LOCUS       NM_024504               2269 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens PR/SET domain 14 (PRDM14), mRNA.
ACCESSION   NM_024504
VERSION     NM_024504.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Li,X., Wang,C., Wang,Y., Chen,X., Li,Z., Wang,J. and Liu,Y.
  TITLE     Integrated analysis of the role of PR/SET domain 14 in gastric
            cancer
  JOURNAL   BMC Cancer 24 (1), 685 (2024)
   PUBMED   38840106
  REMARK    GeneRIF: Integrated analysis of the role of PR/SET domain 14 in
            gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Kim,M., Ly,S.H., Xie,Y., Duronio,G.N., Ford-Roshon,D., Hwang,J.H.,
            Sulahian,R., Rennhack,J.P., So,J., Gjoerup,O., Talamas,J.A.,
            Grandclaudon,M., Long,H.W., Doench,J.G., Sethi,N.S., Giannakis,M.
            and Hahn,W.C.
  TITLE     YAP1 and PRDM14 converge to promote cell survival and tumorigenesis
  JOURNAL   Dev Cell 57 (2), 212-227 (2022)
   PUBMED   34990589
  REMARK    GeneRIF: YAP1 and PRDM14 converge to promote cell survival and
            tumorigenesis.
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Na,X.Y., Hu,X.Q., Zhao,Y., Hu,C.H. and Shang,X.S.
  TITLE     LncRNA DNAJC3-AS1 functions as oncogene in renal cell carcinoma via
            regulation of the miR-27a-3p/PRDM14 axis
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (3), 1291-1301 (2021)
   PUBMED   33629299
  REMARK    GeneRIF: LncRNA DNAJC3-AS1 functions as oncogene in renal cell
            carcinoma via regulation of the miR-27a-3p/PRDM14 axis.
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Liu,B., Zhang,S., Hui,L., Qiu,X. and Cui,Z.
  TITLE     [Relationship between the expression of PRDM14 in non-small cell
            lung cancer and the clinicopathologic characteristics]
  JOURNAL   Zhongguo Fei Ai Za Zhi 13 (9), 867-872 (2010)
   PUBMED   20840815
  REMARK    GeneRIF: The high expression of PRDM14 in non-small cell lung
            cancer is associated with differentiation and histological type.
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   Tsuneyoshi,N., Sumi,T., Onda,H., Nojima,H., Nakatsuji,N. and
            Suemori,H.
  TITLE     PRDM14 suppresses expression of differentiation marker genes in
            human embryonic stem cells
  JOURNAL   Biochem Biophys Res Commun 367 (4), 899-905 (2008)
   PUBMED   18194669
  REMARK    GeneRIF: These results suggest that PRDM14 is involved in the
            maintenance of the self-renewal of human ES cells by suppression of
            gene expression.
REFERENCE   8  (bases 1 to 2269)
  AUTHORS   Nishikawa,N., Toyota,M., Suzuki,H., Honma,T., Fujikane,T.,
            Ohmura,T., Nishidate,T., Ohe-Toyota,M., Maruyama,R., Sonoda,T.,
            Sasaki,Y., Urano,T., Imai,K., Hirata,K. and Tokino,T.
  TITLE     Gene amplification and overexpression of PRDM14 in breast cancers
  JOURNAL   Cancer Res 67 (20), 9649-9657 (2007)
   PUBMED   17942894
  REMARK    GeneRIF: PRDM14 mRNA is overexpressed in about two thirds of breast
            cancers; moreover, immunohistochemical analysis showed that
            expression of PRDM14 protein is also up-regulated.
REFERENCE   9  (bases 1 to 2269)
  AUTHORS   Xiao,B., Wilson,J.R. and Gamblin,S.J.
  TITLE     SET domains and histone methylation
  JOURNAL   Curr Opin Struct Biol 13 (6), 699-705 (2003)
   PUBMED   14675547
  REMARK    Review article
REFERENCE   10 (bases 1 to 2269)
  AUTHORS   Jiang,G.L. and Huang,S.
