LOCUS       NM_001367895            5826 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens PR/SET domain 10 (PRDM10), transcript variant 14,
            mRNA.
ACCESSION   NM_001367895
VERSION     NM_001367895.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5826)
  AUTHORS   Li,L., Hongying,C. and Heng,G.
  TITLE     Autophagy-related LncRNA PRDM10-DT responds to UVB radiation in
            keratinocytes
  JOURNAL   Biochem Biophys Res Commun 677, 105-112 (2023)
   PUBMED   37566921
  REMARK    GeneRIF: Autophagy-related LncRNA PRDM10-DT responds to UVB
            radiation in keratinocytes.
REFERENCE   2  (bases 1 to 5826)
  AUTHORS   Schmidt,L.S., Vocke,C.D., Ricketts,C.J., Blake,Z., Choo,K.K.,
            Nielsen,D., Gautam,R., Crooks,D.R., Reynolds,K.L., Krolus,J.L.,
            Bashyal,M., Karim,B., Cowen,E.W., Malayeri,A.A., Merino,M.J.,
            Srinivasan,R., Ball,M.W., Zbar,B. and Marston Linehan,W.
  TITLE     PRDM10 RCC: A Birt-Hogg-Dube-like Syndrome Associated With Lipoma
            and Highly Penetrant, Aggressive Renal Tumors Morphologically
            Resembling Type 2 Papillary Renal Cell Carcinoma
  JOURNAL   Urology 179, 58-70 (2023)
   PUBMED   37331486
  REMARK    GeneRIF: PRDM10 RCC: A Birt-Hogg-Dube-like Syndrome Associated With
            Lipoma and Highly Penetrant, Aggressive Renal Tumors
            Morphologically Resembling Type 2 Papillary Renal Cell Carcinoma.
REFERENCE   3  (bases 1 to 5826)
  AUTHORS   Zhao,M., Yin,X., He,H., Fan,Y., Ru,G. and Meng,X.
  TITLE     Recurrent PRDM10 Fusions in Superficial CD34-Positive Fibroblastic
            Tumors : A Clinicopathologic and Molecular Study of 10 Additional
            Cases of an Emerging Novel Entity
  JOURNAL   Am J Clin Pathol 159 (4), 367-378 (2023)
   PUBMED   36812381
  REMARK    GeneRIF: Recurrent PRDM10 Fusions in Superficial CD34-Positive
            Fibroblastic Tumors : A Clinicopathologic and Molecular Study of 10
            Additional Cases of an Emerging Novel Entity.
REFERENCE   4  (bases 1 to 5826)
  AUTHORS   van de Beek,I., Glykofridis,I.E., Oosterwijk,J.C., van den
            Akker,P.C., Diercks,G.F.H., Bolling,M.C., Waisfisz,Q.,
            Mensenkamp,A.R., Balk,J.A., Zwart,R., Postma,A.V.,
            Meijers-Heijboer,H.E.J., van Moorselaar,R.J.A., Wolthuis,R.M.F. and
            Houweling,A.C.
  TITLE     PRDM10 directs FLCN expression in a novel disorder overlapping with
            Birt-Hogg-Dube syndrome and familial lipomatosis
  JOURNAL   Hum Mol Genet 32 (7), 1223-1235 (2023)
   PUBMED   36440963
  REMARK    GeneRIF: PRDM10 directs FLCN expression in a novel disorder
            overlapping with Birt-Hogg-Dube syndrome and familial lipomatosis.
REFERENCE   5  (bases 1 to 5826)
  AUTHORS   Hofvander,J., Puls,F., Pillay,N., Steele,C.D., Flanagan,A.M.,
            Magnusson,L., Nilsson,J. and Mertens,F.
  TITLE     Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a
            distinct gene expression profile
  JOURNAL   J Pathol 249 (4), 425-434 (2019)
   PUBMED   31313299
  REMARK    GeneRIF: PRDM10-fusions represent the critical driver mutations in
            undifferentiated pleomorphic sarcomas.
REFERENCE   6  (bases 1 to 5826)
  AUTHORS   Schrors,B., Lubcke,S., Lennerz,V., Fatho,M., Bicker,A., Wolfel,C.,
            Derigs,P., Hankeln,T., Schadendorf,D., Paschen,A. and Wolfel,T.
