LOCUS       NM_001367899            6005 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens PR/SET domain 10 (PRDM10), transcript variant 8, mRNA.
ACCESSION   NM_001367899
VERSION     NM_001367899.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6005)
  AUTHORS   Li,L., Hongying,C. and Heng,G.
  TITLE     Autophagy-related LncRNA PRDM10-DT responds to UVB radiation in
            keratinocytes
  JOURNAL   Biochem Biophys Res Commun 677, 105-112 (2023)
   PUBMED   37566921
  REMARK    GeneRIF: Autophagy-related LncRNA PRDM10-DT responds to UVB
            radiation in keratinocytes.
REFERENCE   2  (bases 1 to 6005)
  AUTHORS   Schmidt,L.S., Vocke,C.D., Ricketts,C.J., Blake,Z., Choo,K.K.,
            Nielsen,D., Gautam,R., Crooks,D.R., Reynolds,K.L., Krolus,J.L.,
            Bashyal,M., Karim,B., Cowen,E.W., Malayeri,A.A., Merino,M.J.,
            Srinivasan,R., Ball,M.W., Zbar,B. and Marston Linehan,W.
  TITLE     PRDM10 RCC: A Birt-Hogg-Dube-like Syndrome Associated With Lipoma
            and Highly Penetrant, Aggressive Renal Tumors Morphologically
            Resembling Type 2 Papillary Renal Cell Carcinoma
  JOURNAL   Urology 179, 58-70 (2023)
   PUBMED   37331486
  REMARK    GeneRIF: PRDM10 RCC: A Birt-Hogg-Dube-like Syndrome Associated With
            Lipoma and Highly Penetrant, Aggressive Renal Tumors
            Morphologically Resembling Type 2 Papillary Renal Cell Carcinoma.
REFERENCE   3  (bases 1 to 6005)
  AUTHORS   Zhao,M., Yin,X., He,H., Fan,Y., Ru,G. and Meng,X.
  TITLE     Recurrent PRDM10 Fusions in Superficial CD34-Positive Fibroblastic
            Tumors : A Clinicopathologic and Molecular Study of 10 Additional
            Cases of an Emerging Novel Entity
  JOURNAL   Am J Clin Pathol 159 (4), 367-378 (2023)
   PUBMED   36812381
  REMARK    GeneRIF: Recurrent PRDM10 Fusions in Superficial CD34-Positive
            Fibroblastic Tumors : A Clinicopathologic and Molecular Study of 10
            Additional Cases of an Emerging Novel Entity.
REFERENCE   4  (bases 1 to 6005)
  AUTHORS   van de Beek,I., Glykofridis,I.E., Oosterwijk,J.C., van den
            Akker,P.C., Diercks,G.F.H., Bolling,M.C., Waisfisz,Q.,
            Mensenkamp,A.R., Balk,J.A., Zwart,R., Postma,A.V.,
            Meijers-Heijboer,H.E.J., van Moorselaar,R.J.A., Wolthuis,R.M.F. and
            Houweling,A.C.
  TITLE     PRDM10 directs FLCN expression in a novel disorder overlapping with
            Birt-Hogg-Dube syndrome and familial lipomatosis
  JOURNAL   Hum Mol Genet 32 (7), 1223-1235 (2023)
   PUBMED   36440963
  REMARK    GeneRIF: PRDM10 directs FLCN expression in a novel disorder
            overlapping with Birt-Hogg-Dube syndrome and familial lipomatosis.
REFERENCE   5  (bases 1 to 6005)
  AUTHORS   Hofvander,J., Puls,F., Pillay,N., Steele,C.D., Flanagan,A.M.,
            Magnusson,L., Nilsson,J. and Mertens,F.
  TITLE     Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a
            distinct gene expression profile
  JOURNAL   J Pathol 249 (4), 425-434 (2019)
   PUBMED   31313299
  REMARK    GeneRIF: PRDM10-fusions represent the critical driver mutations in
            undifferentiated pleomorphic sarcomas.
REFERENCE   6  (bases 1 to 6005)
  AUTHORS   Schrors,B., Lubcke,S., Lennerz,V., Fatho,M., Bicker,A., Wolfel,C.,
            Derigs,P., Hankeln,T., Schadendorf,D., Paschen,A. and Wolfel,T.
