LOCUS       NM_014931               3984 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 6 regulatory subunit 1 (PPP6R1),
            mRNA.
ACCESSION   NM_014931 XM_375651
VERSION     NM_014931.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3984)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3984)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3984)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   4  (bases 1 to 3984)
  AUTHORS   Lant,B., Yu,B., Goudreault,M., Holmyard,D., Knight,J.D., Xu,P.,
            Zhao,L., Chin,K., Wallace,E., Zhen,M., Gingras,A.C. and Derry,W.B.
  TITLE     CCM-3/STRIPAK promotes seamless tube extension through endocytic
            recycling
  JOURNAL   Nat Commun 6, 6449 (2015)
   PUBMED   25743393
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3984)
  AUTHORS   Couzens,A.L., Knight,J.D., Kean,M.J., Teo,G., Weiss,A.,
            Dunham,W.H., Lin,Z.Y., Bagshaw,R.D., Sicheri,F., Pawson,T.,
            Wrana,J.L., Choi,H. and Gingras,A.C.
  TITLE     Protein interaction network of the mammalian Hippo pathway reveals
            mechanisms of kinase-phosphatase interactions
  JOURNAL   Sci Signal 6 (302), rs15 (2013)
   PUBMED   24255178
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3984)
  AUTHORS   Zeng,K., Bastos,R.N., Barr,F.A. and Gruneberg,U.
  TITLE     Protein phosphatase 6 regulates mitotic spindle formation by
            controlling the T-loop phosphorylation state of Aurora A bound to
            its activator TPX2
  JOURNAL   J Cell Biol 191 (7), 1315-1332 (2010)
   PUBMED   21187329
REFERENCE   7  (bases 1 to 3984)
  AUTHORS   Stefansson,B., Ohama,T., Daugherty,A.E. and Brautigan,D.L.
  TITLE     Protein phosphatase 6 regulatory subunits composed of ankyrin
            repeat domains
  JOURNAL   Biochemistry 47 (5), 1442-1451 (2008)
   PUBMED   18186651
REFERENCE   8  (bases 1 to 3984)
  AUTHORS   Stefansson,B. and Brautigan,D.L.
  TITLE     Protein phosphatase 6 subunit with conserved Sit4-associated
            protein domain targets IkappaBepsilon
  JOURNAL   J Biol Chem 281 (32), 22624-22634 (2006)
   PUBMED   16769727
REFERENCE   9  (bases 1 to 3984)
  AUTHORS   Nasu-Nishimura,Y., Hayashi,T., Ohishi,T., Okabe,T., Ohwada,S.,
            Hasegawa,Y., Senda,T., Toyoshima,C., Nakamura,T. and Akiyama,T.
  TITLE     Role of the Rho GTPase-activating protein RICS in neurite outgrowth
  JOURNAL   Genes Cells 11 (6), 607-614 (2006)
   PUBMED   16716191
REFERENCE   10 (bases 1 to 3984)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116342.2, AL544921.3, BG772019.1, BC002799.2 and AC010327.8.
            
            On Nov 23, 2018 this sequence version replaced NM_014931.3.
            
            Summary: Protein phosphatase regulatory subunits, such as SAPS1,
            modulate the activity of protein phosphatase catalytic subunits by
            restricting substrate specificity, recruiting substrates, and
            determining the intracellular localization of the holoenzyme. SAPS1
            is a regulatory subunit for the protein phosphatase-6 catalytic
            subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed
            16769727]).[supplied by OMIM, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094753.1, AB029038.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412770.7/ ENSP00000414202.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AC116342.2         33168-33514         c
            348-350             AL544921.3         1-3
            351-561             AC116342.2         32954-33164         c
            562-745             BG772019.1         82-265
            746-3892            BC002799.2         1-3147
            3893-3893           AC010327.8         123316-123316       c
            3894-3984           BC002799.2         3149-3239
FEATURES             Location/Qualifiers
     source          1..3984
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..3984
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /note="protein phosphatase 6 regulatory subunit 1"
                     /db_xref="GeneID:22870"
                     /db_xref="HGNC:HGNC:29195"
                     /db_xref="MIM:610875"
     exon            1..583