  TITLE     HLA class I loss in metachronous metastases prevents continuous T
            cell recognition of mutated neoantigens in a human melanoma model
  JOURNAL   Oncotarget 8 (17), 28312-28327 (2017)
   PUBMED   28423700
REFERENCE   7  (bases 1 to 5826)
  AUTHORS   Hofvander,J., Tayebwa,J., Nilsson,J., Magnusson,L., Brosjo,O.,
            Larsson,O., Vult von Steyern,F., Mandahl,N., Fletcher,C.D. and
            Mertens,F.
  TITLE     Recurrent PRDM10 gene fusions in undifferentiated pleomorphic
            sarcoma
  JOURNAL   Clin Cancer Res 21 (4), 864-869 (2015)
   PUBMED   25516889
  REMARK    GeneRIF: Our results suggest that PRDM10 fusions are present in
            around 5% of Undifferentiated pleomorphic sarcoma
REFERENCE   8  (bases 1 to 5826)
  AUTHORS   Bhatti,P., Doody,M.M., Rajaraman,P., Alexander,B.H., Yeager,M.,
            Hutchinson,A., Burdette,L., Thomas,G., Hunter,D.J., Simon,S.L.,
            Weinstock,R.M., Rosenstein,M., Stovall,M., Preston,D.L.,
            Linet,M.S., Hoover,R.N., Chanock,S.J. and Sigurdson,A.J.
  TITLE     Novel breast cancer risk alleles and interaction with ionizing
            radiation among U.S. radiologic technologists
  JOURNAL   Radiat Res 173 (2), 214-224 (2010)
   PUBMED   20095854
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 5826)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 5826)
  AUTHORS   Siegel,D.A., Huang,M.K. and Becker,S.F.
  TITLE     Ectopic dendrite initiation: CNS pathogenesis as a model of CNS
            development
  JOURNAL   Int J Dev Neurosci 20 (3-5), 373-389 (2002)
   PUBMED   12175877
  REMARK    Erratum:[Int J Dev Neurosci. 2003 May;21(3):169-70]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003041.3, AP003326.2 and
            AP003327.3.
            
            Summary: The protein encoded by this gene is a transcription factor
            that contains C2H2-type zinc-fingers. It also contains a positive
            regulatory domain, which has been found in several other
            zinc-finger transcription factors including those involved in B
            cell differentiation and tumor suppression. Studies of the mouse
            counterpart suggest that this protein may be involved in the
            development of the central nerve system (CNS), as well as in the
            pathogenesis of neuronal storage disease. Multiple alternatively
            spliced transcript variants encoding distinct isoforms have been
            observed. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AP003041.3         4681-4706           c
            27-86               AP003041.3         4188-4247           c
            87-312              AP003326.2         45603-45828         c
            313-554             AP003326.2         43229-43470         c
            555-758             AP003326.2         40884-41087         c
            759-831             AP003327.3         187282-187354       c
            832-949             AP003327.3         184785-184902       c
            950-1079            AP003327.3         181786-181915       c
            1080-1322           AP003327.3         180700-180942       c
            1323-1670           AP003327.3         174566-174913       c
            1671-1826           AP003327.3         172932-173087       c
            1827-2006           AP003327.3         168223-168402       c
            2007-2117           AP003327.3         166811-166921       c
            2118-2318           AP003327.3         165344-165544       c
            2319-2633           AP003327.3         164388-164702       c
            2634-2735           AP003327.3         161808-161909       c
            2736-2916           AP003327.3         160160-160340       c
