LOCUS       NM_002721               4103 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C),
            transcript variant 2, mRNA.
ACCESSION   NM_002721 NM_016294
VERSION     NM_002721.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4103)
  AUTHORS   Hou,P.X., Fan,Q., Zhang,Q., Liu,J.J. and Wu,Q.
  TITLE     M6A-induced transcription factor IRF5 contributes to the
            progression of cervical cancer by upregulating PPP6C
  JOURNAL   Clin Exp Pharmacol Physiol 51 (7), e13868 (2024)
   PUBMED   38745265
  REMARK    GeneRIF: M6A-induced transcription factor IRF5 contributes to the
            progression of cervical cancer by upregulating PPP6C.
REFERENCE   2  (bases 1 to 4103)
  AUTHORS   Bynigeri,R.R., Malireddi,R.K.S., Mall,R., Connelly,J.P.,
            Pruett-Miller,S.M. and Kanneganti,T.D.
  TITLE     The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis
  JOURNAL   BMC Biol 22 (1), 122 (2024)
   PUBMED   38807188
  REMARK    GeneRIF: The protein phosphatase PP6 promotes RIPK1-dependent
            PANoptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4103)
  AUTHORS   Wu,G., Li,D., Liang,W., Sun,W., Xie,X., Tong,Y., Shan,B., Zhang,M.,
            Lu,X., Yuan,J. and Li,Y.
  TITLE     PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1
            and c-FLIPL to promote TNFalpha-mediated cell death
  JOURNAL   Cell Death Dis 13 (9), 773 (2022)
   PUBMED   36071040
  REMARK    GeneRIF: PP6 negatively modulates LUBAC-mediated M1-ubiquitination
            of RIPK1 and c-FLIPL to promote TNFalpha-mediated cell death.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4103)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4103)
  AUTHORS   Bao,F., Zhang,L., Pei,X., Lian,C., Liu,Y., Tan,H. and Lei,P.
  TITLE     MiR-20a-5p functions as a potent tumor suppressor by targeting
            PPP6C in acute myeloid leukemia
  JOURNAL   PLoS One 16 (9), e0256995 (2021)
   PUBMED   34587164
  REMARK    GeneRIF: MiR-20a-5p functions as a potent tumor suppressor by
            targeting PPP6C in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4103)
  AUTHORS   Cuticchia,A.J., Kulkarni,R.D., Parris,W.E., Cooley,P.C., Hall,R.D.
            and Silk,G.W.
  TITLE     Inconsistencies between human genetic cytolocations and those
            derived using genomic sequence
  JOURNAL   Cytogenet Genome Res 112 (1-2), 1-5 (2006)
   PUBMED   16276083
REFERENCE   7  (bases 1 to 4103)
  AUTHORS   Gingras,A.C., Caballero,M., Zarske,M., Sanchez,A., Hazbun,T.R.,
            Fields,S., Sonenberg,N., Hafen,E., Raught,B. and Aebersold,R.
  TITLE     A novel, evolutionarily conserved protein phosphatase complex
            involved in cisplatin sensitivity
  JOURNAL   Mol Cell Proteomics 4 (11), 1725-1740 (2005)
   PUBMED   16085932
REFERENCE   8  (bases 1 to 4103)
  AUTHORS   Chen,J., Peterson,R.T. and Schreiber,S.L.
  TITLE     Alpha 4 associates with protein phosphatases 2A, 4, and 6
  JOURNAL   Biochem Biophys Res Commun 247 (3), 827-832 (1998)
   PUBMED   9647778
REFERENCE   9  (bases 1 to 4103)
  AUTHORS   Bastians,H., Krebber,H., Vetrie,D., Hoheisel,J., Lichter,P.,
            Ponstingl,H. and Joos,S.
  TITLE     Localization of the novel serine/threonine protein phosphatase 6
            gene (PPP6C) to human chromosome Xq22.3
  JOURNAL   Genomics 41 (2), 296-297 (1997)
   PUBMED   9143513
REFERENCE   10 (bases 1 to 4103)
  AUTHORS   Bastians,H. and Ponstingl,H.
  TITLE     The novel human protein serine/threonine phosphatase 6 is a
            functional homologue of budding yeast Sit4p and fission yeast ppe1,
            which are involved in cell cycle regulation
  JOURNAL   J Cell Sci 109 (Pt 12), 2865-2874 (1996)
   PUBMED   9013334
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB037210.1, BC006990.1,
            AA251321.1, AL445930.11 and CB250498.1.
            
            On Jun 3, 2019 this sequence version replaced NM_002721.4.
