LOCUS       NM_001256696            1859 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens PR/SET domain 11 (PRDM11), transcript variant 2, mRNA.
ACCESSION   NM_001256696 XM_003118628 XM_003119496
VERSION     NM_001256696.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1859)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1859)
  AUTHORS   Fog,C.K., Asmar,F., Come,C., Jensen,K.T., Johansen,J.V.,
            Kheir,T.B., Jacobsen,L., Friis,C., Louw,A., Rosgaard,L., Obro,N.F.,
            Marquart,H.V., Anthonsen,K., Braat,A.K., van Lohuizen,M.,
            Ralfkiaer,E., Gronbaek,K. and Lund,A.H.
  TITLE     Loss of PRDM11 promotes MYC-driven lymphomagenesis
  JOURNAL   Blood 125 (8), 1272-1281 (2015)
   PUBMED   25499759
  REMARK    GeneRIF: We characterize PRDM11 as a putative novel tumor
            suppressor that controls the expression of key oncogenes, and we
            add new mechanistic insight into B-cell lymphomagenesis.
REFERENCE   3  (bases 1 to 1859)
  AUTHORS   Loth,D.W., Soler Artigas,M., Gharib,S.A., Wain,L.V.,
            Franceschini,N., Koch,B., Pottinger,T.D., Smith,A.V., Duan,Q.,
            Oldmeadow,C., Lee,M.K., Strachan,D.P., James,A.L., Huffman,J.E.,
            Vitart,V., Ramasamy,A., Wareham,N.J., Kaprio,J., Wang,X.Q.,
            Trochet,H., Kahonen,M., Flexeder,C., Albrecht,E., Lopez,L.M., de
            Jong,K., Thyagarajan,B., Alves,A.C., Enroth,S., Omenaas,E.,
            Joshi,P.K., Fall,T., Vinuela,A., Launer,L.J., Loehr,L.R.,
            Fornage,M., Li,G., Wilk,J.B., Tang,W., Manichaikul,A., Lahousse,L.,
            Harris,T.B., North,K.E., Rudnicka,A.R., Hui,J., Gu,X., Lumley,T.,
            Wright,A.F., Hastie,N.D., Campbell,S., Kumar,R., Pin,I.,
            Scott,R.A., Pietilainen,K.H., Surakka,I., Liu,Y., Holliday,E.G.,
            Schulz,H., Heinrich,J., Davies,G., Vonk,J.M., Wojczynski,M.,
            Pouta,A., Johansson,A., Wild,S.H., Ingelsson,E., Rivadeneira,F.,
            Volzke,H., Hysi,P.G., Eiriksdottir,G., Morrison,A.C., Rotter,J.I.,
            Gao,W., Postma,D.S., White,W.B., Rich,S.S., Hofman,A., Aspelund,T.,
            Couper,D., Smith,L.J., Psaty,B.M., Lohman,K., Burchard,E.G.,
            Uitterlinden,A.G., Garcia,M., Joubert,B.R., McArdle,W.L.,
            Musk,A.B., Hansel,N., Heckbert,S.R., Zgaga,L., van Meurs,J.B.,
            Navarro,P., Rudan,I., Oh,Y.M., Redline,S., Jarvis,D.L., Zhao,J.H.,
            Rantanen,T., O'Connor,G.T., Ripatti,S., Scott,R.J., Karrasch,S.,
            Grallert,H., Gaddis,N.C., Starr,J.M., Wijmenga,C., Minster,R.L.,
            Lederer,D.J., Pekkanen,J., Gyllensten,U., Campbell,H., Morris,A.P.,
            Glaser,S., Hammond,C.J., Burkart,K.M., Beilby,J., Kritchevsky,S.B.,
            Gudnason,V., Hancock,D.B., Williams,O.D., Polasek,O., Zemunik,T.,
            Kolcic,I., Petrini,M.F., Wjst,M., Kim,W.J., Porteous,D.J.,
            Scotland,G., Smith,B.H., Viljanen,A., Heliovaara,M., Attia,J.R.,
            Sayers,I., Hampel,R., Gieger,C., Deary,I.J., Boezen,H.M.,
            Newman,A., Jarvelin,M.R., Wilson,J.F., Lind,L., Stricker,B.H.,
            Teumer,A., Spector,T.D., Melen,E., Peters,M.J., Lange,L.A.,
            Barr,R.G., Bracke,K.R., Verhamme,F.M., Sung,J., Hiemstra,P.S.,
            Cassano,P.A., Sood,A., Hayward,C., Dupuis,J., Hall,I.P.,
            Brusselle,G.G., Tobin,M.D. and London,S.J.