            2917-3020           AP003327.3         155322-155425       c
            3021-5826           AP003327.3         149395-152200       c
FEATURES             Location/Qualifiers
     source          1..5826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..5826
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="PR/SET domain 10"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
     exon            1..26
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            27..86
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            87..312
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            313..554
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            555..758
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             642..3224
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="isoform 14 is encoded by transcript variant 14;
                     PRDM zinc finger transcription factor; PR-domain family
                     member 7; PR domain zinc finger protein 10; tristanin; PR
                     domain-containing protein 10; PR domain containing 10; PR
                     domain 10"
                     /codon_start=1
                     /product="PR domain zinc finger protein 10 isoform 14"
                     /protein_id="NP_001354824.1"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
                     /translation="MMFVRPAQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKVWYAA
                     SYAEFVNQKIHDISEEERKVLREQEKNWPCYECNRRFISSEQLQQHLNSHDEKLDVFS
                     RTRGRGRGRGKRRFGPGRRPGRPPKFIRLEITSENGEKSDDGTQDLLHFPTKEQFDEA
                     EPATLNGLDQPEQTTIPIPQLPQETQSSLEHEPETHTLHLQPQHEESVVPTQSTLTAD
                     DMRRAKRIRNAALQHLFIRKSFRPFKCLQCGKAFREKDKLDQHLRFHGREGNCPLTCD
                     LCNKGFISSTSLESHMKLHSDQKTYSCIFCPESFDRLDLLKDHVAIHINDGYFTCPTC
                     KKRFPDFIQVKKHVRSFHSEKIYQCTECDKAFCRPDKLRLHMLRHSDRKDFLCSTCGK
                     QFKRKDKLREHMQRMHNPEREAKKADRISRSKTFKPRITSTDYDSFTFKCRLCMMGFR
                     RRGMLVNHLSKRHPDMKIEEVPELTLPIIKPNRDYFCQYCDKVYKSASKRKAHILKNH
                     PGAELPPSIRKLRPAGPGEPDPMLSTHTQLTGTIATPPVCCPHCSKQYSSKTKMVQHI
                     RKKHPEFAQLSNTIHTPLTTAVISATPAVLTTDSATGETVVTTDLLTQAMTELSQTLT
                     TDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQSTVDVGQLH
                     DPQPYPQHAIQVQHIQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQN
                     SSVQHTYLPSAWNSFRGYSSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVL
                     SESQSELEEKQTSALSGGVQVEPPAHSDSLDPQTNSQQQTTQYIITTTTNGNGSSEVH
                     ITKP"
     exon            759..831
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            832..949
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1079
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1322
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1670
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1826
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2006
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2117
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2318
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2633
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2735
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2916
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3020
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..5826
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5787..5792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="hexamer: AATATA"
     regulatory      5799..5804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="hexamer: AATAAA"
     polyA_site      5804
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="major polyA site"
