LOCUS       NM_001367896            5861 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens PR/SET domain 10 (PRDM10), transcript variant 13,
            mRNA.
ACCESSION   NM_001367896
VERSION     NM_001367896.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5861)
  AUTHORS   Li,L., Hongying,C. and Heng,G.
  TITLE     Autophagy-related LncRNA PRDM10-DT responds to UVB radiation in
            keratinocytes
  JOURNAL   Biochem Biophys Res Commun 677, 105-112 (2023)
   PUBMED   37566921
  REMARK    GeneRIF: Autophagy-related LncRNA PRDM10-DT responds to UVB
            radiation in keratinocytes.
REFERENCE   2  (bases 1 to 5861)
  AUTHORS   Schmidt,L.S., Vocke,C.D., Ricketts,C.J., Blake,Z., Choo,K.K.,
            Nielsen,D., Gautam,R., Crooks,D.R., Reynolds,K.L., Krolus,J.L.,
            Bashyal,M., Karim,B., Cowen,E.W., Malayeri,A.A., Merino,M.J.,
            Srinivasan,R., Ball,M.W., Zbar,B. and Marston Linehan,W.
  TITLE     PRDM10 RCC: A Birt-Hogg-Dube-like Syndrome Associated With Lipoma
            and Highly Penetrant, Aggressive Renal Tumors Morphologically
            Resembling Type 2 Papillary Renal Cell Carcinoma
  JOURNAL   Urology 179, 58-70 (2023)
   PUBMED   37331486
  REMARK    GeneRIF: PRDM10 RCC: A Birt-Hogg-Dube-like Syndrome Associated With
            Lipoma and Highly Penetrant, Aggressive Renal Tumors
            Morphologically Resembling Type 2 Papillary Renal Cell Carcinoma.
REFERENCE   3  (bases 1 to 5861)
  AUTHORS   Zhao,M., Yin,X., He,H., Fan,Y., Ru,G. and Meng,X.
  TITLE     Recurrent PRDM10 Fusions in Superficial CD34-Positive Fibroblastic
            Tumors : A Clinicopathologic and Molecular Study of 10 Additional
            Cases of an Emerging Novel Entity
  JOURNAL   Am J Clin Pathol 159 (4), 367-378 (2023)
   PUBMED   36812381
  REMARK    GeneRIF: Recurrent PRDM10 Fusions in Superficial CD34-Positive
            Fibroblastic Tumors : A Clinicopathologic and Molecular Study of 10
            Additional Cases of an Emerging Novel Entity.
REFERENCE   4  (bases 1 to 5861)
  AUTHORS   van de Beek,I., Glykofridis,I.E., Oosterwijk,J.C., van den
            Akker,P.C., Diercks,G.F.H., Bolling,M.C., Waisfisz,Q.,
            Mensenkamp,A.R., Balk,J.A., Zwart,R., Postma,A.V.,
            Meijers-Heijboer,H.E.J., van Moorselaar,R.J.A., Wolthuis,R.M.F. and
            Houweling,A.C.
  TITLE     PRDM10 directs FLCN expression in a novel disorder overlapping with
            Birt-Hogg-Dube syndrome and familial lipomatosis
  JOURNAL   Hum Mol Genet 32 (7), 1223-1235 (2023)
   PUBMED   36440963
  REMARK    GeneRIF: PRDM10 directs FLCN expression in a novel disorder
            overlapping with Birt-Hogg-Dube syndrome and familial lipomatosis.
REFERENCE   5  (bases 1 to 5861)
  AUTHORS   Hofvander,J., Puls,F., Pillay,N., Steele,C.D., Flanagan,A.M.,
            Magnusson,L., Nilsson,J. and Mertens,F.
  TITLE     Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a
            distinct gene expression profile
  JOURNAL   J Pathol 249 (4), 425-434 (2019)
   PUBMED   31313299
  REMARK    GeneRIF: PRDM10-fusions represent the critical driver mutations in
            undifferentiated pleomorphic sarcomas.
REFERENCE   6  (bases 1 to 5861)
  AUTHORS   Schrors,B., Lubcke,S., Lennerz,V., Fatho,M., Bicker,A., Wolfel,C.,
            Derigs,P., Hankeln,T., Schadendorf,D., Paschen,A. and Wolfel,T.
