LOCUS       NM_001198               5148 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens PR/SET domain 1 (PRDM1), transcript variant 1, mRNA.
ACCESSION   NM_001198
VERSION     NM_001198.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5148)
  AUTHORS   Yu,C., Li,J., Kuang,W., Ni,S., Cao,Y. and Duan,Y.
  TITLE     PRDM1 promotes nucleus pulposus cell pyroptosis leading to
            intervertebral disc degeneration via activating CASP1 transcription
  JOURNAL   Cell Biol Toxicol 40 (1), 89 (2024)
   PUBMED   39432156
  REMARK    GeneRIF: PRDM1 promotes nucleus pulposus cell pyroptosis leading to
            intervertebral disc degeneration via activating CASP1
            transcription.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5148)
  AUTHORS   Nakata,Y., Nagasawa,S., Sera,Y., Yamasaki,N., Kanai,A.,
            Kobatake,K., Ueda,T., Koizumi,M., Manabe,I., Kaminuma,O. and
            Honda,H.
  TITLE     PTIP epigenetically regulates DNA damage-induced cell cycle arrest
            by upregulating PRDM1
  JOURNAL   Sci Rep 14 (1), 17987 (2024)
   PUBMED   39097652
  REMARK    GeneRIF: PTIP epigenetically regulates DNA damage-induced cell
            cycle arrest by upregulating PRDM1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5148)
  AUTHORS   Truong,B.T., Shull,L.C., Zepeda,B.J., Lencer,E. and Artinger,K.B.
  TITLE     Human split hand/foot variants are not as functional as wildtype
            human PRDM1 in the rescue of craniofacial defects
  JOURNAL   Birth Defects Res 116 (3), e2327 (2024)
   PUBMED   38456586
  REMARK    GeneRIF: Human split hand/foot variants are not as functional as
            wildtype human PRDM1 in the rescue of craniofacial defects.
REFERENCE   4  (bases 1 to 5148)
  AUTHORS   Di Zazzo,E., Rienzo,M., Casamassimi,A., De Rosa,C., Medici,N.,
            Gazzerro,P., Bifulco,M. and Abbondanza,C.
  TITLE     Exploring the putative role of PRDM1 and PRDM2 transcripts as
            mediators of T lymphocyte activation
  JOURNAL   J Transl Med 21 (1), 217 (2023)
   PUBMED   36964555
  REMARK    GeneRIF: Exploring the putative role of PRDM1 and PRDM2 transcripts
            as mediators of T lymphocyte activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5148)
  AUTHORS   Zhao,Q., Xia,N., Xu,J., Wang,Y., Feng,L., Su,D. and Cheng,Z.
  TITLE     Pro-Inflammatory of PRDM1/SIRT2/NLRP3 Axis in Monosodium
            Urate-Induced Acute Gouty Arthritis
  JOURNAL   J Innate Immun 15 (1), 614-628 (2023)
   PUBMED   37385228
  REMARK    GeneRIF: Pro-Inflammatory of PRDM1/SIRT2/NLRP3 Axis in Monosodium
            Urate-Induced Acute Gouty Arthritis.
REFERENCE   6  (bases 1 to 5148)
  AUTHORS   Ren,B., Chee,K.J., Kim,T.H. and Maniatis,T.
  TITLE     PRDI-BF1/Blimp-1 repression is mediated by corepressors of the
            Groucho family of proteins
  JOURNAL   Genes Dev 13 (1), 125-137 (1999)
   PUBMED   9887105
REFERENCE   7  (bases 1 to 5148)
  AUTHORS   Mock,B.A., Liu,L., LePaslier,D. and Huang,S.
  TITLE     The B-lymphocyte maturation promoting transcription factor
            BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and
            the syntenic region of mouse chromosome 10
  JOURNAL   Genomics 37 (1), 24-28 (1996)
   PUBMED   8921366
REFERENCE   8  (bases 1 to 5148)
  AUTHORS   Huang,S.
  TITLE     Blimp-1 is the murine homolog of the human transcriptional
            repressor PRDI-BF1
  JOURNAL   Cell 78 (1), 9 (1994)
   PUBMED   8033216
REFERENCE   9  (bases 1 to 5148)
  AUTHORS   Turner,C.A. Jr., Mack,D.H. and Davis,M.M.
  TITLE     Blimp-1, a novel zinc finger-containing protein that can drive the
            maturation of B lymphocytes into immunoglobulin-secreting cells
  JOURNAL   Cell 77 (2), 297-306 (1994)
   PUBMED   8168136
REFERENCE   10 (bases 1 to 5148)
  AUTHORS   Keller,A.D. and Maniatis,T.
