LOCUS       NM_001384648           10729 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens PR/SET domain 11 (PRDM11), transcript variant 4, mRNA.
ACCESSION   NM_001384648 XM_011520223
VERSION     NM_001384648.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10729)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 10729)
  AUTHORS   Fog,C.K., Asmar,F., Come,C., Jensen,K.T., Johansen,J.V.,
            Kheir,T.B., Jacobsen,L., Friis,C., Louw,A., Rosgaard,L., Obro,N.F.,
            Marquart,H.V., Anthonsen,K., Braat,A.K., van Lohuizen,M.,
            Ralfkiaer,E., Gronbaek,K. and Lund,A.H.
  TITLE     Loss of PRDM11 promotes MYC-driven lymphomagenesis
  JOURNAL   Blood 125 (8), 1272-1281 (2015)
   PUBMED   25499759
  REMARK    GeneRIF: We characterize PRDM11 as a putative novel tumor
            suppressor that controls the expression of key oncogenes, and we
            add new mechanistic insight into B-cell lymphomagenesis.
REFERENCE   3  (bases 1 to 10729)
  AUTHORS   Loth,D.W., Soler Artigas,M., Gharib,S.A., Wain,L.V.,
            Franceschini,N., Koch,B., Pottinger,T.D., Smith,A.V., Duan,Q.,
            Oldmeadow,C., Lee,M.K., Strachan,D.P., James,A.L., Huffman,J.E.,
            Vitart,V., Ramasamy,A., Wareham,N.J., Kaprio,J., Wang,X.Q.,
            Trochet,H., Kahonen,M., Flexeder,C., Albrecht,E., Lopez,L.M., de
            Jong,K., Thyagarajan,B., Alves,A.C., Enroth,S., Omenaas,E.,
            Joshi,P.K., Fall,T., Vinuela,A., Launer,L.J., Loehr,L.R.,
            Fornage,M., Li,G., Wilk,J.B., Tang,W., Manichaikul,A., Lahousse,L.,
            Harris,T.B., North,K.E., Rudnicka,A.R., Hui,J., Gu,X., Lumley,T.,
            Wright,A.F., Hastie,N.D., Campbell,S., Kumar,R., Pin,I.,
            Scott,R.A., Pietilainen,K.H., Surakka,I., Liu,Y., Holliday,E.G.,
            Schulz,H., Heinrich,J., Davies,G., Vonk,J.M., Wojczynski,M.,
            Pouta,A., Johansson,A., Wild,S.H., Ingelsson,E., Rivadeneira,F.,
            Volzke,H., Hysi,P.G., Eiriksdottir,G., Morrison,A.C., Rotter,J.I.,
            Gao,W., Postma,D.S., White,W.B., Rich,S.S., Hofman,A., Aspelund,T.,
            Couper,D., Smith,L.J., Psaty,B.M., Lohman,K., Burchard,E.G.,
            Uitterlinden,A.G., Garcia,M., Joubert,B.R., McArdle,W.L.,
            Musk,A.B., Hansel,N., Heckbert,S.R., Zgaga,L., van Meurs,J.B.,
            Navarro,P., Rudan,I., Oh,Y.M., Redline,S., Jarvis,D.L., Zhao,J.H.,
            Rantanen,T., O'Connor,G.T., Ripatti,S., Scott,R.J., Karrasch,S.,
            Grallert,H., Gaddis,N.C., Starr,J.M., Wijmenga,C., Minster,R.L.,
            Lederer,D.J., Pekkanen,J., Gyllensten,U., Campbell,H., Morris,A.P.,
            Glaser,S., Hammond,C.J., Burkart,K.M., Beilby,J., Kritchevsky,S.B.,
            Gudnason,V., Hancock,D.B., Williams,O.D., Polasek,O., Zemunik,T.,
            Kolcic,I., Petrini,M.F., Wjst,M., Kim,W.J., Porteous,D.J.,
            Scotland,G., Smith,B.H., Viljanen,A., Heliovaara,M., Attia,J.R.,
            Sayers,I., Hampel,R., Gieger,C., Deary,I.J., Boezen,H.M.,
            Newman,A., Jarvelin,M.R., Wilson,J.F., Lind,L., Stricker,B.H.,
            Teumer,A., Spector,T.D., Melen,E., Peters,M.J., Lange,L.A.,
            Barr,R.G., Bracke,K.R., Verhamme,F.M., Sung,J., Hiemstra,P.S.,
            Cassano,P.A., Sood,A., Hayward,C., Dupuis,J., Hall,I.P.,
            Brusselle,G.G., Tobin,M.D. and London,S.J.
