LOCUS       NM_001367891            6245 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens PR/SET domain 10 (PRDM10), transcript variant 7, mRNA.
ACCESSION   NM_001367891
VERSION     NM_001367891.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6245)
  AUTHORS   Li,L., Hongying,C. and Heng,G.
  TITLE     Autophagy-related LncRNA PRDM10-DT responds to UVB radiation in
            keratinocytes
  JOURNAL   Biochem Biophys Res Commun 677, 105-112 (2023)
   PUBMED   37566921
  REMARK    GeneRIF: Autophagy-related LncRNA PRDM10-DT responds to UVB
            radiation in keratinocytes.
REFERENCE   2  (bases 1 to 6245)
  AUTHORS   Schmidt,L.S., Vocke,C.D., Ricketts,C.J., Blake,Z., Choo,K.K.,
            Nielsen,D., Gautam,R., Crooks,D.R., Reynolds,K.L., Krolus,J.L.,
            Bashyal,M., Karim,B., Cowen,E.W., Malayeri,A.A., Merino,M.J.,
            Srinivasan,R., Ball,M.W., Zbar,B. and Marston Linehan,W.
  TITLE     PRDM10 RCC: A Birt-Hogg-Dube-like Syndrome Associated With Lipoma
            and Highly Penetrant, Aggressive Renal Tumors Morphologically
            Resembling Type 2 Papillary Renal Cell Carcinoma
  JOURNAL   Urology 179, 58-70 (2023)
   PUBMED   37331486
  REMARK    GeneRIF: PRDM10 RCC: A Birt-Hogg-Dube-like Syndrome Associated With
            Lipoma and Highly Penetrant, Aggressive Renal Tumors
            Morphologically Resembling Type 2 Papillary Renal Cell Carcinoma.
REFERENCE   3  (bases 1 to 6245)
  AUTHORS   Zhao,M., Yin,X., He,H., Fan,Y., Ru,G. and Meng,X.
  TITLE     Recurrent PRDM10 Fusions in Superficial CD34-Positive Fibroblastic
            Tumors : A Clinicopathologic and Molecular Study of 10 Additional
            Cases of an Emerging Novel Entity
  JOURNAL   Am J Clin Pathol 159 (4), 367-378 (2023)
   PUBMED   36812381
  REMARK    GeneRIF: Recurrent PRDM10 Fusions in Superficial CD34-Positive
            Fibroblastic Tumors : A Clinicopathologic and Molecular Study of 10
            Additional Cases of an Emerging Novel Entity.
REFERENCE   4  (bases 1 to 6245)
  AUTHORS   van de Beek,I., Glykofridis,I.E., Oosterwijk,J.C., van den
            Akker,P.C., Diercks,G.F.H., Bolling,M.C., Waisfisz,Q.,
            Mensenkamp,A.R., Balk,J.A., Zwart,R., Postma,A.V.,
            Meijers-Heijboer,H.E.J., van Moorselaar,R.J.A., Wolthuis,R.M.F. and
            Houweling,A.C.
  TITLE     PRDM10 directs FLCN expression in a novel disorder overlapping with
            Birt-Hogg-Dube syndrome and familial lipomatosis
  JOURNAL   Hum Mol Genet 32 (7), 1223-1235 (2023)
   PUBMED   36440963
  REMARK    GeneRIF: PRDM10 directs FLCN expression in a novel disorder
            overlapping with Birt-Hogg-Dube syndrome and familial lipomatosis.
REFERENCE   5  (bases 1 to 6245)
  AUTHORS   Hofvander,J., Puls,F., Pillay,N., Steele,C.D., Flanagan,A.M.,
            Magnusson,L., Nilsson,J. and Mertens,F.
  TITLE     Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a
            distinct gene expression profile
  JOURNAL   J Pathol 249 (4), 425-434 (2019)
   PUBMED   31313299
  REMARK    GeneRIF: PRDM10-fusions represent the critical driver mutations in
            undifferentiated pleomorphic sarcomas.
