LOCUS       NM_005973               2068 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens proline rich mitotic checkpoint control factor (PRCC),
            mRNA.
ACCESSION   NM_005973
VERSION     NM_005973.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2068)
  AUTHORS   Wang,B., Yin,X., Gan,W., Pan,F., Li,S., Xiang,Z., Han,X. and Li,D.
  TITLE     PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes
            cell survival and proliferation in PRCC-TFE3 translocation renal
            cell carcinoma
  JOURNAL   Autophagy 17 (9), 2475-2493 (2021)
   PUBMED   33019842
  REMARK    GeneRIF: PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy
            promotes cell survival and proliferation in PRCC-TFE3 translocation
            renal cell carcinoma.
REFERENCE   2  (bases 1 to 2068)
  AUTHORS   Xiong,L., Chen,X., Liu,N., Wang,Z., Miao,B., Gan,W., Li,D. and
            Guo,H.
  TITLE     PRCC-TFE3 dual-fusion FISH assay: A new method for identifying
            PRCC-TFE3 renal cell carcinoma in paraffin-embedded tissue
  JOURNAL   PLoS One 12 (9), e0185337 (2017)
   PUBMED   28949976
  REMARK    GeneRIF: results reveal that PRCC-TFE3 dual-fusion FISH probe is an
            efficient and concise technique for diagnosing PRCC-TFE3 RCC in
            paraffin-embedded tissue
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2068)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2068)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 2068)
  AUTHORS   Weterman,M.J., van Groningen,J.J., Jansen,A. and van Kessel,A.G.
  TITLE     Nuclear localization and transactivating capacities of the
            papillary renal cell carcinoma-associated TFE3 and PRCC (fusion)
            proteins
  JOURNAL   Oncogene 19 (1), 69-74 (2000)
   PUBMED   10644981
REFERENCE   6  (bases 1 to 2068)
  AUTHORS   Weterman,M.A., Wilbrink,M. and Geurts van Kessel,A.
  TITLE     Fusion of the transcription factor TFE3 gene to a novel gene, PRCC,
            in t(X;1)(p11;q21)-positive papillary renal cell carcinomas
  JOURNAL   Proc Natl Acad Sci U S A 93 (26), 15294-15298 (1996)
   PUBMED   8986805
REFERENCE   7  (bases 1 to 2068)
  AUTHORS   Sidhar,S.K., Clark,J., Gill,S., Hamoudi,R., Crew,A.J., Gwilliam,R.,
            Ross,M., Linehan,W.M., Birdsall,S., Shipley,J. and Cooper,C.S.
  TITLE     The t(X;1)(p11.2;q21.2) translocation in papillary renal cell
            carcinoma fuses a novel gene PRCC to the TFE3 transcription factor
            gene
  JOURNAL   Hum Mol Genet 5 (9), 1333-1338 (1996)
   PUBMED   8872474
REFERENCE   8  (bases 1 to 2068)
  AUTHORS   Zbar,B., Glenn,G., Lubensky,I., Choyke,P., Walther,M.M.,
            Magnusson,G., Bergerheim,U.S., Pettersson,S., Amin,M. and Hurley,K.
  TITLE     Hereditary papillary renal cell carcinoma: clinical studies in 10
            families
  JOURNAL   J Urol 153 (3 Pt 2), 907-912 (1995)
   PUBMED   7853572
  REMARK    Review article
REFERENCE   9  (bases 1 to 2068)
  AUTHORS   Satoh,Y., Kashimura,M., Kaneko,S., Karasaki,Y., Higashi,K. and
            Gotoh,S.
  TITLE     Cloning of cDNAs with possible association with senescence and
            immortalization of human cells
  JOURNAL   Mutat Res 316 (1), 25-36 (1994)
   PUBMED   7507566
REFERENCE   10 (bases 1 to 2068)
  AUTHORS   Meloni,A.M., Dobbs,R.M., Pontes,J.E. and Sandberg,A.A.
