LOCUS       NM_015062               5328 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens PPARG related coactivator 1 (PPRC1), transcript
            variant 1, mRNA.
ACCESSION   NM_015062
VERSION     NM_015062.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5328)
  AUTHORS   Slowly,M., Domingo-Relloso,A., Santella,R.M., Haack,K.,
            Fallin,D.M., Terry,M.B., Rhoades,D.A., Herreros-Martinez,M.,
            Garcia-Esquinas,E., Cole,S.A., Tellez-Plaza,M., Navas-Acien,A. and
            Wu,H.C.
  TITLE     Blood DNA methylation and liver cancer in American Indians:
            evidence from the Strong Heart Study
  JOURNAL   Cancer Causes Control 35 (4), 661-669 (2024)
   PUBMED   38010586
  REMARK    GeneRIF: Blood DNA methylation and liver cancer in American
            Indians: evidence from the Strong Heart Study.
REFERENCE   2  (bases 1 to 5328)
  AUTHORS   Ruan,X., Cui,G., Li,C. and Sun,Z.
  TITLE     Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker
            in Ovarian Cancer and Hepatocellular Carcinoma
  JOURNAL   Medicina (Kaunas) 59 (4), 784 (2023)
   PUBMED   37109742
  REMARK    GeneRIF: Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic
            Biomarker in Ovarian Cancer and Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5328)
  AUTHORS   Zhang,X.J., Gu,Y. and Fu,W.
  TITLE     A novel PPRC1 point mutation in a Chinese family with premature
            ovarian failure: A case study
  JOURNAL   J Gene Med 23 (6), e3335 (2021)
   PUBMED   33818872
  REMARK    GeneRIF: A novel PPRC1 point mutation in a Chinese family with
            premature ovarian failure: A case study.
REFERENCE   4  (bases 1 to 5328)
  AUTHORS   Gleyzer,N. and Scarpulla,R.C.
  TITLE     Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in
            the Stress Response to Mitochondrial Dysfunction
  JOURNAL   J Biol Chem 291 (49), 25529-25541 (2016)
   PUBMED   27789709
  REMARK    GeneRIF: PRC and c-MYC can act in concert through Akt-GSK-3
            signaling to reprogram gene expression in response to mitochondrial
            stress.
REFERENCE   5  (bases 1 to 5328)
  AUTHORS   Chengye,Z., Daixing,Z., Qiang,Z. and Shusheng,L.
  TITLE     PGC-1-related coactivator (PRC) negatively regulates endothelial
            adhesion of monocytes via inhibition of NF kappaB activity
  JOURNAL   Biochem Biophys Res Commun 439 (1), 121-125 (2013)
   PUBMED   23954632
  REMARK    GeneRIF: PRC is a negative regulator of endothelial inflammation;
            it negatively regulates endothelial adhesion of monocytes via
            inhibition of NF kappaB activity
REFERENCE   6  (bases 1 to 5328)
  AUTHORS   Gleyzer,N., Vercauteren,K. and Scarpulla,R.C.
  TITLE     Control of mitochondrial transcription specificity factors (TFB1M
            and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and
            PGC-1 family coactivators
  JOURNAL   Mol Cell Biol 25 (4), 1354-1366 (2005)
   PUBMED   15684387
  REMARK    GeneRIF: Coordinate regulation of nucleus-encoded mitochondrial
            transcription factors by NRFs and PGC-1 family coactivators is
            essential to the control of mitochondrial biogenesis
REFERENCE   7  (bases 1 to 5328)
  AUTHORS   Yamamoto,T., Shimano,H., Nakagawa,Y., Ide,T., Yahagi,N.,
            Matsuzaka,T., Nakakuki,M., Takahashi,A., Suzuki,H., Sone,H.,
            Toyoshima,H., Sato,R. and Yamada,N.
  TITLE     SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and
            interferes with PGC-1 recruitment to suppress hepatic gluconeogenic
            genes
  JOURNAL   J Biol Chem 279 (13), 12027-12035 (2004)
   PUBMED   14722127
  REMARK    GeneRIF: PGC-1 has a role in regulating gluconeogenic genes along
            with HNF-4alpha and SREBP-1
REFERENCE   8  (bases 1 to 5328)
  AUTHORS   Savagner,F., Mirebeau,D., Jacques,C., Guyetant,S., Morgan,C.,
            Franc,B., Reynier,P. and Malthiery,Y.
