LOCUS       NM_206956               2304 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens PRAME nuclear receptor transcriptional regulator
            (PRAME), transcript variant 5, mRNA.
ACCESSION   NM_206956
VERSION     NM_206956.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2304)
  AUTHORS   Ichiki,T., Ito,T., Shiraishi,S., Nakashima,Y., Nakahara,T. and
            Oda,Y.
  TITLE     PRAME expression in fibrosarcomatous dermatofibrosarcoma
            protuberans
  JOURNAL   Sci Rep 14 (1), 22973 (2024)
   PUBMED   39362949
  REMARK    GeneRIF: PRAME expression in fibrosarcomatous dermatofibrosarcoma
            protuberans.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2304)
  AUTHORS   Forchhammer,S., Aebischer,V., Lenders,D., Seitz,C.M., Schroeder,C.,
            Liebmann,A., Abele,M., Wild,H., Bien,E., Krawczyk,M.,
            Schneider,D.T., Brecht,I.B., Flatz,L. and Hahn,M.
  TITLE     Characterization of PRAME immunohistochemistry reveals lower
            expression in pediatric melanoma compared to adult melanoma
  JOURNAL   Pigment Cell Melanoma Res 37 (4), 453-461 (2024)
   PUBMED   38509752
  REMARK    GeneRIF: Characterization of PRAME immunohistochemistry reveals
            lower expression in pediatric melanoma compared to adult melanoma.
REFERENCE   3  (bases 1 to 2304)
  AUTHORS   Alrohaibani,A., Yu,Y., Gao,L., McLean,K.M., Hetts,J. and Saglam,O.
  TITLE     PReferentially Expressed Antigen in MElanoma Expression in Uterine
            and Ovarian Carcinosarcomas
  JOURNAL   Int J Gynecol Pathol 43 (3), 284-289 (2024)
   PUBMED   38085958
  REMARK    GeneRIF: PReferentially Expressed Antigen in MElanoma Expression in
            Uterine and Ovarian Carcinosarcomas.
REFERENCE   4  (bases 1 to 2304)
  AUTHORS   Yang,J., Chen,M., Ye,J. and Ma,H.
  TITLE     Targeting PRAME for acute myeloid leukemia therapy
  JOURNAL   Front Immunol 15, 1378277 (2024)
   PUBMED   38596687
  REMARK    GeneRIF: Targeting PRAME for acute myeloid leukemia therapy.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2304)
  AUTHORS   Cassalia,F., Danese,A., Tudurachi,I., Federico,S., Zambello,A.,
            Guidotti,A., Franceschin,L., Bolzon,A., Naldi,L. and Belloni
            Fortina,A.
  TITLE     PRAME Updated: Diagnostic, Prognostic, and Therapeutic Role in Skin
            Cancer
  JOURNAL   Int J Mol Sci 25 (3), 1582 (2024)
   PUBMED   38338862
  REMARK    GeneRIF: PRAME Updated: Diagnostic, Prognostic, and Therapeutic
            Role in Skin Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2304)
  AUTHORS   Neumann,E., Engelsberg,A., Decker,J., Storkel,S., Jaeger,E.,
            Huber,C. and Seliger,B.
  TITLE     Heterogeneous expression of the tumor-associated antigens RAGE-1,
            PRAME, and glycoprotein 75 in human renal cell carcinoma:
            candidates for T-cell-based immunotherapies?
  JOURNAL   Cancer Res 58 (18), 4090-4095 (1998)
   PUBMED   9751617
REFERENCE   7  (bases 1 to 2304)
  AUTHORS   van Baren,N., Chambost,H., Ferrant,A., Michaux,L., Ikeda,H.,
            Millard,I., Olive,D., Boon,T. and Coulie,P.G.
  TITLE     PRAME, a gene encoding an antigen recognized on a human melanoma by
            cytolytic T cells, is expressed in acute leukaemia cells
  JOURNAL   Br J Haematol 102 (5), 1376-1379 (1998)
   PUBMED   9753074
REFERENCE   8  (bases 1 to 2304)
  AUTHORS   Williams,J.M., Chen,G.C., Zhu,L. and Rest,R.F.
  TITLE     Using the yeast two-hybrid system to identify human epithelial cell
            proteins that bind gonococcal Opa proteins: intracellular gonococci
            bind pyruvate kinase via their Opa proteins and require host
            pyruvate for growth
  JOURNAL   Mol Microbiol 27 (1), 171-186 (1998)
   PUBMED   9466265
REFERENCE   9  (bases 1 to 2304)
  AUTHORS   Kirkin,A.F., Dzhandzhugazyan,K. and Zeuthen,J.