  TITLE     Genome-wide association analysis identifies six new loci associated
            with forced vital capacity
  JOURNAL   Nat Genet 46 (7), 669-677 (2014)
   PUBMED   24929828
REFERENCE   4  (bases 1 to 10729)
  AUTHORS   Porcu,E., Medici,M., Pistis,G., Volpato,C.B., Wilson,S.G.,
            Cappola,A.R., Bos,S.D., Deelen,J., den Heijer,M., Freathy,R.M.,
            Lahti,J., Liu,C., Lopez,L.M., Nolte,I.M., O'Connell,J.R.,
            Tanaka,T., Trompet,S., Arnold,A., Bandinelli,S., Beekman,M.,
            Bohringer,S., Brown,S.J., Buckley,B.M., Camaschella,C., de
            Craen,A.J., Davies,G., de Visser,M.C., Ford,I., Forsen,T.,
            Frayling,T.M., Fugazzola,L., Gogele,M., Hattersley,A.T.,
            Hermus,A.R., Hofman,A., Houwing-Duistermaat,J.J., Jensen,R.A.,
            Kajantie,E., Kloppenburg,M., Lim,E.M., Masciullo,C., Mariotti,S.,
            Minelli,C., Mitchell,B.D., Nagaraja,R., Netea-Maier,R.T.,
            Palotie,A., Persani,L., Piras,M.G., Psaty,B.M., Raikkonen,K.,
            Richards,J.B., Rivadeneira,F., Sala,C., Sabra,M.M., Sattar,N.,
            Shields,B.M., Soranzo,N., Starr,J.M., Stott,D.J., Sweep,F.C.,
            Usala,G., van der Klauw,M.M., van Heemst,D., van Mullem,A.,
            Vermeulen,S.H., Visser,W.E., Walsh,J.P., Westendorp,R.G., Widen,E.,
            Zhai,G., Cucca,F., Deary,I.J., Eriksson,J.G., Ferrucci,L.,
            Fox,C.S., Jukema,J.W., Kiemeney,L.A., Pramstaller,P.P.,
            Schlessinger,D., Shuldiner,A.R., Slagboom,E.P., Uitterlinden,A.G.,
            Vaidya,B., Visser,T.J., Wolffenbuttel,B.H., Meulenbelt,I.,
            Rotter,J.I., Spector,T.D., Hicks,A.A., Toniolo,D., Sanna,S.,
            Peeters,R.P. and Naitza,S.
  TITLE     A meta-analysis of thyroid-related traits reveals novel loci and
            gender-specific differences in the regulation of thyroid function
  JOURNAL   PLoS Genet 9 (2), e1003266 (2013)
   PUBMED   23408906
REFERENCE   5  (bases 1 to 10729)
  AUTHORS   Xiao,B., Wilson,J.R. and Gamblin,S.J.
  TITLE     SET domains and histone methylation
  JOURNAL   Curr Opin Struct Biol 13 (6), 699-705 (2003)
   PUBMED   14675547
  REMARK    Review article
REFERENCE   6  (bases 1 to 10729)
  AUTHORS   Jiang,G.L. and Huang,S.
  TITLE     The yin-yang of PR-domain family genes in tumorigenesis
  JOURNAL   Histol Histopathol 15 (1), 109-117 (2000)
   PUBMED   10668202
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103681.4.