  TITLE     PGC-1-related coactivator and targets are upregulated in thyroid
            oncocytoma
  JOURNAL   Biochem Biophys Res Commun 310 (3), 779-784 (2003)
   PUBMED   14550271
  REMARK    GeneRIF: overexpression of the PRC pathway is responsible for
            mitochondrial proliferation in the context of thyroid oncocytoma
REFERENCE   9  (bases 1 to 5328)
  AUTHORS   Scarpulla,R.C.
  TITLE     Transcriptional activators and coactivators in the nuclear control
            of mitochondrial function in mammalian cells
  JOURNAL   Gene 286 (1), 81-89 (2002)
   PUBMED   11943463
REFERENCE   10 (bases 1 to 5328)
  AUTHORS   Andersson,U. and Scarpulla,R.C.
  TITLE     Pgc-1-related coactivator, a novel, serum-inducible coactivator of
            nuclear respiratory factor 1-dependent transcription in mammalian
            cells
  JOURNAL   Mol Cell Biol 21 (11), 3738-3749 (2001)
   PUBMED   11340167
  REMARK    GeneRIF: PRC is a functional relative of PGC-1 that operates
            through NRF-1 and possibly other activators in response to
            proliferative signals
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY023373.1, AB011167.2 and
            BU742486.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015062.4.
            
            Summary: The protein encoded by this gene is similar to PPAR-gamma
            coactivator 1 (PPARGC1/PGC-1), a protein that can activate
            mitochondrial biogenesis in part through a direct interaction with
            nuclear respiratory factor 1 (NRF1). This protein has been shown to
            interact with NRF1. It is thought to be a functional relative of
            PPAR-gamma coactivator 1 that activates mitochondrial biogenesis
            through NRF1 in response to proliferative signals. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF325193.1, AB011167.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278070.7/ ENSP00000278070.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                HY023373.1         48-69
            23-5319             AB011167.2         1-5297
            5320-5328           BU742486.1         17-25               c
FEATURES             Location/Qualifiers
     source          1..5328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..5328
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /note="PPARG related coactivator 1"
                     /db_xref="GeneID:23082"
                     /db_xref="HGNC:HGNC:30025"
                     /db_xref="MIM:617462"
     exon            1..182
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..5024
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PGC-1-related coactivator; peroxisome
                     proliferator-activated receptor gamma, coactivator-related
                     1"
                     /codon_start=1
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator-related protein 1 isoform 1"
                     /protein_id="NP_055877.3"
                     /db_xref="CCDS:CCDS7529.1"
                     /db_xref="GeneID:23082"
                     /db_xref="HGNC:HGNC:30025"
                     /db_xref="MIM:617462"
                     /translation="MAARRGRRDGVAPPPSGGPGPDPGGGARGSGWGSRSQAPYGTLG
                     AVSGGEQVLLHEEAGDSGFVSLSRLGPSLRDKDLEMEELMLQDETLLGTMQSYMDASL
                     ISLIEDFGSLGESRLSLEDQNEVSLLTALTEILDNADSENLSPFDSIPDSELLVSPRE