  TITLE     The immunogenic properties of melanoma-associated antigens
            recognized by cytotoxic T lymphocytes
  JOURNAL   Exp Clin Immunogenet 15 (1), 19-32 (1998)
   PUBMED   9619397
  REMARK    Review article
REFERENCE   10 (bases 1 to 2304)
  AUTHORS   Ikeda,H., Lethe,B., Lehmann,F., van Baren,N., Baurain,J.F., de
            Smet,C., Chambost,H., Vitale,M., Moretta,A., Boon,T. and
            Coulie,P.G.
  TITLE     Characterization of an antigen that is recognized on a melanoma
            showing partial HLA loss by CTL expressing an NK inhibitory
            receptor
  JOURNAL   Immunity 6 (2), 199-208 (1997)
   PUBMED   9047241
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC022008.1, DB024053.1 and
            AK304593.1.
            
            On Nov 23, 2018 this sequence version replaced NM_206956.2.
            
            Summary: This gene encodes an antigen that is preferentially
            expressed in human melanomas and that is recognized by cytolytic T
            lymphocytes. It is not expressed in normal tissues, except testis.
            The encoded protein acts as a repressor of retinoic acid receptor,
            and likely confers a growth advantage to cancer cells via this
            function. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (5) differs in the 5' UTR,
            compared to variant 2. Variants 1-7 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.183151.1,
                                           SRR5189661.160769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405655.8/ ENSP00000384343.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BC022008.1         108-123
            17-97               DB024053.1         1-81
            98-331              AK304593.1         1-234
            332-2304            BC022008.1         870-2842
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.22"
     gene            1..2304
                     /gene="PRAME"
                     /gene_synonym="CT130; MAPE; OIP-4; OIP4"
                     /note="PRAME nuclear receptor transcriptional regulator"
                     /db_xref="GeneID:23532"
                     /db_xref="HGNC:HGNC:9336"
                     /db_xref="MIM:606021"
     exon            1..295
                     /gene="PRAME"
                     /gene_synonym="CT130; MAPE; OIP-4; OIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            296..331
                     /gene="PRAME"
                     /gene_synonym="CT130; MAPE; OIP-4; OIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            332..429
                     /gene="PRAME"
                     /gene_synonym="CT130; MAPE; OIP-4; OIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..1938
                     /gene="PRAME"
                     /gene_synonym="CT130; MAPE; OIP-4; OIP4"
                     /note="isoform a is encoded by transcript variant 5;
                     melanoma antigen preferentially expressed in tumors;
                     preferentially expressed antigen in melanoma;
                     Opa-interacting protein OIP4; cancer/testis antigen 130;
                     opa-interacting protein 4; preferentially expressed
                     antigen of melanoma"
                     /codon_start=1
                     /product="melanoma antigen preferentially expressed in
                     tumors isoform a"
                     /protein_id="NP_996839.1"
                     /db_xref="CCDS:CCDS13801.1"
                     /db_xref="GeneID:23532"
                     /db_xref="HGNC:HGNC:9336"
                     /db_xref="MIM:606021"
                     /translation="MERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEALAIAA
                     LELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCLPLGVLMKGQHLHLETFKAVLD
                     GLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRASLYSFPEPEAAQPMTKKRK
                     VDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVKRKKNVLRLCCKKLKIFAM
                     PMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSPYLGQMINLRRLLLSHIHASSYI