            
            On Jun 23, 2020 this sequence version replaced XM_011520223.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2144120 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683152.1/ ENSP00000507575.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC103681.4         135400-135638       c
            240-364             AC103681.4         100392-100516       c
            365-468             AC103681.4         99928-100031        c
            469-731             AC103681.4         99154-99416         c
            732-799             AC103681.4         77499-77566         c
            800-987             AC103681.4         62520-62707         c
            988-1614            AC103681.4         57434-58060         c
            1615-10729          AC103681.4         47168-56282         c
FEATURES             Location/Qualifiers
     source          1..10729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..10729
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /note="PR/SET domain 11"
                     /db_xref="GeneID:56981"
                     /db_xref="HGNC:HGNC:13996"
                     /db_xref="MIM:616347"
     exon            1..239
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     exon            240..364
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..3779
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /note="isoform 1 is encoded by transcript variant 4;
                     PR-domain containing protein 11"
                     /codon_start=1
                     /product="PR domain-containing protein 11 isoform 1"
                     /protein_id="NP_001371577.1"
                     /db_xref="CCDS:CCDS73277.1"
                     /db_xref="GeneID:56981"
                     /db_xref="HGNC:HGNC:13996"
                     /db_xref="MIM:616347"
                     /translation="MTENMKECLAQTNAAVGDMVTVVKTEVCSPLRDQEYGQPCSRRP
                     DSSAMEVEPKKLKGKRDLIVPKSFQQVDFWFCESCQEYFVDECPNHGPPVFVSDTPVP
                     VGIPDRAALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFS
                     WLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPG
                     EWLRVWYSEDYMKRLHSMSQETIHRNLARGEKRLQREKSEQVLDNPEDLRGPIHLSVL
                     RQGKSPYKRGFDEGDVHPQAKKKKIDLIFKDVLEASLESAKVEAHQLALSTSLVIRKV
                     PKYQDDAYSQCATTMTHGVQNIGQTQGEGDWKVPQGVSKEPGQLEDEEEEPSSFKADS
                     PAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPPVLPPQVLELP
                     EFSDPAASESMVSGPAIMEDDDQEVDSADESVSNDMMTATDEPSKMSSATGRRIRRFK
                     QEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLH
                     KKCLQLYKLRMHPEKTEEMCRNMTLLFNTAYHLALEGRPYLDFRPLAELLRKCELKVV
                     DQYMNEGDCQILIHHIARALREDLVERIRQSPCLSVILDGQSDDLLADTVAVYVQYTS
                     SDGPPATEFLSLQELGFSSTESYLQALDRAFSALGIRLQDEKPTVGLGVDGANITASL
                     RASMFMTIRKTLPWLLCLPFMVHRPHLEILDAISGKELPCLEELENNLKQLLSFYRYS
