LOCUS       NM_001367892            6251 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens PR/SET domain 10 (PRDM10), transcript variant 6, mRNA.
ACCESSION   NM_001367892
VERSION     NM_001367892.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6251)
  AUTHORS   Li,L., Hongying,C. and Heng,G.
  TITLE     Autophagy-related LncRNA PRDM10-DT responds to UVB radiation in
            keratinocytes
  JOURNAL   Biochem Biophys Res Commun 677, 105-112 (2023)
   PUBMED   37566921
  REMARK    GeneRIF: Autophagy-related LncRNA PRDM10-DT responds to UVB
            radiation in keratinocytes.
REFERENCE   2  (bases 1 to 6251)
  AUTHORS   Schmidt,L.S., Vocke,C.D., Ricketts,C.J., Blake,Z., Choo,K.K.,
            Nielsen,D., Gautam,R., Crooks,D.R., Reynolds,K.L., Krolus,J.L.,
            Bashyal,M., Karim,B., Cowen,E.W., Malayeri,A.A., Merino,M.J.,
            Srinivasan,R., Ball,M.W., Zbar,B. and Marston Linehan,W.
  TITLE     PRDM10 RCC: A Birt-Hogg-Dube-like Syndrome Associated With Lipoma
            and Highly Penetrant, Aggressive Renal Tumors Morphologically
            Resembling Type 2 Papillary Renal Cell Carcinoma
  JOURNAL   Urology 179, 58-70 (2023)
   PUBMED   37331486
  REMARK    GeneRIF: PRDM10 RCC: A Birt-Hogg-Dube-like Syndrome Associated With
            Lipoma and Highly Penetrant, Aggressive Renal Tumors
            Morphologically Resembling Type 2 Papillary Renal Cell Carcinoma.
REFERENCE   3  (bases 1 to 6251)
  AUTHORS   Zhao,M., Yin,X., He,H., Fan,Y., Ru,G. and Meng,X.
  TITLE     Recurrent PRDM10 Fusions in Superficial CD34-Positive Fibroblastic
            Tumors : A Clinicopathologic and Molecular Study of 10 Additional
            Cases of an Emerging Novel Entity
  JOURNAL   Am J Clin Pathol 159 (4), 367-378 (2023)
   PUBMED   36812381
  REMARK    GeneRIF: Recurrent PRDM10 Fusions in Superficial CD34-Positive
            Fibroblastic Tumors : A Clinicopathologic and Molecular Study of 10
            Additional Cases of an Emerging Novel Entity.
REFERENCE   4  (bases 1 to 6251)
  AUTHORS   van de Beek,I., Glykofridis,I.E., Oosterwijk,J.C., van den
            Akker,P.C., Diercks,G.F.H., Bolling,M.C., Waisfisz,Q.,
            Mensenkamp,A.R., Balk,J.A., Zwart,R., Postma,A.V.,
            Meijers-Heijboer,H.E.J., van Moorselaar,R.J.A., Wolthuis,R.M.F. and
            Houweling,A.C.
  TITLE     PRDM10 directs FLCN expression in a novel disorder overlapping with
            Birt-Hogg-Dube syndrome and familial lipomatosis
  JOURNAL   Hum Mol Genet 32 (7), 1223-1235 (2023)
   PUBMED   36440963
  REMARK    GeneRIF: PRDM10 directs FLCN expression in a novel disorder
            overlapping with Birt-Hogg-Dube syndrome and familial lipomatosis.
REFERENCE   5  (bases 1 to 6251)
  AUTHORS   Hofvander,J., Puls,F., Pillay,N., Steele,C.D., Flanagan,A.M.,
            Magnusson,L., Nilsson,J. and Mertens,F.
  TITLE     Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a
            distinct gene expression profile
  JOURNAL   J Pathol 249 (4), 425-434 (2019)
   PUBMED   31313299
  REMARK    GeneRIF: PRDM10-fusions represent the critical driver mutations in
            undifferentiated pleomorphic sarcomas.
