LOCUS       NM_032152               2195 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens PML-RARA regulated adaptor molecule 1 (PRAM1), mRNA.
ACCESSION   NM_032152
VERSION     NM_032152.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2195)
  AUTHORS   Xu,S., Wang,S., Xing,S., Yu,D., Rong,B., Gao,H., Sheng,M., Tan,Y.,
            Sun,X., Wang,K., Xue,K., Shi,Z. and Lan,F.
  TITLE     KDM5A suppresses PML-RARalpha target gene expression and APL
            differentiation through repressing H3K4me2
  JOURNAL   Blood Adv 5 (17), 3241-3253 (2021)
   PUBMED   34448811
  REMARK    GeneRIF: KDM5A suppresses PML-RARalpha target gene expression and
            APL differentiation through repressing H3K4me2.
            Erratum:[Blood Adv. 2022 Apr 12;6(7):2443. doi:
            10.1182/bloodadvances.2021006376.. PMID: 35404434]
REFERENCE   2  (bases 1 to 2195)
  AUTHORS   Yu,X., Mansouri,A., Liu,Z., Gao,R., Li,K., Chen,C., Huang,Y.,
            Chen,Z., Chen,S., Lu,Y., Li,Y., Zeng,C. and Zeng,Y.
  TITLE     NRF2 activation induced by PML-RARalpha promotes microRNA 125b-1
            expression and confers resistance to chemotherapy in acute
            promyelocytic leukemia
  JOURNAL   Clin Transl Med 11 (5), e418 (2021)
   PUBMED   34047481
  REMARK    GeneRIF: NRF2 activation induced by PML-RARalpha promotes microRNA
            125b-1 expression and confers resistance to chemotherapy in acute
            promyelocytic leukemia.
REFERENCE   3  (bases 1 to 2195)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2195)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2195)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2195)
  AUTHORS   Denis,F.M., Benecke,A., Di Gioia,Y., Touw,I.P., Cayre,Y.E. and
            Lutz,P.G.
  TITLE     PRAM-1 potentiates arsenic trioxide-induced JNK activation
  JOURNAL   J Biol Chem 280 (10), 9043-9048 (2005)
   PUBMED   15637062
  REMARK    GeneRIF: Caspase 3-cleaved SH3 domain of HIP-55 is likely involved
            in PRAM-1-mediated JNK activation upon arsenic trioxide-induced
            differentiation of NB4 cells.
REFERENCE   7  (bases 1 to 2195)
  AUTHORS   Clemens,R.A., Newbrough,S.A., Chung,E.Y., Gheith,S., Singer,A.L.,
            Koretzky,G.A. and Peterson,E.J.
  TITLE     PRAM-1 is required for optimal integrin-dependent neutrophil
            function
  JOURNAL   Mol Cell Biol 24 (24), 10923-10932 (2004)
   PUBMED   15572693
  REMARK    GeneRIF: PRAM-1 is required for optimal integrin-dependent
            neutrophil function.
REFERENCE   8  (bases 1 to 2195)
  AUTHORS   Moog-Lutz,C., Peterson,E.J., Lutz,P.G., Eliason,S., Cave-Riant,F.,
            Singer,A., Di Gioia,Y., Dmowski,S., Kamens,J., Cayre,Y.E. and
            Koretzky,G.
  TITLE     PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA)
            and promyelocytic leukemia (PML)-RA receptor alpha in acute
            promyelocytic leukemia cells
  JOURNAL   J Biol Chem 276 (25), 22375-22381 (2001)
   PUBMED   11301322
REFERENCE   9  (bases 1 to 2195)
  AUTHORS   Cao,T., Duprez,E., Borden,K.L., Freemont,P.S. and Etkin,L.D.
  TITLE     Ret finger protein is a normal component of PML nuclear bodies and
            interacts directly with PML
  JOURNAL   J Cell Sci 111 (Pt 10), 1319-1329 (1998)
   PUBMED   9570750
REFERENCE   10 (bases 1 to 2195)
  AUTHORS   Boddy,M.N., Howe,K., Etkin,L.D., Solomon,E. and Freemont,P.S.
  TITLE     PIC 1, a novel ubiquitin-like protein which interacts with the PML
            component of a multiprotein complex that is disrupted in acute
            promyelocytic leukaemia
  JOURNAL   Oncogene 13 (5), 971-982 (1996)
   PUBMED   8806687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ272324.1, DA350460.1,
            AC092298.2, AK308227.1 and BC028012.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032152.4.