                     PRLMCELRSTAATLCEETEFLGDIRAVRWIIGEQNVLNALIKDYLEVVAHLKEVSSQT
                     QRADASAIALALLQFLMDYQSIKLIYFLLDVIAVLSRLAYIFQGEYLLVSQVDDKIEE
                     AIQEISRLADSPGEYLQEFEENFRESFNGIAMKNLRVAEAKFQSIREKICQKTQVILA
                     QRFDSRSRIFVKACQVFDLAAWPRSSEELMSYGKEDMVQIFDHLEAIPTFSRDVCREG
                     LDPRGSLLMEWRELKADYYTKNGFKDLISHICKYKQRFPLLNKIIQVLKVLPTSTACC
                     EKGRNALQRVRKNHRSRLTLEQLSDLLTIAVNGPPITNFDAKRALDSWFEEKSGNSYA
                     LSAEVLSRMSALEQKPALQTMDHGTEFYPDI"
     exon            365..468
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     exon            469..731
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     exon            732..799
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     exon            800..987
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1614
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..10729
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10710..10715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /note="hexamer: AATAAA"
     polyA_site      10729
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /note="major polyA site"
ORIGIN      
        1 gtcatttcct gtactaataa gatggtggtc aaagcagggg aggagagcag cagcgagtcg
       61 ccgccgccgc cgcgccgagg ctggcgctga aactttgcct cgccggggac cagcgcgccc
      121 gcagcgcggc cgctccctcc gcgggggccg ccagccgagg ccgcgccgcc tccgccgagc
      181 cgcccgccgg gccgctctcg ccgcccgggc cccgcggctg ccgcagcatt cccgggaagg
      241 acagaatgac cgagaacatg aaggagtgct tggcccagac caatgcagcc gtgggggata
      301 tggtgacggt ggtgaagacg gaggtctgct caccactccg agaccaggag tatggccagc
      361 cctgctctag gagaccggac tcctcggcca tggaagttga gcccaagaaa ctgaagggga
      421 agcgcgacct catcgtgccc aaaagcttcc agcaagtgga cttctggttc tgtgagtcct
      481 gccaggagta cttcgtggat gaatgcccaa accatggccc cccggtgttt gtgtctgaca
      541 caccggtgcc cgtgggcatc ccagaccggg cggcgctcac catcccacag ggcatggagg
      601 tggtcaagga cactagtgga gagagtgacg tgcgatgtgt aaacgaggtc atccccaagg
      661 gccacatctt cggcccctat gaggggcaga tctccaccca ggacaaatca gctggcttct
      721 tctcctggct gattgtggac aagaacaacc gctataagtc catagatggc tcagacgaga
      781 ccaaagccaa ctggatgagg tacgtggtca tctcccggga ggagagggag cagaacctgc
      841 tggcgttcca gcacagtgag cgcatctact tccgggcgtg cagggacatc cggcctgggg
      901 agtggctgcg ggtctggtac agcgaggact acatgaagcg cctgcacagc atgtcccagg
      961 aaaccattca ccgcaacctg gccagaggag agaagaggtt gcagagggag aagtctgagc
     1021 aggttctgga taacccagaa gacctgaggg gtcccattca tctctctgtg ctgagacagg
     1081 gcaaaagtcc ctacaagcgt ggctttgatg agggggatgt acacccccaa gctaagaaga
     1141 agaaaattga cctgattttc aaggatgttc tggaggcctc actggaatct gcgaaggtgg
     1201 aagcccacca gttggccctg agcacctcac tggtcatcag gaaagtcccc aaataccagg
     1261 atgacgccta cagtcagtgt gcaacaacaa tgacccatgg tgtgcagaat ataggccaga
     1321 cccaggggga gggggactgg aaggtccccc agggggtctc caaggagcca ggccaattgg