REFERENCE   6  (bases 1 to 6245)
  AUTHORS   Schrors,B., Lubcke,S., Lennerz,V., Fatho,M., Bicker,A., Wolfel,C.,
            Derigs,P., Hankeln,T., Schadendorf,D., Paschen,A. and Wolfel,T.
  TITLE     HLA class I loss in metachronous metastases prevents continuous T
            cell recognition of mutated neoantigens in a human melanoma model
  JOURNAL   Oncotarget 8 (17), 28312-28327 (2017)
   PUBMED   28423700
REFERENCE   7  (bases 1 to 6245)
  AUTHORS   Hofvander,J., Tayebwa,J., Nilsson,J., Magnusson,L., Brosjo,O.,
            Larsson,O., Vult von Steyern,F., Mandahl,N., Fletcher,C.D. and
            Mertens,F.
  TITLE     Recurrent PRDM10 gene fusions in undifferentiated pleomorphic
            sarcoma
  JOURNAL   Clin Cancer Res 21 (4), 864-869 (2015)
   PUBMED   25516889
  REMARK    GeneRIF: Our results suggest that PRDM10 fusions are present in
            around 5% of Undifferentiated pleomorphic sarcoma
REFERENCE   8  (bases 1 to 6245)
  AUTHORS   Bhatti,P., Doody,M.M., Rajaraman,P., Alexander,B.H., Yeager,M.,
            Hutchinson,A., Burdette,L., Thomas,G., Hunter,D.J., Simon,S.L.,
            Weinstock,R.M., Rosenstein,M., Stovall,M., Preston,D.L.,
            Linet,M.S., Hoover,R.N., Chanock,S.J. and Sigurdson,A.J.
  TITLE     Novel breast cancer risk alleles and interaction with ionizing
            radiation among U.S. radiologic technologists
  JOURNAL   Radiat Res 173 (2), 214-224 (2010)
   PUBMED   20095854
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 6245)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 6245)
  AUTHORS   Siegel,D.A., Huang,M.K. and Becker,S.F.
  TITLE     Ectopic dendrite initiation: CNS pathogenesis as a model of CNS
            development
  JOURNAL   Int J Dev Neurosci 20 (3-5), 373-389 (2002)
   PUBMED   12175877
  REMARK    Erratum:[Int J Dev Neurosci. 2003 May;21(3):169-70]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003041.3, AP003326.2 and
            AP003327.3.
            
            Summary: The protein encoded by this gene is a transcription factor
            that contains C2H2-type zinc-fingers. It also contains a positive
            regulatory domain, which has been found in several other
            zinc-finger transcription factors including those involved in B
            cell differentiation and tumor suppression. Studies of the mouse
            counterpart suggest that this protein may be involved in the
            development of the central nerve system (CNS), as well as in the
            pathogenesis of neuronal storage disease. Multiple alternatively
            spliced transcript variants encoding distinct isoforms have been
            observed. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.185815.1,
                                           SRR1660809.82863.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AP003041.3         51398-51511         c
            115-301             AP003041.3         9572-9758           c
            302-466             AP003041.3         6422-6586           c
            467-692             AP003326.2         45603-45828         c
            693-934             AP003326.2         43229-43470         c
            935-1138            AP003326.2         40884-41087         c