  TITLE     HLA class I loss in metachronous metastases prevents continuous T
            cell recognition of mutated neoantigens in a human melanoma model
  JOURNAL   Oncotarget 8 (17), 28312-28327 (2017)
   PUBMED   28423700
REFERENCE   7  (bases 1 to 6005)
  AUTHORS   Hofvander,J., Tayebwa,J., Nilsson,J., Magnusson,L., Brosjo,O.,
            Larsson,O., Vult von Steyern,F., Mandahl,N., Fletcher,C.D. and
            Mertens,F.
  TITLE     Recurrent PRDM10 gene fusions in undifferentiated pleomorphic
            sarcoma
  JOURNAL   Clin Cancer Res 21 (4), 864-869 (2015)
   PUBMED   25516889
  REMARK    GeneRIF: Our results suggest that PRDM10 fusions are present in
            around 5% of Undifferentiated pleomorphic sarcoma
REFERENCE   8  (bases 1 to 6005)
  AUTHORS   Bhatti,P., Doody,M.M., Rajaraman,P., Alexander,B.H., Yeager,M.,
            Hutchinson,A., Burdette,L., Thomas,G., Hunter,D.J., Simon,S.L.,
            Weinstock,R.M., Rosenstein,M., Stovall,M., Preston,D.L.,
            Linet,M.S., Hoover,R.N., Chanock,S.J. and Sigurdson,A.J.
  TITLE     Novel breast cancer risk alleles and interaction with ionizing
            radiation among U.S. radiologic technologists
  JOURNAL   Radiat Res 173 (2), 214-224 (2010)
   PUBMED   20095854
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 6005)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 6005)
  AUTHORS   Siegel,D.A., Huang,M.K. and Becker,S.F.
  TITLE     Ectopic dendrite initiation: CNS pathogenesis as a model of CNS
            development
  JOURNAL   Int J Dev Neurosci 20 (3-5), 373-389 (2002)
   PUBMED   12175877
  REMARK    Erratum:[Int J Dev Neurosci. 2003 May;21(3):169-70]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003326.2, BC143612.1 and
            AP003327.3.
            
            Summary: The protein encoded by this gene is a transcription factor
            that contains C2H2-type zinc-fingers. It also contains a positive
            regulatory domain, which has been found in several other
            zinc-finger transcription factors including those involved in B
            cell differentiation and tumor suppression. Studies of the mouse
            counterpart suggest that this protein may be involved in the
            development of the central nerve system (CNS), as well as in the
            pathogenesis of neuronal storage disease. Multiple alternatively
            spliced transcript variants encoding distinct isoforms have been
            observed. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.204470.1, BC117415.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AP003326.2         45920-46042         c
            124-3431            BC143612.1         1-3308
            3432-6005           AP003327.3         149395-151968       c
FEATURES             Location/Qualifiers
     source          1..6005
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..6005
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="PR/SET domain 10"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
     exon            1..440
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..3403
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="isoform 8 is encoded by transcript variant 8; PRDM
                     zinc finger transcription factor; PR-domain family member
                     7; PR domain zinc finger protein 10; tristanin; PR
                     domain-containing protein 10; PR domain containing 10; PR
                     domain 10"
                     /codon_start=1
                     /product="PR domain zinc finger protein 10 isoform 8"
