LOCUS       NM_023013               2160 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens PRAME family member 1 (PRAMEF1), transcript variant 1,
            mRNA.
ACCESSION   NM_023013
VERSION     NM_023013.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2160)
  AUTHORS   Birtle,Z., Goodstadt,L. and Ponting,C.
  TITLE     Duplication and positive selection among hominin-specific PRAME
            genes
  JOURNAL   BMC Genomics 6, 120 (2005)
   PUBMED   16159394
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA903707.1, AL049686.1,
            BC144199.1 and AC244670.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 25, 2014 this sequence version replaced NM_023013.3.
            
            Summary: This gene is a member of the PRAME (preferentially
            expressed antigen of melanoma) gene family which is expressed in
            many cancers but may function in reproductive tissues during
            development. Alternative promoter usage generates two transcript
            variants, which encode different isoforms. [provided by RefSeq, Jun
            2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125568.1, BC144199.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332296.7/ ENSP00000332134.7
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-562               DA903707.1         1-562
            563-856             AL049686.1         563-856
            857-870             BC144199.1         827-840
            871-1217            AL049686.1         871-1217
            1218-2160           AC244670.3         200918-201860
FEATURES             Location/Qualifiers
     source          1..2160
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..2160
                     /gene="PRAMEF1"
                     /note="PRAME family member 1"
                     /db_xref="GeneID:65121"
                     /db_xref="HGNC:HGNC:28840"
     exon            1..78
                     /gene="PRAMEF1"
                     /inference="alignment:Splign:2.1.0"
     exon            79..390
                     /gene="PRAMEF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1528
                     /gene="PRAMEF1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="PRAME family member 1 isoform 1"
                     /protein_id="NP_075389.2"
                     /db_xref="CCDS:CCDS148.1"
                     /db_xref="GeneID:65121"
                     /db_xref="HGNC:HGNC:28840"
                     /translation="MSIQAPPRLLELAGQSLLRDQALSISAMEELPRVLYLPLFMEAF
                     SRRHFQTLTVMVQAWPFTCLPLGSLMKTLHLETLKALLEGLHMLLTQKDRPRRWKLQV
                     LDLRDVDENFWARWPGAWALSCFPETTSKRQTAEDCPRMGEHQPLKVFIDICLKEIPQ
                     DECLRYLFQWVYQRRGLVHLCCSKLVNYLTPIKYLRKSLKIIYLNSIQELEIRNMSWP
                     RLIRKLRCYLKEMKNLRKLVFSRCHHYTSDNELEGRLVAKFSSVFLRLEHLQLLKIKL
                     ITFFSGHLEQLIRCLQNPLENLELTYGYLLEEDMKCLSQYPSLGYLKHLNLSYVLLFR
                     ISLEPLGALLEKIAASLKTLILEGCQIHYSQLSAILPGLSRCSQLTTFYFGRNCMSID
                     ALKDLLRHTSGLSKLSLETYPAPEESLNSLVRVNWEIFTPLRAELMCTLREVRQPKRI
                     FIGPTPCPSCGSSPSEELELHLCC"
     exon            391..969
                     /gene="PRAMEF1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..2160
                     /gene="PRAMEF1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccacagca ctcattcctg gagctactgg ttggtttcct gagaggtccc agaactctgc
       61 gaagtgagtc cagcgctgag attttccttg cagatctatc aggatgagca tccaggcccc
      121 acccagacta ctggagctgg cagggcagag cctgctgaga gaccaggcct tgtccatctc
      181 tgccatggag gagctgccca gggtgctcta tctcccactc ttcatggagg ccttcagcag
      241 gagacacttc cagactctga cggtgatggt tcaggcctgg cccttcacct gcctccctct
      301 gggatcactg atgaagacgc ttcatttgga gaccttaaaa gcattgctgg aagggcttca
      361 tatgctgctt acacagaagg atcgccccag gaggtggaaa cttcaagtgc tggatttgcg
      421 ggatgttgac gagaatttct gggccagatg gcctggagcc tgggccctgt cctgcttccc
      481 agagaccacg agtaagaggc agacagcaga ggactgtcca aggatgggag agcaccagcc
      541 cttaaaggtg ttcatagaca tctgcctcaa ggaaataccc caggatgaat gcctgagata
      601 cctcttccag tgggtttacc aaaggagagg tttagtacac ctgtgctgta gtaagctggt
      661 caattatcta acgccgatta aatatctcag aaagtcattg aaaataatat acctgaatag
      721 tattcaagag ctggaaattc gcaacatgtc ctggccacgt ctgataagaa agcttcgttg
      781 ttacctgaag gagatgaaga atcttcgcaa actcgttttc tccaggtgcc atcattacac
      841 gtcagataat gaactcgaag gacggttagt tgccaaattc agctctgtgt tcctcaggct
      901 ggaacacctt cagttgctta aaataaaatt gatcaccttc ttcagtgggc acctggaaca
      961 gctgatcagg tgcctccaga accccttgga gaacttggaa ttaacttatg gctacctatt
     1021 ggaagaagac atgaagtgtc tctcccagta cccaagcctc ggttacctaa agcatctgaa
     1081 tctcagctac gtgctgctgt tccgcatcag tcttgaaccc ctcggagctc tgctggagaa
     1141 aattgctgcc tctctcaaaa ccctcatctt ggagggctgt cagatccact actcccaact
     1201 cagtgccatc ctgcctggcc tgagccgctg ctcccagctc accaccttct actttggcag
     1261 aaattgcatg tctattgacg ccctgaagga cctgctgcgc cacaccagtg ggctgagcaa
     1321 gttaagcctg gagacgtatc ctgcccctga ggagagtttg aattccttgg ttcgtgtcaa
     1381 ttgggagatc ttcaccccac ttcgggctga gctgatgtgt acactgaggg aagtcaggca
     1441 gcccaagagg atcttcattg gccccacccc ctgcccttcc tgtggctcat caccgtctga
     1501 ggaactggag ctccatcttt gctgctaggg aaggcgtgcc cagtggggta gagaaatcca
     1561 aagttctctt ccaggcactt ggacactaaa atctactatg tgggtgcaaa ctatttttct
     1621 cttttcttat ttatttcatt ttttaataat tccaaaattt ttattaaaga caatttgaga
     1681 cagggtttcg ctgtgttgct ccagctggtc tcaaactgct gggcttatgg gatcctcctg
     1741 cctcagcttc ctaaagtgct gggattactg gcatgagtga ctgtgtccag gccacatgca
     1801 acttaaagga agcacaggca agtgttcagt gtgagggaaa aaacataaca gcagggggca
     1861 aggttggagg aaaatgttga ggtgacatca gtgagaactt cagggacccg tgtcctagag
     1921 tcggaaagag aagctaaagt tctacagtga tgagactgtt atccctgcaa ggatggttac
     1981 caaggaatat cagcaataaa gagcacctga atgaaaactt ttaacctgtt gtgcaattta
     2041 tccatcagaa atctctagtt atcgagttac ggatggaaaa ataacgaaat actaatttgt
     2101 ctgtgattga gtttcagttg tagaacatca aagcaaccaa ataaaaatta gatcattttg
//
