LOCUS       NM_139283               4994 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein phosphatase targeting COQ7 (PPTC7), transcript
            variant 1, mRNA.
ACCESSION   NM_139283
VERSION     NM_139283.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4994)
  AUTHORS   Nguyen-Dien,G.T., Townsend,B., Kulkarni,P.G., Kozul,K.L., Ooi,S.S.,
            Eldershaw,D.N., Weeratunga,S., Liu,M., Jones,M.J., Millard,S.S.,
            Ng,D.C., Pagano,M., Bonfim-Melo,A., Schneider,T., Komander,D.,
            Lazarou,M., Collins,B.M. and Pagan,J.K.
  TITLE     PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation
            via SCFFBXL4
  JOURNAL   EMBO Rep 25 (8), 3324-3347 (2024)
   PUBMED   38992176
  REMARK    GeneRIF: PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX
            degradation via SCF[FBXL4].
REFERENCE   2  (bases 1 to 4994)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 4994)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4994)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4994)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4994)
  AUTHORS   Gonzalez-Mariscal,I., Martin-Montalvo,A., Vazquez-Fonseca,L.,
            Pomares-Viciana,T., Sanchez-Cuesta,A., Fernandez-Ayala,D.J.,
            Navas,P. and Santos-Ocana,C.
  TITLE     The mitochondrial phosphatase PPTC7 orchestrates mitochondrial
            metabolism regulating coenzyme Q10 biosynthesis
  JOURNAL   Biochim Biophys Acta Bioenerg 1859 (11), 1235-1248 (2018)
   PUBMED   30267671
  REMARK    GeneRIF: PPTC7 is a regulatory protein of CoQ10 biosynthesis
            required for human cell survival.
REFERENCE   7  (bases 1 to 4994)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 4994)
  AUTHORS   Floyd,B.J., Wilkerson,E.M., Veling,M.T., Minogue,C.E., Xia,C.,
            Beebe,E.T., Wrobel,R.L., Cho,H., Kremer,L.S., Alston,C.L.,
            Gromek,K.A., Dolan,B.K., Ulbrich,A., Stefely,J.A., Bohl,S.L.,
            Werner,K.M., Jochem,A., Westphall,M.S., Rensvold,J.W., Taylor,R.W.,
            Prokisch,H., Kim,J.P., Coon,J.J. and Pagliarini,D.J.
  TITLE     Mitochondrial Protein Interaction Mapping Identifies Regulators of
            Respiratory Chain Function
  JOURNAL   Mol Cell 63 (4), 621-632 (2016)
   PUBMED   27499296
REFERENCE   9  (bases 1 to 4994)
  AUTHORS   Mao,M., Biery,M.C., Kobayashi,S.V., Ward,T., Schimmack,G.,
            Burchard,J., Schelter,J.M., Dai,H., He,Y.D. and Linsley,P.S.
  TITLE     T lymphocyte activation gene identification by coregulated
            expression on DNA microarrays
  JOURNAL   Genomics 83 (6), 989-999 (2004)
   PUBMED   15177553
  REMARK    GeneRIF: Microarray evidence for coexpression of TA-PP2C with IL2
            in T-cells and other cell types.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002350.1 and AF385435.1.
            
            On Nov 22, 2018 this sequence version replaced NM_139283.1.
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.154128.1,
                                           SRR1803613.8994.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354300.5/ ENSP00000346255.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC002350.1         32487-32545
            60-3807             AF385435.1         1-3748
            3808-4994           AC002350.1         81374-82560
FEATURES             Location/Qualifiers
     source          1..4994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..4994
                     /gene="PPTC7"
                     /gene_synonym="TA-PP2C; TAPP2C"
                     /note="protein phosphatase targeting COQ7"
                     /db_xref="GeneID:160760"
                     /db_xref="HGNC:HGNC:30695"
                     /db_xref="MIM:609668"
     exon            1..510
                     /gene="PPTC7"
                     /gene_synonym="TA-PP2C; TAPP2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1202
                     /gene="PPTC7"
                     /gene_synonym="TA-PP2C; TAPP2C"
                     /EC_number="3.1.3.16"
                     /note="PTC7 protein phosphatase homolog"
