LOCUS       NM_006247               2139 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 5 catalytic subunit (PPP5C),
            transcript variant 1, mRNA.
ACCESSION   NM_006247
VERSION     NM_006247.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2139)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2139)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2139)
  AUTHORS   Dou,L., Wang,J., Deng,R., Wang,C., Xie,Z. and Yong,W.
  TITLE     Over-expression of human PP5 gene in mice induces corneal
            hyperplasia and leads to ocular surface squamous neoplasia
  JOURNAL   Biochem Biophys Res Commun 529 (2), 487-493 (2020)
   PUBMED   32703456
  REMARK    GeneRIF: Over-expression of human PP5 gene in mice induces corneal
            hyperplasia and leads to ocular surface squamous neoplasia.
REFERENCE   4  (bases 1 to 2139)
  AUTHORS   Wang,L. and Yan,F.
  TITLE     Exploring the role of active site Mn2+ ions in the binding of
            protein phosphatase 5 with its substrate using molecular dynamics
            simulations
  JOURNAL   Biochem Biophys Res Commun 511 (3), 612-618 (2019)
   PUBMED   30826056
  REMARK    GeneRIF: The role of the catalytic Mn(2+) ions in regulating the
            binding of PP5 with its substrate was investigated through MD
            simulations. Results reveal that the different states of Mn(2+)
            ions can alter the structure of the active site and the
            conformations of the residues coordinating the Mn(2+) ions or the
            substrate.
REFERENCE   5  (bases 1 to 2139)
  AUTHORS   Sager,R.A., Woodford,M.R., Backe,S.J., Makedon,A.M.,
            Baker-Williams,A.J., DiGregorio,B.T., Loiselle,D.R., Haystead,T.A.,
            Zachara,N.E., Prodromou,C., Bourboulia,D., Schmidt,L.S.,
            Linehan,W.M., Bratslavsky,G. and Mollapour,M.
  TITLE     Post-translational Regulation of FNIP1 Creates a Rheostat for the
            Molecular Chaperone Hsp90
  JOURNAL   Cell Rep 26 (5), 1344-1356 (2019)
   PUBMED   30699359
REFERENCE   6  (bases 1 to 2139)
  AUTHORS   Zhao,S. and Sancar,A.
  TITLE     Human blue-light photoreceptor hCRY2 specifically interacts with
            protein serine/threonine phosphatase 5 and modulates its activity
  JOURNAL   Photochem Photobiol 66 (5), 727-731 (1997)
   PUBMED   9383998
REFERENCE   7  (bases 1 to 2139)
  AUTHORS   Silverstein,A.M., Galigniana,M.D., Chen,M.S., Owens-Grillo,J.K.,
            Chinkers,M. and Pratt,W.B.
  TITLE     Protein phosphatase 5 is a major component of glucocorticoid
            receptor.hsp90 complexes with properties of an FK506-binding
            immunophilin
  JOURNAL   J Biol Chem 272 (26), 16224-16230 (1997)
   PUBMED   9195923
REFERENCE   8  (bases 1 to 2139)
  AUTHORS   Xu,X., Lagercrantz,J., Zickert,P., Bajalica-Lagercrantz,S. and
            Zetterberg,A.
  TITLE     Chromosomal localization and 5' sequence of the human protein
            serine/threonine phosphatase 5' gene
  JOURNAL   Biochem Biophys Res Commun 218 (2), 514-517 (1996)
   PUBMED   8561788
REFERENCE   9  (bases 1 to 2139)
  AUTHORS   Yong,W.H., Ueki,K., Chou,D., Reeves,S.A., von Deimling,A.,
            Gusella,J.F., Mohrenweiser,H.W., Buckler,A.J. and Louis,D.N.
  TITLE     Cloning of a highly conserved human protein serine-threonine
            phosphatase gene from the glioma candidate region on chromosome
            19q13.3
  JOURNAL   Genomics 29 (2), 533-536 (1995)
   PUBMED   8666404
REFERENCE   10 (bases 1 to 2139)
  AUTHORS   Chen,M.X., McPartlin,A.E., Brown,L., Chen,Y.H., Barker,H.M. and
            Cohen,P.T.
  TITLE     A novel human protein serine/threonine phosphatase, which possesses
            four tetratricopeptide repeat motifs and localizes to the nucleus
  JOURNAL   EMBO J 13 (18), 4278-4290 (1994)
   PUBMED   7925273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001970.1 and AC007193.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006247.3.
            
            Summary: This gene encodes a serine/threonine phosphatase which is
            a member of the protein phosphatase catalytic subunit family.
