LOCUS       NM_006249               1101 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens proline rich protein BstNI subfamily 3 (PRB3),
            transcript variant 1, mRNA.
ACCESSION   NM_006249 XM_001128803
VERSION     NM_006249.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1101)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1101)
  AUTHORS   Manconi,B., Castagnola,M., Cabras,T., Olianas,A., Vitali,A.,
            Desiderio,C., Sanna,M.T. and Messana,I.
  TITLE     The intriguing heterogeneity of human salivary proline-rich
            proteins: Short title: Salivary proline-rich protein species
  JOURNAL   J Proteomics 134, 47-56 (2016)
   PUBMED   26375204
REFERENCE   3  (bases 1 to 1101)
  AUTHORS   Wang,F., Gao,H., Li,C., Bai,J., Lu,R., Cao,L., Wu,Y., Hong,L.,
            Wu,Y., Lan,X. and Zhang,Y.
  TITLE     Low levels of PRB3 mRNA are associated with dopamine-agonist
            resistance and tumor recurrence in prolactinomas
  JOURNAL   J Neurooncol 116 (1), 83-88 (2014)
   PUBMED   24135847
  REMARK    GeneRIF: The results of this study suggested that low levels of
            PRB3 mRNA may have a role in dopamine-agonist resistance and tumor
            recurrence of prolactinomas.
REFERENCE   4  (bases 1 to 1101)
  AUTHORS   Vitorino,R., Alves,R., Barros,A., Caseiro,A., Ferreira,R.,
            Lobo,M.C., Bastos,A., Duarte,J., Carvalho,D., Santos,L.L. and
            Amado,F.L.
  TITLE     Finding new posttranslational modifications in salivary
            proline-rich proteins
  JOURNAL   Proteomics 10 (20), 3732-3742 (2010)
   PUBMED   20879038
REFERENCE   5  (bases 1 to 1101)
  AUTHORS   Helmerhorst,E.J., Sun,X., Salih,E. and Oppenheim,F.G.
  TITLE     Identification of Lys-Pro-Gln as a novel cleavage site specificity
            of saliva-associated proteases
  JOURNAL   J Biol Chem 283 (29), 19957-19966 (2008)
   PUBMED   18463091
REFERENCE   6  (bases 1 to 1101)
  AUTHORS   Gillece-Castro,B.L., Prakobphol,A., Burlingame,A.L., Leffler,H. and
            Fisher,S.J.
  TITLE     Structure and bacterial receptor activity of a human salivary
            proline-rich glycoprotein
  JOURNAL   J Biol Chem 266 (26), 17358-17368 (1991)
   PUBMED   1894623
REFERENCE   7  (bases 1 to 1101)
  AUTHORS   Azen,E.A., Minaguchi,K., Latreille,P. and Kim,H.S.
  TITLE     Alleles at the PRB3 locus coding for a disulfide-bonded human
            salivary proline-rich glycoprotein (Gl 8) and a null in an
            Ashkenazi Jew
  JOURNAL   Am J Hum Genet 47 (4), 686-697 (1990)
   PUBMED   2171329
REFERENCE   8  (bases 1 to 1101)
  AUTHORS   Lyons,K.M., Stein,J.H. and Smithies,O.
  TITLE     Length polymorphisms in human proline-rich protein genes generated
            by intragenic unequal crossing over
  JOURNAL   Genetics 120 (1), 267-278 (1988)
   PUBMED   2851479
REFERENCE   9  (bases 1 to 1101)
  AUTHORS   Azen,E.A. and Maeda,N.
  TITLE     Molecular genetics of human salivary proteins and their
            polymorphisms
  JOURNAL   Adv Hum Genet 17, 141-199 (1988)
   PUBMED   3055850
  REMARK    Review article
REFERENCE   10 (bases 1 to 1101)
  AUTHORS   Maeda,N., Kim,H.S., Azen,E.A. and Smithies,O.
  TITLE     Differential RNA splicing and post-translational cleavages in the
            human salivary proline-rich protein gene system
  JOURNAL   J Biol Chem 260 (20), 11123-11130 (1985)
   PUBMED   2993301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010176.12 and AC244131.2.
            
            On Apr 24, 2014 this sequence version replaced NM_006249.4.
