LOCUS       NM_001080830            2889 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens PRAME family member 12 (PRAMEF12), mRNA.
ACCESSION   NM_001080830 XM_372760 XM_938351
VERSION     NM_001080830.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2889)
  AUTHORS   Li,J., Zhong,J., Tang,A., Yin,J. and Li,S.
  TITLE     PRAMEF12, a novel cancer/testis gene, regulates proliferation and
            apoptosis to promote progression of glioma
  JOURNAL   Biomark Med 18 (8), 385-397 (2024)
   PUBMED   38913622
  REMARK    GeneRIF: PRAMEF12, a novel cancer/testis gene, regulates
            proliferation and apoptosis to promote progression of glioma.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244670.3.
            
            On Nov 27, 2019 this sequence version replaced NM_001080830.4.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357726.5/ ENSP00000350358.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1417              AC244670.3         178970-180386
            1418-1993           AC244670.3         180775-181350
            1994-2889           AC244670.3         182243-183138
FEATURES             Location/Qualifiers
     source          1..2889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..2889
                     /gene="PRAMEF12"
                     /note="PRAME family member 12"
                     /db_xref="GeneID:390999"
                     /db_xref="HGNC:HGNC:22125"
     exon            1..1417
                     /gene="PRAMEF12"
                     /inference="alignment:Splign:2.1.0"
     CDS             1131..2582
                     /gene="PRAMEF12"
                     /codon_start=1
                     /product="PRAME family member 12"
                     /protein_id="NP_001074299.2"
                     /db_xref="CCDS:CCDS41254.1"
                     /db_xref="GeneID:390999"
                     /db_xref="HGNC:HGNC:22125"
                     /translation="MSLQAPPRLLELAEQSLLRDRALAIPTLEELPRELFPPLFMEAF
                     TRRCCETLTTMVQAWPFTCLPLGSLMKSCNLEIFRAVLEGLDALLAQKVRPRRWKLQV
                     LDLRNVDENFWGIWSGASALSPEALSKRRTAGNCPRPGGQQPLMVILDLCFKNGTLDE
                     CLTHFLEWGKQRKGLLHVCCKELQIFGIAIHRIIEVLNTVELDCIQEVEVCCPWELSI
                     LIRFAPYLGQMRNLRKLVLFNIHVSACIPLDRKEQFVIQFTSQFLKLDYFQKLYMHSV
                     SFLEGHLDQLLRCLQAPLETVVMTECLLSESDLKHLSWCPSIRQLKELDLRGITLTHF
                     SPEPLSVLLEQAEATLQTLDLEDCGIVDSQLSAILPALSRCSQLSTFSFCGNLISMAA
                     LENLLRHTVGLSKLSLELYPAPLESYDAQGALCWGRFSQLGAELMKTLRDLRQPKIIV
                     FSTVPCPRCGIRASYDLEPSHCLLNACCQGGFI"
     exon            1418..1993
                     /gene="PRAMEF12"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2889
                     /gene="PRAMEF12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2867..2872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRAMEF12"
                     /note="hexamer: AATAAA"
     polyA_site      2889
                     /gene="PRAMEF12"
                     /note="major polyA site"
ORIGIN      
        1 aatccaaggc gctgacacct ggagctactg ctcggttctc tgagaggttg cagcaccctg
       61 caaactgagt ccagatctgg taagtcacca cctccttagg gtcatgccca tctgatctgc
      121 agccagccag ccagtcaggg atggtgacat gcagcccaag gtggcagaga gaattttctt
      181 gtctgttttc agaagaacaa atttaggctt tgatttttcc tctaaatgta gttttgtctt