                     /codon_start=1
                     /product="protein phosphatase PTC7 homolog"
                     /protein_id="NP_644812.1"
                     /db_xref="CCDS:CCDS9149.1"
                     /db_xref="GeneID:160760"
                     /db_xref="HGNC:HGNC:30695"
                     /db_xref="MIM:609668"
                     /translation="MFSVLSYGRLVARAVLGGLSQTDPRAGGGGGGDYGLVTAGCGFG
                     KDFRKGLLKKGACYGDDACFVARHRSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCE
                     RLVKEGRFVPSNPIGILTTSYCELLQNKVPLLGSSTACIVVLDRTSHRLHTANLGDSG
                     FLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEAEGVVLSDSPDAADSTSFDVQLGDII
                     LTATDGLFDNMPDYMILQELKKLKNSNYESIQQTARSIAEQAHELAYDPNYMSPFAQF
                     ACDNGLNVRGGKPDDITVLLSIVAEYTD"
     exon            511..690
                     /gene="PPTC7"
                     /gene_synonym="TA-PP2C; TAPP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            691..889
                     /gene="PPTC7"
                     /gene_synonym="TA-PP2C; TAPP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1013
                     /gene="PPTC7"
                     /gene_synonym="TA-PP2C; TAPP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1143
                     /gene="PPTC7"
                     /gene_synonym="TA-PP2C; TAPP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..4994
                     /gene="PPTC7"
                     /gene_synonym="TA-PP2C; TAPP2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4976..4981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPTC7"
                     /gene_synonym="TA-PP2C; TAPP2C"
                     /note="hexamer: AATATA"
     polyA_site      4994
                     /gene="PPTC7"
                     /gene_synonym="TA-PP2C; TAPP2C"
                     /note="major polyA site"
ORIGIN      
        1 gctagtggag cggaagatgg cggcggcggc ggcggccgct gcagccggga cttcagttgg
       61 gctgaggcgg aggagccgcc gcttctgacc tcgctctggc tccggtgcgc gcggctgagc
      121 gcgtgcgagg ccccgcgcgt cgggcagggg cggcggcggc cactgcgcgc cgccctgagg
      181 agcgccccag cggcggcgcg actgcggctg aggagagagc cggctccggg cctccgcgtc
      241 ctcctgctcc cccggccccc cgcctcctcg ggggggcggc ggcggcgatg ttctcggtcc
      301 tctcgtacgg gcggctggtg gcccgcgccg tgctcggcgg cctctcgcag accgacccca
      361 gggccggcgg cggcggcggc ggcgactacg gactggtgac ggccggctgc ggcttcggga
      421 aggacttccg taagggcctc ctcaagaagg gcgcgtgcta cggggacgac gcgtgcttcg
      481 tggcccggca ccgttccgcg gacgtgctcg gggttgcaga tggtgtagga ggctggagag
      541 actatggagt tgatccatct caattctcag ggactttaat gcggacgtgt gaacgtttag
      601 taaaagaagg acggttcgta cctagtaatc ccattggaat tctcaccaca agctactgtg
      661 agttgctgca aaataaagtc cctttgctcg gtagcagcac cgcctgcatt gtggtgctgg
      721 acagaaccag ccaccgctta cacacagcaa acctgggcga ttcaggcttc ctggttgtca
      781 ggggtggtga agtcgtgcac cgatcagatg agcagcagca ttacttcaac actccattcc
      841 agctctcaat cgctccccct gaagccgagg gagtcgtctt gagcgacagt ccggatgctg
      901 ctgatagcac gtctttcgat gtccagctag gagacattat cctgacggca acagatggac
      961 tctttgacaa catgcctgat tatatgattc ttcaggagct aaaaaagtta aagaattcaa
     1021 attatgagag tatacaacag actgccagaa gcattgctga gcaagctcat gagctggcct
     1081 atgacccaaa ttatatgtca ccttttgcac agtttgcatg tgacaatgga ttgaatgtga
     1141 gaggtggaaa gccagatgac atcaccgtcc ttctttcaat agtggctgag tatacagact
     1201 agctgaggtg tcaagtcctg cctttccttt catcatccca aatttcccct gccatgtgtg
     1261 ctgatcctgc tggcaggacc acatttcttt gccactgatc tcaatggcca gtgatgtaag
     1321 tcttttgcct gtcttcttga gactcgttga gatctttgtt gagaaccact actatcattc
     1381 actagctcat atctgccggc agcaattgaa gagatccaat atttgaagat tggccttcat
     1441 ttctcgatgt tctttccatg atggggatgg aggtgttcag tgccaccgtg gctgttactt
     1501 ttcaaagtag ttgaagtatt gaaaatgagt aatgttggta aagtgaattc aaaatcctag
     1561 tatgctaaag ggatggtaca agtctaacac aaattgtacg taatgataca tctactagaa
     1621 acatacatta ttcatcaaaa gaaatgttac atgtgtactc cacaggcata gtctttgtta
     1681 tgatgattgg tgtggcttta tgtctttgtt ataaactcct atttttcagg ggcttatgat
