatttat gagaattatt ttatgttatt tatgtatata
     5341 attaactgtt ttatacatag tagtctcatc aaatgaattc gggcttgggg tgatattgtc
     5401 tccattctcc agatacaagt gctccaggca tccatggaat cagcaggaga ccagggctcc
     5461 taagatatat ttttaaaaat cagtatcgat ttctttttgc ctttgcagaa tctaaagggc
     5521 aaatgacctc gcagagactc ccaacgggct ttgggctcat gacgaaacac ccactagcat
     5581 tgatctttta ttcctcttcc ctataaaata aaggccttgg aaatcacaat tttatttttt
     5641 taaagaagtt gttttagtgc ctagagtaag accgcatcaa atgttgttaa agaacctaat
     5701 ttagattgtg tggtatatac cactgtttat ctcaatacac agacacctct tacttcttgt
     5761 tataagtgag aactctaaag aaaaatcaaa ctcccaagtt ttctgtaaac atacgtggtc
     5821 ttaatagggt cactgtctga ggcaaaatgg gttgtcttaa agcaattgct acaaatttgc
     5881 atcaaagaaa ctagatagca aaatacaaca accatgtacc acccaggcag aagagtcctc
     5941 acctatacgc agttctgcat attgatcatc atgacaggaa gtatttcgtt ttttaactga
     6001 tcccaggtgc acagatgtat tcataaagga agacattaga tccagccatt gtggccacca
     6061 ggctctgtgg acccatctca gtggagaatt cgttttggac ccgtggctcc gtgcagctgt
     6121 ggactcgagt gccatccact ggtgtgagtc ttgcggggag gccacaggta cagctgctcc
     6181 ccgtgaatcc tggtctgtgg gttgagaagg ggctcgggcc tctggaatgc tctagcgtgt
     6241 gacgtgttct caggaaaacg ttctgtgcca agtgccgcct cgctgtgtcc ggcatgggac
     6301 tgcgctggag ggtccggcgt ggaaggcaga cctcctgtac ctctatcgtt cccatttgtg
     6361 gcatccaaag gcggaaggct catggcttcc ccactagagg cggcgtcttg ggctttccca
     6421 ttggattgtg aaaggcatta agactgtttg gagatgttgg ctgtatttcc tgtcacatca
     6481 ggttgtatga tgacgaataa aaggtgctgt gacccgtgtt ttcaa
//