      241 catcccccaa aattggattt gtgcttggtt tttgtcattt caaaattctt attgaagcag
      301 tttttttttt aacaagagat attaaaaagt tacaactggt tgaattttta tttcgtgaca
      361 tttgaaataa ttggtttttg tgcccttaaa ttatagttca tagacttggt ggcatcgtga
      421 ttttacatgt taggccttag tttttactaa taccttaaag atattccata ggccattctc
      481 aagagtggag tctttgttct gaacatggga cccatttttt tcccctagat tccatcccaa
      541 agtgggtcat tgtgagtctg tgtaagagat caacattgga accttcatct gagagttagt
      601 gtttttatcc ctaactttca caggctctag aacactgtca tgctgttttt acaatttctt
      661 gttacaattt ttcaaaataa aaaataatgg cgctgattcc aaggagtccc tttagtcttc
      721 tgcaagcatg tcaattgtgg gaactgagaa tgtaggctgt gtggggccac aggacattct
      781 cgttcccatt gttttagggt ggtaagtgac aagaaatatt ttctcaaaaa ggtggagctt
      841 agctttcagg atcctcagca acgcttccca gtgttactga gatttagtgc agcaatggtt
      901 gaaaatgaat gggccagtgg ttaccttgcc ctctcctcat tgtttggaag acattcttta
      961 tggtaccagc aagggcagaa ttacagattt gtgtccagaa agtgcagagt ggaattgggg
     1021 tgaactaatt acctttccac ctctaccaga gcaatgacat tggcactagg agatgatgaa
     1081 gtgatgtgat ttgccgtaag aatgatgttt ttttctctag attcatcagg atgagcctcc
     1141 aggccccacc tagactcctg gagctggctg agcagagtct gctgagagac cgggccttgg
     1201 ccatccccac cctggaggag ctgcccaggg agctctttcc cccactgttc atggaggcct
     1261 ttaccaggag atgctgcgag accctgacaa ctatggtgca ggcctggccc ttcacctgcc
     1321 ttcctctagg gtccctgatg aagtcatgta atctagagat ctttcgagct gtgctggagg
     1381 ggcttgatgc actgcttgcc cagaaggttc gccccaggcg gtggaaactt caagtgttgg
     1441 acttgcggaa tgtggatgag aacttctggg gcatatggtc tggagcttct gcactctccc
     1501 cagaggccct gagtaagaga cgaacagcag ggaactgtcc aaggccgggt gggcagcagc
     1561 ccttgatggt gatcctagac ctttgcttca agaatgggac gctggatgaa tgcctcaccc
     1621 acttcttaga gtggggcaag cagagaaaag gcttactgca cgtgtgttgc aaggagctgc
     1681 agatttttgg aatagccatc cacaggatca tagaggtcct gaacacggtg gagctagact
     1741 gtatccagga ggtggaagtg tgctgcccgt gggagctgtc cattcttata aggttcgccc
     1801 cttacctggg ccagatgagg aatctccgca aacttgttct cttcaacatc catgtctctg
     1861 cctgcattcc cctagacagg aaggagcagt ttgtcatcca gttcacctct cagttcctca
     1921 agctggacta cttccagaag ctttacatgc actctgtctc tttcctcgaa ggccacctgg
     1981 accagctgct caggtgtctc caggccccct tggagacagt cgtaatgacc gaatgcctgc
     2041 tgtcagagtc ggacctgaag catctctctt ggtgcccgag catccgtcag ctaaaagagc
     2101 tagacctgag gggcatcaca ctgacccatt tcagtcctga gcccctctca gttctgctgg
     2161 agcaagctga ggccaccctg cagaccctgg acttagagga ctgtgggatc gtggattccc
     2221 aactcagcgc catcctgcct gccctgagcc gctgctccca gctcagcacc ttcagcttct
     2281 gtgggaacct catctccatg gccgccctgg agaacctgct gcgccacacc gtcgggctga
     2341 gcaagctaag cctggagctg tatcctgccc ctctggagag ttatgatgcc cagggtgctc
     2401 tctgctgggg aagattttct caacttgggg ctgagctgat gaagacactg agggacttaa
     2461 ggcagcccaa gataattgtg ttcagcactg tcccctgccc tcgctgtggc atcagggcct
     2521 cctatgacct ggagcccagt cactgtctgt tgaatgcctg ctgtcagggt ggatttattt
     2581 aaagctttct tctggtcatt tggcaactga atcctaggcc atgagtgtat gtcaaaggga
     2641 gcacagaccc atcgtttcat atgcctgctc aatgtgaacc ggaaaggaaa ggggatgcag
     2701 gaagggaggg actgggggaa aagttgagtt ggagtcaata ggagctttag agacctgtgt
     2761 cccagagaat cagaaatggg aatctgaatt gctagaatga gaatcaggta ggagagacac
     2821 atgagacagt tacccctgca cggatggttg taaagaaaca gtcagaaata aagggaagct
     2881 gagtggaaa
//