REFERENCE   6  (bases 1 to 6251)
  AUTHORS   Schrors,B., Lubcke,S., Lennerz,V., Fatho,M., Bicker,A., Wolfel,C.,
            Derigs,P., Hankeln,T., Schadendorf,D., Paschen,A. and Wolfel,T.
  TITLE     HLA class I loss in metachronous metastases prevents continuous T
            cell recognition of mutated neoantigens in a human melanoma model
  JOURNAL   Oncotarget 8 (17), 28312-28327 (2017)
   PUBMED   28423700
REFERENCE   7  (bases 1 to 6251)
  AUTHORS   Hofvander,J., Tayebwa,J., Nilsson,J., Magnusson,L., Brosjo,O.,
            Larsson,O., Vult von Steyern,F., Mandahl,N., Fletcher,C.D. and
            Mertens,F.
  TITLE     Recurrent PRDM10 gene fusions in undifferentiated pleomorphic
            sarcoma
  JOURNAL   Clin Cancer Res 21 (4), 864-869 (2015)
   PUBMED   25516889
  REMARK    GeneRIF: Our results suggest that PRDM10 fusions are present in
            around 5% of Undifferentiated pleomorphic sarcoma
REFERENCE   8  (bases 1 to 6251)
  AUTHORS   Bhatti,P., Doody,M.M., Rajaraman,P., Alexander,B.H., Yeager,M.,
            Hutchinson,A., Burdette,L., Thomas,G., Hunter,D.J., Simon,S.L.,
            Weinstock,R.M., Rosenstein,M., Stovall,M., Preston,D.L.,
            Linet,M.S., Hoover,R.N., Chanock,S.J. and Sigurdson,A.J.
  TITLE     Novel breast cancer risk alleles and interaction with ionizing
            radiation among U.S. radiologic technologists
  JOURNAL   Radiat Res 173 (2), 214-224 (2010)
   PUBMED   20095854
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 6251)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 6251)
  AUTHORS   Siegel,D.A., Huang,M.K. and Becker,S.F.
  TITLE     Ectopic dendrite initiation: CNS pathogenesis as a model of CNS
            development
  JOURNAL   Int J Dev Neurosci 20 (3-5), 373-389 (2002)
   PUBMED   12175877
  REMARK    Erratum:[Int J Dev Neurosci. 2003 May;21(3):169-70]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003041.3, AP003326.2 and
            AP003327.3.
            
            Summary: The protein encoded by this gene is a transcription factor
            that contains C2H2-type zinc-fingers. It also contains a positive
            regulatory domain, which has been found in several other
            zinc-finger transcription factors including those involved in B
            cell differentiation and tumor suppression. Studies of the mouse
            counterpart suggest that this protein may be involved in the
            development of the central nerve system (CNS), as well as in the
            pathogenesis of neuronal storage disease. Multiple alternatively
            spliced transcript variants encoding distinct isoforms have been
            observed. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.25915.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AP003041.3         51398-51511         c
            115-301             AP003041.3         9572-9758           c
            302-466             AP003041.3         6422-6586           c
            467-526             AP003041.3         4188-4247           c
            527-686             AP003326.2         45669-45828         c
            687-928             AP003326.2         43229-43470         c
            929-1132            AP003326.2         40884-41087         c
            1133-1205           AP003327.3         187282-187354       c