  TITLE     Identification and characterization of a novel repressor of
            beta-interferon gene expression
  JOURNAL   Genes Dev 5 (5), 868-879 (1991)
   PUBMED   1851123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY198414.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001198.3.
            
            Summary: This gene encodes a protein that acts as a repressor of
            beta-interferon gene expression. The protein binds specifically to
            the PRDI (positive regulatory domain I element) of the beta-IFN
            gene promoter. Transcription of this gene increases upon virus
            induction. Two alternatively spliced transcript variants that
            encode different isoforms have been reported. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1), also known as PRDM1alpha,
            encodes the longer isoform (1). The protein encoded by this
            transcript has also been named PRDI-BF1alpha.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY198414.1, AL832963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369096.9/ ENSP00000358092.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5148              AY198414.1         17-5164
FEATURES             Location/Qualifiers
     source          1..5148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..5148
                     /gene="PRDM1"
                     /gene_synonym="BLIMP-1; BLIMP1; PRDI-BF1"
                     /note="PR/SET domain 1"
                     /db_xref="GeneID:639"
                     /db_xref="HGNC:HGNC:9346"
                     /db_xref="MIM:603423"
     exon            1..260
                     /gene="PRDM1"
                     /gene_synonym="BLIMP-1; BLIMP1; PRDI-BF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2696
                     /gene="PRDM1"
                     /gene_synonym="BLIMP-1; BLIMP1; PRDI-BF1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     B-lymphocyte-induced maturation protein 1; beta-interferon
                     gene positive-regulatory domain I binding factor;
                     PRDI-binding factor-1; PR domain zinc finger protein 1; PR
                     domain 1; PR domain containing 1, with ZNF domain"
                     /codon_start=1
                     /product="PR domain zinc finger protein 1 isoform 1"
                     /protein_id="NP_001189.2"
                     /db_xref="CCDS:CCDS5054.2"
                     /db_xref="GeneID:639"
                     /db_xref="HGNC:HGNC:9346"
                     /db_xref="MIM:603423"
                     /translation="MLDICLEKRVGTTLAAPKCNSSTVRFQGLAEGTKGTMKMDMEDA
                     DMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVM
                     SKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMR
                     YVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTM
                     MNLTQTQSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTS
                     EKDLDDFRRRGSPEMPFYPRVVYPIRAPLPEDFLKASLAYGIERPTYITRSPIPSSTT
                     PSPSARSSPDQSLKSSSPHSSPGNTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPGY
                     APLPHLPPAFIPSYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVYSNL
                     LGGGSLPHPMLNPTSLPSSLPSDGARRLLQPEHPREVLVPAPHSAFSFTGAAASMKDK
                     ACSPTSGSPTAGTAATAEHVVQPKATSAAMAAPSSDEAMNLIKNKRNMTGYKTLPYPL
                     KKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLV
                     HTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKVCPAKFTQFVHLKLHKRLHT
                     RERPHKCSQCHKNYIHLCSLKVHLKGNCAAAPAPGLPLEDLTRINEEIEKFDISDNAD
                     RLEDVEDDISVISVVEKEILAVVRKEKEETGLKVSLQRNMGNGLLSSGCSLYESSDLP
                     LMKLPPSNPLPLVPVKVKQETVEPMDP"
     exon            261..509
                     /gene="PRDM1"