  TITLE     HLA class I loss in metachronous metastases prevents continuous T
            cell recognition of mutated neoantigens in a human melanoma model
  JOURNAL   Oncotarget 8 (17), 28312-28327 (2017)
   PUBMED   28423700
REFERENCE   7  (bases 1 to 5861)
  AUTHORS   Hofvander,J., Tayebwa,J., Nilsson,J., Magnusson,L., Brosjo,O.,
            Larsson,O., Vult von Steyern,F., Mandahl,N., Fletcher,C.D. and
            Mertens,F.
  TITLE     Recurrent PRDM10 gene fusions in undifferentiated pleomorphic
            sarcoma
  JOURNAL   Clin Cancer Res 21 (4), 864-869 (2015)
   PUBMED   25516889
  REMARK    GeneRIF: Our results suggest that PRDM10 fusions are present in
            around 5% of Undifferentiated pleomorphic sarcoma
REFERENCE   8  (bases 1 to 5861)
  AUTHORS   Bhatti,P., Doody,M.M., Rajaraman,P., Alexander,B.H., Yeager,M.,
            Hutchinson,A., Burdette,L., Thomas,G., Hunter,D.J., Simon,S.L.,
            Weinstock,R.M., Rosenstein,M., Stovall,M., Preston,D.L.,
            Linet,M.S., Hoover,R.N., Chanock,S.J. and Sigurdson,A.J.
  TITLE     Novel breast cancer risk alleles and interaction with ionizing
            radiation among U.S. radiologic technologists
  JOURNAL   Radiat Res 173 (2), 214-224 (2010)
   PUBMED   20095854
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 5861)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 5861)
  AUTHORS   Siegel,D.A., Huang,M.K. and Becker,S.F.
  TITLE     Ectopic dendrite initiation: CNS pathogenesis as a model of CNS
            development
  JOURNAL   Int J Dev Neurosci 20 (3-5), 373-389 (2002)
   PUBMED   12175877
  REMARK    Erratum:[Int J Dev Neurosci. 2003 May;21(3):169-70]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003041.3, AP003326.2 and
            AP003327.3.
            
            Summary: The protein encoded by this gene is a transcription factor
            that contains C2H2-type zinc-fingers. It also contains a positive
            regulatory domain, which has been found in several other
            zinc-finger transcription factors including those involved in B
            cell differentiation and tumor suppression. Studies of the mouse
            counterpart suggest that this protein may be involved in the
            development of the central nerve system (CNS), as well as in the
            pathogenesis of neuronal storage disease. Multiple alternatively
            spliced transcript variants encoding distinct isoforms have been
            observed. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.176715.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AP003041.3         241-322             c
            83-308              AP003326.2         45603-45828         c
            309-550             AP003326.2         43229-43470         c
            551-754             AP003326.2         40884-41087         c
            755-827             AP003327.3         187282-187354       c
            828-945             AP003327.3         184785-184902       c
            946-1075            AP003327.3         181786-181915       c
            1076-1318           AP003327.3         180700-180942       c
            1319-1666           AP003327.3         174566-174913       c
            1667-1822           AP003327.3         172932-173087       c
            1823-2002           AP003327.3         168223-168402       c
            2003-2113           AP003327.3         166811-166921       c
            2114-2314           AP003327.3         165344-165544       c
            2315-2629           AP003327.3         164388-164702       c
            2630-2770           AP003327.3         161769-161909       c
            2771-2951           AP003327.3         160160-160340       c