            1139-1211           AP003327.3         187282-187354       c
            1212-1329           AP003327.3         184785-184902       c
            1330-1459           AP003327.3         181786-181915       c
            1460-1702           AP003327.3         180700-180942       c
            1703-2050           AP003327.3         174566-174913       c
            2051-2206           AP003327.3         172932-173087       c
            2207-2386           AP003327.3         168223-168402       c
            2387-2497           AP003327.3         166811-166921       c
            2498-2698           AP003327.3         165344-165544       c
            2699-3013           AP003327.3         164388-164702       c
            3014-3154           AP003327.3         161769-161909       c
            3155-3335           AP003327.3         160160-160340       c
            3336-3439           AP003327.3         155322-155425       c
            3440-6245           AP003327.3         149395-152200       c
FEATURES             Location/Qualifiers
     source          1..6245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..6245
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="PR/SET domain 10"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
     exon            1..114
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            115..301
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..3643
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="isoform 7 is encoded by transcript variant 7; PRDM
                     zinc finger transcription factor; PR-domain family member
                     7; PR domain zinc finger protein 10; tristanin; PR
                     domain-containing protein 10; PR domain containing 10; PR
                     domain 10"
                     /codon_start=1
                     /product="PR domain zinc finger protein 10 isoform 7"
                     /protein_id="NP_001354820.1"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
                     /translation="MDSKDESSHVWPTSAEHEQNAAQVHFVPDTGTVAQIVYTDDQVR
                     PPQQVVYTADGASYTSVDGPEHTLVYIHPVEAAQASLPVHNQVLPSIESVDGSDPLAT
                     LQTPLGRLEAKEEEDEDEDEDTEEDEEEDGEDTDLDDWEPDPPRPFDPHDLWCEECNN
                     AHASVCPKHGPLHPIPNRPVLTRARASLPLVLYIDRFLGGVFSKRRIPKRTQFGPVEG
                     PLVRGSELKDCYIHLKVSLDKGDRKERDLHEDLWFELSDETLCNWMMFVRPAQNHLEQ
                     NLVAYQYGHHVYYTTIKNVEPKQELKVWYAASYAEFVNQKIHDISEEERKVLREQEKN
                     WPCYECNRRFISSEQLQQHLNSHDEKLDVFSRTRGRGRGRGKRRFGPGRRPGRPPKFI
                     RLEITSENGEKSDDGTQDLLHFPTKEQFDEAEPATLNGLDQPEQTTIPIPQLPQETQS
                     SLEHEPETHTLHLQPQHEESVVPTQSTLTADDMRRAKRIRNAALQHLFIRKSFRPFKC
                     LQCGKAFREKDKLDQHLRFHGREGNCPLTCDLCNKGFISSTSLESHMKLHSDQKTYSC
                     IFCPESFDRLDLLKDHVAIHINDGYFTCPTCKKRFPDFIQVKKHVRSFHSEKIYQCTE
                     CDKAFCRPDKLRLHMLRHSDRKDFLCSTCGKQFKRKDKLREHMQRMHNPEREAKKADR
                     ISRSKTFKPRITSTDYDSFTFKCRLCMMGFRRRGMLVNHLSKRHPDMKIEEVPELTLP
                     IIKPNRDYFCQYCDKVYKSASKRKAHILKNHPGAELPPSIRKLRPAGPGEPDPMLSTH
                     TQLTGTIATPPVCCPHCSKQYSSKTKMVQHIRKKHPEFAQLSNTIHTPLTTAVISATP
                     AVLTTDSATGETVVTTDLLTQAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQ
                     PQHIQLQVVQVASATSPHQSQQSTVDVGQLHDPQPYPQHAIQVQHIQVSEPTASAPSS
                     AQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQNSSVQHTYLPSAWNS
                     FRGYSSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVLSESQSELEEKQTSA
                     LSGGVQVEPPAHSDSLDPQTNSQQQTTQYIITTTTNGNGSSEVHITKP"
     exon            302..466
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            467..692
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            693..934
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1138
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1211
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1329
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1459
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1702
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..2050
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2206
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2386
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2497
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2698
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..3013
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3154
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3335
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3439
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..6245
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6206..6211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="hexamer: AATATA"
     regulatory      6218..6223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="hexamer: AATAAA"
     polyA_site      6223
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="major polyA site"
     polyA_site      6245
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /note="major polyA site"
ORIGIN      
        1 actctgcggc gggaagaacc acctggaggt ggcggggggg gttgatttct atcaccccta
       61 gggagagagg atcggggacc cgctgatctt ccagctcccc tcacccaacg tcgtgcatgc
      121 tgcagacaga cctttccgtc cttcatgaac acacgtgtgg tagacagatg actgtcctgt
      181 accctgtgct gctctaggtg tgccagacgt ggagctgtcc agttgggaga agatggattc
      241 caaagatgaa agctcgcatg tgtggccgac atctgcagag catgaacaga atgccgcaca
      301 ggtgcacttt gttccggaca caggaacagt ggctcagatt gtctataccg atgaccaggt
      361 tcgcccccca cagcaggtgg tgtacacggc agatggtgcc tcctacacat cagtggatgg
      421 tccagagcac acgctggtgt acatccaccc ggtggaagct gcacaggcct cattgccagt
      481 tcataaccag gtgctgcctt ccatcgagag tgtagatggg tccgaccctt tggcaactct
      541 gcagacccct ctaggcagac tggaggccaa agaggaagag gatgaggatg aggacgagga
      601 cactgaggaa gatgaggaag aagacggtga ggacacggat ctggatgact gggagccaga
      661 cccgccccgg cccttcgacc cacacgactt gtggtgtgag gagtgcaata acgcgcatgc
      721 ttcagtgtgt ccgaagcacg gccccttgca cccgatcccc aaccggccgg tgctcacccg
      781 ggccagggcg agcctccccc tggtgctcta catagacagg tttctgggcg gggtgttctc
      841 caagcggcgc atccccaagc gcacccagtt tggccccgtg gaggggcctc tcgtcagggg
      901 ctcggagctg aaagactgtt acattcacct caaggtttct cttgataaag gggacaggaa
      961 agaaagggat ttacatgaag acctatggtt tgagttgtct gatgagacgc tttgtaactg
     1021 gatgatgttt gtacggccag cccagaatca cctggagcag aacctggtgg cttaccagta