  TITLE     Genome-wide association analysis identifies six new loci associated
            with forced vital capacity
  JOURNAL   Nat Genet 46 (7), 669-677 (2014)
   PUBMED   24929828
REFERENCE   4  (bases 1 to 1859)
  AUTHORS   Porcu,E., Medici,M., Pistis,G., Volpato,C.B., Wilson,S.G.,
            Cappola,A.R., Bos,S.D., Deelen,J., den Heijer,M., Freathy,R.M.,
            Lahti,J., Liu,C., Lopez,L.M., Nolte,I.M., O'Connell,J.R.,
            Tanaka,T., Trompet,S., Arnold,A., Bandinelli,S., Beekman,M.,
            Bohringer,S., Brown,S.J., Buckley,B.M., Camaschella,C., de
            Craen,A.J., Davies,G., de Visser,M.C., Ford,I., Forsen,T.,
            Frayling,T.M., Fugazzola,L., Gogele,M., Hattersley,A.T.,
            Hermus,A.R., Hofman,A., Houwing-Duistermaat,J.J., Jensen,R.A.,
            Kajantie,E., Kloppenburg,M., Lim,E.M., Masciullo,C., Mariotti,S.,
            Minelli,C., Mitchell,B.D., Nagaraja,R., Netea-Maier,R.T.,
            Palotie,A., Persani,L., Piras,M.G., Psaty,B.M., Raikkonen,K.,
            Richards,J.B., Rivadeneira,F., Sala,C., Sabra,M.M., Sattar,N.,
            Shields,B.M., Soranzo,N., Starr,J.M., Stott,D.J., Sweep,F.C.,
            Usala,G., van der Klauw,M.M., van Heemst,D., van Mullem,A.,
            Vermeulen,S.H., Visser,W.E., Walsh,J.P., Westendorp,R.G., Widen,E.,
            Zhai,G., Cucca,F., Deary,I.J., Eriksson,J.G., Ferrucci,L.,
            Fox,C.S., Jukema,J.W., Kiemeney,L.A., Pramstaller,P.P.,
            Schlessinger,D., Shuldiner,A.R., Slagboom,E.P., Uitterlinden,A.G.,
            Vaidya,B., Visser,T.J., Wolffenbuttel,B.H., Meulenbelt,I.,
            Rotter,J.I., Spector,T.D., Hicks,A.A., Toniolo,D., Sanna,S.,
            Peeters,R.P. and Naitza,S.
  TITLE     A meta-analysis of thyroid-related traits reveals novel loci and
            gender-specific differences in the regulation of thyroid function
  JOURNAL   PLoS Genet 9 (2), e1003266 (2013)
   PUBMED   23408906
REFERENCE   5  (bases 1 to 1859)
  AUTHORS   Xiao,B., Wilson,J.R. and Gamblin,S.J.
  TITLE     SET domains and histone methylation
  JOURNAL   Curr Opin Struct Biol 13 (6), 699-705 (2003)
   PUBMED   14675547
  REMARK    Review article
REFERENCE   6  (bases 1 to 1859)
  AUTHORS   Jiang,G.L. and Huang,S.
  TITLE     The yin-yang of PR-domain family genes in tumorigenesis
  JOURNAL   Histol Histopathol 15 (1), 109-117 (2000)
   PUBMED   10668202
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103681.4.