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..816
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             590..3235
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /note="SAPS domain family, member 1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 1"
                     /protein_id="NP_055746.3"
                     /db_xref="CCDS:CCDS46186.1"
                     /db_xref="GeneID:22870"
                     /db_xref="HGNC:HGNC:29195"
                     /db_xref="MIM:610875"
                     /translation="MFWKFDLHTSSHLDTLLEREDLSLPELLDEEDVLQECKVVNRKL
                     LDFLLQPPHLQAMVAWVTQEPPDSGEERLRYKYPSVACEILTSDVPQINDALGADESL
                     LNRLYGFLQSTGSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLQHIGTS
                     AIMDLLLRLLTCVERPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQHSNASQSLCDI
                     IRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLL
                     EPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRPRLSCFHQLLLEP
                     PKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAALTHELLALDVPNTMLDLFFH
                     YVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEEN
                     DRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSG
                     PLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFI
                     DHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDDE
                     EEEDEEEAQGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEE
                     DEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRVSGEEELHTGPP
                     APQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQAL
                     VSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQ
                     SAQALTPPPIPNGSAPEGPASPGSQ"
     exon            817..1003
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1141
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1207
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1320
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1434
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1597
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1750
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1885
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1950
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2066
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2152
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2242
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2340
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2398
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2577
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2714
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2895
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..2966
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3048
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3159
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3231
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3984
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3963..3968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /note="hexamer: AATAAA"
     polyA_site      3984
                     /gene="PPP6R1"
                     /gene_synonym="KIAA1115; PP6R1; SAP190; SAPS1"
                     /note="major polyA site"
ORIGIN      
        1 gattgtggga tagtggcgga gggagccggg cgtcggaggc cctgaggccg gccgcagagc
       61 ccggagattg agcggctttg gggaaggggt ggttaaggaa gtaggcctcg gcttccgtcg
      121 gtcgctgctc ggctctgcgg cccgtttgga ccgcggagga ggtcgccttc ccctcccgtg
      181 gggcgctcgg ttggactgtg gaaaccgggg caacttcccc cgtcttcccg gctgaggcgc
      241 ctgcgtgggc ctcgcgaccc ggctcgccaa cccgcctcgg cccgcacgcc cacctcgcct
      301 gcggaccccg gaggtgccta cgcggactag tgacgccccc cgcccgtcgg caactccacc
      361 cggcgctgac cccctcaact ctgcaggacc cggcgcgcga ggaccccacg acccgcgggc
      421 gcctgcgcgg accccgcgag ccccggcgcc tgcgcgagtc cccgacgccg cccccgcccc
      481 cactcaccgg gccccgcagc aggggccgga gccgccggcg gcggggcggg ggggggcgcc
      541 ccgatgagcc ccgagtgcga ggagccgccg ccccccctcg cagggcgcca tgttttggaa
      601 gtttgacctg cacacaagct cgcacctgga cacgctgctg gagcgggagg acctgagcct