            
            Summary: This gene encodes a member of the heterogeneous family of
            basic, proline-rich, human salivary glycoproteins. Multiple alleles
            of this gene exhibiting variations in the length of the tandem
            repeats have been identified. The reference genome encodes the
            'Long' allele. The protein isoforms encoded by this gene are
            recognized as the 'first line of oral defense' against the
            detrimental effects of polyphenols in the diet and pathogen
            infections. This gene is located in a cluster of closely related
            salivary proline-rich proteins on chromosome 12. [provided by
            RefSeq, Nov 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096211.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150585, SAMN03465412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC010176.12        107680-107781
            103-138             AC010176.12        108719-108754
            139-687             AC010176.12        109239-109787
            688-752             AC010176.12        109914-109978
            753-985             AC244131.2         69558-69790
            986-1101            AC244131.2         70937-71052
FEATURES             Location/Qualifiers
     source          1..1101
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1101
                     /gene="PRB3"
                     /gene_synonym="G1; PRG"
                     /note="proline rich protein BstNI subfamily 3"
                     /db_xref="GeneID:5544"
                     /db_xref="HGNC:HGNC:9339"
                     /db_xref="MIM:168840"
     exon            1..102
                     /gene="PRB3"
                     /gene_synonym="G1; PRG"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..968
                     /gene="PRB3"
                     /gene_synonym="G1; PRG"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; G1 parotid salivary glycoprotein; BstNI type
                     basic salivary proline-rich protein 3; proline-rich
                     protein G1; parotid salivary glycoprotein G1"
                     /codon_start=1
                     /product="basic salivary proline-rich protein 3 isoform 1
                     precursor"
                     /protein_id="NP_006240.4"
                     /db_xref="GeneID:5544"
                     /db_xref="HGNC:HGNC:9339"
                     /db_xref="MIM:168840"
                     /translation="MLLILLSVALLALSSAQSLNEDVSQEESPSVISGKPEGRRPQGG
                     NQPQRTPPPPGKPEGRPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGQ
                     PPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPG
                     KPEGPPPQGGNQSQGPPPHPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGP
                     PPRPGKPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGNKPQRPPPPGRPQGPPPPGGNP
                     QQPLPPPAGKPQGPPPPPQGGRPHRPPQGQPPQ"
     exon            103..138
                     /gene="PRB3"
                     /gene_synonym="G1; PRG"
                     /inference="alignment:Splign:2.1.0"
     exon            139..687
                     /gene="PRB3"
                     /gene_synonym="G1; PRG"
                     /inference="alignment:Splign:2.1.0"
     exon            688..985
                     /gene="PRB3"
                     /gene_synonym="G1; PRG"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1101
                     /gene="PRB3"
                     /gene_synonym="G1; PRG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1079..1084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRB3"
                     /gene_synonym="G1; PRG"
                     /note="hexamer: AATAAA"
     polyA_site      1101
                     /gene="PRB3"
                     /gene_synonym="G1; PRG"
                     /note="major polyA site"
ORIGIN      
        1 agcacagagt tgggagtgac tccagagcct ccagcaagat gctactgatt ctgctgtcgg
       61 tggccctgct ggccctgagc tcagctcaga gcttaaatga agatgtcagc caggaagaat
      121 ctccctccgt aatatcagga aagccagaag gacgacgccc acaaggagga aaccagcccc
      181 aacgtacccc acctcctcca ggaaagccag aaggacgacc cccacaagga ggcaaccagt
      241 cccaaggtcc cccacctcgt ccaggaaagc cagaaggacc acccccacaa ggaggaaacc
      301 agtcccaagg tcccccacct cgtccgggaa agccagaagg acaaccccca caaggaggaa
      361 accagtccca aggtccccca cctcgtccgg gaaagccaga aggaccaccc ccacaaggag
      421 gaaaccagtc ccaaggtccc ccgcctcgtc cgggaaagcc agaaggacca cccccacaag
      481 gaggaaacca gtcccaaggt cccccgcctc gtccgggaaa gccagaagga ccacccccac
      541 aaggaggaaa ccagtcccaa ggtcccccgc ctcatccggg aaagccagaa ggaccacccc
      601 cacaaggagg aaaccagtcc caaggtcccc cacctcgtcc gggaaagcca gaaggaccac
      661 ccccacaagg aggaaaccag tcccaaggtc ccccacctcg tccaggaaag ccagaaggac
      721 caccttcaca aggaggcaac aaacctcaag gtcccccacc tcatccagga aagccacaag
      781 gaccaccccc acaagaaggt aacaaacctc aacgtccccc tcctccagga aggccacaag
      841 gaccaccccc accaggaggc aatccccagc agcctctgcc acctcccgct ggaaagcccc
      901 agggaccacc tccacctcct caagggggca gaccacacag acctccccag ggacagcctc
      961 cccagtaatc aaggttcaat gacaggaagt gaacaagaag atgacagtga ttcaaatgat
     1021 tcaaatgcca tgacattgga agaaggtggt catagctcta cctttaatat accaataaaa
     1081 taaacagctt acaatttctg a
//