            2952-3055           AP003327.3         155322-155425       c
            3056-5861           AP003327.3         149395-152200       c
FEATURES             Location/Qualifiers
     source          1..5861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..5861
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="PR/SET domain 10"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
     exon            1..82
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            83..308
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            309..550
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            551..754
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             638..3259
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="isoform 13 is encoded by transcript variant 13;
                     PRDM zinc finger transcription factor; PR-domain family
                     member 7; PR domain zinc finger protein 10; tristanin; PR
                     domain-containing protein 10; PR domain containing 10; PR
                     domain 10"
                     /codon_start=1
                     /product="PR domain zinc finger protein 10 isoform 13"
                     /protein_id="NP_001354825.1"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
                     /translation="MMFVRPAQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKVWYAA
                     SYAEFVNQKIHDISEEERKVLREQEKNWPCYECNRRFISSEQLQQHLNSHDEKLDVFS
                     RTRGRGRGRGKRRFGPGRRPGRPPKFIRLEITSENGEKSDDGTQDLLHFPTKEQFDEA
                     EPATLNGLDQPEQTTIPIPQLPQETQSSLEHEPETHTLHLQPQHEESVVPTQSTLTAD
                     DMRRAKRIRNAALQHLFIRKSFRPFKCLQCGKAFREKDKLDQHLRFHGREGNCPLTCD
                     LCNKGFISSTSLESHMKLHSDQKTYSCIFCPESFDRLDLLKDHVAIHINDGYFTCPTC
                     KKRFPDFIQVKKHVRSFHSEKIYQCTECDKAFCRPDKLRLHMLRHSDRKDFLCSTCGK
                     QFKRKDKLREHMQRMHNPEREAKKADRISRSKTFKPRITSTDYDSFTFKCRLCMMGFR
                     RRGMLVNHLSKRHPDMKIEEVPELTLPIIKPNRDYFCQYCDKVYKSASKRKAHILKNH
                     PGAELPPSIRKLRPAGPGEPDPMLSTHTQLTGTIATPPVCCPHCSKQYSSKTKMVQHI
                     RKKHPEFAQLSNTIHTPLTTAVISATPAVLTTDSATGETVVTTDLLTQAMTELSQTLT
                     TDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLH
                     DPQPYPQHAIQVQHIQVSEPTASAPSSAQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQ
                     GQALQQQQQQQQNSSVQHTYLPSAWNSFRGYSSEIQMMTLPPGQFVITDSGVATPVTT
                     GQVKAVTSGHYVLSESQSELEEKQTSALSGGVQVEPPAHSDSLDPQTNSQQQTTQYII
                     TTTTNGNGSSEVHITKP"
     exon            755..827
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            828..945
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1075
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1318
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1666
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1822
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2002
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2113
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2314
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2629
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2770
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2951
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3055
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..5861
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5822..5827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="hexamer: AATATA"
     regulatory      5834..5839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="hexamer: AATAAA"
     polyA_site      5839
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="major polyA site"
     polyA_site      5861