      661 gcccgagctg ctggacgagg aagacgtgct gcaggagtgc aaggtcgtca accgcaagct
      721 gctggacttc ctgctgcagc caccccacct gcaagcaatg gtggcctggg tcacccagga
      781 gccgccagat agcggtgagg agcggctgcg ctacaagtac cccagtgtgg cctgcgagat
      841 tctgacctca gatgtgcccc agatcaatga tgccctgggt gctgatgagt cccttctgaa
      901 ccggctctac ggcttcctgc agagcaccgg cagcctcaac ccactgctgg ccagcttctt
      961 cagcaaggtc atgggcatcc tcatcaaccg caagacagac cagctcgtgt cctttcttcg
     1021 gaagaaggat gacttcgtgg acctgctgct gcagcacatt ggcacctcgg ccatcatgga
     1081 cctcctgctg cgcctgctca cctgtgtgga gcggcctcag ctgaggcagg atgttgtcaa
     1141 ttggctcaac gaggagaaga tcgtccagcg gctgattgag cagatccacc cgtcgaagga
     1201 tgagaatcaa cattccaacg catcccagtc cctgtgtgac atcatccgcc tgagccggga
     1261 gcagatgatc caagtccagg acagcccaga gcctgaccaa ctgctggcca ccctggagaa
     1321 gcaggagacg attgagcagc tcttaagcaa catgttcgag ggggagcaga gccagtctgt
     1381 catcgtcagt gggatccagg tgctgctgac cctgctggag cccaggaggc cgaggtccga
     1441 gtccgtgacc gtgaacagct tcttcagcag tgtggatggg cagctggagc tcctggccca
     1501 gggggccctg gaaagcactg tgtccagtgt gggcgccttg cacgccctac gcccgcggct
     1561 cagctgcttc caccagctcc tgctggagcc tcccaagctg gagccgctac agatgacatg
     1621 gggcatgctg gctccgcctc tgggcaacac gcggctgcac gtggtcaagc tcctggccag
     1681 tgccctgagc gccaatgatg cagccctgac gcacgagctc ctggcactgg acgtgcccaa
     1741 caccatgctg gacctcttct tccattatgt cttcaacaac ttcttgcatg cccaagtaga
     1801 gggatgcgtg agcaccatgc tgagcttggg gccacctcct gacagcagcc ctgagacgcc
     1861 catccaaaac cctgttgtga aacatctgct gcagcagtgc cgcctggtgg agcggatcct
     1921 gacgtcctgg gaggagaacg accgtgtaca gtgtgcggga ggccctcgga aaggctacat
     1981 gggtcacctg acaagagtgg ccggtgccct ggtgcagaac acggagaagg ggcccaatgc
     2041 agagcagctg cggcagctgc tgaaggagct gcccagcgag cagcaggagc agtgggaagc
     2101 cttcgtatcg gggcccctgg cggagaccaa caagaagaac atggtggacc tggtgaacac
     2161 ccaccaccta cactcctcca gtgacgatga ggacgaccgg ctcaaggagt tcaacttccc
     2221 tgaggaggct gtgctgcagc aggccttcat ggacttccag atgcagcgca tgacctctgc
     2281 cttcattgac cacttcggct tcaatgatga ggagtttggg gagcaggagg agagtgtgaa
     2341 cgcacctttt gacaagacag ccaacatcac cttctccctc aatgctgacg atgagaaccc
     2401 caacgccaac ctacttgaga tatgctacaa ggaccgcatc cagcagtttg atgatgatga
     2461 ggaagaggag gacgaggaag aggcccaggg ctcaggggag tctgatggag aagatggcgc
     2521 ctggcagggc agccagctgg ccaggggggc ccgtctgggc cagccacctg gtgtccggag
     2581 tggaggcagc acagacagtg aggacgaaga agaggaggac gaggaggagg aggaagacga
     2641 ggagggcatt ggctgtgcag cccgtggagg ggccacccct ctgtcctacc ccagccctgg
     2701 ccctcagcct ccaggcccca gctggacagc cacctttgac ccagtgccta cagatgcccc
     2761 gaccagcccc cgagtctccg gggaggaaga gctgcacact gggcctccag ccccacaggg
     2821 gcccctcagt gtgccccagg gcctccccac tcagagcctg gccagccctc ctgcccgtga
     2881 cgccctgcag ctcaggtctc aggaccccac acccccctca gcacctcagg aagccacaga
     2941 aggcagcaaa gtcacggagc cctcagcccc ttgccaggcc ttggttagca tcggggacct
     3001 tcaggccacc ttccacggga tccgttctgc ccccagctcc tcggacagtg caaccagaga
     3061 cccctctacc tctgtcccag cctccggggc ccaccagccc ccccagacca cagaagggga
     3121 gaagagccca gagcccttgg ggcttcccca aagccagagt gcccaggccc tcacgcctcc
     3181 tccgataccc aatggctctg ccccggaagg gcctgcatcc ccaggctccc aatagctgcc
     3241 tggtgcggca gcggcggcca aatcttccgt cctcccgtgg atctcccggg gtgggggcag
     3301 ggcgggtccc acgatggccc ccattgccct catcaccctg acacccccac attctctcct
     3361 ctggaccccc aggaggctgg tgccagggag acaggcccaa cccaccccca tttgcactga
     3421 gaagagaagt tttggagcgt tgcctcctag aataaagata cagagagtca aatagagaga
     3481 atggagagag agaaacatat attatatatt atatagagag agggaggaga gcgagagaga
     3541 gtgaggacac cgaactgggc tggcggctcc aaagcacagc cttccctgtt ccgtcccagc
     3601 gggagctggt gttaggggtc ccaaggttgc cacccacgtg cccagctgtc ccacgctgca
     3661 gcgcagacgg ccacgcccac acccggcctt ttagctcagg tccaccatgg gggacggccc
     3721 agcgtgggtg ggggtgccag agggtcccga gtgggggccg tgcctttgcc cagaccctgc
     3781 actttcaacc aggccagtcc ggctctgggg agcaggggcc tccccggcaa cagccccagg
     3841 ggccttgagg gtctgaggtc ccagccctgt tgccaagtga ccttgtcccc agctccctcc
     3901 tcccaggctg gtgtgagtgt gcgtgcgttt gtgccgagct tctatttcat attgcaaata
     3961 taaataaagg aaggcagttt acga
//