            
            On Jun 23, 2020 this sequence version replaced NM_001256696.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094792.1, SRR14372080.4332832.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145313, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC103681.4         134696-134934       c
            240-364             AC103681.4         100392-100516       c
            365-468             AC103681.4         99928-100031        c
            469-731             AC103681.4         99154-99416         c
            732-799             AC103681.4         77499-77566         c
            800-987             AC103681.4         62520-62707         c
            988-1859            AC103681.4         57189-58060         c
FEATURES             Location/Qualifiers
     source          1..1859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..1859
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /note="PR/SET domain 11"
                     /db_xref="GeneID:56981"
                     /db_xref="HGNC:HGNC:13996"
                     /db_xref="MIM:616347"
     exon            1..239
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     exon            240..364
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1679
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /note="isoform 2 is encoded by transcript variant 2;
                     PR-domain containing protein 11"
                     /codon_start=1
                     /product="PR domain-containing protein 11 isoform 2"
                     /protein_id="NP_001243625.1"
                     /db_xref="CCDS:CCDS58130.1"
                     /db_xref="GeneID:56981"
                     /db_xref="HGNC:HGNC:13996"
                     /db_xref="MIM:616347"
                     /translation="MTENMKECLAQTNAAVGDMVTVVKTEVCSPLRDQEYGQPCSRRP
                     DSSAMEVEPKKLKGKRDLIVPKSFQQVDFWFCESCQEYFVDECPNHGPPVFVSDTPVP
                     VGIPDRAALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFS
                     WLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPG
                     EWLRVWYSEDYMKRLHSMSQETIHRNLARGEKRLQREKSEQVLDNPEDLRGPIHLSVL
                     RQGKSPYKRGFDEGDVHPQAKKKKIDLIFKDVLEASLESAKVEAHQLALSTSLVIRKV
                     PKYQDDAYSQCATTMTHGVQNIGQTQGEGDWKVPQGVSKEPGQLEDEEEEPSSFKADS
                     PAEASLASDPHELPTTSFCPNCIRLKKKVRELQAELDMLKSGKLPEPPVLPPQVLELP
                     EFSDPAGKLVWMRLLSEGRVRSGLCGG"
     exon            365..468
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     exon            469..731
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     exon            732..799
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     exon            800..987
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1859
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1839..1844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /note="hexamer: AATAAA"
     polyA_site      1859
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /note="major polyA site"
ORIGIN      
        1 agttctcgcg gacgccctcg gccccgcgcc gggggctgct gcggggtgct cggggatgaa
       61 ggtgggaggc gtcctttggg atgcgacgaa gccttctcca tcgcggttcg cgattgcccg
      121 cgaagcgtgg ccgagccgga gggcatttct ggaatgcgtt ttaagtgtca gttgcggtgt
      181 agactcttcg ggaaacctct ccggagcgta gcctccaccc cccactcgca gtccccaagg
      241 acagaatgac cgagaacatg aaggagtgct tggcccagac caatgcagcc gtgggggata
      301 tggtgacggt ggtgaagacg gaggtctgct caccactccg agaccaggag tatggccagc
      361 cctgctctag gagaccggac tcctcggcca tggaagttga gcccaagaaa ctgaagggga
      421 agcgcgacct catcgtgccc aaaagcttcc agcaagtgga cttctggttc tgtgagtcct
      481 gccaggagta cttcgtggat gaatgcccaa accatggccc cccggtgttt gtgtctgaca
      541 caccggtgcc cgtgggcatc ccagaccggg cggcgctcac catcccacag ggcatggagg
      601 tggtcaagga cactagtgga gagagtgacg tgcgatgtgt aaacgaggtc atccccaagg
      661 gccacatctt cggcccctat gaggggcaga tctccaccca ggacaaatca gctggcttct
      721 tctcctggct gattgtggac aagaacaacc gctataagtc catagatggc tcagacgaga
      781 ccaaagccaa ctggatgagg tacgtggtca tctcccggga ggagagggag cagaacctgc
      841 tggcgttcca gcacagtgag cgcatctact tccgggcgtg cagggacatc cggcctgggg
      901 agtggctgcg ggtctggtac agcgaggact acatgaagcg cctgcacagc atgtcccagg
      961 aaaccattca ccgcaacctg gccagaggag agaagaggtt gcagagggag aagtctgagc
     1021 aggttctgga taacccagaa gacctgaggg gtcccattca tctctctgtg ctgagacagg
     1081 gcaaaagtcc ctacaagcgt ggctttgatg agggggatgt acacccccaa gctaagaaga
     1141 agaaaattga cctgattttc aaggatgttc tggaggcctc actggaatct gcgaaggtgg
     1201 aagcccacca gttggccctg agcacctcac tggtcatcag gaaagtcccc aaataccagg
     1261 atgacgccta cagtcagtgt gcaacaacaa tgacccatgg tgtgcagaat ataggccaga
     1321 cccaggggga gggggactgg aaggtccccc agggggtctc caaggagcca ggccaattgg
     1381 aggatgaaga agaggagcct tcatcattca aggccgacag tcctgccgag gcctcccttg
     1441 catctgaccc tcatgaactt cccaccacct ctttttgccc taactgtatt cgcctaaaga
     1501 agaaggttcg ggagctccag gcagaattag acatgcttaa gtctgggaaa cttcctgagc
     1561 cccccgtatt gccaccacag gtactggagc tcccagagtt ctcggaccct gcaggtaagt
     1621 tggtttggat gagattattg tcggagggca gagtacgcag tgggctgtgt ggagggtagc
     1681 ctaaagctct ctgtggaaac caccttccgg gagacctgag gagtgtaacg tggaggcggc
     1741 tacctccgtg ggtgggagcc caggtcctca gtgtctctgg cagacccatc ggcagctctg
     1801 ccaggtgctc catgtgttgc ccttgtatcc tccttgtcaa taaaggaagt tccgctgca
//