            
            Summary: This gene encodes the catalytic subunit of protein
            phosphatase, a component of a signaling pathway regulating cell
            cycle progression. Splice variants encoding different protein
            isoforms exist. The pseudogene of this gene is located on
            chromosome X. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            and lacks an exon in the coding region, compared to variant 1; it
            encodes a shorter isoform (b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence and transcripts to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.30857.1,
                                           SRR11853564.27809.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373547.9/ ENSP00000362648.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DB037210.1         137-153
            18-1133             BC006990.1         1-1116
            1134-1552           AA251321.1         22-440              c
            1553-3980           AL445930.11        102853-105280       c
            3981-4103           CB250498.1         18-140              c
FEATURES             Location/Qualifiers
     source          1..4103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..4103
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /note="protein phosphatase 6 catalytic subunit"
                     /db_xref="GeneID:5537"
                     /db_xref="HGNC:HGNC:9323"
                     /db_xref="MIM:612725"
     exon            1..160
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1003
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /EC_number="3.1.3.16"
                     /note="isoform b is encoded by transcript variant 2;
                     serine/threonine protein phosphatase catalytic subunit;
                     serine/threonine-protein phosphatase 6 catalytic subunit"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 6 catalytic
                     subunit isoform b"
                     /protein_id="NP_002712.1"
                     /db_xref="CCDS:CCDS6861.1"
                     /db_xref="GeneID:5537"
                     /db_xref="HGNC:HGNC:9323"
                     /db_xref="MIM:612725"
                     /translation="MAPLDLDKYVEIARLCKYLPENDLKRLCDYVCDLLLEESNVQPV
                     STPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAK
                     WPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQIL
                     CVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGA
                     KVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKD
                     VNTREPKLFRAVPDSERVIPPRTTTPYFL"
     exon            161..256
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /inference="alignment:Splign:2.1.0"
     exon            257..322
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /inference="alignment:Splign:2.1.0"
     exon            323..464
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /inference="alignment:Splign:2.1.0"
     exon            465..544
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /inference="alignment:Splign:2.1.0"
     exon            545..754
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /inference="alignment:Splign:2.1.0"
     exon            755..4103
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1529..1534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /note="hexamer: AATAAA"
     polyA_site      1548
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /note="major polyA site"
     regulatory      3422..3427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /note="hexamer: AATAAA"
     polyA_site      3446
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
     regulatory      4003..4008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /note="hexamer: ATTACA"
     polyA_site      4025
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
     regulatory      4081..4086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
                     /note="hexamer: ATTAAA"
     polyA_site      4103
                     /gene="PPP6C"
                     /gene_synonym="PP6; PP6C"
ORIGIN      
        1 aaagttccgg cttcggcctc cgccgctgcc gccgccgctg ctacagccgc cgccgccgct
       61 gttgccgcgg cttgttattc ttaaaatggc gccgctagac ctggacaagt atgtggaaat
      121 agcgcggctg tgcaagtacc tgccagagaa cgacctgaag cggctatgtg actacgtttg
      181 tgacctcctc ttagaagagt caaatgttca gccagtatca acaccagtaa cagtgtgtgg
      241 agatatccat ggacagtttt atgacctttg tgaactgttc agaactggag gtcaggttcc
      301 tgacacaaac tacatattta tgggtgattt tgtagacaga ggttactata gtttggagac
      361 cttcacttac cttcttgcat taaaggctaa atggcctgat cgtattacac ttttgcgagg