                     GSSLHKLLTLSRTPPERDLITPVDPLGPSTGSSRGSGVEMSLPDPSWDFSPPSFLETS
                     SPKLPSWRPPRSRPRWGQSPPPQQRSDGEEEEEVASFSGQILAGELDNCVSSIPDFPM
                     HLACPEEEDKATAAEMAVPAAGDESISSLSELVRAMHPYCLPNLTHLASLEDELQEQP
                     DDLTLPEGCVVLEIVGQAATAGDDLEIPVVVRQVSPGPRPVLLDDSLETSSALQLLMP
                     TLESETEAAVPKVTLCSEKEGLSLNSEEKLDSACLLKPREVVEPVVPKEPQNPPANAA
                     PGSQRARKGRKKKSKEQPAACVEGYARRLRSSSRGQSTVGTEVTSQVDNLQKQPQEEL
                     QKESGPLQGKGKPRAWARAWAAALENSSPKNLERSAGQSSPAKEGPLDLYPKLADTIQ
                     TNPIPTHLSLVDSAQASPMPVDSVEADPTAVGPVLAGPVPVDPGLVDLASTSSELVEP
                     LPAEPVLINPVLADSAAVDPAVVPISDNLPPVDAVPSGPAPVDLALVDPVPNDLTPVD
                     PVLVKSRPTDPRRGAVSSALGGSAPQLLVESESLDPPKTIIPEVKEVVDSLKIESGTS
                     ATTHEARPRPLSLSEYRRRRQQRQAETEERSPQPPTGKWPSLPETPTGLADIPCLVIP
                     PAPAKKTALQRSPETPLEICLVPVGPSPASPSPEPPVSKPVASSPTEQVPSQEMPLLA
                     RPSPPVQSVSPAVPTPPSMSAALPFPAGGLGMPPSLPPPPLQPPSLPLSMGPVLPDPF
                     THYAPLPSWPCYPHVSPSGYPCLPPPPTVPLVSGTPGAYAVPPTCSVPWAPPPAPVSP
                     YSSTCTYGPLGWGPGPQHAPFWSTVPPPPLPPASIGRAVPQPKMESRGTPAGPPENVL
                     PLSMAPPLSLGLPGHGAPQTEPTKVEVKPVPASPHPKHKVSALVQSPQMKALACVSAE
                     GVTVEEPASERLKPETQETRPREKPPLPATKAVPTPRQSTVPKLPAVHPARLRKLSFL
                     PTPRTQGSEDVVQAFISEIGIEASDLSSLLEQFEKSEAKKECPPPAPADSLAVGNSGG
                     VDIPQEKRPLDRLQAPELANVAGLTPPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGT
                     LKPEGVTEAKHPAAVRLQEGVHGPSRVHVGSGDHDYCVRSRTPPKKMPALVIPEVGSR
                     WNVKRHQDITIKPVLSLGPAAPPPPCIAASREPLDHRTSSEQADPSAPCLAPSSLLSP
                     EASPCRNDMNTRTPPEPSAKQRSMRCYRKACRSASPSSQGWQGRRGRNSRSVSSGSNR
                     TSEASSSSSSSSSSSRSRSRSLSPPHKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSS
                     SSSSSRSRSRSPSPRRRSDRRRRYSSYRSHDHYQRQRVLQKERAIEERRVVFIGKIPG
                     RMTRSELKQRFSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQ
                     PFDLCFGGRRQFCKRSYSDLDSNREDFDPAPVKSKFDSLDFDTLLKQAQKNLRR"
     exon            183..371
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            372..518
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            519..620
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            621..3525
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            3526..3579
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            3580..3637
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3708
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..4429
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            4430..4579
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            4580..4646
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            4647..4768
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            4769..4920
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     exon            4921..5328
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5153..5158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /note="hexamer: AATAAA"
     polyA_site      5175
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /note="major polyA site"
     regulatory      5300..5305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /note="hexamer: AATAAA"
     polyA_site      5328
                     /gene="PPRC1"