     polyA_site      5826
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="major polyA site"
ORIGIN      
        1 acatttgaaa tagctgtaat ccttggactc tgtttacaga ccccggccag gtagcttatg
       61 tccaacagga tgctacagct cagcaggcct cattgccagt tcataaccag gtgctgcctt
      121 ccatcgagag tgtagatggg tccgaccctt tggcaactct gcagacccct ctaggcagac
      181 tggaggccaa agaggaagag gatgaggatg aggacgagga cactgaggaa gatgaggaag
      241 aagacggtga ggacacggat ctggatgact gggagccaga cccgccccgg cccttcgacc
      301 cacacgactt gtggtgtgag gagtgcaata acgcgcatgc ttcagtgtgt ccgaagcacg
      361 gccccttgca cccgatcccc aaccggccgg tgctcacccg ggccagggcg agcctccccc
      421 tggtgctcta catagacagg tttctgggcg gggtgttctc caagcggcgc atccccaagc
      481 gcacccagtt tggccccgtg gaggggcctc tcgtcagggg ctcggagctg aaagactgtt
      541 acattcacct caaggtttct cttgataaag gggacaggaa agaaagggat ttacatgaag
      601 acctatggtt tgagttgtct gatgagacgc tttgtaactg gatgatgttt gtacggccag
      661 cccagaatca cctggagcag aacctggtgg cttaccagta tggccaccat gtgtattata
      721 caaccataaa aaatgtggag cccaagcagg aactgaaggt gtggtatgcc gcatcctatg
      781 ctgagttcgt gaaccagaaa attcatgaca tttctgagga agaaaggaaa gttcttcgag
      841 agcaagagaa gaattggccc tgctatgaat gtaaccgccg atttataagc tcggagcagt
      901 tgcaacagca tctcaattct catgatgaga aactagatgt gtttagcaga acaagaggca
      961 gaggaagggg acgaggcaag aggcgattcg gtccaggtcg acggccgggg cgtcctccaa
     1021 aatttatccg cctggaaatc accagcgaaa atggggaaaa gagtgacgat gggacacagg
     1081 acttgctaca ttttcccaca aaggagcaat ttgatgaggc tgaaccagcc actctgaatg
     1141 ggctggatca accagaacag accactatcc caatccctca gctgccacag gaaacccagt
     1201 cttccctgga acatgaacca gaaactcaca ccctgcacct gcagccgcag catgaagaga
     1261 gcgtggtgcc cacccagagc acgctgacag ccgacgacat gcgcagagcc aagcgcatcc
     1321 gaaatgcagc tcttcagcat ctgtttattc ggaagtcctt ccggcctttt aaatgcttgc
     1381 agtgtgggaa ggccttccgg gaaaaggaca aactggacca gcacttacgc ttccatgggc
     1441 gggaggggaa ctgcccactg acctgtgatc tctgtaacaa gggcttcatc agcagcacat
     1501 ccttggagag ccacatgaag ctccactcag accagaagac ttactcttgc attttttgcc
     1561 cagaatcctt tgaccgcctt gatttgttga aagatcatgt ggccattcat atcaatgatg
     1621 gctacttcac ctgcccaact tgtaagaaac ggttcccaga ttttatccag gtgaaaaaac
     1681 acgtgcgcag cttccactca gaaaagatct accagtgcac agagtgtgac aaggccttct
     1741 gtcgccccga taaactgcga ctccacatgc tccggcattc ggaccgcaaa gacttcctgt
     1801 gttccacctg tgggaagcaa tttaagcgaa aagacaaact acgggaacac atgcagagga
     1861 tgcataatcc tgagagggag gccaagaaag ccgaccgcat cagccgctcc aagacgttca
     1921 agccccgcat cacgtccaca gactacgaca gcttcacgtt caagtgccgc ctgtgcatga
     1981 tgggcttccg gcggcgcggc atgctggtaa atcacttatc gaagagacac ccagacatga
     2041 agatagaaga ggtgccagag ttaactctac ccatcataaa acccaatcgt gattactttt
     2101 gtcagtattg cgataaggtt tataaaagtg ccagcaagcg caaagcccac attctgaaga
     2161 accacccagg agcagagctc ccaccgagca ttcggaagct ccgacccgct ggtcctggag
     2221 agccagaccc catgctgagc acacacaccc agctgacggg caccatcgcc acccctcccg
     2281 tctgctgtcc ccactgctcc aagcagtaca gcagcaagac caagatggtc cagcacattc
     2341 gaaagaagca tccagagttc gcccagctct ccaacaccat acacacacca ctgacgacag
     2401 ctgtgatcag tgccacccca gcggttttga ctacagacag cgccactgga gagactgtgg
     2461 tgacgacgga cctgctcacc caagcaatga cagaactgtc ccagacctta acgacagact
     2521 accgaacgcc acaaggggat taccagagaa ttcagtacat ccctgtgtcg cagtcggcgt
     2581 ctggcctcca gcagcctcag cacatacagc tgcaagtggt tcaagtggcc tcggccactt
     2641 cccctcacca gtcacagcag tccactgtgg atgttggcca gctccatgat cctcagccct
     2701 acccccagca cgccatccag gtgcagcaca tccaggtatc tgggcagccg ttgagtccct
     2761 cagcccagca ggctcagcag gggctcagcc cctcccacat ccagggcagt tcttccacac
     2821 aggggcaggc tctgcagcag cagcagcagc agcagcagaa ttcctctgtg cagcacacgt