     1381 aggatgaaga agaggagcct tcatcattca aggccgacag tcctgccgag gcctcccttg
     1441 catctgaccc tcatgaactt cccaccacct ctttttgccc taactgtatt cgcctaaaga
     1501 agaaggttcg ggagctccag gcagaattag acatgcttaa gtctgggaaa cttcctgagc
     1561 cccccgtatt gccaccacag gtactggagc tcccagagtt ctcggaccct gcagcctcag
     1621 aaagcatggt ctccggcccc gccatcatgg aggatgatga ccaggaagtc gattcagcag
     1681 atgaatctgt ctccaatgat atgatgacag cgacggatga gccctccaag atgtcatcgg
     1741 ccaccgggcg ccgaatccgg cgctttaagc aggaatggct gaagaagttc tggttcctgc
     1801 ggtactcccc aaccctcaat gagatgtggt gccacgtctg ccgccagtac acggtgcagt
     1861 cctcacgcac ctcggccttc atcattggct ccaagcagtt taagattcac accatcaaac
     1921 ttcacagcca gagcaacctg cacaagaagt gcctgcaact gtacaagctc cgcatgcacc
     1981 cggagaagac agaggagatg tgtcgcaaca tgaccctgct cttcaacacc gcctaccacc
     2041 tggccttgga gggcaggccc tacctggact tccggcccct ggcggagctg ctgaggaagt
     2101 gtgagctcaa ggtggtggac cagtacatga atgagggaga ctgccagatc ctcatccatc
     2161 acatcgcccg ggccctgcgg gaagacctgg tggagcgcat ccgccagtca ccttgcctca
     2221 gcgtcatcct ggatgggcag agcgacgacc tgctggccga cacggtggct gtctatgttc
     2281 agtacaccag cagtgatggg cccccggcca cagagttcct gtccctgcag gagctgggat
     2341 tctctagcac agaaagctat ctccaggcac ttgaccgggc cttctcggcc ttgggcatcc
     2401 ggttgcagga tgaaaagcca actgttggct tgggtgtaga tggagccaac atcacagcca
     2461 gcctccgtgc cagcatgttc atgaccatcc gcaagacgct gccctggctg ctgtgcctgc
     2521 ccttcatggt gcaccggccc cacctggaga tcctggatgc catcagcggg aaggagctcc
     2581 catgcctgga ggagctggag aacaacctga agcagctgct gagcttctac cgctactcac
     2641 cgcgcctcat gtgcgagctg cggtccacgg cggccaccct ttgtgaggag acagagttcc
     2701 tgggcgatat ccgggcagtg cggtggatca tcggcgagca gaacgtcctc aacgctctca
     2761 tcaaggacta cctggaggtg gtggcccatc tcaaggaggt cagcagccag acccagcggg
     2821 cagacgcctc ggccatcgca ctggccctgc tgcagttcct catggactac cagtccatca
     2881 agctcatcta cttcctgctg gacgtgattg ctgtgctctc gcgtctggcc tacatcttcc
     2941 agggcgagta cctgctggtg tcccaggtgg atgacaagat cgaggaggcc atccaggaga
     3001 tcagccggct ggctgactcc ccgggagaat acctgcagga gttcgaggag aatttccgag
     3061 agagcttcaa cgggatcgcc atgaagaacc tcagggtggc tgaagccaag ttccagtcca
     3121 tcagggagaa gatctgccag aagacccagg tcatcctggc tcagaggttc gactcccgca
     3181 gccggatctt tgtgaaggcc tgccaggtgt ttgacctggc tgcctggccc aggagcagtg
     3241 aggagctgat gagctatggc aaggaggata tggtgcaaat atttgatcac ctggaggcca
     3301 tcccgacctt ttcccgggat gtctgtaggg aagggctgga cccccggggt agtctgttga
     3361 tggagtggcg agaactcaag gctgattact acaccaaaaa tggcttcaaa gacctgatca
     3421 gccacatttg caagtacaaa cagaggtttc cactcttgaa caagatcatc caggttctta
     3481 aagtcctccc cacttccacc gcttgctgcg agaaaggccg caatgccctc cagcgagttc
     3541 gcaaaaacca ccgctcccgc ctgaccctgg agcagcttag cgacctgttg acaatcgctg
     3601 taaacggacc gccaatcacc aactttgatg ccaagcgagc cctggacagc tggtttgagg
     3661 agaagtctgg gaacagttac gcgctgtctg cagaagtcct cagtaggatg tctgcgctgg
