LOCUS       NM_032391                382 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens PRAC1 small nuclear protein (PRAC1), mRNA.
ACCESSION   NM_032391
VERSION     NM_032391.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 382)
  AUTHORS   Jiang,Y., Yan,X., Liu,K., Shi,Y., Wang,C., Hu,J., Li,Y., Wu,Q.,
            Xiang,M. and Zhao,R.
  TITLE     Discovering the molecular differences between right- and left-sided
            colon cancer using machine learning methods
  JOURNAL   BMC Cancer 20 (1), 1012 (2020)
   PUBMED   33076847
  REMARK    GeneRIF: Discovering the molecular differences between right- and
            left-sided colon cancer using machine learning methods.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 382)
  AUTHORS   Kim,Y.W., Yoon,H.Y., Seo,S.P., Lee,S.K., Kang,H.W., Kim,W.T.,
            Bang,H.J., Ryu,D.H., Yun,S.J., Lee,S.C., Kim,W.J. and Kim,Y.J.
  TITLE     Clinical Implications and Prognostic Values of Prostate Cancer
            Susceptibility Candidate Methylation in Primary Nonmuscle Invasive
            Bladder Cancer
  JOURNAL   Dis Markers 2015, 402963 (2015)
   PUBMED   26074659
  REMARK    GeneRIF: Enhanced methylation of PRAC was positively associated
            with a high rate of recurrence and progression in nonmuscle
            invasive bladder cancer patients.
REFERENCE   3  (bases 1 to 382)
  AUTHORS   Lenka,G., Weng,W.H., Chuang,C.K., Ng,K.F. and Pang,S.T.
  TITLE     Aberrant expression of the PRAC gene in prostate cancer
  JOURNAL   Int J Oncol 43 (6), 1960-1966 (2013)
   PUBMED   24100630
  REMARK    GeneRIF: the pathogenesis of prostate cancer may be due to the
            expression levels of PRAC protein, and this protein can serve as a
            potential biomarker for the management of prostate cancer.
REFERENCE   4  (bases 1 to 382)
  AUTHORS   Liu,X.F., Olsson,P., Wolfgang,C.D., Bera,T.K., Duray,P., Lee,B. and
            Pastan,I.
  TITLE     PRAC: A novel small nuclear protein that is specifically expressed
            in human prostate and colon
  JOURNAL   Prostate 47 (2), 125-131 (2001)
   PUBMED   11340635
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF331165.1 and BC030950.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032391.2.
            
            Summary: This gene is reported to be specifically expressed in
            prostate, rectum and distal colon. Sequence analysis suggests that
            it may play a regulatory role in the nucleus. [provided by RefSeq,
            Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF124750.1, AF331165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290294.5/ ENSP00000290294.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               AF331165.1         3-381
            380-382             BC030950.1         380-382
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..382
                     /gene="PRAC1"
                     /gene_synonym="C17orf92; PRAC"
                     /note="PRAC1 small nuclear protein"
                     /db_xref="GeneID:84366"
                     /db_xref="HGNC:HGNC:30591"
                     /db_xref="MIM:609819"
     exon            1..201
                     /gene="PRAC1"
                     /gene_synonym="C17orf92; PRAC"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..300
                     /gene="PRAC1"
                     /gene_synonym="C17orf92; PRAC"
                     /note="small nuclear protein PRAC; prostate, rectum and
                     colon expressed gene protein; prostate cancer
                     susceptibility candidate protein 1; prostate cancer
                     susceptibility candidate 1"
                     /codon_start=1
                     /product="small nuclear protein PRAC1"
                     /protein_id="NP_115767.1"
                     /db_xref="CCDS:CCDS11535.1"
                     /db_xref="GeneID:84366"
                     /db_xref="HGNC:HGNC:30591"
                     /db_xref="MIM:609819"
                     /translation="MLCAHFSDQGPAHLTTSKSAFLSNKKTSTLKHLLGETRSDGSAC
                     NSGISGGRGRKIP"
     exon            202..382
                     /gene="PRAC1"
                     /gene_synonym="C17orf92; PRAC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      358..363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRAC1"
                     /gene_synonym="C17orf92; PRAC"
                     /note="hexamer: AATAAA"
     polyA_site      382
                     /gene="PRAC1"
                     /gene_synonym="C17orf92; PRAC"
                     /note="major polyA site"
ORIGIN      
        1 ccttcctctc ctagcctaag gcgtgcaaac agagcgccac tgggaggctg aaacctttag
       61 gccgatgctt gcttgcaagg tcaggcaagc tggattctgg tccccacctt tgcagagaga
      121 acagcgatgt tgtgcgccca tttctcagat caaggaccgg cccatcttac tacctccaag
      181 agtgcttttc tctctaataa gaaaacatct actttgaaac atctactggg cgagaccagg
      241 agtgatggct cagcctgtaa ttctggaatt tcgggaggcc gaggcaggaa gattccttga
      301 gcacaggagt tccagaccag cctgggcaat gtagcaagac gctgtctcta tttatacaat
      361 aaaatttttt taaaaaagga aa
//