     1081 tggccaccat gtgtattata caaccataaa aaatgtggag cccaagcagg aactgaaggt
     1141 gtggtatgcc gcatcctatg ctgagttcgt gaaccagaaa attcatgaca tttctgagga
     1201 agaaaggaaa gttcttcgag agcaagagaa gaattggccc tgctatgaat gtaaccgccg
     1261 atttataagc tcggagcagt tgcaacagca tctcaattct catgatgaga aactagatgt
     1321 gtttagcaga acaagaggca gaggaagggg acgaggcaag aggcgattcg gtccaggtcg
     1381 acggccgggg cgtcctccaa aatttatccg cctggaaatc accagcgaaa atggggaaaa
     1441 gagtgacgat gggacacagg acttgctaca ttttcccaca aaggagcaat ttgatgaggc
     1501 tgaaccagcc actctgaatg ggctggatca accagaacag accactatcc caatccctca
     1561 gctgccacag gaaacccagt cttccctgga acatgaacca gaaactcaca ccctgcacct
     1621 gcagccgcag catgaagaga gcgtggtgcc cacccagagc acgctgacag ccgacgacat
     1681 gcgcagagcc aagcgcatcc gaaatgcagc tcttcagcat ctgtttattc ggaagtcctt
     1741 ccggcctttt aaatgcttgc agtgtgggaa ggccttccgg gaaaaggaca aactggacca
     1801 gcacttacgc ttccatgggc gggaggggaa ctgcccactg acctgtgatc tctgtaacaa
     1861 gggcttcatc agcagcacat ccttggagag ccacatgaag ctccactcag accagaagac
     1921 ttactcttgc attttttgcc cagaatcctt tgaccgcctt gatttgttga aagatcatgt
     1981 ggccattcat atcaatgatg gctacttcac ctgcccaact tgtaagaaac ggttcccaga
     2041 ttttatccag gtgaaaaaac acgtgcgcag cttccactca gaaaagatct accagtgcac
     2101 agagtgtgac aaggccttct gtcgccccga taaactgcga ctccacatgc tccggcattc
     2161 ggaccgcaaa gacttcctgt gttccacctg tgggaagcaa tttaagcgaa aagacaaact
     2221 acgggaacac atgcagagga tgcataatcc tgagagggag gccaagaaag ccgaccgcat
     2281 cagccgctcc aagacgttca agccccgcat cacgtccaca gactacgaca gcttcacgtt
     2341 caagtgccgc ctgtgcatga tgggcttccg gcggcgcggc atgctggtaa atcacttatc
     2401 gaagagacac ccagacatga agatagaaga ggtgccagag ttaactctac ccatcataaa
     2461 acccaatcgt gattactttt gtcagtattg cgataaggtt tataaaagtg ccagcaagcg
     2521 caaagcccac attctgaaga accacccagg agcagagctc ccaccgagca ttcggaagct
     2581 ccgacccgct ggtcctggag agccagaccc catgctgagc acacacaccc agctgacggg
     2641 caccatcgcc acccctcccg tctgctgtcc ccactgctcc aagcagtaca gcagcaagac
     2701 caagatggtc cagcacattc gaaagaagca tccagagttc gcccagctct ccaacaccat
     2761 acacacacca ctgacgacag ctgtgatcag tgccacccca gcggttttga ctacagacag
     2821 cgccactgga gagactgtgg tgacgacgga cctgctcacc caagcaatga cagaactgtc
     2881 ccagacctta acgacagact accgaacgcc acaaggggat taccagagaa ttcagtacat
     2941 ccctgtgtcg cagtcggcgt ctggcctcca gcagcctcag cacatacagc tgcaagtggt
     3001 tcaagtggcc tcggccactt cccctcacca gtcacagcag tccactgtgg atgttggcca
     3061 gctccatgat cctcagccct acccccagca cgccatccag gtgcagcaca tccaggtcag
     3121 cgagcctacc gcctcggccc cgtcctccgc ccaggtatct gggcagccgt tgagtccctc
     3181 agcccagcag gctcagcagg ggctcagccc ctcccacatc cagggcagtt cttccacaca
     3241 ggggcaggct ctgcagcagc agcagcagca gcagcagaat tcctctgtgc agcacacgta
     3301 cctgcccagt gcttggaatt ccttccgtgg ctattcatct gagattcaaa tgatgacgct
     3361 tcctccgggt cagtttgtga ttacagacag tggtgtggca actccagtta ctactggcca
     3421 ggtgaaggcg gttacttcgg gtcattatgt gttatcagaa agtcaatcag aattggaaga
     3481 aaagcaaact tctgccctct ctggtggagt ccaggtcgag ccacctgcac acagtgactc
     3541 cctggacccc cagaccaaca gccaacagca gaccacacag tacatcatca ccaccaccac
     3601 caacgggaac ggaagcagcg aagtgcatat caccaaacca tgacttccac cctggagctt