                     /protein_id="NP_001354828.1"
                     /db_xref="CCDS:CCDS91624.1"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
                     /translation="MSAYSVPSTFAQASLPVHNQVLPSIESVDGSDPLATLQTPLGRL
                     EAKEEEDEDEDEDTEEDEEEDGEDTDLDDWEPDPPRPFDPHDLWCEECNNAHASVCPK
                     HGPLHPIPNRPVLTRARASLPLVLYIDRFLGGVFSKRRIPKRTQFGPVEGPLVRGSEL
                     KDCYIHLKVSLDKGDRKERDLHEDLWFELSDETLCNWMMFVRPAQNHLEQNLVAYQYG
                     HHVYYTTIKNVEPKQELKVWYAASYAEFVNQKIHDISEEERKVLREQEKNWPCYECNR
                     RFISSEQLQQHLNSHDEKLDVFSRTRGRGRGRGKRRFGPGRRPGRPPKFIRLEITSEN
                     GEKSDDGTQDLLHFPTKEQFDEAEPATLNGLDQPEQTTIPIPQLPQETQSSLEHEPET
                     HTLHLQPQHEESVVPTQSTLTADDMRRAKRIRLELQNAALQHLFIRKSFRPFKCLQCG
                     KAFREKDKLDQHLRFHGREGNCPLTCDLCNKGFISSTSLESHMKLHSDQKTYSCIFCP
                     ESFDRLDLLKDHVAIHINDGYFTCPTCKKRFPDFIQVKKHVRSFHSEKIYQCTECDKA
                     FCRPDKLRLHMLRHSDRKDFLCSTCGKQFKRKDKLREHMQRMHNPEREAKKADRISRS
                     KTFKPRITSTDYDSFTFKCRLCMMGFRRRGMLVNHLSKRHPDMKIEEVPELTLPIIKP
                     NRDYFCQYCDKVYKSASKRKAHILKNHPGAELPPSIRKLRPAGPGEPDPMLSTHTQLT
                     GTIATPPVCCPHCSKQYSSKTKMVQHIRKKHPEFAQLSNTIHTPLTTAVISATPAVLT
                     TDSATGETVVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHI
                     QLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHAIQVQHIQVSEPTASAPSSAQVS
                     GQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQNSSVQHTYLPSAWNSFRGY
                     SSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVLSESQSELEEKQTSALSGG
                     VQVEPPAHSDSLDPQTNSQQQTTQYIITTTTNGNGSSEVHITKP"
     exon            441..682
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            683..886
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            887..959
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1077
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1207
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1450
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1462
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1810
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1966
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2146
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2257
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2458
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2773
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2914
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3095
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3199
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..6005
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5966..5971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="hexamer: AATATA"
     regulatory      5978..5983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="hexamer: AATAAA"
     polyA_site      5983
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="major polyA site"
     polyA_site      6005
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="major polyA site"
ORIGIN      
        1 gcagaggctt aaaggctgtg agcagtcaga tcaaaaatga agccagctct tcctcacagc
       61 cggtagatgg aagtcatttt tccagggcct ggaaggagtt ggtaggaaga ctagatttca
      121 gccagccctt gcgccctgtt tgtgccagca ggcaccagcg aaccaaaagc aggtgtccat
      181 gtctgcttac tctgtgcctt caacttttgc ccaggcctca ttgccagttc ataaccaggt
      241 gctgccttcc atcgagagtg tagatgggtc cgaccctttg gcaactctgc agacccctct
      301 aggcagactg gaggccaaag aggaagagga tgaggatgag gacgaggaca ctgaggaaga