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="major polyA site"
ORIGIN      
        1 ataaattgta tcctgaaatg cattatgtcc tttcagaaat aattacagag agtggtatta
       61 agtgggaagg agaaagtata ccgcctcatt gccagttcat aaccaggtgc tgccttccat
      121 cgagagtgta gatgggtccg accctttggc aactctgcag acccctctag gcagactgga
      181 ggccaaagag gaagaggatg aggatgagga cgaggacact gaggaagatg aggaagaaga
      241 cggtgaggac acggatctgg atgactggga gccagacccg ccccggccct tcgacccaca
      301 cgacttgtgg tgtgaggagt gcaataacgc gcatgcttca gtgtgtccga agcacggccc
      361 cttgcacccg atccccaacc ggccggtgct cacccgggcc agggcgagcc tccccctggt
      421 gctctacata gacaggtttc tgggcggggt gttctccaag cggcgcatcc ccaagcgcac
      481 ccagtttggc cccgtggagg ggcctctcgt caggggctcg gagctgaaag actgttacat
      541 tcacctcaag gtttctcttg ataaagggga caggaaagaa agggatttac atgaagacct
      601 atggtttgag ttgtctgatg agacgctttg taactggatg atgtttgtac ggccagccca
      661 gaatcacctg gagcagaacc tggtggctta ccagtatggc caccatgtgt attatacaac
      721 cataaaaaat gtggagccca agcaggaact gaaggtgtgg tatgccgcat cctatgctga
      781 gttcgtgaac cagaaaattc atgacatttc tgaggaagaa aggaaagttc ttcgagagca
      841 agagaagaat tggccctgct atgaatgtaa ccgccgattt ataagctcgg agcagttgca
      901 acagcatctc aattctcatg atgagaaact agatgtgttt agcagaacaa gaggcagagg
      961 aaggggacga ggcaagaggc gattcggtcc aggtcgacgg ccggggcgtc ctccaaaatt
     1021 tatccgcctg gaaatcacca gcgaaaatgg ggaaaagagt gacgatggga cacaggactt
     1081 gctacatttt cccacaaagg agcaatttga tgaggctgaa ccagccactc tgaatgggct
     1141 ggatcaacca gaacagacca ctatcccaat ccctcagctg ccacaggaaa cccagtcttc
     1201 cctggaacat gaaccagaaa ctcacaccct gcacctgcag ccgcagcatg aagagagcgt
     1261 ggtgcccacc cagagcacgc tgacagccga cgacatgcgc agagccaagc gcatccgaaa
     1321 tgcagctctt cagcatctgt ttattcggaa gtccttccgg ccttttaaat gcttgcagtg
     1381 tgggaaggcc ttccgggaaa aggacaaact ggaccagcac ttacgcttcc atgggcggga
     1441 ggggaactgc ccactgacct gtgatctctg taacaagggc ttcatcagca gcacatcctt
     1501 ggagagccac atgaagctcc actcagacca gaagacttac tcttgcattt tttgcccaga
     1561 atcctttgac cgccttgatt tgttgaaaga tcatgtggcc attcatatca atgatggcta
     1621 cttcacctgc ccaacttgta agaaacggtt cccagatttt atccaggtga aaaaacacgt
     1681 gcgcagcttc cactcagaaa agatctacca gtgcacagag tgtgacaagg ccttctgtcg
     1741 ccccgataaa ctgcgactcc acatgctccg gcattcggac cgcaaagact tcctgtgttc
     1801 cacctgtggg aagcaattta agcgaaaaga caaactacgg gaacacatgc agaggatgca
     1861 taatcctgag agggaggcca agaaagccga ccgcatcagc cgctccaaga cgttcaagcc
     1921 ccgcatcacg tccacagact acgacagctt cacgttcaag tgccgcctgt gcatgatggg
     1981 cttccggcgg cgcggcatgc tggtaaatca cttatcgaag agacacccag acatgaagat
     2041 agaagaggtg ccagagttaa ctctacccat cataaaaccc aatcgtgatt acttttgtca
     2101 gtattgcgat aaggtttata aaagtgccag caagcgcaaa gcccacattc tgaagaacca
     2161 cccaggagca gagctcccac cgagcattcg gaagctccga cccgctggtc ctggagagcc
     2221 agaccccatg ctgagcacac acacccagct gacgggcacc atcgccaccc ctcccgtctg
     2281 ctgtccccac tgctccaagc agtacagcag caagaccaag atggtccagc acattcgaaa
     2341 gaagcatcca gagttcgccc agctctccaa caccatacac acaccactga cgacagctgt
     2401 gatcagtgcc accccagcgg ttttgactac agacagcgcc actggagaga ctgtggtgac
     2461 gacggacctg ctcacccaag caatgacaga actgtcccag accttaacga cagactaccg
     2521 aacgccacaa ggggattacc agagaattca gtacatccct gtgtcgcagt cggcgtctgg
     2581 cctccagcag cctcagcaca tacagctgca agtggttcaa gtggcctcgg ccacttcccc
     2641 tcaccagtca cagcagtcca ctgtggatgt tggccagctc catgatcctc agccctaccc
     2701 ccagcacgcc atccaggtgc agcacatcca ggtcagcgag cctaccgcct cggccccgtc
     2761 ctccgcccag gtatctgggc agccgttgag tccctcagcc cagcaggctc agcaggggct
     2821 cagcccctcc cacatccagg gcagttcttc cacacagggg caggctctgc agcagcagca