  TITLE     Translocation (X;1) in papillary renal cell carcinoma. A new
            cytogenetic subtype
  JOURNAL   Cancer Genet Cytogenet 65 (1), 1-6 (1993)
   PUBMED   8431910
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM423590.1, BC010450.1 and
            BC004913.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005973.4.
            
            Summary: This gene encodes a protein that may play a role in
            pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that
            result in fusion of this gene to TFE3 (GeneID 7030) have been
            associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion
            protein is expressed in affected carcinomas and is likely
            associated with altered gene transactivation. This fusion protein
            has also been associated with disruption of the cell
            cycle.[provided by RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.952875.1,
                                           SRR3476690.72566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271526.9/ ENSP00000271526.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BM423590.1         36-54
            20-31               BC010450.1         1-12
            32-2068             BC004913.2         1-2037
FEATURES             Location/Qualifiers
     source          1..2068
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..2068
                     /gene="PRCC"
                     /gene_synonym="RCCP1; TPRC"
                     /note="proline rich mitotic checkpoint control factor"
                     /db_xref="GeneID:5546"
                     /db_xref="HGNC:HGNC:9343"
                     /db_xref="MIM:179755"
     exon            1..705
                     /gene="PRCC"
                     /gene_synonym="RCCP1; TPRC"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1713
                     /gene="PRCC"
                     /gene_synonym="RCCP1; TPRC"
                     /note="papillary renal cell carcinoma
                     translocation-associated gene protein; papillary renal
                     cell carcinoma (translocation-associated); PRCC, proline
                     rich mitotic checkpoint control factor"
                     /codon_start=1
                     /product="proline-rich protein PRCC"
                     /protein_id="NP_005964.3"
                     /db_xref="CCDS:CCDS1157.1"
                     /db_xref="GeneID:5546"
                     /db_xref="HGNC:HGNC:9343"
                     /db_xref="MIM:179755"
                     /translation="MSLVAYASSDESEPDEAEPEPEEEEAVAPTSGPALGGLFASLPA
                     PKGPALLPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGFPPPPGVSPAEAA
                     GVGEGLGLGLPSPRGPGLNLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDSDSE
                     EDEPTKKKTILQGSSEGTGLSALLPQPKNLTVKETNRLLLPHAFSRKPSDGSPDTKPS
                     RLASKTKTSSLAPVVGTTTTTPSPSAIKAAAKSAALQVTKQITQEEDDSDEEVAPENF
                     FSLPEKAEPPGVEPYPYPIPTVPEELPPGTEPEPAFQDDAANAPLEFKMAAGSSGAPW
                     MPKPGDDYSYNQFSTYGDANAAGAYYQDYYSGGYYPAQDPALVPPQEIAPDASFIDDE
                     AFKRLQGKRNRGREEINFVEIKGDDQLSGAQQWMTKSLTEEKTMKSFSKKKGEQPTGQ
                     QRRKHQITYLIHQAKERELELKNTWSENKLSRRQTQAKYGF"
     exon            706..753
                     /gene="PRCC"
                     /gene_synonym="RCCP1; TPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1320
                     /gene="PRCC"
                     /gene_synonym="RCCP1; TPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1416
