LOCUS       NM_001282275             560 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens PRAC2 small nuclear protein (PRAC2), transcript
            variant 2, mRNA.
ACCESSION   NM_001282275 NR_024103
VERSION     NM_001282275.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 560)
  AUTHORS   Xiong,Y., Kuang,W., Lu,S., Guo,H., Wu,M., Ye,M. and Wu,L.
  TITLE     Long noncoding RNA HOXB13-AS1 regulates HOXB13 gene methylation by
            interacting with EZH2 in glioma
  JOURNAL   Cancer Med 7 (9), 4718-4728 (2018)
   PUBMED   30105866
  REMARK    GeneRIF: our study indicated that HOXB13-AS1 could regulate HOXB13
            gene expression by methylation HOXB13 promoter and acts as an
            epigenetic oncogenic in glioma.
REFERENCE   2  (bases 1 to 560)
  AUTHORS   Barnicle,A., Seoighe,C., Greally,J.M., Golden,A. and Egan,L.J.
  TITLE     Inflammation-associated DNA methylation patterns in epithelium of
            ulcerative colitis
  JOURNAL   Epigenetics 12 (8), 591-606 (2017)
   PUBMED   28557546
REFERENCE   3  (bases 1 to 560)
  AUTHORS   Olsson,P., Motegi,A., Bera,T.K., Lee,B. and Pastan,I.
  TITLE     PRAC2: a new gene expressed in human prostate and prostate cancer
  JOURNAL   Prostate 56 (2), 123-130 (2003)
   PUBMED   12746837
  REMARK    GeneRIF: PRAC2 may have a function in prostate growth and
            development(PRAC2)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF532777.1, BX106051.1 and AI201489.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001282275.1.
            
            Summary: This gene is highly expressed in prostate, rectum, colon,
            and testis. This gene may produce a non-coding RNA or may encode a
            short protein that might localize to the nucleus. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Aug 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (b) has a shorter N-terminus, compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB048077.1, AF532777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422730.4/ ENSP00000481367.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-447               AF532777.1         6-452
            448-553             BX106051.1         399-504
            554-560             AI201489.1         8-14                c
FEATURES             Location/Qualifiers
     source          1..560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..560
                     /gene="PRAC2"
                     /gene_synonym="C17orf93; HOXB-AS5; HOXB13-AS1; HOXBAS5;
                     NCRNA00253"
                     /note="PRAC2 small nuclear protein"
                     /db_xref="GeneID:360205"
                     /db_xref="HGNC:HGNC:30143"
                     /db_xref="MIM:610787"
     exon            1..129
                     /gene="PRAC2"
                     /gene_synonym="C17orf93; HOXB-AS5; HOXB13-AS1; HOXBAS5;
                     NCRNA00253"
                     /inference="alignment:Splign:2.1.0"
     exon            130..560
                     /gene="PRAC2"
                     /gene_synonym="C17orf93; HOXB-AS5; HOXB13-AS1; HOXBAS5;
                     NCRNA00253"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..485
                     /gene="PRAC2"
                     /gene_synonym="C17orf93; HOXB-AS5; HOXB13-AS1; HOXBAS5;
                     NCRNA00253"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; prostate, rectum and colon 2; small nuclear
                     protein PRAC2; prostate, rectum and colon expressed gene 2
                     protein; prostate, rectum and colon expressed gene protein
                     2; putative protein PRAC2; putative protein PRCA2;
                     prostate cancer susceptibility candidate 2; HOXB cluster
                     antisense RNA 5"
                     /codon_start=1
                     /product="putative protein PRAC2 isoform b precursor"
                     /protein_id="NP_001269204.1"
                     /db_xref="CCDS:CCDS74100.1"
                     /db_xref="GeneID:360205"
                     /db_xref="HGNC:HGNC:30143"
                     /db_xref="MIM:610787"
                     /translation="MDRRRMALRPGSRRPTAFFFHSRWLVPNLLAFFLGLSGAGPIHL
                     PMPWPNGRRHRVLDPHTQLSTHEAPGRWKPVAPRTMKACPQVLLEW"
     regulatory      541..546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRAC2"
                     /gene_synonym="C17orf93; HOXB-AS5; HOXB13-AS1; HOXBAS5;
                     NCRNA00253"
                     /note="hexamer: AATAAA"
     polyA_site      560
                     /gene="PRAC2"
                     /gene_synonym="C17orf93; HOXB-AS5; HOXB13-AS1; HOXBAS5;
                     NCRNA00253"
                     /note="major polyA site"
ORIGIN      
        1 gagctttctc ccctcttccc tggagagcga ctgttcggga gggtgagaat ggtataaatt
       61 tcaaaaacaa cgaaaccttc ttttgccccc tccgcagcag tcgcctccgg gctttattgc
      121 aagtttacgg ttccatacaa gtaaatccga aaaaaagtgt gtgtgggggg gtccacacca
      181 ctaattatta tggcgaggaa gataaagaag acatggacag aaggcggatg gctctgcggc
      241 ctggctcccg cagaccgacc gccttcttct tccattcgag atggctcgta ccgaacctcc
      301 ttgccttctt cctgggtctc tcgggggctg gaccaataca tctgccgatg ccctggccga
      361 atggcaggcg acatcgggtc ctggaccccc acacgcagct cagtacccac gaggccccag
      421 gccgctggaa gcctgtagct ccgcggacga tgaaagcctg cccgcaggtt ctcctggagt
      481 ggtgagcctc tgtcggaagg gggcgcccac gtctttttaa tggtcctaac acaccagtgg
      541 aataaatctc taagattcca
//