            1206-1323           AP003327.3         184785-184902       c
            1324-1453           AP003327.3         181786-181915       c
            1454-1696           AP003327.3         180700-180942       c
            1697-1708           AP003327.3         179094-179105       c
            1709-2056           AP003327.3         174566-174913       c
            2057-2212           AP003327.3         172932-173087       c
            2213-2392           AP003327.3         168223-168402       c
            2393-2503           AP003327.3         166811-166921       c
            2504-2704           AP003327.3         165344-165544       c
            2705-3019           AP003327.3         164388-164702       c
            3020-3160           AP003327.3         161769-161909       c
            3161-3341           AP003327.3         160160-160340       c
            3342-3445           AP003327.3         155322-155425       c
            3446-6251           AP003327.3         149395-152200       c
FEATURES             Location/Qualifiers
     source          1..6251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..6251
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="PR/SET domain 10"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
     exon            1..114
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            115..301
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..3649
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="isoform 6 is encoded by transcript variant 6; PRDM
                     zinc finger transcription factor; PR-domain family member
                     7; PR domain zinc finger protein 10; tristanin; PR
                     domain-containing protein 10; PR domain containing 10; PR
                     domain 10"
                     /codon_start=1
                     /product="PR domain zinc finger protein 10 isoform 6"
                     /protein_id="NP_001354821.1"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
                     /translation="MDSKDESSHVWPTSAEHEQNAAQVHFVPDTGTVAQIVYTDDQVR
                     PPQQVVYTADGASYTSVDGPEHTLVYIHPVEAAQTLFTDPGQVAYVQQDATAQQASLP
                     VHNQVLPSIESVDGSDPLATLQTPLGRLEAKEEEDEDEDEDTEEDEEEDGCEECNNAH
                     ASVCPKHGPLHPIPNRPVLTRARASLPLVLYIDRFLGGVFSKRRIPKRTQFGPVEGPL
                     VRGSELKDCYIHLKVSLDKGDRKERDLHEDLWFELSDETLCNWMMFVRPAQNHLEQNL
                     VAYQYGHHVYYTTIKNVEPKQELKVWYAASYAEFVNQKIHDISEEERKVLREQEKNWP
                     CYECNRRFISSEQLQQHLNSHDEKLDVFSRTRGRGRGRGKRRFGPGRRPGRPPKFIRL
                     EITSENGEKSDDGTQDLLHFPTKEQFDEAEPATLNGLDQPEQTTIPIPQLPQETQSSL
                     EHEPETHTLHLQPQHEESVVPTQSTLTADDMRRAKRIRLELQNAALQHLFIRKSFRPF
                     KCLQCGKAFREKDKLDQHLRFHGREGNCPLTCDLCNKGFISSTSLESHMKLHSDQKTY
                     SCIFCPESFDRLDLLKDHVAIHINDGYFTCPTCKKRFPDFIQVKKHVRSFHSEKIYQC
                     TECDKAFCRPDKLRLHMLRHSDRKDFLCSTCGKQFKRKDKLREHMQRMHNPEREAKKA
                     DRISRSKTFKPRITSTDYDSFTFKCRLCMMGFRRRGMLVNHLSKRHPDMKIEEVPELT
                     LPIIKPNRDYFCQYCDKVYKSASKRKAHILKNHPGAELPPSIRKLRPAGPGEPDPMLS
                     THTQLTGTIATPPVCCPHCSKQYSSKTKMVQHIRKKHPEFAQLSNTIHTPLTTAVISA
                     TPAVLTTDSATGETVVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGL
                     QQPQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHAIQVQHIQVSEPTASAP
                     SSAQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQNSSVQHTYLPSAW
                     NSFRGYSSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVLSESQSELEEKQT
                     SALSGGVQVEPPAHSDSLDPQTNSQQQTTQYIITTTTNGNGSSEVHITKP"
     exon            302..466
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            467..526
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            527..686
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            687..928
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1132
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1205
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1323
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1453
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1696
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1708
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..2056
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2212
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2392
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2503
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2704
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..3019
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3160
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3341
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3445
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..6251
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6212..6217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="hexamer: AATATA"
     regulatory      6224..6229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="hexamer: AATAAA"
     polyA_site      6229
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="major polyA site"
     polyA_site      6251
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="major polyA site"
ORIGIN      
        1 actctgcggc gggaagaacc acctggaggt ggcggggggg gttgatttct atcaccccta
       61 gggagagagg atcggggacc cgctgatctt ccagctcccc tcacccaacg tcgtgcatgc
      121 tgcagacaga cctttccgtc cttcatgaac acacgtgtgg tagacagatg actgtcctgt
      181 accctgtgct gctctaggtg tgccagacgt ggagctgtcc agttgggaga agatggattc
      241 caaagatgaa agctcgcatg tgtggccgac atctgcagag catgaacaga atgccgcaca
      301 ggtgcacttt gttccggaca caggaacagt ggctcagatt gtctataccg atgaccaggt
      361 tcgcccccca cagcaggtgg tgtacacggc agatggtgcc tcctacacat cagtggatgg
      421 tccagagcac acgctggtgt acatccaccc ggtggaagct gcacagactc tgtttacaga
      481 ccccggccag gtagcttatg tccaacagga tgctacagct cagcaggcct cattgccagt
      541 tcataaccag gtgctgcctt ccatcgagag tgtagatggg tccgaccctt tggcaactct
      601 gcagacccct ctaggcagac tggaggccaa agaggaagag gatgaggatg aggacgagga
      661 cactgaggaa gatgaggaag aagacgggtg tgaggagtgc aataacgcgc atgcttcagt
      721 gtgtccgaag cacggcccct tgcacccgat ccccaaccgg ccggtgctca cccgggccag
      781 ggcgagcctc cccctggtgc tctacataga caggtttctg ggcggggtgt tctccaagcg
      841 gcgcatcccc aagcgcaccc agtttggccc cgtggagggg cctctcgtca ggggctcgga
      901 gctgaaagac tgttacattc acctcaaggt ttctcttgat aaaggggaca ggaaagaaag
      961 ggatttacat gaagacctat ggtttgagtt gtctgatgag acgctttgta actggatgat