     2881 acctgcccag tgcttggaat tccttccgtg gctattcatc tgagattcaa atgatgacgc
     2941 ttcctccggg tcagtttgtg attacagaca gtggtgtggc aactccagtt actactggcc
     3001 aggtgaaggc ggttacttcg ggtcattatg tgttatcaga aagtcaatca gaattggaag
     3061 aaaagcaaac ttctgccctc tctggtggag tccaggtcga gccacctgca cacagtgact
     3121 ccctggaccc ccagaccaac agccaacagc agaccacaca gtacatcatc accaccacca
     3181 ccaacgggaa cggaagcagc gaagtgcata tcaccaaacc atgacttcca ccctggagct
     3241 tgaatccagc acccacctca tgtctgttct cataagtctg aaagctctga cacgtagagc
     3301 tcttttgtaa gatttattat tcactcaaga gttcggaaac cacagttttg tctctcatcc
     3361 atacactggg gtttattttg ccaaggtcat ctttatcaaa ttgactcttc aaaccctcgg
     3421 tttttgccac agaacagaga tctttcaggg gaaagtagat ttcgaggtgg agagaatttg
     3481 ccttgctctt gagctggtct tttaacatac tgacgagcct tacttttcct ttgtggaaat
     3541 attaagtggc atattgtgtt cataccaaag gtggagacag gatgtgccaa gttcatggtt
     3601 actggacttc ttattccaag ccatggcacc aaaggagaag gggcattttg tgggtgtgca
     3661 ttaggtctga actgctttat cttgttttag ttttcagtaa tttaacaaag ggagcctgct
     3721 gaataacaaa attaaaatga tgaaacaaaa gtttgacagt gatattctga agcaaaaact
     3781 gtcatctaaa tttttcttgc tgattttttt taacttccct attttagaaa actattgttg
     3841 ggctgttggt agtgctttcc acagatgctg gtcctcagtg gattaggtca gaagctcatg
     3901 ttctgatagt tcttcattat ttcacaaagg tggacaacct gaaagagaaa aggctgcttg
     3961 atgtcagcag aatctaaacc cctacattaa agctttgcct cccattctgt ggttgtggtg
     4021 gtggtaagaa ggagatattg gtaccaagaa aaatttccaa aactattgag agagagagag
     4081 agaaagtatt gaaattttgt tctgccttgc aggatccatt tatcattcat tggtaaagga
     4141 tatattcctt gttcttacca agtgtacatt taactcttgc tgacatgttc agtgtatttt
     4201 attactttta atgctgtctt aaaatgaaca ttctttaaag ttggacagga aggtggcatt
     4261 tcttatttat taacattttt aactttaaac atattgtgac tcatctagac cttttaataa
     4321 gacggtcaac ttcacactta gggaaaaaat taaaatgtga tggccacttc taataattca
     4381 ggtagttata agggatctgg aagaaatcca gtctttatga atatactatt agttgggcat
     4441 taaaaaatca gtatatattt taactttttg tgacatgcta acacattttc agaataatta
     4501 ttgcatagta gaatttatta ctccagaaca gaaagacctt acttcatttc aaatgaagtt
     4561 aattaattta catttctggg taaaaactgg ttctataaat taagtagagt agcttcttta
     4621 tgataaagac aattttctga aaagtgaaca attctgttaa aagaacttta ttgatgtgta
     4681 gatttcgcac tttatttctg agactgcgtt catgtagttg ttccccaatg tttgagtact
     4741 aagagaactt gagaaaatta cttcataaac atatggaaac tgaaaatgga ctctctttgt
     4801 gacaaagata ttcaacagaa aatattgacc ctgcattgca aaacacaggt tcgggttccc
     4861 taagtcccac agtgtaatga ttacaaatat cctagtgtcc ggtctagaaa gactttctag
     4921 gagaagacta gtggaatttt ctaaaggttc agttttagct tttataactt aaatttggcc
     4981 ctgttacgtt ctttttaatt tgaaccataa ggtatctccc ctcccttcag gaataactta
     5041 ttggaaaact gaaaagaatc actgaatgga atgttcattt tatggcagtt gttttaagtt
     5101 ttaaaataca cagaggaaaa tattgtggaa ggacctcttt gttgctttcc cttctaagtt
     5161 gtcttcttct tcttcttctt cttcttcttc tttggtcctt aagtgaaata aagactctaa
     5221 aactaatttg tatattatca gccagagatg cggatggcag tcgagccaaa tcgcatggct
     5281 ttcagatcag gtattctgca cattcattcc aaggtcatag atttttaaaa ggacctggat
     5341 ttgaagagat ggcaaatgat gagccatcag aaaacttaat ttggaaaaca tgtatgtagc
     5401 cagtgtggat attgtggcct ctctcaagac acattgacac tgtagacttc attcagtcca
     5461 gtgtgagtat tttggagtag gttggatgta gattttgttt ttatcattga tttgtaccga
     5521 cagaaataga catttcatca tgtaaaattc ctgttattct ggaaaaacct attgttttga
     5581 tcttcttgtt ttctgacttg gaagtatcct ttcaaaaaaa ctcttaagat atctaggtct
     5641 aaaaagcact tcatgagatg ctaaagctga cccactggtt gaaaatgttg accctatcct
     5701 gttatttaaa tgtgaacatt tattgtacat tcagtgagtt atagtgttaa tagtcttgtg
     5761 ctatgcagca ggtgtaaaaa ttaataaata tattttttaa taaacatgtt tgtatgtgtg
     5821 aagcta
//