     1741 tctgctctaa aacattgctc tgggttatac agttttgatc ccaaaagctt ttttgttaca
     1801 aatcgggaga aaaatccatt ttagttctat ggatggaaat atttcatgct tttaaaaaga
     1861 tgtttgtgtt cctgtggtta aagttttggc agtttattga ttagtccaaa tcacaggcta
     1921 aggcctgatc tccaggaggg gtaggggaga cactttacca gtattttttt atggaaataa
     1981 tactcaaggt tgtaaaaccc ctcaaagcct agaaatttaa ttgttatggc tgaaattcct
     2041 cctagttgtc tgatagaatg cccctgaatg ggaactctag gtcccaaggc ctgaagggtt
     2101 gagaacagac agctgtaact ttgaattttg ttggctttca gtggtcatgc tacctaccca
     2161 tactcgtact ctcagacctt ttattagtag ccttgctttc tatagagcat gcaccaaatc
     2221 cagtgagtcc atgtggagag agcactgtgt gcgcagcggc agcagcacag acgtccatga
     2281 ggaaaactcc cagtgatgat ctgacattta caattacccc acatggaaat ttaggggttt
     2341 ctgaatcaag cttaatgttt acagtttcca aatagccatt ttgcagtgta tagtttcctt
     2401 acaaaactac cccgcattca gttttcacat tatctgcaag ctgaaactta tttttaagtt
     2461 ttgtgtacaa gttgactgct gtaaagatat atatttttgg gtcagttttt ttccttcatt
     2521 aacttggtgg tagaaaaaaa tatatactta gaaatcctta aattaaagcc atgttttata
     2581 tataagtcag gtaacattgg tgtatagatg agaatgcaat taaacctgat gagaatctac
     2641 ttgagaatat agaaagtctt tctctaaagg agatactgac tccctggttt attgcattaa
     2701 aatttatgtt tgaggttacc tcaacttgtt ttaaaagatt ttgttttgtg aatttgtact
     2761 gtatatttga gtaactgtca ggcttttatt taaaattgtt taacatgtac catgtacatg
     2821 tcattactat atttcaatgc atcatgcttg taacaggcat ttcatttata ataagaatga
     2881 gttattcatt tgtaagccgt tcagtaattt atctactatt cctaaattgg cataatgtta
     2941 gataatctat tttgaatcac ctttaattac atgtcagaat gccttaacta ccctaacttg
     3001 acaaaacaga attctttggt agacgcggtg ggggcggggt ggggggtctg gacggagtct
     3061 ctatttaagg agaaatcatc atgctatgat aaaacacaga agcatgagtg gcaagtggcg
     3121 gggtatttat tttgcacaaa ctatttgcag tctctgtgta tttaaaaagt aaagaaagtt
     3181 gcatccagaa gggttttgtt agaatgaata catttatatt aggactgaca acttcagctc
     3241 ttttgtttag gttttcaatt atttttggta agagtatgta gccttatgat ctggatatat
     3301 tttgcattca ttttccaacg cctacattta attcctggta agagcagtgc tcgtcaagtt
     3361 tctggttttt ctctgctctc atttaacccg tcaaacacaa tctttgtaaa gctagattgg
     3421 tggtgtttta tacaacttat ttactcagct tacctttttg agaaacgatt gttagaaatt
     3481 gacgatgtgt ttgttccagt gatactgaaa gtagtggggg caagaattga gtttcacagt
     3541 ggaattggct ttggatctgg cctatagatt agtgacataa aatattttct ctattttccc
     3601 ctgttctttt tgtgttatgc acttaatttt atgactgccg ggggggtcag ctggagtgct
     3661 gcttaacaag tatctctcct actctcagtg gtcagaggct gtgttggacc catagtagaa
     3721 ttttccaggt cacagaccca agcttccatg ggttgttact gtgctgtacc acttggtggg
     3781 tctgattctg aacctgatgt gtgtgttaat tatattttaa gcaacacaca cacacacaca
     3841 cgcctcatgt aatggacttt tataacaaaa gaaaaaattt ggatttctaa tttacaaatg
     3901 gcaaattatt tatccctctc tggatgcacc aaagaccagt aaagtttata gcttttccat
     3961 ctatatttat aaagcaatac tgtattataa aaatcaatat ttttatcaca tgcttgaaat
     4021 ttttattttg ttgttttaaa atgtgcactc taaacatatc agaaccttat ttcttcctat
     4081 gaacttaagc tgcctgcgca caaaaaaaaa aaaaatttac caaatggaga tgcagtagag
     4141 tccataggct ctaaaaacta aaagaaatgg gatgcagggg gaacaagtta tttgtcctga
     4201 gttactgtac ttgcttgaca tggttgttgg gtactaaatc acaaaagaat ccattccagg
     4261 tatgcatgtc tgggggttgg gctgtgtcta gattagaaac tgggtttcaa gctttgcatg
     4321 atgggagagc gtcctctcct ctatcagctg cgtgtgttct ggataggaca gtagcccgga
     4381 gatggaaacc accttcagta ccattagccc accataccaa gtaacaagtt aggcaggaat
     4441 cgtgggaatt tattgagtca gctttgagtg tttgagagaa tgtaaacaag attggctcga
     4501 attgtaaacg tttgtacttt ggatgagttc atggttcttt aggtcacctt aataccagct
     4561 atctttggta gaagctacag cattcagttt ctctggaaac tgtatcacat ttttgcattt
     4621 taaaaatttt acagtatcaa aaaaccaaaa tctgcttatg aaacaaaaca tgaagcagga
     4681 catatttgga ttctatttat ttaaaattaa attctttgca aaattgaact tctcaactaa
     4741 aacgtgtcca tgtcagaatt ttaactgtta gcaggtagtt tgtggcaaag atggctaaat
     4801 aatgaagcaa attagaatct gtgtgtatac taatgagctg ctttttttct gttgagacta
     4861 tcattatttg tcttattacc caagaggcaa ttacctgaat ttggatgtct gaattataac
     4921 ttatgcagga atagttctgt aaatacattt aaataaactg taaagatatt taataaatat
     4981 agtatttata ctaa
//