     3721 agcagaagcc agcactacag accatggacc acgggacgga gttttacccc gacatttagg
     3781 gagctggcgc tgcagagttc actaagctgt tgaatatttt tttaatctat actcataagc
     3841 tttgatatat tatataaata tatattatat tatattatat tatattatat atatatatat
     3901 atataaactc acactgaaaa tttttaaaaa ccaaggtgac gcgtccacca gaagccactg
     3961 ggagatttca gaaaggaaaa atgttggaaa ctgactcttg tctacaaaat ttggcagctg
     4021 caacatacat ggcaactcat tttcactcac agaagcacgt gctggggcct cctgtgttcc
     4081 caccttactg tccaccaaca gcataagcta aaatgacagg tctctgtcat cacctttagg
     4141 tagctcattt tgtttatgtt ttcatttgcg ggtggcgggg ctctgggttt gggtttatgt
     4201 tcttgccttt tcttttttca tttggtttta tgatgggagg gagctcctca gcctcctcat
     4261 tgacattctg gtccggctga atcagatctc tgacttaagt cagggtgggt tgtctgtctg
     4321 catttgggag gcaggggggt tgacctttct ccctccccac ctgacttcag cttgagatct
     4381 ttttttattc atttcctgat gagggttcct tcactgtcct acaaacaaaa gtgtcggtca
     4441 aactgtgaca ctgccacacc tcacctctgt tgcctcgtcc atccctgggt tgtggatccc
     4501 ttccttccag ccccccctgg aaactcacaa tattacccat tatactgaag gcaacattgc
     4561 ctcaccgctg agcttgaaat cctggggaag ggagaagggg taagctttta gcattcctgt
     4621 ttttacgagg tggaggataa aacaatataa ttccattcca atccagggct tttggggaga
     4681 tgaagagcca agaagtccag accccaacag gggagtgatt tttggctaaa aaacaaggaa
     4741 aatgaaaagt acatattcga gttacatgga ttatttatac tttttcttta taatcatatc
     4801 atgtgttgag ggtatttttt ttcctttaat aatcaagaaa tgcctgctat agttcagtgg
     4861 caggtagtgt caatgcaaat tgtgccctaa gttatgcata actcaaatga gagtctgtag
     4921 agatgtggtc ctccttttgc aacaaggctg ataacatgct acatggtcat aggaaactgg
     4981 ggaatgtgtc tctgcctgta aactcttcct tttttgaaca gggtagagat gtcctaaaga
     5041 aatggagaaa agaagagagg actctcaagg catcagccta cacagacaca cacacacaca
     5101 cagacacaca cacacacaca gacacacaca cacacacaca atcacaatat acaatataag
     5161 ctttagaaat agccacttgc ctattccctg gggcaagtag tggtttaaac tagaggagtc
     5221 tgatcaatgc tctttcattc atttaactac cggtatacct cgcaagggag ttttaaaaaa
     5281 tgtgcgtgag ctgttaaaaa cttctgttca tgttcctaca tctgatttat gcatatttta
     5341 tatgcagaga tcctatcacg tggatgcagg tcattttggg ggagggagga agatctgaat
     5401 tatatacatg tggtcagttc tgctgagagc ttcatctctt ggttggcaga gggtggtgtt
     5461 atctggccac aggcaaggcc ccaatgtctt cagcctgctt ggttcagaca ttataaaact
     5521 gtggtggctt ccttccttct tggtttatgt tgtctctgag gcctcatgcc accgttgaga
     5581 accatagtgg aaatgtcatc aacactgaac atgttatagc cctttcttgg ttccaccagt
     5641 cccttcatcc cctaccaatc ccttcccctt cacctccatg gtcttggtgc taagataact
     5701 ttagaatcat tgctgctagt caatagcttt tcattatata aatatattat atatattata
     5761 tattattttt gaaatatttt tgtttgtttt caacagtgat gtagcatgtt aaaaaacaaa
     5821 aaacaaaaaa aaatgggttc ctccaactgt cccactgcca ggcctcatat gctgccttct
     5881 tcaacaaatc aatgcacccc tgcctggtga catccacccc acctcccacc ccagttgcac
     5941 acatgcttcc ctaccctcct ctgagcaaga agacagttag caggaactag caaggaaagg
     6001 ctgaaagcct ccttctgagg ctttgagatt cccagcccca ttccacttcc ccactttaaa