  TITLE     The yin-yang of PR-domain family genes in tumorigenesis
  JOURNAL   Histol Histopathol 15 (1), 109-117 (2000)
   PUBMED   10668202
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF319458.1, CX788380.1 and
            CX166395.1.
            
            On May 17, 2019 this sequence version replaced NM_024504.3.
            
            Summary: This gene encodes a member of the PRDI-BF1 and RIZ
            homology domain containing (PRDM) family of transcriptional
            regulators. The encoded protein may possess histone
            methyltransferase activity and plays a critical role in cell
            pluripotency by suppressing the expression of differentiation
            marker genes. Expression of this gene may play a role in breast
            cancer. [provided by RefSeq, Dec 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF319458.1, AK022595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276594.3/ ENSP00000276594.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1542              AF319458.1         76-1617
            1543-2263           CX788380.1         29-749
            2264-2269           CX166395.1         382-387
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.3"
     gene            1..2269
                     /gene="PRDM14"
                     /gene_synonym="PFM11"
                     /note="PR/SET domain 14"
                     /db_xref="GeneID:63978"
                     /db_xref="HGNC:HGNC:14001"
                     /db_xref="MIM:611781"
     exon            1..103
                     /gene="PRDM14"
                     /gene_synonym="PFM11"
                     /inference="alignment:Splign:2.1.0"
     exon            104..827
                     /gene="PRDM14"
                     /gene_synonym="PFM11"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1843
                     /gene="PRDM14"
                     /gene_synonym="PFM11"
                     /note="PR domain-containing protein 14; PR
                     domain-containing 14; PR domain 14"
                     /codon_start=1
                     /product="PR domain zinc finger protein 14"
                     /protein_id="NP_078780.1"
                     /db_xref="CCDS:CCDS6206.1"
                     /db_xref="GeneID:63978"
                     /db_xref="HGNC:HGNC:14001"
                     /db_xref="MIM:611781"
                     /translation="MALPRPSEAVPQDKVCYPPESSPQNLAAYYTPFPSYGHYRNSLA
                     TVEEDFQPFRQLEAAASAAPAMPPFPFRMAPPLLSPGLGLQREPLYDLPWYSKLPPWY
                     PIPHVPREVPPFLSSSHEYAGASSEDLGHQIIGGDNESGPCCGPDTLIPPPPADASLL
                     PEGLRTSQLLPCSPSKQSEDGPKPSNQEGKSPARFQFTEEDLHFVLYGVTPSLEHPAS
                     LHHAISGLLVPPDSSGSDSLPQTLDKDSLQLPEGLCLMQTVFGEVPHFGVFCSSFIAK
                     GVRFGPFQGKVVNASEVKTYGDNSVMWEIFEDGHLSHFIDGKGGTGNWMSYVNCARFP
                     KEQNLVAVQCQGHIFYESCKEIHQNQELLVWYGDCYEKFLDIPVSLQVTEPGKQPSGP
                     SEESAEGYRCERCGKVFTYKYYRDKHLKYTPCVDKGDRKFPCSLCKRSFEKRDRLRIH
                     ILHVHEKHRPHKCSTCGKCFSQSSSLNKHMRVHSGDRPYQCVYCTKRFTASSILRTHI
                     RQHSGEKPFKCKYCGKSFASHAAHDSHVRRSHKEDDGCSCSICGKIFSDQETFYSHMK
                     FHEDY"
     exon            828..881
                     /gene="PRDM14"
                     /gene_synonym="PFM11"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1039
                     /gene="PRDM14"
