LOCUS       NM_007213               1260 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens PRA1 domain family member 2 (PRAF2), mRNA.
ACCESSION   NM_007213
VERSION     NM_007213.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Da Silva,E., Scott,M.G.H., Enslen,H. and Marullo,S.
  TITLE     Control of CCR5 Cell-Surface Targeting by the PRAF2 Gatekeeper
  JOURNAL   Int J Mol Sci 24 (24), 17438 (2023)
   PUBMED   38139265
  REMARK    GeneRIF: Control of CCR5 Cell-Surface Targeting by the PRAF2
            Gatekeeper.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Qian,Z., Wei,B., Zhou,Y., Wang,Q., Wang,J., Sun,Y., Gao,Y. and
            Chen,X.
  TITLE     PRAF2 overexpression predicts poor prognosis and promotes
            tumorigenesis in esophageal squamous cell carcinoma
  JOURNAL   BMC Cancer 19 (1), 585 (2019)
   PUBMED   31200670
  REMARK    GeneRIF: PRAF2 could be used as a potential prognostic biomarker
            and represent a potential therapeutic target for ESCC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Yco,L.P., Geerts,D., Koster,J. and Bachmann,A.S.
  TITLE     PRAF2 stimulates cell proliferation and migration and predicts poor
            prognosis in neuroblastoma
  JOURNAL   Int J Oncol 42 (4), 1408-1416 (2013)
   PUBMED   23440329
  REMARK    GeneRIF: PRAF2 plays an essential role in neuroblastoma
            tumorigenesis and metastasis.
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Koomoa,D.L., Go,R.C., Wester,K. and Bachmann,A.S.
  TITLE     Expression profile of PRAF2 in the human brain and enrichment in
            synaptic vesicles
  JOURNAL   Neurosci Lett 436 (2), 171-176 (2008)
   PUBMED   18395978
  REMARK    GeneRIF: The expression of PRAF2 in specific regions of the brain
            including SVs suggest an important physiological function for this
            novel protein, possibly by participating in multiple aspects of SV
            maturation, transport, and signal transmission.
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Geerts,D., Wallick,C.J., Koomoa,D.L., Koster,J., Versteeg,R.,
            Go,R.C. and Bachmann,A.S.
  TITLE     Expression of prenylated Rab acceptor 1 domain family, member 2
            (PRAF2) in neuroblastoma: correlation with clinical features,
            cellular localization, and cerulenin-mediated apoptosis regulation
  JOURNAL   Clin Cancer Res 13 (21), 6312-6319 (2007)
   PUBMED   17975142
  REMARK    GeneRIF: PRAF2 has a role in progression of neuroblastoma
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Fo,C.S., Coleman,C.S., Wallick,C.J., Vine,A.L. and Bachmann,A.S.
  TITLE     Genomic organization, expression profile, and characterization of
            the new protein PRA1 domain family, member 2 (PRAF2)
  JOURNAL   Gene 371 (1), 154-165 (2006)
   PUBMED   16481131
  REMARK    GeneRIF: CCR5-interacting PRAF2 protein is expressed in several
            human tissues with a possible function in ER/Golgi transport and
            vesicular traffic.
REFERENCE   10 (bases 1 to 1260)
  AUTHORS   Schweneker,M., Bachmann,A.S. and Moelling,K.
  TITLE     JM4 is a four-transmembrane protein binding to the CCR5 receptor
  JOURNAL   FEBS Lett 579 (7), 1751-1758 (2005)
   PUBMED   15757671
  REMARK    GeneRIF: PRAF2 (JM4) is CCR5-interacting protein, which is
            suggested to function in trafficking and membrane localisation of
            the receptor.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ005896.1 and AC231657.2.