     6061 ctgatgtctc cctccatctg ctcctcccat cagggtcaaa acctaactgt ggtcaaatgg
     6121 gatgctgttg caaagcacca ggtcccacct ggcccagccc cagccttggg acttcctctc
     6181 ccctcacaca cgcaaactgc tgtgtctggg gagttttcac tgaacattgc agagactaag
     6241 aagggttgag ggcagagatg gctagcaaga cagggcttgg tgagggcaga aacagtaggt
     6301 tgagatcctt tcttctagcc aacagttgcc ttacacctta cattgggtaa tgggtaggga
     6361 ggagcaggct aaggctcccg ctcatttgaa aaccaggaag agagaaccag tgtcttcctg
     6421 agcacctggt cagttggagc tactcttttt cctctcaaga gatcatggcc aaaatgagct
     6481 aaaatcttca gctagaaggg gaaaagctta tgggccagtg ccagtgccta ccctgtagtt
     6541 cctgagaaag ctgagagcag gtgacccact tctggcctag cagaatgagc tgctatgcac
     6601 agcatgcagc tgcaggggtc acttcctgag ctggccacca gacctcggaa aagctaacct
     6661 ctcaggtggt cttgaagtta ggttagggca tccctaaaac tctgggtgct tgtggcttct
     6721 gctgaattta gccatgccag ggctgtggca gacactctgt aggccacact gccatgggac
     6781 agggaataat ttgggtgata caccactgca atttacacgg ggtctcttct cagcttggat
     6841 gctccctggg aggcccagtg cttctgtcct gtgaattctg catgtgatta cccatgattt
     6901 ctgtcatagg catttcccac tcttctgctt gcttgagaag gacttggact gatgggacac
     6961 tcagggtcta gcccagggag catatgcttg gctaacctaa tctccccttg atgtgtatac
     7021 agaactgtgg aaaagcagtt ggtggatccc aaatgttgtt acttcagaca agacagagcc
     7081 ctttaactca gcctctggct taggagtgat gactacaggc ttagaatgaa gtgtgtctct
     7141 ggggctgaga cttggcataa ctgggctggc tgattagtga ctttctttgg ctcgtagggt
     7201 tggtgggaag tgagatcaac cttgaggccc aggtttgtgg ccaactgtgc caaggtgata
     7261 cctggcagag cctgggagcc agagccctta tgattaatat gatctgcttt tccttcatgg
     7321 aggacaaaga aaaaatccac tgccatctag tatctgtgaa acatgaggac agcgcagtca
     7381 agtctgtaac tcttgccatg tcagaatccc caagttttgc ctgcctggtt gaatatgaga
     7441 gtccaggcat cagaaacagc agccttattt aatttaattt ttctaatgac tggcctatga
     7501 caccttgtga tgctaggcac atcctcattt ccccatcctc acttgggact gagagcaggc
     7561 tcaagttcca gggtccctgg atggcaaggt tcagtgctgg gccctggaat ctatggcact
     7621 tgggggtctc tgacctcagc ctctgccaca tgtttccaag ttgagttgtt ttgctgaggt
     7681 ggtcctcccc ttgagttgct tatgccaacc ctttaattta ggaaaagtac cttgtaatta
     7741 cttaaggtaa tgtttaaatg ttttccattc atttggaggt ggtgccaaca ggggggaaag
     7801 catgcagaag gctggaaaca atagctgaga ccctactgtg ggcccacagc cctggcccag
     7861 ccggcactga ggggctggtg ccatgttact tgatcacctg gagcctgatg ggacccagga
     7921 ggtggcctga ggggttgaag tataacttcc ctcttctgga tccccccttt cattttcctt
     7981 ctaccccctc taggaatggg agttctagac ctaggtctgc ttttggcttt cagtctgggt
     8041 tgatttccaa gtcgaattca tgctttttct tggcccatag gtccaatttt ggcagaaggc
     8101 attggacttg tgccccctcc ctgcttcaag aggcagatct agccaggcca ggctgaaaca
     8161 gctgaaacag gcaggccagt cctcctcaga caagaaaggg gttttcagag ggcagtggtg
     8221 tgcccattcc agacaccagt cttctgggga ggtggtgccg tgtcatgggt tctagtctgg
     8281 cctcttcctc agtcctcagg aggacccaag agactggcac ggcccttctc ctgcttggag
     8341 ggaaacccat ctcccacttg gtgggggccc ttctcttgcc atctgttggt tagggtgctt