                     /gene_synonym="PFM11"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1310
                     /gene="PRDM14"
                     /gene_synonym="PFM11"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1513
                     /gene="PRDM14"
                     /gene_synonym="PFM11"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1615
                     /gene="PRDM14"
                     /gene_synonym="PFM11"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..2269
                     /gene="PRDM14"
                     /gene_synonym="PFM11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgaagtc taccgagccc gagtggccta ccgagcccga gtggccccgc agcgtccagg
       61 aggcgcccgc tccgcggtgg cgctcttgga ggtggtgtcg gagagccgcc gagcgtgcgg
      121 tcccgggatg gctctacccc ggccaagtga ggccgtgcct caggacaagg tgtgctaccc
      181 gccggagagc agcccgcaga acctggccgc gtactacacg cctttcccgt cctatggaca
      241 ctacagaaac agcctggcca ccgtggagga agacttccaa cctttccggc agctggaggc
      301 cgcagcgtct gctgcccccg ccatgccccc cttccccttc cggatggcgc ctcccttgct
      361 gagcccgggt ctgggcctac agagggagcc tctctacgat ctgccctggt acagcaagct
      421 gccaccgtgg tacccaattc cccacgtccc cagggaagtg ccgcccttcc tgagcagcag
      481 ccacgagtac gcgggtgcca gcagtgaaga tctgggccac caaatcattg gtggcgacaa
      541 cgagagtggc ccgtgttgtg gacctgacac tttaattcca ccgccccctg cggatgcttc
      601 tctgttacct gaggggctga ggacctccca gttattacct tgctcaccca gcaagcagtc
      661 agaggatggt cccaaaccct ccaaccaaga agggaagtcc cctgctcggt tccagttcac
      721 ggaggaggac ctgcacttcg ttctgtacgg ggtcactccc agcctggagc acccagccag
      781 cctgcaccat gcgatttcag gcctcctggt ccccccagac agctctggat ctgattctct
      841 tcctcaaact ctggataaag actcccttca acttccagaa ggtctatgcc tcatgcagac
      901 ggtgtttggt gaagtcccac attttggtgt gttctgcagt agttttatcg ccaaaggagt
      961 caggtttggg ccctttcaag gtaaagtggt caatgccagt gaagtgaaga cctacggaga
     1021 caattctgtg atgtgggaga tctttgaaga tggtcatttg agccacttta tagatggaaa
     1081 aggaggtacg gggaactgga tgtcctatgt caactgtgcc cgcttcccca aggagcagaa
     1141 cctagttgct gtgcagtgtc aagggcatat attttatgag agctgcaaag agatccatca
     1201 gaaccaagag ctccttgtgt ggtatggaga ctgctatgag aaatttctgg atattcctgt
     1261 gagccttcag gtcacagagc cggggaagca gccatctggg ccctctgaag agtctgcaga
     1321 aggctacaga tgtgaaagat gtgggaaggt atttacctac aaatattaca gagataagca
     1381 cctcaagtac accccctgtg tggacaaggg cgataggaaa tttccctgtt ctctctgcaa
     1441 acgatccttt gagaagcggg accggcttcg gatccacatt cttcatgttc atgagaagca
     1501 ccggcctcac aagtgttcta catgtgggaa atgtttctct caatcttcca gcctaaacaa
     1561 acacatgcga gtccactctg gagacagacc ataccagtgt gtgtattgta ctaagaggtt
     1621 cacagcctcc agcatactcc gcacacacat caggcagcac tccggggaga agcccttcaa
     1681 atgcaagtac tgtggtaaat cttttgcatc ccatgctgcc catgacagcc atgtccggcg
     1741 ttcacacaag gaggatgatg gctgctcatg cagcatctgt gggaaaatct tctcagatca
     1801 agaaacattc tactcccaca tgaagtttca tgaagactac tagccctgcc aggcacaatg
     1861 actcacgcct gtaatcccag cactttggga ggcagaggtg ggtggatcac tcaagtccag
     1921 gagttcgaga ccagcctggg caacatggtg aaatcctgtc tctaccaaaa aaatacaaaa
     1981 atcagctggg ggtggtggca catgcctgtg gttccagcca ctcaggaggt cgaggtggca
     2041 ggatggtttg agcacaggag acggaggttg ctgtgagctg agatcgcccc actgcttttc
     2101 aacctgggtg acagaaccag accctgtctc aaaacaaaac aaaacaaaaa aaatgagtag
     2161 ccctcaagag tgtggagaca atgtaaaaac aagagattcg gattctctct atttcctttt
     2221 atgggttata gaagtccctg cagttggctg tgtgtggtgg ctcacgcct
//