     1021 gtttgtacgg ccagcccaga atcacctgga gcagaacctg gtggcttacc agtatggcca
     1081 ccatgtgtat tatacaacca taaaaaatgt ggagcccaag caggaactga aggtgtggta
     1141 tgccgcatcc tatgctgagt tcgtgaacca gaaaattcat gacatttctg aggaagaaag
     1201 gaaagttctt cgagagcaag agaagaattg gccctgctat gaatgtaacc gccgatttat
     1261 aagctcggag cagttgcaac agcatctcaa ttctcatgat gagaaactag atgtgtttag
     1321 cagaacaaga ggcagaggaa ggggacgagg caagaggcga ttcggtccag gtcgacggcc
     1381 ggggcgtcct ccaaaattta tccgcctgga aatcaccagc gaaaatgggg aaaagagtga
     1441 cgatgggaca caggacttgc tacattttcc cacaaaggag caatttgatg aggctgaacc
     1501 agccactctg aatgggctgg atcaaccaga acagaccact atcccaatcc ctcagctgcc
     1561 acaggaaacc cagtcttccc tggaacatga accagaaact cacaccctgc acctgcagcc
     1621 gcagcatgaa gagagcgtgg tgcccaccca gagcacgctg acagccgacg acatgcgcag
     1681 agccaagcgc atccgattgg agctgcagaa tgcagctctt cagcatctgt ttattcggaa
     1741 gtccttccgg ccttttaaat gcttgcagtg tgggaaggcc ttccgggaaa aggacaaact
     1801 ggaccagcac ttacgcttcc atgggcggga ggggaactgc ccactgacct gtgatctctg
     1861 taacaagggc ttcatcagca gcacatcctt ggagagccac atgaagctcc actcagacca
     1921 gaagacttac tcttgcattt tttgcccaga atcctttgac cgccttgatt tgttgaaaga
     1981 tcatgtggcc attcatatca atgatggcta cttcacctgc ccaacttgta agaaacggtt
     2041 cccagatttt atccaggtga aaaaacacgt gcgcagcttc cactcagaaa agatctacca
     2101 gtgcacagag tgtgacaagg ccttctgtcg ccccgataaa ctgcgactcc acatgctccg
     2161 gcattcggac cgcaaagact tcctgtgttc cacctgtggg aagcaattta agcgaaaaga
     2221 caaactacgg gaacacatgc agaggatgca taatcctgag agggaggcca agaaagccga
     2281 ccgcatcagc cgctccaaga cgttcaagcc ccgcatcacg tccacagact acgacagctt
     2341 cacgttcaag tgccgcctgt gcatgatggg cttccggcgg cgcggcatgc tggtaaatca
     2401 cttatcgaag agacacccag acatgaagat agaagaggtg ccagagttaa ctctacccat
     2461 cataaaaccc aatcgtgatt acttttgtca gtattgcgat aaggtttata aaagtgccag
     2521 caagcgcaaa gcccacattc tgaagaacca cccaggagca gagctcccac cgagcattcg
     2581 gaagctccga cccgctggtc ctggagagcc agaccccatg ctgagcacac acacccagct
     2641 gacgggcacc atcgccaccc ctcccgtctg ctgtccccac tgctccaagc agtacagcag
     2701 caagaccaag atggtccagc acattcgaaa gaagcatcca gagttcgccc agctctccaa
     2761 caccatacac acaccactga cgacagctgt gatcagtgcc accccagcgg ttttgactac
     2821 agacagcgcc actggagaga ctgtggtgac gacggacctg ctcacccaag caatgacaga
     2881 actgtcccag accttaacga cagactaccg aacgccacaa ggggattacc agagaattca
     2941 gtacatccct gtgtcgcagt cggcgtctgg cctccagcag cctcagcaca tacagctgca
     3001 agtggttcaa gtggcctcgg ccacttcccc tcaccagtca cagcagtcca ctgtggatgt
     3061 tggccagctc catgatcctc agccctaccc ccagcacgcc atccaggtgc agcacatcca
     3121 ggtcagcgag cctaccgcct cggccccgtc ctccgcccag gtatctgggc agccgttgag
     3181 tccctcagcc cagcaggctc agcaggggct cagcccctcc cacatccagg gcagttcttc
     3241 cacacagggg caggctctgc agcagcagca gcagcagcag cagaattcct ctgtgcagca
     3301 cacgtacctg cccagtgctt ggaattcctt ccgtggctat tcatctgaga ttcaaatgat
     3361 gacgcttcct ccgggtcagt ttgtgattac agacagtggt gtggcaactc cagttactac
     3421 tggccaggtg aaggcggtta cttcgggtca ttatgtgtta tcagaaagtc aatcagaatt
     3481 ggaagaaaag caaacttctg ccctctctgg tggagtccag gtcgagccac ctgcacacag
     3541 tgactccctg gacccccaga ccaacagcca acagcagacc acacagtaca tcatcaccac
     3601 caccaccaac gggaacggaa gcagcgaagt gcatatcacc aaaccatgac ttccaccctg