     8401 gagctgagtg gatggtgctg tgatattttt aaggagcctt tcaggcaatg tttgcatgtt
     8461 agccagaggg agaaaaagtg cccttttggg aggaaaatgg tacgcccctc cacttccatc
     8521 tggcactccc ttccccccca ccccctcaag tggtatcacc ctggaaatac ctatgcaatc
     8581 cagtctccct aggagagagt gcatggaagc aggggtatgt gcagtgtaga atacagatgc
     8641 tacagcatat atgttgtata tatggacata tacagtacgt atacacacag agtaagagag
     8701 taaatcacgt ctatatatct ataaataata tcctatatat ttatacattt ctatgtttta
     8761 aatagatata aaaatagagt ctatagagct gggagagcag tgggaagcct ggcgctgtgc
     8821 tgtgcaaagg ggaagggagc acggccttcg gagagggagc cggggaaggc cagcaggcag
     8881 ggttggctgg caagggggcc tcctacccgg agtgttggag aggagagtgg ctgggtcccg
     8941 gctcgctcca tgcactttct ctccttttcc acaggcttgg tctgaggttg gaaggagata
     9001 ccccctgagc tccagctgag gtgcccccta cctctcccca cccccacagc ccacgcttag
     9061 gcggtcactg ctgcttggca gtaggacgtg gtctctgact cctggtggag ggaccactgc
     9121 acaaactcct tcaaaaccct cccgcaccag gactgagcag cgtcagtggc aataggaaag
     9181 gtccaaactg gatcaagagc tggtccagga aagataccgc ccctgccctg ttagatgctt
     9241 ctgctgcccc tagaggccaa gcccctgaag tgcagccgtc ctggcctccc tcacttgctc
     9301 aaccactgtc aggaggagag gatgtgggca gcatgagcat cgccaggcag cgctgcccac
     9361 catccacagg ctttctggcc agggcagggg gcatcagcta gcaggaaacg gtgggagaga
     9421 catatctgca cactcataaa ttcaatggct actccagtcc agaagcaggg ctttggccca
     9481 gcccgctccg cgcagcagct gctgctggct gtactcagga caacgctgtt ccccctccct
     9541 cacagaggcc ccgtggcccc taccccactc ccgccgtaac aggcaggttt agttcacata
     9601 cactgttcgc attctgtgac ttgaggcaga ggctgagctg ggatacccca agctcatcca
     9661 ctttcgttgg ggagggcccc tccctgggtt tatcaccagc tcctagcccg ggccgggcgg
     9721 ggatgtctgg gggccacgcg ggggcactgg tgcaagctgg cagcatgaca gagggcttgt
     9781 gcagccctga cgggacccag aagcccattt gctcgcagtt tcctctctct gtttttttcc
     9841 tcctggaggt aggagagagg gcctgaccag gcaccagatg atggagcaag ggcagctgca
     9901 tgctccctct ctccagacca gccttctgct tttggggtcc gaaggggcat ttgctcccat
     9961 cctgagcctc ctctgcccct gtcttgctct tccccaccat cctacaagta cctcagtctc
    10021 cagcaggccc acccctccac ctgcagccca gggcgggtct gttctgccaa tgcccacctc
    10081 cttgagccac agttagctgc caactgggtc ttgggacacc ctccagtacc tggctcaaga
    10141 gagaccaggc cgggccgagc cttcttccca ctgcagtgga ctagacccac ggccagggga
    10201 tgggcatccc caggtagcaa tcccacaatg cactgtacct cagagagaga gcacgccagg
    10261 ggcaccaagg gaccgagccc tctgtccaga gggggacagc ggtcacaata ctgctcacca
    10321 aaagacaaag gccaggctgc cctcgggcac ctctcagtct tcacttttgt ctctccggaa
    10381 gaaccagcag tctgattccg tctatttcag cccccgtctc tctcttctcc acccccacgc
    10441 tgctgaacca ttttcatgtc aatcacaaag gaaaaataag tggggatggg gggaaatacc
    10501 taggagtcta ttatcacata catattaata tgttaatact ttctttaaaa aaaacctctt
    10561 gatgttatta ttttgcagac tacgctttat agtacctgtg tgacgggacc tagaacactg
    10621 gatacaaata gagctatgtt ggtttatcat aatatgtacg cagaaacttt ctttttgtca
    10681 tattatcctt gtaatgtaag aagattgtta ataaaagcat ttaaattta
//