                     /gene_synonym="BLIMP-1; BLIMP1; PRDI-BF1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..629
                     /gene="PRDM1"
                     /gene_synonym="BLIMP-1; BLIMP1; PRDI-BF1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..882
                     /gene="PRDM1"
                     /gene_synonym="BLIMP-1; BLIMP1; PRDI-BF1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1991
                     /gene="PRDM1"
                     /gene_synonym="BLIMP-1; BLIMP1; PRDI-BF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2120
                     /gene="PRDM1"
                     /gene_synonym="BLIMP-1; BLIMP1; PRDI-BF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..5148
                     /gene="PRDM1"
                     /gene_synonym="BLIMP-1; BLIMP1; PRDI-BF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5124..5129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRDM1"
                     /gene_synonym="BLIMP-1; BLIMP1; PRDI-BF1"
                     /note="hexamer: TATAAA"
     polyA_site      5148
                     /gene="PRDM1"
                     /gene_synonym="BLIMP-1; BLIMP1; PRDI-BF1"
                     /note="major polyA site"
ORIGIN      
        1 aacacagaca aagtgctgcc gtgacactcg gccctccagt gttgcggaga ggcaagagca
       61 gcgaccgcgg cacctgtccg cccggagctg ggacgcgggc gcccgggcgg ccggacgaag
      121 cgaggaggga ccgccgaggt gcgcgtctgt gcggctcagc ctggcggggg acgcggggag
      181 aatgtggact gggtagagat gaacgagact tttctcagat gttggatatt tgcttggaaa
      241 aacgtgtggg tacgaccttg gctgccccca agtgtaactc cagcactgtg aggtttcagg
      301 gattggcaga ggggaccaag gggaccatga aaatggacat ggaggatgcg gatatgactc
      361 tgtggacaga ggctgagttt gaagagaagt gtacatacat tgtgaacgac cacccctggg
      421 attctggtgc tgatggcggt acttcggttc aggcggaggc atccttacca aggaatctgc
      481 ttttcaagta tgccaccaac agtgaagagg ttattggagt gatgagtaaa gaatacatac
      541 caaagggcac acgttttgga cccctaatag gtgaaatcta caccaatgac acagttccta
      601 agaacgccaa caggaaatat ttttggagga tctattccag aggggagctt caccacttca
      661 ttgacggctt taatgaagag aaaagcaact ggatgcgcta tgtgaatcca gcacactctc
      721 cccgggagca aaacctggct gcgtgtcaga acgggatgaa catctacttc tacaccatta
      781 agcccatccc tgccaaccag gaacttcttg tgtggtattg tcgggacttt gcagaaaggc
      841 ttcactaccc ttatcccgga gagctgacaa tgatgaatct cacacaaaca cagagcagtc
      901 taaagcaacc gagcactgag aaaaatgaac tctgcccaaa gaatgtccca aagagagagt
      961 acagcgtgaa agaaatccta aaattggact ccaacccctc caaaggaaag gacctctacc
     1021 gttctaacat ttcacccctc acatcagaaa aggacctcga tgactttaga agacgtggga
     1081 gccccgaaat gcccttctac cctcgggtcg tttaccccat ccgggcccct ctgccagaag
     1141 actttttgaa agcttccctg gcctacggga tcgagagacc cacgtacatc actcgctccc
     1201 ccattccatc ctccaccact ccaagcccct ctgcaagaag cagccccgac caaagcctca
     1261 agagctccag ccctcacagc agccctggga atacggtgtc ccctgtgggc cccggctctc
     1321 aagagcaccg ggactcctac gcttacttga acgcgtccta cggcacggaa ggtttgggct
     1381 cctaccctgg ctacgcaccc ctgccccacc tcccgccagc tttcatcccc tcgtacaacg
     1441 ctcactaccc caagttcctc ttgcccccct acggcatgaa ttgtaatggc ctgagcgctg
     1501 tgagcagcat gaatggcatc aacaactttg gcctcttccc gaggctgtgc cctgtctaca
     1561 gcaatctcct cggtgggggc agcctgcccc accccatgct caaccccact tctctcccga
     1621 gctcgctgcc ctcagatgga gcccggaggt tgctccagcc ggagcatccc agggaggtgc
     1681 ttgtcccggc gccccacagt gccttctcct ttaccggggc cgccgccagc atgaaggaca
     1741 aggcctgtag ccccacaagc gggtctccca cggcgggaac agccgccacg gcagaacatg
     1801 tggtgcagcc caaagctacc tcagcagcga tggcagcccc cagcagcgac gaagccatga
     1861 atctcattaa aaacaaaaga aacatgaccg gctacaagac ccttccctac ccgctgaaga
     1921 agcagaacgg caagatcaag tacgaatgca acgtttgcgc caagactttc ggccagctct
     1981 ccaatctgaa ggtccacctg agagtgcaca gtggagaacg gcctttcaaa tgtcagactt
     2041 gcaacaaggg ctttactcag ctcgcccacc tgcagaaaca ctacctggta cacacgggag