      361 tgaggaagaa gacggtgagg acacggatct ggatgactgg gagccagacc cgccccggcc
      421 cttcgaccca cacgacttgt ggtgtgagga gtgcaataac gcgcatgctt cagtgtgtcc
      481 gaagcacggc cccttgcacc cgatccccaa ccggccggtg ctcacccggg ccagggcgag
      541 cctccccctg gtgctctaca tagacaggtt tctgggcggg gtgttctcca agcggcgcat
      601 ccccaagcgc acccagtttg gccccgtgga ggggcctctc gtcaggggct cggagctgaa
      661 agactgttac attcacctca aggtttctct tgataaaggg gacaggaaag aaagggattt
      721 acatgaagac ctatggtttg agttgtctga tgagacgctt tgtaactgga tgatgtttgt
      781 acggccagcc cagaatcacc tggagcagaa cctggtggct taccagtatg gccaccatgt
      841 gtattataca accataaaaa atgtggagcc caagcaggaa ctgaaggtgt ggtatgccgc
      901 atcctatgct gagttcgtga accagaaaat tcatgacatt tctgaggaag aaaggaaagt
      961 tcttcgagag caagagaaga attggccctg ctatgaatgt aaccgccgat ttataagctc
     1021 ggagcagttg caacagcatc tcaattctca tgatgagaaa ctagatgtgt ttagcagaac
     1081 aagaggcaga ggaaggggac gaggcaagag gcgattcggt ccaggtcgac ggccggggcg
     1141 tcctccaaaa tttatccgcc tggaaatcac cagcgaaaat ggggaaaaga gtgacgatgg
     1201 gacacaggac ttgctacatt ttcccacaaa ggagcaattt gatgaggctg aaccagccac
     1261 tctgaatggg ctggatcaac cagaacagac cactatccca atccctcagc tgccacagga
     1321 aacccagtct tccctggaac atgaaccaga aactcacacc ctgcacctgc agccgcagca
     1381 tgaagagagc gtggtgccca cccagagcac gctgacagcc gacgacatgc gcagagccaa
     1441 gcgcatccga ttggagctgc agaatgcagc tcttcagcat ctgtttattc ggaagtcctt
     1501 ccggcctttt aaatgcttgc agtgtgggaa ggccttccgg gaaaaggaca aactggacca
     1561 gcacttacgc ttccatgggc gggaggggaa ctgcccactg acctgtgatc tctgtaacaa
     1621 gggcttcatc agcagcacat ccttggagag ccacatgaag ctccactcag accagaagac
     1681 ttactcttgc attttttgcc cagaatcctt tgaccgcctt gatttgttga aagatcatgt
     1741 ggccattcat atcaatgatg gctacttcac ctgcccaact tgtaagaaac ggttcccaga
     1801 ttttatccag gtgaaaaaac acgtgcgcag cttccactca gaaaagatct accagtgcac
     1861 agagtgtgac aaggccttct gtcgccccga taaactgcga ctccacatgc tccggcattc
     1921 ggaccgcaaa gacttcctgt gttccacctg tgggaagcaa tttaagcgaa aagacaaact
     1981 acgggaacac atgcagagga tgcataatcc tgagagggag gccaagaaag ccgaccgcat
     2041 cagccgctcc aagacgttca agccccgcat cacgtccaca gactacgaca gcttcacgtt
     2101 caagtgccgc ctgtgcatga tgggcttccg gcggcgcggc atgctggtaa atcacttatc
     2161 gaagagacac ccagacatga agatagaaga ggtgccagag ttaactctac ccatcataaa
     2221 acccaatcgt gattactttt gtcagtattg cgataaggtt tataaaagtg ccagcaagcg
     2281 caaagcccac attctgaaga accacccagg agcagagctc ccaccgagca ttcggaagct
     2341 ccgacccgct ggtcctggag agccagaccc catgctgagc acacacaccc agctgacggg
     2401 caccatcgcc acccctcccg tctgctgtcc ccactgctcc aagcagtaca gcagcaagac
     2461 caagatggtc cagcacattc gaaagaagca tccagagttc gcccagctct ccaacaccat
     2521 acacacacca ctgacgacag ctgtgatcag tgccacccca gcggttttga ctacagacag
     2581 cgccactgga gagactgtgg tgacgacgga cctgctcacc caagcaatga cagaactgtc
     2641 ccagacctta acgacagact accgaacgcc acaaggggat taccagagaa ttcagtacat
     2701 ccctgtgtcg cagtcggcgt ctggcctcca gcagcctcag cacatacagc tgcaagtggt
     2761 tcaagtggcc tcggccactt cccctcacca gtcacagcag tccactgtgg atgttggcca
     2821 gctccatgat cctcagccct acccccagca cgccatccag gtgcagcaca tccaggtcag
     2881 cgagcctacc gcctcggccc cgtcctccgc ccaggtatct gggcagccgt tgagtccctc
     2941 agcccagcag gctcagcagg ggctcagccc ctcccacatc cagggcagtt cttccacaca
     3001 ggggcaggct ctgcagcagc agcagcagca gcagcagaat tcctctgtgc agcacacgta
     3061 cctgcccagt gcttggaatt ccttccgtgg ctattcatct gagattcaaa tgatgacgct
     3121 tcctccgggt cagtttgtga ttacagacag tggtgtggca actccagtta ctactggcca
