LOCUS       NM_001009611            1840 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens PRAME family member 4 (PRAMEF4), mRNA.
ACCESSION   NM_001009611 XM_291396
VERSION     NM_001009611.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Li,B., Li,T., Pignon,J.C., Wang,B., Wang,J., Shukla,S.A., Dou,R.,
            Chen,Q., Hodi,F.S., Choueiri,T.K., Wu,C., Hacohen,N.,
            Signoretti,S., Liu,J.S. and Liu,X.S.
  TITLE     Landscape of tumor-infiltrating T cell repertoire of human cancers
  JOURNAL   Nat Genet 48 (7), 725-732 (2016)
   PUBMED   27240091
  REMARK    GeneRIF: PRAMEF4 mutation is associated with cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC245034.2.
            
            On Apr 9, 2014 this sequence version replaced NM_001009611.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL049681.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000235349.6/ ENSP00000235349.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC245034.2         68184-68238
            56-364              AC245034.2         70975-71283
            365-946             AC245034.2         71950-72531
            947-1840            AC245034.2         74280-75173
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..1840
                     /gene="PRAMEF4"
                     /note="PRAME family member 4"
                     /db_xref="GeneID:400735"
                     /db_xref="HGNC:HGNC:31971"
     exon            1..55
                     /gene="PRAMEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            56..364
                     /gene="PRAMEF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1508
                     /gene="PRAMEF4"
                     /note="RP5-845O24.6"
                     /codon_start=1
                     /product="PRAME family member 4"
                     /protein_id="NP_001009611.2"
                     /db_xref="CCDS:CCDS30592.1"
                     /db_xref="GeneID:400735"
                     /db_xref="HGNC:HGNC:31971"
                     /translation="MKMSIWTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFME
                     AFSRRRCEALKLMVQSWPFRRLPLRPLIKMPCLEAFQAVLDGLDALLNLGVRPRRWKL
                     QVLDLQDVCENFWMVWSEAMAHGCFLNAKRNKKPVEDCPRMKGRQPLTVFVELWLKNR
                     TLDEYLTCLLLWVKQRKDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKW
                     VLPILTQFTPYLGHMRNLQKLILSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLY
                     MNSVSFLEGHLDQLLSCLKTSLKFLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIR
                     LTNYSLVPLQILLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPI
                     CMATLENLLSHTIILKNLCVELYPAPRESYGADGTLCWSRFAQIRAELMNRVRDLRHP
                     KRILFCTDYCPDCGNRSFYDLEADQYCC"
     exon            365..946
                     /gene="PRAMEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1840
                     /gene="PRAMEF4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcctgcttg gttcttcctg agatctgaga accttctaga ctacatccag atctgttttc
       61 cctgcagatt catgaagatg agcatctgga ctccacccag actcctggag cttgcagggc
      121 ggagcctgct aagggaccaa gctttggcca tgtccaccct ggaggagctg cccacagaac
      181 ttttcccccc actgttcatg gaggccttca gcaggagacg ctgtgaggcc ctgaagctga
      241 tggtgcagtc ctggcccttc cgccgcctcc ctctgaggcc tctgataaag atgccttgtc
      301 tggaggcctt ccaagctgtg ctcgatgggc tggatgcact gcttaaccta ggggttcgtc
      361 ccaggaggtg gaaacttcaa gtgctggatt tacaggatgt ctgtgagaac ttctggatgg
      421 tttggtctga agctatggcc catgggtgct tcctcaatgc caagaggaac aaaaaaccag
      481 tggaggactg tccaaggatg aaaggacggc agcccttgac tgtgttcgta gaactttggc
      541 tcaagaacag gactctggat gaatacctca cctgcctcct tctatgggtc aagcagagga
      601 aagatttact acacctgtgc tgtaagaagc tgaaaatttt gggaatgccc ttccgcaata
      661 tcagaagcat cctgaaaatg gtgaacctag actgtatcca ggaggtggaa gtgaattgca
      721 agtgggtact gcccatcctg acacagttta ccccatacct gggccacatg aggaatcttc
      781 agaaactcat tctctcccac atggatgtct ctcgctacgt ttccccagag cagaagaagg
      841 agattgttac ccagttcacc actcagttcc tcaagctgcg ctgcctccaa aagctttata
      901 tgaactctgt ttctttcctc gaaggccacc tggaccagct gctcagctgt ctgaagacct
      961 cgttaaagtt cctcacaata actaactgtg tgcttttgga atcagacttg aagcatctat
     1021 cccagtgccc gagtatcagt caactaaaga ccctggacct gagtggcatc agactgacca
     1081 attacagtct tgtgcctctc caaattctcc tagaaaaagt tgcagccacc cttgagtacc
     1141 tggatttaga tgactgtggc atcatagact cccaagtcaa cgccatcttg cctgccctga
     1201 gccgctgctt tgagctcaac accttcagct tctgtggaaa tcccatctgc atggccaccc
     1261 tggagaacct gctgagccac acaatcatac tcaaaaactt atgcgtggag ctgtatcctg
     1321 ccccccggga gagttatggt gctgatggta ctctctgctg gagcagattt gctcaaatta
     1381 gggctgagct gatgaacaga gtgagggact taaggcaccc caagaggatc ttgttctgta
     1441 ctgactactg ccctgactgt ggcaacaggt cattttatga cctggaggca gatcaatact
     1501 gctgttgaat gcctgcctat ttggatgggt atgtcaaacg ctttcttctg gacacttgga
     1561 aactaaaacc taggtcttag gtacatccta aagggagcac agaacccatc atttcacaca
     1621 taggctctga aagtgggaaa ggaaagctga tcaagcaggg gccggacttg ggggaaatgt
     1681 tgccatggat tcgatgggac tttggggacc tgtgtcctgt agagtcgaaa atgggaatct
     1741 gaatgtctag agtggaattc aggcttgaga atacatgagg gagttactct tgcatggatg
     1801 gttgtaaaga aacaatcaga aataaaggaa aactgagcag
//