            
            On Nov 23, 2018 this sequence version replaced NM_007213.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ005896.1, SRR1660807.243742.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000553851.3/ ENSP00000451962.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-777               AJ005896.1         2-778
            778-911             AC231657.2         100819-100952       c
            912-1260            AJ005896.1         915-1263
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..1260
                     /gene="PRAF2"
                     /gene_synonym="JM4; Yip6a"
                     /note="PRA1 domain family member 2"
                     /db_xref="GeneID:11230"
                     /db_xref="HGNC:HGNC:28911"
                     /db_xref="MIM:300840"
     exon            1..194
                     /gene="PRAF2"
                     /gene_synonym="JM4; Yip6a"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..552
                     /gene="PRAF2"
                     /gene_synonym="JM4; Yip6a"
                     /note="Jena-Muenchen 4"
                     /codon_start=1
                     /product="PRA1 family protein 2"
                     /protein_id="NP_009144.1"
                     /db_xref="CCDS:CCDS14317.1"
                     /db_xref="GeneID:11230"
                     /db_xref="HGNC:HGNC:28911"
                     /db_xref="MIM:300840"
                     /translation="MSEVRLPPLRALDDFVLGSARLAAPDPCDPQRWCHRVINNLLYY
                     QTNYLLCFGIGLALAGYVRPLHTLLSALVVAVALGVLVWAAETRAAVRRCRRSHPAAC
                     LAAVLAVGLLVLWVAGGACTFLFSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKR
                     TPMGLLLEALGQEQEAGS"
     exon            195..412
                     /gene="PRAF2"
                     /gene_synonym="JM4; Yip6a"
                     /inference="alignment:Splign:2.1.0"
     exon            413..1260
                     /gene="PRAF2"
                     /gene_synonym="JM4; Yip6a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1232..1237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRAF2"
                     /gene_synonym="JM4; Yip6a"
                     /note="hexamer: AATAAA"
     polyA_site      1260
                     /gene="PRAF2"
                     /gene_synonym="JM4; Yip6a"
                     /note="major polyA site"
ORIGIN      
        1 acattaaccg gcaggatgtc ggaggtgcgg ctgccaccgc tacgcgccct ggacgacttt
       61 gttctggggt cggcgcgtct ggcggctccg gatccatgcg acccgcagcg atggtgccac
      121 cgcgtcatca acaacctcct ctactaccaa accaactacc ttctctgctt cggcatcggc
      181 ctcgctctcg ccgggtacgt gcggccactt catacgctcc tgagcgcgct ggtagtggcg
      241 gtggccctcg gcgtgctggt gtgggcagct gagacccgcg cagctgtgcg ccgctgccgc
      301 cgcagccacc ctgcagcctg cctggccgca gtgcttgccg tcggcctcct ggtgctctgg
      361 gtcgcgggcg gcgcttgcac cttcctgttc agcatcgccg ggccggtgct tctgatcctg
      421 gtgcacgcct cgttgcgcct gcgcaacctt aagaacaaga ttgagaacaa gatcgagagc
      481 attggtctca agcggacgcc aatgggcctg ctactagagg cactgggaca agagcaggag
      541 gctggatcct aggcccctgg gatctgtacc caggacctgg agaataccac cccaccccca
      601 gcccataatt gggacccaga gccctttccc agcacttaaa acaggagcct agagccccct
      661 gcccaaacaa aacaggacat ctgtgaccgc cctaccccca cgccagcccc aaactaagat
      721 atccctcaca cccagccccc attacctagg gacaagagtc ttccccagcc ttgaacccag
      781 gaccaagagc cacctacatc cagccccaaa actggcttca ggccagagca tccatggcca
      841 atttcaaatt gtgaacccag agacactccc atccaccctt ctccatgctc atccccaaac
      901 tggggcctgg ggcaaggcac tctcaaatct tgaaccctgg accaaagctt ttccagaccc
      961 caccctacct tccaacccag gtcaagacat tgccaaatct tgaactcaga acccaagtgt
     1021 tccatgcccc tgtgtggatg gagtcgggta tcctgactgt tggacccctg gtccaggtga
     1081 tcccgaccct caccagtccc atttgcctcc ctccagctct gcttaggcat tttgcccctc
     1141 accccaatgt tccacaccat cgacaaccaa ggggtgaggt ggggacaggc ctcagcaggg
     1201 aatggggcgt atatgttagt gttgctgcaa caataaagcc tgttgcatct ctcatgccaa
//