     2881 gcagcagcag cagaattcct ctgtgcagca cacgtacctg cccagtgctt ggaattcctt
     2941 ccgtggctat tcatctgaga ttcaaatgat gacgcttcct ccgggtcagt ttgtgattac
     3001 agacagtggt gtggcaactc cagttactac tggccaggtg aaggcggtta cttcgggtca
     3061 ttatgtgtta tcagaaagtc aatcagaatt ggaagaaaag caaacttctg ccctctctgg
     3121 tggagtccag gtcgagccac ctgcacacag tgactccctg gacccccaga ccaacagcca
     3181 acagcagacc acacagtaca tcatcaccac caccaccaac gggaacggaa gcagcgaagt
     3241 gcatatcacc aaaccatgac ttccaccctg gagcttgaat ccagcaccca cctcatgtct
     3301 gttctcataa gtctgaaagc tctgacacgt agagctcttt tgtaagattt attattcact
     3361 caagagttcg gaaaccacag ttttgtctct catccataca ctggggttta ttttgccaag
     3421 gtcatcttta tcaaattgac tcttcaaacc ctcggttttt gccacagaac agagatcttt
     3481 caggggaaag tagatttcga ggtggagaga atttgccttg ctcttgagct ggtcttttaa
     3541 catactgacg agccttactt ttcctttgtg gaaatattaa gtggcatatt gtgttcatac
     3601 caaaggtgga gacaggatgt gccaagttca tggttactgg acttcttatt ccaagccatg
     3661 gcaccaaagg agaaggggca ttttgtgggt gtgcattagg tctgaactgc tttatcttgt
     3721 tttagttttc agtaatttaa caaagggagc ctgctgaata acaaaattaa aatgatgaaa
     3781 caaaagtttg acagtgatat tctgaagcaa aaactgtcat ctaaattttt cttgctgatt
     3841 ttttttaact tccctatttt agaaaactat tgttgggctg ttggtagtgc tttccacaga
     3901 tgctggtcct cagtggatta ggtcagaagc tcatgttctg atagttcttc attatttcac
     3961 aaaggtggac aacctgaaag agaaaaggct gcttgatgtc agcagaatct aaacccctac
     4021 attaaagctt tgcctcccat tctgtggttg tggtggtggt aagaaggaga tattggtacc
     4081 aagaaaaatt tccaaaacta ttgagagaga gagagagaaa gtattgaaat tttgttctgc
     4141 cttgcaggat ccatttatca ttcattggta aaggatatat tccttgttct taccaagtgt
     4201 acatttaact cttgctgaca tgttcagtgt attttattac ttttaatgct gtcttaaaat
     4261 gaacattctt taaagttgga caggaaggtg gcatttctta tttattaaca tttttaactt
     4321 taaacatatt gtgactcatc tagacctttt aataagacgg tcaacttcac acttagggaa
     4381 aaaattaaaa tgtgatggcc acttctaata attcaggtag ttataaggga tctggaagaa
     4441 atccagtctt tatgaatata ctattagttg ggcattaaaa aatcagtata tattttaact
     4501 ttttgtgaca tgctaacaca ttttcagaat aattattgca tagtagaatt tattactcca
     4561 gaacagaaag accttacttc atttcaaatg aagttaatta atttacattt ctgggtaaaa
     4621 actggttcta taaattaagt agagtagctt ctttatgata aagacaattt tctgaaaagt
     4681 gaacaattct gttaaaagaa ctttattgat gtgtagattt cgcactttat ttctgagact
     4741 gcgttcatgt agttgttccc caatgtttga gtactaagag aacttgagaa aattacttca
     4801 taaacatatg gaaactgaaa atggactctc tttgtgacaa agatattcaa cagaaaatat
     4861 tgaccctgca ttgcaaaaca caggttcggg ttccctaagt cccacagtgt aatgattaca
     4921 aatatcctag tgtccggtct agaaagactt tctaggagaa gactagtgga attttctaaa
     4981 ggttcagttt tagcttttat aacttaaatt tggccctgtt acgttctttt taatttgaac
     5041 cataaggtat ctcccctccc ttcaggaata acttattgga aaactgaaaa gaatcactga
     5101 atggaatgtt cattttatgg cagttgtttt aagttttaaa atacacagag gaaaatattg
     5161 tggaaggacc tctttgttgc tttcccttct aagttgtctt cttcttcttc ttcttcttct
     5221 tcttctttgg tccttaagtg aaataaagac tctaaaacta atttgtatat tatcagccag
     5281 agatgcggat ggcagtcgag ccaaatcgca tggctttcag atcaggtatt ctgcacattc
     5341 attccaaggt catagatttt taaaaggacc tggatttgaa gagatggcaa atgatgagcc
     5401 atcagaaaac ttaatttgga aaacatgtat gtagccagtg tggatattgt ggcctctctc
     5461 aagacacatt gacactgtag acttcattca gtccagtgtg agtattttgg agtaggttgg
     5521 atgtagattt tgtttttatc attgatttgt accgacagaa atagacattt catcatgtaa
     5581 aattcctgtt attctggaaa aacctattgt tttgatcttc ttgttttctg acttggaagt
     5641 atcctttcaa aaaaactctt aagatatcta ggtctaaaaa gcacttcatg agatgctaaa
     5701 gctgacccac tggttgaaaa tgttgaccct atcctgttat ttaaatgtga acatttattg
     5761 tacattcagt gagttatagt gttaatagtc ttgtgctatg cagcaggtgt aaaaattaat
     5821 aaatatattt tttaataaac atgtttgtat gtgtgaagct a
//