     2101 aaaagccaca tgaatgccag gtctgccaca agagatttag cagcaccagc aatctcaaga
     2161 cccacctgcg actccattct ggagagaaac cataccaatg caaggtgtgc cctgccaagt
     2221 tcacccagtt tgtgcacctg aaactgcaca agcgtctgca cacccgggag cggccccaca
     2281 agtgctccca gtgccacaag aactacatcc atctctgtag cctcaaggtt cacctgaaag
     2341 ggaactgcgc tgcggccccg gcgcctgggc tgcccttgga agatctgacc cgaatcaatg
     2401 aagaaatcga gaagtttgac atcagtgaca atgctgaccg gctcgaggac gtggaggatg
     2461 acatcagtgt gatctctgta gtggagaagg aaattctggc cgtggtcaga aaagagaaag
     2521 aagaaactgg cctgaaagtg tctttgcaaa gaaacatggg gaatggactc ctctcctcag
     2581 ggtgcagcct ttatgagtca tcagatctac ccctcatgaa gttgcctccc agcaacccac
     2641 tacctctggt acctgtaaag gtcaaacaag aaacagttga accaatggat ccttaagatt
     2701 ttcagaaaac acttattttg tttcttaagt tatgacttgg tgagtcaggg tgcctgtagg
     2761 aagtggcttg tacataatcc cagctctgca aagctctctc gacagcaaat ggtttcccct
     2821 cacctctgga attaaagaag gaactccaaa gttactgaaa tctcagggca tgaacaaggc
     2881 aaaggccata tatatatata tatatatatc tgtatacata ttatatatac ttatttacac
     2941 ctgtgtctat atatttgccc ctgtgtattt tgaatatttg tgtggacatg tttgcatagc
     3001 cttcccatta ctaagactat tacctagtca taattatttt ttcaatgata atccttcata
     3061 atttattata caatttatca ttcagaaagc aataattaaa aaagtttaca atgactggaa
     3121 agattccttg taatttgagt ataaatgtat ttttgtcttg tggccattct ttgtagataa
     3181 tttctgcaca tctgtataag tacctaagat ttagttaaac aaatatatga cttcagtcaa
     3241 cctctctctc taataatggt ttgaaaatga ggtttgggta attgccaatg ttggacagtt
     3301 gatgtgttca ttcctgggat cctatcattt gaacagcatt gtacataact tgggggtatg
     3361 tgtgcaggat tacccaagaa taacttaagt agaagaaaca agaaagggaa tcttgtatat
     3421 ttttgttgat agttcatgtt tttcccccag ccacaatttt accggaaggg tgacaggaag
     3481 gctttaccaa cctgtctctc cctccaaaag agcagaatcc tcccaccgcc ctgccctccc
     3541 caccgagtcc tgtggccatt cagagcggcc acatgacttt tgcatccatt gtattatcag
     3601 aaaatgtgaa gaagaaaaaa atgccatgtt ttaaaaccac tgcgaaaatt tccccaaagc
     3661 ataggtggct ttgtgtgtgt gcgatttggg ggcttgagtc tgggtggtgt tttgttgttg
     3721 gtttttgttg cttttttttt tttttttttt ttaatgtcaa aattgcacaa acatggtgct
     3781 ctaccaggaa ggattcgagg tagataggct caggccacac tttaaaaaca aacacacaaa
     3841 caacaaaaaa cgggtattct agtcatcttg gggtaaaagc gggtaatgaa cattcctatc
     3901 cccaacacat caattgtatt ttttctgtaa aactcagatt ttcctcagta tttgtgtttt
     3961 tacattttat ggttaattta atggaagatg aaagggcatt gcaaagttgt tcaacaacag
     4021 ttacctcatt gagtgtgtcc agtagtgcag gaaatgatgt cttatctaat gatttgcttc
     4081 tctagaggag aaaccgagta aatgtgctcc agcaagatag actttgtgtt attctatctt
     4141 ttattctgct aagcccaaag attacatgtt ggtgttcaaa gtgtagcaaa aaatgatgta
     4201 tatttataaa tctatttata ccactatatc atatgtatat atatttataa ccacttaaat
     4261 tgtgagccaa gccatgtaaa agatctactt tttctaaggg caaaaaaaaa aaaaaaaaaa
     4321 aaagaacact cctttctgag actttgctta atacttggtg acctcacaat cacgtcggta
     4381 tgattgggca cccttgccta ctgtaagaga ccctaaaacc ttggtgcagt ggtggggacc
     4441 acaaaacaac cagggaggaa gagatacatc attttttagt attaaggacc atctaagaca
     4501 gctctatttt ttttttgcca ctttatgatt atgtggtcac acccaagtca cagaaataaa
     4561 aaactgactt taccgctgca atttttctgt tttcctcctt actaaatact gatacattac
     4621 tccaatctat tttataatta tatttgacat tttgttcaca tcaactaatg ttcacctgta
     4681 gaagagaaca aatttcgaat aatccaggga aacccaagag ccttactggt cttctgtaac
     4741 ttccaagact gacagctttt tatgtatcag tgtttgataa acacagtcct taactgaagg
     4801 taaaccaaag catcacgttg acattagacc aaatactttt gattcccaac tactcgtttg
     4861 ttctttttct ccttttgtgc tttcccatag tgagaatttt tataaagact tcttgcttct
     4921 ctcaccatcc atccttctct tttctgcctc ttacatgtga atgttgagcc cacaatcaac
     4981 agtggtttta ttttttcctc tactcaaagt taaaactgac caaagttact ggctttttac
     5041 tttgctagaa caacaaacta tcttatgttt acatactggt ttacaatgtt atttatgtgc
     5101 aaattgtcaa aatgtaaatt aaatataaat gttcatgctt taccaaaa
//