            
            Summary: The protein encoded by this gene is similar to FYN binding
            protein (FYB/SLAP-130), an adaptor protein involved in T cell
            receptor mediated signaling. This gene is expressed and regulated
            during normal myelopoiesis. The expression of this gene is induced
            by retinoic acid and is inhibited by the expression of
            PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and
            the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028012.1, AK308227.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000423345.5/ ENSP00000408342.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AJ272324.1         15-231
            218-567             DA350460.1         218-567
            568-1481            AC092298.2         2897-3810           c
            1482-2184           AK308227.1         1479-2181
            2185-2195           BC028012.1         2156-2166
FEATURES             Location/Qualifiers
     source          1..2195
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2195
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /note="PML-RARA regulated adaptor molecule 1"
                     /db_xref="GeneID:84106"
                     /db_xref="HGNC:HGNC:30091"
                     /db_xref="MIM:606466"
     exon            1..76
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..2062
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /note="PML-RARA target gene encoding an Adaptor
                     Molecule-1; PRAM"
                     /codon_start=1
                     /product="PML-RARA-regulated adapter molecule 1"
                     /protein_id="NP_115528.4"
                     /db_xref="CCDS:CCDS45954.2"
                     /db_xref="GeneID:84106"
                     /db_xref="HGNC:HGNC:30091"
                     /db_xref="MIM:606466"
                     /translation="MAHHLPAAMESHQDFRSIKAKFQASQPEPSDLPKKPPKPEFGKL
                     KKFSQPELSEHPKKAPLPEFGAVSLKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTD
                     LPKKPPPPEVTDLPKKPSKLELSDLSKKFPQLGATPFPRKPLQPEVGEAPLKASLPEP
                     GAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKPAQ
                     PEFNVYPKKPPQPQVGGLPKKSVPQPEFSEAAQTPLWKPQSSEPKRDSSAFPKKASQP
                     PLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSS
                     EPEFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESS
                     LPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHSGGARPGLRPSHPPRRRPLPPASSL
                     GHPPAKPPLPPGPVDMQSFRRPSAASIDLRRTRSAAGLHFQDRQPEDIPQVPDEIYEL
                     YDDVEPRDDSSPSPKGRDEAPSVQQAARRPPQDPALRKEKDPQPQQLPPMDPKLLKQL
                     RKAEKAEREFRKKFKFEGEIVVHTKMMIDPNAKTRRGGGKHLGIRRGEILEVIEFTSN
                     EEMLCRDPKGKYGYVPRTALLPLETEVYDDVDFCDPLENQPLPLGR"
     exon            77..1481
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1548
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1625
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1683
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1792
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1955
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..1989
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2024
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2195
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2174..2179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /note="hexamer: CATAAA"
     polyA_site      2195
                     /gene="PRAM1"
                     /gene_synonym="PML-RAR; PRAM-1"
                     /note="major polyA site"
ORIGIN      
        1 acagtcactt cctgaaggca gcggccccag ctcgggtccc actcatccca tggcccatca
       61 cctgcctgca gccatggaga gccatcagga cttccggagc atcaaagcaa agttccaggc
      121 ctctcagccg gagcccagcg acctgcccaa aaaacctccg aagcctgagt ttggtaaact
      181 gaagaagttc tcccagcctg agctaagcga gcaccccaag aaggccccgc tgcctgagtt
      241 tggtgcagtg tccttgaagc ccccgccgcc tgaggtcact gacctcccca agaagccccc
      301 gccgcctgag gtcactgacc tccccaagaa gcccccgccg cctgaggtca ctgacctccc
      361 caagaagccc ccgccgcctg aggtcactga cctccccaag aagccgtcca aactggagtt
      421 gagtgacctc tccaagaagt tcccacagct gggggccact ccgtttccaa ggaagcccct
      481 gcagcctgag gtcggtgagg cccctttgaa ggcctcgctg ccggagcctg gtgcgccggc
      541 ccggaaaccc ctgcagcccg acgaactcag tcaccccgcc agacccccct ccgaacccaa
      601 atccggcgca ttccccagga agctctggca acccgaggcc ggtgaggcta ccccgaggtc
      661 cccgcagcct gagttgagta cctttcccaa gaagcctgcg cagcctgagt tcaacgtgta
      721 ccccaaaaag cctccgcagc ctcaggtcgg tggcctccct aagaagtccg tgccgcagcc
      781 tgagttcagc gaggccgctc agactcccct ctggaagcct cagtccagcg agccgaagcg
      841 cgactccagc gcctttccca aaaaggcctc ccagcctccg ctgagtgact ttcccaagaa
      901 gcctccgcag cctgagcttg gggacctcac caggacctcc tcagagcccg aagtcagcgt
      961 gcttcccaag aggccgcggc cggccgaatt caaagcgctc tccaagaagc ccccgcagcc
     1021 cgagctgggc ggcctcccca ggacctcctc agagcccgag ttcaactcac tccccaggaa
     1081 gctgctgcag ccggagcgcc gggggccacc ccgcaagttc tcacagcctg agcccagcgc
     1141 tgtcctcaag agacacccgc agcctgagtt cttcggtgat ctccctcgaa agcctccact
     1201 ccccagctcc gcttccgaga gctcactgcc tgcggccgtg gccggcttca gctcccggca
     1261 cccgctcagc cctgggtttg gagcggctgg gacaccccgc tggaggtcag gaggcctggt
     1321 tcacagtgga ggggccaggc caggcctcag acccagccat ccaccccggc ggaggcctct
     1381 gccccctgcc agcagcctgg gacaccctcc agccaagccc ccgctgcccc cggggcccgt
     1441 ggatatgcag agctttcgga gaccctctgc agcatccata gatctacgga ggacccgctc
     1501 ggccgctggg ctccacttcc aggaccgaca gcctgaagac atcccgcagg tcccagatga
     1561 gatctacgag ctgtatgacg atgtggaacc cagagatgac tccagcccca gccccaaggg
     1621 cagagatgaa gcgccctcag ttcagcaagc cgccaggagg ccaccacaag acccagcgct
     1681 caggaaggag aaggatcccc agccacagca gttgccaccc atggacccaa agttgctgaa
     1741 gcagctgagg aaggcagaga aggccgagag ggagttccgg aagaagttca agtttgaagg
     1801 ggagatcgtg gttcacacga agatgatgat cgaccccaac gctaagacac gtcgcggggg
     1861 tggcaagcac ctcgggatcc ggcgcgggga gatcctggag gtgatcgagt tcaccagcaa
     1921 tgaggagatg ctgtgccggg accccaaagg caaatatggc tacgtgccca gaacagcgct
     1981 cctgcccctg gagacggagg tgtacgatga tgtcgacttc tgcgatcccc tggaaaacca
     2041 accactcccc ctgggacggt aagaccggta ggcgtggggc caggacagcc agccagccca
     2101 gcgcccgctc acccaggagc cctggatccc ggcgcgggaa agtcacagag ctgcctgggc
     2161 ttgtacctgg ccacataaag ccccagttta aagca
//