     3661 gaatccagca cccacctcat gtctgttctc ataagtctga aagctctgac acgtagagct
     3721 cttttgtaag atttattatt cactcaagag ttcggaaacc acagttttgt ctctcatcca
     3781 tacactgggg tttattttgc caaggtcatc tttatcaaat tgactcttca aaccctcggt
     3841 ttttgccaca gaacagagat ctttcagggg aaagtagatt tcgaggtgga gagaatttgc
     3901 cttgctcttg agctggtctt ttaacatact gacgagcctt acttttcctt tgtggaaata
     3961 ttaagtggca tattgtgttc ataccaaagg tggagacagg atgtgccaag ttcatggtta
     4021 ctggacttct tattccaagc catggcacca aaggagaagg ggcattttgt gggtgtgcat
     4081 taggtctgaa ctgctttatc ttgttttagt tttcagtaat ttaacaaagg gagcctgctg
     4141 aataacaaaa ttaaaatgat gaaacaaaag tttgacagtg atattctgaa gcaaaaactg
     4201 tcatctaaat ttttcttgct gatttttttt aacttcccta ttttagaaaa ctattgttgg
     4261 gctgttggta gtgctttcca cagatgctgg tcctcagtgg attaggtcag aagctcatgt
     4321 tctgatagtt cttcattatt tcacaaaggt ggacaacctg aaagagaaaa ggctgcttga
     4381 tgtcagcaga atctaaaccc ctacattaaa gctttgcctc ccattctgtg gttgtggtgg
     4441 tggtaagaag gagatattgg taccaagaaa aatttccaaa actattgaga gagagagaga
     4501 gaaagtattg aaattttgtt ctgccttgca ggatccattt atcattcatt ggtaaaggat
     4561 atattccttg ttcttaccaa gtgtacattt aactcttgct gacatgttca gtgtatttta
     4621 ttacttttaa tgctgtctta aaatgaacat tctttaaagt tggacaggaa ggtggcattt
     4681 cttatttatt aacattttta actttaaaca tattgtgact catctagacc ttttaataag
     4741 acggtcaact tcacacttag ggaaaaaatt aaaatgtgat ggccacttct aataattcag
     4801 gtagttataa gggatctgga agaaatccag tctttatgaa tatactatta gttgggcatt
     4861 aaaaaatcag tatatatttt aactttttgt gacatgctaa cacattttca gaataattat
     4921 tgcatagtag aatttattac tccagaacag aaagacctta cttcatttca aatgaagtta
     4981 attaatttac atttctgggt aaaaactggt tctataaatt aagtagagta gcttctttat
     5041 gataaagaca attttctgaa aagtgaacaa ttctgttaaa agaactttat tgatgtgtag
     5101 atttcgcact ttatttctga gactgcgttc atgtagttgt tccccaatgt ttgagtacta
     5161 agagaacttg agaaaattac ttcataaaca tatggaaact gaaaatggac tctctttgtg
     5221 acaaagatat tcaacagaaa atattgaccc tgcattgcaa aacacaggtt cgggttccct
     5281 aagtcccaca gtgtaatgat tacaaatatc ctagtgtccg gtctagaaag actttctagg
     5341 agaagactag tggaattttc taaaggttca gttttagctt ttataactta aatttggccc
     5401 tgttacgttc tttttaattt gaaccataag gtatctcccc tcccttcagg aataacttat
     5461 tggaaaactg aaaagaatca ctgaatggaa tgttcatttt atggcagttg ttttaagttt
     5521 taaaatacac agaggaaaat attgtggaag gacctctttg ttgctttccc ttctaagttg
     5581 tcttcttctt cttcttcttc ttcttcttct ttggtcctta agtgaaataa agactctaaa
     5641 actaatttgt atattatcag ccagagatgc ggatggcagt cgagccaaat cgcatggctt
     5701 tcagatcagg tattctgcac attcattcca aggtcataga tttttaaaag gacctggatt
     5761 tgaagagatg gcaaatgatg agccatcaga aaacttaatt tggaaaacat gtatgtagcc
     5821 agtgtggata ttgtggcctc tctcaagaca cattgacact gtagacttca ttcagtccag
     5881 tgtgagtatt ttggagtagg ttggatgtag attttgtttt tatcattgat ttgtaccgac
     5941 agaaatagac atttcatcat gtaaaattcc tgttattctg gaaaaaccta ttgttttgat
     6001 cttcttgttt tctgacttgg aagtatcctt tcaaaaaaac tcttaagata tctaggtcta
     6061 aaaagcactt catgagatgc taaagctgac ccactggttg aaaatgttga ccctatcctg
     6121 ttatttaaat gtgaacattt attgtacatt cagtgagtta tagtgttaat agtcttgtgc
     6181 tatgcagcag gtgtaaaaat taataaatat attttttaat aaacatgttt gtatgtgtga
     6241 agcta
//