                     /gene_synonym="PRC"
                     /note="major polyA site"
ORIGIN      
        1 agagcagcgc tgggtgttca ggggccaaga tggcggcgcg ccggggacgg agagacggag
       61 tcgcgccgcc cccgagtggg ggccccggtc cggaccctgg cgggggagcc cgcggcagtg
      121 gttggggaag tcgaagccaa gcgccgtatg ggactttggg cgctgtgagc ggcggcgagc
      181 aggtgctgct gcatgaggag gcgggtgatt ctggctttgt cagtctctct cggctgggcc
      241 catctctgag ggacaaggac ctggaaatgg aggagctaat gctgcaggat gagacactgc
      301 tggggaccat gcagagctac atggatgcct cccttatctc cctcattgag gattttggga
      361 gccttggaga gagcaggtta tctctggagg accagaatga agtgtcgctg ctcacggctc
      421 tgacggagat cttggacaat gcagattctg agaacctttc tccatttgac agcattcctg
      481 attcggagct gcttgtgtca ccccgggagg gctcctctct gcacaagctg cttactctct
      541 ctcggacacc cccagaacgt gacctcatca ccccagttga cccactgggg cccagtacag
      601 gcagcagtag agggagtggg gttgaaatgt ctcttccaga tccctcttgg gacttctccc
      661 caccctcttt cttagagacc tcttccccca agcttcctag ctggagaccc ccaagatcaa
      721 gaccacgctg gggccaatcc ccacctcccc agcagcgcag tgatggagaa gaagaggagg
      781 aggtggccag cttcagtggc cagattcttg ccggggagct tgacaactgt gtgagcagta
      841 tcccggactt ccccatgcat ttggcctgcc ctgaggagga agataaagca acagcagcag
      901 agatggcagt gccagcagct ggtgatgaga gcatctcctc cctgagtgag ctggtgcggg
      961 ccatgcaccc atactgcctg cccaacctca cccacctggc atcacttgag gatgagcttc
     1021 aggagcagcc agatgatttg acactgcctg agggctgcgt agtgctggag attgtggggc
     1081 aggcagccac agctggcgat gacctggaga tcccagttgt ggtgcgacag gtctctcctg
     1141 gaccccggcc tgtgctcctg gatgactcgc tagagactag ttctgccttg cagctgctta
     1201 tgcctacact ggagtcagag acagaggctg ctgtgcccaa ggtaaccctc tgctctgaga
     1261 aagaggggtt gtcattgaac tcagaggaga agctggactc agcctgctta ttgaagccca
     1321 gggaggtcgt ggagccggtg gtgcccaagg agcctcagaa cccacctgcc aatgcagcac
     1381 caggttccca gagagctcga aagggcagga agaagaagag caaggagcag ccagcagcct
     1441 gtgtggaagg ctatgccagg aggctgaggt catcttctcg cgggcagtct actgtaggta
     1501 cagaagtgac ctctcaggta gacaacttgc agaaacagcc tcaggaagaa cttcaaaaag
     1561 agtctgggcc tctccagggt aaggggaagc cccgggcttg ggctcgggcc tgggcagctg
     1621 ccttggagaa ttctagccct aagaacttgg agagaagtgc tggacaaagt agtcctgcta
     1681 aagaaggccc tctagacctc tacccaaagc tggctgacac tatccaaacc aatcctatac
     1741 caacccatct ctcattggtc gactctgccc aagccagccc catgccagtt gactctgttg
     1801 aagctgatcc cactgcagtt ggccctgttc tagctggccc tgtacctgtt gaccctgggt
     1861 tggttgacct tgcttcaacc agctcagaac tggttgagcc tctcccggct gagccagtgc
     1921 tgatcaaccc agtcctggct gactcagcag cagttgaccc tgcagtggtt cccatctcag
     1981 ataacttgcc accagttgat gctgtcccgt ctggcccagc accagttgat ctagcactgg
     2041 ttgaccctgt tcctaatgac ctgactccag ttgacccagt gctagttaag tccagaccaa
     2101 ctgatcccag acgtggtgca gtgtcatcag ccctgggggg ttcagcaccc cagctcctcg
     2161 tggagtcaga gtccttggac ccaccaaaga ccatcatccc tgaagtcaaa gaggttgtgg
     2221 attctctgaa aattgaaagt ggtaccagtg ctacaaccca tgaagccaga cctcggcctc
     2281 tcagcttatc tgagtaccgg cgacgaaggc agcaacgcca agcagaaaca gaagagagaa
     2341 gtccacagcc cccaactggg aagtggccta gccttccaga gactcccaca gggctggcag
     2401 acatcccttg tcttgtcatc ccaccagccc cagccaagaa gacagctctg cagagaagcc
     2461 ctgaaacacc ccttgagatt tgccttgtgc ctgtaggtcc cagccctgct tctcctagtc
     2521 ctgagccacc tgtaagcaaa cctgtggcct catctcccac tgagcaggtg ccatcccagg
     2581 agatgccact gttggcgaga ccttcccctc ctgtgcagtc tgtgtcccct gctgtgccca