     3181 ggtgaaggcg gttacttcgg gtcattatgt gttatcagaa agtcaatcag aattggaaga
     3241 aaagcaaact tctgccctct ctggtggagt ccaggtcgag ccacctgcac acagtgactc
     3301 cctggacccc cagaccaaca gccaacagca gaccacacag tacatcatca ccaccaccac
     3361 caacgggaac ggaagcagcg aagtgcatat caccaaacca tgacttccac cctggagctt
     3421 gaatccagca cccacctcat gtctgttctc ataagtctga aagctctgac acgtagagct
     3481 cttttgtaag atttattatt cactcaagag ttcggaaacc acagttttgt ctctcatcca
     3541 tacactgggg tttattttgc caaggtcatc tttatcaaat tgactcttca aaccctcggt
     3601 ttttgccaca gaacagagat ctttcagggg aaagtagatt tcgaggtgga gagaatttgc
     3661 cttgctcttg agctggtctt ttaacatact gacgagcctt acttttcctt tgtggaaata
     3721 ttaagtggca tattgtgttc ataccaaagg tggagacagg atgtgccaag ttcatggtta
     3781 ctggacttct tattccaagc catggcacca aaggagaagg ggcattttgt gggtgtgcat
     3841 taggtctgaa ctgctttatc ttgttttagt tttcagtaat ttaacaaagg gagcctgctg
     3901 aataacaaaa ttaaaatgat gaaacaaaag tttgacagtg atattctgaa gcaaaaactg
     3961 tcatctaaat ttttcttgct gatttttttt aacttcccta ttttagaaaa ctattgttgg
     4021 gctgttggta gtgctttcca cagatgctgg tcctcagtgg attaggtcag aagctcatgt
     4081 tctgatagtt cttcattatt tcacaaaggt ggacaacctg aaagagaaaa ggctgcttga
     4141 tgtcagcaga atctaaaccc ctacattaaa gctttgcctc ccattctgtg gttgtggtgg
     4201 tggtaagaag gagatattgg taccaagaaa aatttccaaa actattgaga gagagagaga
     4261 gaaagtattg aaattttgtt ctgccttgca ggatccattt atcattcatt ggtaaaggat
     4321 atattccttg ttcttaccaa gtgtacattt aactcttgct gacatgttca gtgtatttta
     4381 ttacttttaa tgctgtctta aaatgaacat tctttaaagt tggacaggaa ggtggcattt
     4441 cttatttatt aacattttta actttaaaca tattgtgact catctagacc ttttaataag
     4501 acggtcaact tcacacttag ggaaaaaatt aaaatgtgat ggccacttct aataattcag
     4561 gtagttataa gggatctgga agaaatccag tctttatgaa tatactatta gttgggcatt
     4621 aaaaaatcag tatatatttt aactttttgt gacatgctaa cacattttca gaataattat
     4681 tgcatagtag aatttattac tccagaacag aaagacctta cttcatttca aatgaagtta
     4741 attaatttac atttctgggt aaaaactggt tctataaatt aagtagagta gcttctttat
     4801 gataaagaca attttctgaa aagtgaacaa ttctgttaaa agaactttat tgatgtgtag
     4861 atttcgcact ttatttctga gactgcgttc atgtagttgt tccccaatgt ttgagtacta
     4921 agagaacttg agaaaattac ttcataaaca tatggaaact gaaaatggac tctctttgtg
     4981 acaaagatat tcaacagaaa atattgaccc tgcattgcaa aacacaggtt cgggttccct
     5041 aagtcccaca gtgtaatgat tacaaatatc ctagtgtccg gtctagaaag actttctagg
     5101 agaagactag tggaattttc taaaggttca gttttagctt ttataactta aatttggccc
     5161 tgttacgttc tttttaattt gaaccataag gtatctcccc tcccttcagg aataacttat
     5221 tggaaaactg aaaagaatca ctgaatggaa tgttcatttt atggcagttg ttttaagttt
     5281 taaaatacac agaggaaaat attgtggaag gacctctttg ttgctttccc ttctaagttg
     5341 tcttcttctt cttcttcttc ttcttcttct ttggtcctta agtgaaataa agactctaaa
     5401 actaatttgt atattatcag ccagagatgc ggatggcagt cgagccaaat cgcatggctt
     5461 tcagatcagg tattctgcac attcattcca aggtcataga tttttaaaag gacctggatt
     5521 tgaagagatg gcaaatgatg agccatcaga aaacttaatt tggaaaacat gtatgtagcc
     5581 agtgtggata ttgtggcctc tctcaagaca cattgacact gtagacttca ttcagtccag
     5641 tgtgagtatt ttggagtagg ttggatgtag attttgtttt tatcattgat ttgtaccgac
     5701 agaaatagac atttcatcat gtaaaattcc tgttattctg gaaaaaccta ttgttttgat
     5761 cttcttgttt tctgacttgg aagtatcctt tcaaaaaaac tcttaagata tctaggtcta
     5821 aaaagcactt catgagatgc taaagctgac ccactggttg aaaatgttga ccctatcctg
     5881 ttatttaaat gtgaacattt attgtacatt cagtgagtta tagtgttaat agtcttgtgc
     5941 tatgcagcag gtgtaaaaat taataaatat attttttaat aaacatgttt gtatgtgtga
     6001 agcta
//