                     /gene="PRCC"
                     /gene_synonym="RCCP1; TPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1560
                     /gene="PRCC"
                     /gene_synonym="RCCP1; TPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1626
                     /gene="PRCC"
                     /gene_synonym="RCCP1; TPRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..2068
                     /gene="PRCC"
                     /gene_synonym="RCCP1; TPRC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2046..2051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRCC"
                     /gene_synonym="RCCP1; TPRC"
                     /note="hexamer: AATAAA"
     polyA_site      2068
                     /gene="PRCC"
                     /gene_synonym="RCCP1; TPRC"
                     /note="major polyA site"
ORIGIN      
        1 ggccattagc tgtgtgtagt tgcccgggac taggagctta agtgaagagg tacgccttgt
       61 tcggtggaaa tcagccgtag ccatgagttt ctgccggggc tagccctaga gtacggagca
      121 ggcggacttt tcggttcccc gccccgccag gtggcggggc ctactaggcc tccgggcatc
      181 cccggtctca agtaggcctc atctgccggc aagggcgccc gaaacgcggg aggcgccatg
      241 tcgctggttg cttacgccag cagcgatgag agcgagccgg atgaggctga gcccgagccg
      301 gaggaagagg aggcggtggc tcctacatct gggcccgctt tagggggctt gttcgcttct
      361 ctccctgcgc ccaagggtcc ggccttgctg cctccgcccc ctcagatgct ggcgccagcc
      421 tttcccccgc cgctgttgct tcccccaccc accggagacc ccaggcttca gcctcctccc
      481 cccttgccct tcggcctggg aggcttcccc ccacctccag gcgtgagccc ggctgaagcg
      541 gcgggagttg gggagggact gggattgggg ttgccctcgc cccgaggccc tggcctcaat
      601 ctgccccctc caattggcgg tgccggtccc ccgctggggc ttcccaagcc aaagaagagg
      661 aaagagcccg tgaagatcgc ggcgccggag ttgcataagg gagattcaga ttctgaggaa
      721 gatgaaccca caaagaagaa aactatcctt cagggatcca gtgaggggac tggtttgtct
      781 gccttgcttc cccaacctaa aaacctgact gtgaaagaga ctaacaggtt gctcctgccc
      841 catgccttct cccgcaaacc ctcggatggc tcccctgata ctaagccctc cagactggct
      901 tctaagacca agacttcctc tcttgcccct gttgtgggca ccacaaccac cactccgtcg
      961 ccctctgcta tcaaggctgc tgccaagagt gctgccctgc aggtgacaaa gcagatcacg
     1021 caggaagaag acgacagtga tgaggaagta gcccccgaaa actttttctc cctccctgaa
     1081 aaggctgagc cacctggagt tgagccatac ccttacccca tccccactgt ccctgaagag
     1141 ctgcctccag gcacggaacc agagccggct ttccaggacg atgcagccaa tgcccccctt
     1201 gaattcaaga tggcagcagg ttcaagtggg gccccttgga tgcctaagcc tggggacgac
     1261 tacagctaca atcagttttc cacatatggc gatgccaatg ccgctggtgc ttattatcag
     1321 gattattaca gtggtggcta ctatcctgca caggacccgg ccctggtccc cccccaggaa
     1381 attgccccag atgcctcctt catcgatgac gaagcattta agcggctgca gggcaagagg
     1441 aaccgaggga gagaagaaat caactttgtg gagatcaaag gtgatgacca gctcagtggg
     1501 gcccagcaat ggatgactaa gtcattgaca gaagagaaaa ccatgaagtc attcagcaaa
     1561 aagaaaggtg agcagccaac aggccagcag cggcggaaac accagatcac atatcttatt
     1621 catcaggcca aggagcggga gctggaactg aagaacacct ggtcagagaa caagctcagc
     1681 cgccgtcaga cccaagccaa atatggattc tagggctctg gaactgattg ctcccaggat
     1741 ctcctgccag cccagctggc ctggccccca gcttcacctc tgggacccca gctgctctaa
     1801 gcccaggatc tctttcccca aggacccagc cctcgcctct gcgagaatga acatatttga
     1861 tagatttttc ttaacaagtt agaaaattca gctcctttct gtcctggagc tagcaaagac
     1921 ttgtgtgatg cctccgaagg ggctctgagt tctggggtgg gagttttgct ctctgtcagg
     1981 tgtgataaaa tgttgaaccc tccccaccac cacttttttt tttttaaacc agggatgtct
     2041 gttgaaataa aacattcagt ctgacaaa
//