     2641 cacctccctc gatgtctgct gccctgcctt tccctgcagg tgggcttggc atgcccccca
     2701 gtctgccccc acctcccttg cagcctccta gtcttccatt gtctatgggg ccagtactac
     2761 ctgatccgtt tactcactat gcccccttgc catcctggcc ttgttatcct catgtgtccc
     2821 cttctggcta tccttgcctg ccccccccac caacggtgcc cctagtgtct ggtactcctg
     2881 gtgcctatgc cgtgcctccc acttgcagtg tgccttgggc accccctcct gccccagtct
     2941 caccttacag ttccacatgt acctatgggc ccttgggatg gggcccaggg cctcaacatg
     3001 ctccattctg gtctactgtt cccccacctc ctttgcctcc agcctccatt gggagagctg
     3061 ttccccaacc taaaatggag tctaggggca ctccagctgg ccctcctgaa aatgtacttc
     3121 ccttgtcgat ggctcctccc ctcagtcttg ggctacctgg ccatggagct cctcagacag
     3181 agcctaccaa ggtggaggtc aagccagtgc ctgcatctcc ccatccgaaa cacaaggtgt
     3241 ctgccctggt gcaaagtccc cagatgaagg ctctagcatg tgtgtctgct gaaggtgtga
     3301 ctgttgagga gcctgcatca gagaggctaa agcctgagac ccaagagacc aggcccaggg
     3361 agaagccccc cttgcctgct accaaggctg ttcccacacc aaggcagagc actgtcccca
     3421 agctgcctgc tgtccaccca gcccgtctaa ggaagctgtc cttcctgcct accccacgta
     3481 ctcagggttc tgaagatgtg gtacaggctt tcatcagtga gattggaatt gaggcatcgg
     3541 acctgtccag tctgctggag cagtttgaga aatcagaagc caaaaaggag tgtcctcctc
     3601 cggctcctgc tgacagcttg gctgtaggaa actcaggcgg cgttgacatt ccccaggaga
     3661 agaggcccct agaccggtta caagccccag aactggccaa cgtggcaggg ctcacccctc
     3721 cagctacccc tccccaccag ttatggaagc ccctggctgc tgtctcactg ctggccaaag
     3781 ccaaatctcc taagtccacc gcccaggagg gaaccctgaa gcctgaagga gttacggagg
     3841 ccaaacatcc agctgcagtt cgcctccaag aaggggtcca tggccctagt cgagtccatg
     3901 tgggctctgg ggaccatgac tattgtgtcc ggagcaggac ccccccaaaa aagatgcctg
     3961 ccctagtcat tccagaggtg ggctcccgat ggaatgtcaa gcgccatcag gacatcacca
     4021 tcaaacctgt cttgtccttg ggcccagctg cccctccgcc cccatgcata gctgcctccc
     4081 gggagccgct tgatcacagg actagcagtg agcaggcaga tccctcagca ccctgccttg
     4141 ccccatccag cttgctgtcc cctgaggcct caccctgccg gaatgacatg aacactagga
     4201 ctccccctga accctcagcc aagcagcggt caatgcgctg ttaccgaaaa gcctgcaggt
     4261 cagccagccc ctcaagccag ggctggcagg gccgccgagg ccgcaacagc cgttctgtca
     4321 gctctgggtc caaccggact agcgaagcat cttcctcatc ctcatcatcg tcttcctcat
     4381 cccgatctcg gtccaggtcc ctctcccccc cacacaagag gtggcgaagg tccagctgta
     4441 gttcctctgg acgttctcga agatgctctt cctcttcttc gtcatcatct tcctcttcgt
     4501 cttcctcatc ctcatcatcc agttctcgaa gccgctcacg atccccatcc ccccgccgga
     4561 gaagtgacag gaggcggcgg tacagctctt atcgttcaca tgaccattac caaaggcaaa
     4621 gagtgctaca aaaggagcgt gcaatagaag aaagaagggt ggtcttcatt ggaaagatac
     4681 ctggccgcat gactcgatca gagctgaaac agaggttctc cgtttttgga gagattgagg
     4741 agtgcaccat ccacttccgt gtccaagggg acaactacgg cttcgtcact tatcgctatg
     4801 ctgaggaggc atttgcagcc attgagagtg gccacaagct gcggcaggca gatgagcagc
     4861 cctttgatct ctgctttggg ggccgaaggc agttctgcaa gaggagctat tctgatcttg
     4921 actccaaccg ggaagacttt gacccagcac ctgtaaagag caaatttgat tctcttgact
     4981 ttgacacatt gttgaaacag gcccagaaga acctcaggag gtaaccttgg gcccttccct
     5041 gctatccttt ttctcctttg gaggtgccca acctcctcca cccccttccc ctactctagg
     5101 ggagagagct gctagtgaga tgactgtttt ataaagaaat ggaaaaaagt gaaataaaaa
     5161 atatgttgaa tcagattttt taaaaggggt atttgttttt ttataacagg tattgaaaca
     5221 agttaacttg cattcctatg taagatagga ggggctgagg ggatccccag tgtttggaac
     5281 ataagtcact atgcagacta ataaacatca actagagaga actcccaa
//