                     SPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHVMNPLETLSITNCRL
                     SEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATLQDLVFDECGITD
                     DQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLSNLTHVLYPVPLESYED
                     IHGTLHLERLAYLHARLRELLCELGRPSMVWLSANPCPHCGDRTFYDPEPILCPCFMP
                     N"
     exon            430..752
                     /gene="PRAME"
                     /gene_synonym="CT130; MAPE; OIP-4; OIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            753..1361
                     /gene="PRAME"
                     /gene_synonym="CT130; MAPE; OIP-4; OIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..2304
                     /gene="PRAME"
                     /gene_synonym="CT130; MAPE; OIP-4; OIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRAME"
                     /gene_synonym="CT130; MAPE; OIP-4; OIP4"
                     /note="hexamer: AATAAA"
     polyA_site      2304
                     /gene="PRAME"
                     /gene_synonym="CT130; MAPE; OIP-4; OIP4"
                     /note="major polyA site"
ORIGIN      
        1 acagctcccc cgcagccaga agccgggcct gcagcgcctc agcaccgctc cgggacaccc
       61 cacccgcttc ccaggcgtga cctgtcaaca ggtctgtatt ggcgacaaaa ggagcagccc
      121 tgaatgtagg gaaagcaggg cggagtcctc tgcaggctcg ggggagggga ggggcgtgaa
      181 tgcgtggatt tctgtggaga gtggaaacac ggggagtcga ggggagcatg cgcgggcctc
      241 agaaagttct gggaaaccga ctcccgggag cagggaggaa cgcgcgctcc agagacaact
      301 tcgcggtgtg gtgaactctc tgaggaaaaa cacgtgcgtg gcaacaagtg actgagacct
      361 agaaatccaa gcgttggagg tcctgaggcc agcctaagtc gcttcaaaat ggaacgaagg
      421 cgtttgtggg gttccattca gagccgatac atcagcatga gtgtgtggac aagcccacgg
      481 agacttgtgg agctggcagg gcagagcctg ctgaaggatg aggccctggc cattgccgcc
      541 ctggagttgc tgcccaggga gctcttcccg ccactcttca tggcagcctt tgacgggaga
      601 cacagccaga ccctgaaggc aatggtgcag gcctggccct tcacctgcct ccctctggga
      661 gtgctgatga agggacaaca tcttcacctg gagaccttca aagctgtgct tgatggactt
      721 gatgtgctcc ttgcccagga ggttcgcccc aggaggtgga aacttcaagt gctggattta
      781 cggaagaact ctcatcagga cttctggact gtatggtctg gaaacagggc cagtctgtac
      841 tcatttccag agccagaagc agctcagccc atgacaaaga agcgaaaagt agatggtttg
      901 agcacagagg cagagcagcc cttcattcca gtagaggtgc tcgtagacct gttcctcaag
      961 gaaggtgcct gtgatgaatt gttctcctac ctcattgaga aagtgaagcg aaagaaaaat
     1021 gtactacgcc tgtgctgtaa gaagctgaag atttttgcaa tgcccatgca ggatatcaag
     1081 atgatcctga aaatggtgca gctggactct attgaagatt tggaagtgac ttgtacctgg
     1141 aagctaccca ccttggcgaa attttctcct tacctgggcc agatgattaa tctgcgtaga
     1201 ctcctcctct cccacatcca tgcatcttcc tacatttccc cggagaagga agagcagtat
     1261 atcgcccagt tcacctctca gttcctcagt ctgcagtgcc tgcaggctct ctatgtggac
     1321 tctttatttt tccttagagg ccgcctggat cagttgctca ggcacgtgat gaaccccttg
     1381 gaaaccctct caataactaa ctgccggctt tcggaagggg atgtgatgca tctgtcccag
     1441 agtcccagcg tcagtcagct aagtgtcctg agtctaagtg gggtcatgct gaccgatgta
     1501 agtcccgagc ccctccaagc tctgctggag agagcctctg ccaccctcca ggacctggtc
     1561 tttgatgagt gtgggatcac ggatgatcag ctccttgccc tcctgccttc cctgagccac
     1621 tgctcccagc ttacgacctt aagcttctac gggaattcca tctccatatc tgccctgcag
     1681 agtctcctgc agcacctcat cgggctgagc aatctgaccc acgtgctgta tcctgtcccc
     1741 ctggagagtt atgaggacat ccatggtacc ctccacctgg agaggcttgc ctatctgcat
     1801 gccaggctca gggagttgct gtgtgagttg gggcggccca gcatggtctg gcttagtgcc
     1861 aacccctgtc ctcactgtgg ggacagaacc ttctatgacc cggagcccat cctgtgcccc
     1921 tgtttcatgc ctaattagct gggtgcacat atcaaatgct tcattctgca tacttggaca
     1981 ctaaagccag gatgtgcatg catcttgaag caacaaagca gccacagttt cagacaaatg
     2041 ttcagtgtga gtgaggaaaa catgttcagt gaggaaaaaa cattcagaca aatgttcagt
     2101 gaggaaaaaa aggggaagtt gggggtaggc agatgttgac ttgaggagtt aatgtgatct
     2161 ttggggagat acatcttata gagttagaaa tagaatctga atttctaaag ggagattctg
     2221 gcttgggaag tacatgtagg agttaatccc tgtgtagact gttgtaaaga aactgttgaa
     2281 aataaagaga agcaatgtga agca
//