     3661 gagcttgaat ccagcaccca cctcatgtct gttctcataa gtctgaaagc tctgacacgt
     3721 agagctcttt tgtaagattt attattcact caagagttcg gaaaccacag ttttgtctct
     3781 catccataca ctggggttta ttttgccaag gtcatcttta tcaaattgac tcttcaaacc
     3841 ctcggttttt gccacagaac agagatcttt caggggaaag tagatttcga ggtggagaga
     3901 atttgccttg ctcttgagct ggtcttttaa catactgacg agccttactt ttcctttgtg
     3961 gaaatattaa gtggcatatt gtgttcatac caaaggtgga gacaggatgt gccaagttca
     4021 tggttactgg acttcttatt ccaagccatg gcaccaaagg agaaggggca ttttgtgggt
     4081 gtgcattagg tctgaactgc tttatcttgt tttagttttc agtaatttaa caaagggagc
     4141 ctgctgaata acaaaattaa aatgatgaaa caaaagtttg acagtgatat tctgaagcaa
     4201 aaactgtcat ctaaattttt cttgctgatt ttttttaact tccctatttt agaaaactat
     4261 tgttgggctg ttggtagtgc tttccacaga tgctggtcct cagtggatta ggtcagaagc
     4321 tcatgttctg atagttcttc attatttcac aaaggtggac aacctgaaag agaaaaggct
     4381 gcttgatgtc agcagaatct aaacccctac attaaagctt tgcctcccat tctgtggttg
     4441 tggtggtggt aagaaggaga tattggtacc aagaaaaatt tccaaaacta ttgagagaga
     4501 gagagagaaa gtattgaaat tttgttctgc cttgcaggat ccatttatca ttcattggta
     4561 aaggatatat tccttgttct taccaagtgt acatttaact cttgctgaca tgttcagtgt
     4621 attttattac ttttaatgct gtcttaaaat gaacattctt taaagttgga caggaaggtg
     4681 gcatttctta tttattaaca tttttaactt taaacatatt gtgactcatc tagacctttt
     4741 aataagacgg tcaacttcac acttagggaa aaaattaaaa tgtgatggcc acttctaata
     4801 attcaggtag ttataaggga tctggaagaa atccagtctt tatgaatata ctattagttg
     4861 ggcattaaaa aatcagtata tattttaact ttttgtgaca tgctaacaca ttttcagaat
     4921 aattattgca tagtagaatt tattactcca gaacagaaag accttacttc atttcaaatg
     4981 aagttaatta atttacattt ctgggtaaaa actggttcta taaattaagt agagtagctt
     5041 ctttatgata aagacaattt tctgaaaagt gaacaattct gttaaaagaa ctttattgat
     5101 gtgtagattt cgcactttat ttctgagact gcgttcatgt agttgttccc caatgtttga
     5161 gtactaagag aacttgagaa aattacttca taaacatatg gaaactgaaa atggactctc
     5221 tttgtgacaa agatattcaa cagaaaatat tgaccctgca ttgcaaaaca caggttcggg
     5281 ttccctaagt cccacagtgt aatgattaca aatatcctag tgtccggtct agaaagactt
     5341 tctaggagaa gactagtgga attttctaaa ggttcagttt tagcttttat aacttaaatt
     5401 tggccctgtt acgttctttt taatttgaac cataaggtat ctcccctccc ttcaggaata
     5461 acttattgga aaactgaaaa gaatcactga atggaatgtt cattttatgg cagttgtttt
     5521 aagttttaaa atacacagag gaaaatattg tggaaggacc tctttgttgc tttcccttct
     5581 aagttgtctt cttcttcttc ttcttcttct tcttctttgg tccttaagtg aaataaagac
     5641 tctaaaacta atttgtatat tatcagccag agatgcggat ggcagtcgag ccaaatcgca
     5701 tggctttcag atcaggtatt ctgcacattc attccaaggt catagatttt taaaaggacc
     5761 tggatttgaa gagatggcaa atgatgagcc atcagaaaac ttaatttgga aaacatgtat
     5821 gtagccagtg tggatattgt ggcctctctc aagacacatt gacactgtag acttcattca
     5881 gtccagtgtg agtattttgg agtaggttgg atgtagattt tgtttttatc attgatttgt
     5941 accgacagaa atagacattt catcatgtaa aattcctgtt attctggaaa aacctattgt
     6001 tttgatcttc ttgttttctg acttggaagt atcctttcaa aaaaactctt aagatatcta
     6061 ggtctaaaaa gcacttcatg agatgctaaa gctgacccac tggttgaaaa tgttgaccct
     6121 atcctgttat ttaaatgtga acatttattg tacattcagt gagttatagt gttaatagtc
     6181 ttgtgctatg cagcaggtgt aaaaattaat aaatatattt tttaataaac atgtttgtat
     6241 gtgtgaagct a
//