      421 aaatcatgag agtagacaga taacacaggt ctatggattt tatgatgagt gccaaaccaa
      481 atatggaaat gctaatgcct ggagatactg taccaaagtt tttgacatgc tcacagtagc
      541 agctttaata gatgagcaga ttttgtgtgt ccatggtggt ttatctcctg atatcaaaac
      601 actggatcaa attcgaacca tcgaacggaa tcaggaaatt cctcataaag gagcattttg
      661 tgatctggtt tggtcagatc ctgaagatgt ggatacctgg gctatcagtc cccgaggagc
      721 aggttggctt tttggagcaa aggtcacaaa tgagtttgtt catatcaaca acttaaaact
      781 catctgcaga gcacatcaac tagtgcacga aggctataaa tttatgtttg atgagaagct
      841 ggtgacagta tggtctgctc ctaattactg ctatcgttgt ggaaatattg cttcgatcat
      901 ggtcttcaaa gatgtaaata caagagaacc aaagttattc cgggcagttc cagattcaga
      961 acgtgttatt cctcccagaa cgacaacgcc atatttcctt tgaggccttc gcccatcctg
     1021 ctgacccatt tttctgccct cttcttaccc caattttctt gtattaccct ctacaatata
     1081 ctttttattg agcactttgc tgctgaaatg ctgcctcttg cctttttttt tttaaatttt
     1141 aaattatcta aatttattgt ttgttgtggt gtctatagca aagtttttct atcaattttc
     1201 ccccatccca tccccaccct ggactcattt gagaagactt gagaaatgtc ttaatactca
     1261 cactgctgca tgtagctctt gcttatttac tggtctggga aacaggatgt gtttcctttt
     1321 tttaaaagcc aattgacaga ttacacctaa atactcctcc ttttgtatca ttcagccttt
     1381 tgttttagtt tggtaagttt taagaaattt cagcagcaaa gttgttattc agtgggcacg
     1441 atggactcca aatgcctcaa gttatgtata cctgtcccag atgtaaactt cattgtcctt
     1501 tgttggatga tattttaaat ggatataaaa taaattggtc taaagggctg ccctccttgt
     1561 tgtgttttta aattttagtt aaaaactgct acagcttatg actttgtact ttaagataat
     1621 tgtattgatc ttttttcaga ttccttgtat tttttaataa agtaatctta aataaaactc
     1681 agataggtta agtgttagaa attttaaaca gcttacattg ttagcgtaaa gttatctttt
     1741 cttttttcct aatcagagtt cttgaccctt tggttattga gtttaaaact tcaattgaaa
     1801 ttcaatagta tttatttttg aaaaaaatca ctaaactgtg cctaaagaac ataactgcca
     1861 tattaatgtt ttggtttata tcctctatag taatagaaaa acatttaata cttgtaatgc
     1921 tgatgtgtta atttgatacc agttgagtag aatgtgatca atccagttta caatctatca
     1981 tgagtattat taactaaaat ctatgtgctt ttcaatagga atcattcttc tcttgctgta
     2041 acacttgacc ttaactttta gaaagtgttc atttttaaac tgcaactgga aaggttgaaa
     2101 agttaggact cttgtatttg tgaactgtaa tctgaagcag attatttaaa gtgtagaaaa
     2161 agaaacaagt tcttcttttt tgcaaaggtc tgtgatacca tatttcagct ttgtgtaagt
     2221 aatttgaata tccaaagggt tgtgatgatc agttctgaat atgcaactgt ccacttaata
     2281 aggacaagta ttccagtatc tcttatgact gtagtcataa atgatgttgg aatgtacatt
     2341 ttgtgaaata gttggtatcc ctttactatg attaattttt gttattccag gaaatacttg
     2401 tgaagccagc caattaataa agcactttag catctgttca ggtagttttg aaaacccact
     2461 tttccccttc aggataagaa cttccaggtt acctaaaaat gcaataaaaa tctttatagt
     2521 ctaagcttct tggcatataa tttttcatca gggttttctt ttattaattg agcacaatac
     2581 tgttttgatt taattttttt ccctcaaacc acccagctcc ttacatagtt tttaattata
     2641 tagctatatg aaagaggtgg ctaagacatt tgctgcacac acttgaacta atgttgggtc
     2701 agtagcttcg tgttactgcc ctgatcccag tgtaattcag gtggaaaggt atttttatct
     2761 cacagggata tgtagctatg tattttacta attgtgaaac actggaaatt aatgatgcag
     2821 acaacttggt gtggtctttg aacagctctc tgcagtattt ttttttttcc tgttaccata
     2881 aattgtattt aagtgcttgc tttccactta agttgtacta atagaaccgg taactcccag
     2941 ccctccctgt ttgacactcc ttagcttaga ttgatgtagt tgtttttgtt atccctataa
     3001 tgtgactttt atttttaagt cattgtgtac tgcatttgtt tgtcactagt tgggcacgtg
     3061 ccaataatat tctctccatt ccttatctgc catctctgtt ttgcctgatt tctcttcaac
     3121 tgaataatgg ctttttgcat ggaaaaaata gtttttacta ttagacgtgt aaagggaaga
     3181 gagagctaat gtattggact ttgtgagcct acaaggaata ttttggatcc ctccaataaa
     3241 taagggctat gtactatatg tactatatag agttatcatg tggtggaaga tacttgcaag
     3301 tcatagattt atgggcagga ggatttgtta ctccctatat ctaggctgaa tgtaaaatcc
     3361 cttatgttgt atcaatgggg gtaaaaacta tttttatttg cctatgatat acttggtttc
     3421 taataaagtg ccctaggctc tagtgagaac tgtctacttt gaattgccat ttactccctt
     3481 tcctcctttg gccgatatgc tcttggctag ctttttataa gttaatgtgt ttccccaaaa
     3541 agtttcacta ctttatattc atttgagtgt gatcctaaaa cacctggatc aacagtacat
     3601 ctcatatgca atctgcatca gctcctattc tgtctggatg tctagaactg ttggaagatt
     3661 ttgacgtctt aagccctagg ttttgctttg ggaaataagg tttgaaatat tgttcattgc
     3721 attaagattt gtgtgtgtgt gctttgtaag cccagaacca ggttttggaa aatgcctgta
     3781 ctgtgaaagc aaattaggac tctttctgag cctctttcat tgtcagaaat agaatcactt
     3841 tccatcagct tccaggaaat tgtgtatctg gagtcgaaga gatttgacat caagaatcca
     3901 gatttttaaa tgtaattgtt ttttaaatgc taatgtttgt aaagcacctt cagttcttcg
     3961 gatgaaaggt gctatattcc ctcagtgtaa attaataaaa agattacagg aagtttgtca
     4021 aaaaattcaa tgcatagtct gtagtatgtc ctgacaagaa gttagcattt tatataagaa
     4081 attaaaaaat gcttattcct cca
//