            Proteins in this family participate in pathways regulated by
            reversible phosphorylation at serine and threonine residues; many
            of these pathways are involved in the regulation of cell growth and
            differentiation. The product of this gene has been shown to
            participate in signaling pathways in response to hormones or
            cellular stress, and elevated levels of this protein may be
            associated with breast cancer development. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Feb
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223222.1, SRR7410570.655620.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000012443.9/ ENSP00000012443.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2012              BC001970.1         51-2062
            2013-2139           AC007193.1         136063-136189
FEATURES             Location/Qualifiers
     source          1..2139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2139
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /note="protein phosphatase 5 catalytic subunit"
                     /db_xref="GeneID:5536"
                     /db_xref="HGNC:HGNC:9322"
                     /db_xref="MIM:600658"
     exon            1..131
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1510
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein phosphatase 5; PP-T; protein
                     phosphatase T"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 5 isoform
                     1"
                     /protein_id="NP_006238.1"
                     /db_xref="CCDS:CCDS12684.1"
                     /db_xref="GeneID:5536"
                     /db_xref="HGNC:HGNC:9322"
                     /db_xref="MIM:600658"
                     /translation="MAMAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDY
                     ENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRR
                     AASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRS
                     VVDSLDIESMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKE
                     VLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRG
                     SFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEV
                     FEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQ
                     NGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPN
                     YCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYANTLLQLGMM"
     exon            132..373
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            374..521
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            522..643
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            644..709
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            710..808
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            809..914
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1057
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1145
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1186
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1365
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1447
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..2139
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /note="hexamer: AATAAA"
     polyA_site      2016
                     /gene="PPP5C"
                     /gene_synonym="PP5; PPP5; PPT"
                     /note="major polyA site"
ORIGIN      
        1 gctttgcggc atggcgatgg cggagggcga gaggactgag tgtgctgagc ccccccggga
       61 cgaacccccg gctgatggag ctctgaagcg ggcagaggag ctcaagactc aggccaatga
      121 ctacttcaaa gccaaggact acgagaacgc catcaagttc tacagccagg ccatcgagct
      181 gaaccccagc aatgccatct actatggcaa ccgcagcctg gcctacctgc gcactgagtg
      241 ctatggctac gcgctgggag acgccacgcg ggccattgag ctggacaaga agtacatcaa
      301 gggttattac cgccgggctg ccagcaacat ggcactgggc aagttccggg ccgcgctgcg
      361 agactacgag acggtggtca aggtgaagcc ccatgacaag gatgccaaaa tgaaatacca
      421 ggagtgcaac aagatcgtga agcagaaggc ctttgagcgg gccatcgcgg gcgacgagca
      481 caagcgctcc gtggtggact cgctggacat cgagagcatg accattgagg atgagtacag
      541 cggacccaag cttgaagacg gcaaagtgac aatcagtttc atgaaggagc tcatgcagtg
      601 gtacaaggac cagaagaaac tgcaccggaa atgtgcctac cagattctgg tacaggtcaa
      661 agaggtcctc tccaagctga gcacgctcgt ggaaaccaca ctcaaagaga cagagaagat
      721 tacagtatgt ggggacaccc atggccagtt ctatgacctc ctcaacatat tcgagctcaa
      781 cggtttaccc tcggagacca acccctatat atttaatggt gactttgtgg accgaggctc
      841 cttctctgta gaagtgatcc tcaccctttt cggcttcaag ctcctgtacc cagatcactt
      901 tcacctcctt cgaggcaacc acgagacaga caacatgaac cagatctacg gtttcgaggg
      961 tgaggtgaag gccaagtaca cagcccagat gtacgagctc tttagcgagg tgttcgagtg
     1021 gctcccgttg gcccagtgca tcaacggcaa agtgctgatc atgcacggag gcctgttcag
     1081 tgaagacggt gtcaccctgg atgacatccg gaaaattgag cggaatcgac aacccccaga
     1141 ttcagggccc atgtgtgacc tgctctggtc agatccacag ccacagaacg ggcgctcgat
     1201 cagcaagcgg ggcgtgagct gtcagtttgg gcctgacgtc accaaggcct tcttggaaga
     1261 gaacaacctg gactatatca tccgcagcca cgaagtcaag gccgagggct acgaggtggc
     1321 tcacggaggc cgctgtgtca ccgtcttctc tgcccccaac tactgcgacc agatggggaa
     1381 caaagcctcc tacatccacc tccagggctc tgacctacgg cctcagttcc accagttcac
     1441 agcagtgcct catcccaacg tcaagcccat ggcctatgcc aacacgctgc tgcagctagg
     1501 aatgatgtga ggtgacgggc ggggcggcct gcatcccagg gcccctccaa tcccaccgga
     1561 cccaggccct gggctagggg cagagcaggc cccgccccag ggcaatgttg gacccccttt
     1621 tactttgtaa agtttgtatt tattcccctt taggtttgca gagggggtag gggcagagtc
     1681 aggggctggc cagagggtct gctccctgga cagagaggaa ggaggtggag cagctggggc
     1741 tgggggcaca gcctgggcat tctgtgggga ggccgtcctc ggggtggggt ggggccgagt
     1801 ggctgccctg cccccctcat ttgcatggct cctcccccac tcaagcaata gggccccgcc
     1861 ataggaagac ccccagagag agggtcagca ggggggcccc gcctgcgcct cccctcctat
     1921 agccccatgg tggggctagg ctggggctca cccccctccc cagctatttt atgtctgtaa
     1981 ttaaatatgt taaaataaag tcattatcgg aagtcagctt gtctctggat ggtggagccg
     2041 aaggagctgc ccgggttggg ttacgcctgc tcaggagatc cggagggtgg ggaggccgca
     2101 aagtcccgct ggccgggccc acccagctct gggctgacc
//
