LOCUS       NM_207319               3135 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens protein phosphatase 4 regulatory subunit 3C (PPP4R3C),
            mRNA.
ACCESSION   NM_207319 NR_002784 XR_001082 XR_001083 XR_001428 XR_001429
VERSION     NM_207319.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3135)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3135)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   3  (bases 1 to 3135)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006210.4.
            
            On May 17, 2019 this sequence version replaced NM_207319.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK131475.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412172.4/ ENSP00000489770.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3135              AC006210.4         43460-46594         c
FEATURES             Location/Qualifiers
     source          1..3135
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.3"
     gene            1..3135
                     /gene="PPP4R3C"
                     /gene_synonym="FLFL3P; PPP4R3CP; SMEK3P; smk1"
                     /note="protein phosphatase 4 regulatory subunit 3C"
                     /db_xref="GeneID:139420"
                     /db_xref="HGNC:HGNC:33146"
     exon            1..3135
                     /gene="PPP4R3C"
                     /gene_synonym="FLFL3P; PPP4R3CP; SMEK3P; smk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..2544
                     /gene="PPP4R3C"
                     /gene_synonym="FLFL3P; PPP4R3CP; SMEK3P; smk1"
                     /note="Putative SMEK homolog 3; Serine/threonine-protein
                     phosphatase 4 regulatory subunit 3C pseudogene; SMEK
                     homolog 3, suppressor of mek1 pseudogene; protein
                     phosphatase 4 regulatory subunit 3C, pseudogene"
                     /codon_start=1
                     /product="protein PPP4R3C"
                     /protein_id="NP_997202.3"
                     /db_xref="CCDS:CCDS87732.1"
                     /db_xref="GeneID:139420"
                     /db_xref="HGNC:HGNC:33146"
                     /translation="MAGLRYSVKVYVLNEDEEWNNLGTGQVSSTYDEQFQGMSLLVRS
                     DSDGSVILRSQIPPDRPYGKYQETLIVWYEAENQGLVLKFQDPAGCQDIWKEICQAQG
                     KDPSIQTTVNISDEPEEDFNEMSVISNMVVLPDCELNTLDQIADIVTSVFSSPVTDRE
                     RLAEILKNEAYIPKLLQLFHTCENLENTEGLHHLYEIIKGILFLNEACLFEIMFSDEC
                     IMDVVGCLEYDPALDQPKRHRDFLTNDAKFKEVIPITNSELRQKIHQTYRLQYIYDIL
                     LPVPSIFEDNFLSTLTTFIFSNKAEIVSMLQKDHKFLYEVFAQLKDETTHDDRRCELL
                     FFFKELCSFSQALQPQSKDALFETLIQLGVLPALKIVMIRDDLQVRSAAAVICAYLVE
                     YSPSRIREFIISEAHVCKDSDLFINVIIKQMICDTDPELGGAVHLMVVLHTLLDPRNM
                     LTTPEKSERSEFLHFFYKHCMHKFTAPLLAATSEHNCEEDDIAGYDKSKNCPNDNQTA
                     QLLALILELLTFCIQHHTFYIRSYILNKDLLRKALILMNSKHTHLILCVLRFMRRMIC
                     LNDEAYNNYIIKGNLFEPVVNALLDNGTRYNMLNSAILELFEYIRVENIKPLVSHIVE
                     KFYNTLESIEYVQTFKGLKIKYEKERDRQSQIQKNLHSVLQNIVVFRGTIEEIGLEEE
                     ICFMEDAGEVVMPPLEDDDEFMETKRTQEGEAVMPPLEDDDKFTETKRTHQEGEAVMP
                     PLEDDDEFMETKRNQEHEGKVDSPKRTSSGDFKFSSSYSACAAIGTGSPSGSSVVRLV
                     DHPDDEEEKEEDEEEKEEDKEDETSPKKKPHLSS"
     regulatory      3110..3115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP4R3C"
                     /gene_synonym="FLFL3P; PPP4R3CP; SMEK3P; smk1"
                     /note="hexamer: ATTAAA"
     polyA_site      3135
                     /gene="PPP4R3C"
                     /gene_synonym="FLFL3P; PPP4R3CP; SMEK3P; smk1"
                     /note="major polyA site"
ORIGIN      
        1 agtgccgtgg agaacagacc tgacggggcg aggccagagg acgctatggc aggcctgagg
       61 tacagtgtaa aagtctatgt cctgaacgaa gacgaggaat ggaacaatct aggcaccggt
      121 caggtctcat ccacctatga cgagcagttc cagggcatgt cgctgcttgt tcggtcagat
      181 tcagatgggt cggtcatcct gcggtcacag atacctccag acaggcccta tgggaaatac
      241 caagagacac taattgtttg gtatgaagct gagaaccagg gtttggtgct aaaattccag
      301 gacccagccg gctgccagga tatttggaaa gaaatttgcc aagctcaagg taaggatccg
      361 tctatccaaa ccacagtgaa catttcagat gaaccagagg aagactttaa tgaaatgtca
      421 gtaattagta atatggttgt gctgcctgac tgtgaactca atacacttga tcaaattgct
      481 gacatagtta cctcagtttt ctcgtcacct gttacggata gggaaagact ggctgagatc
      541 ttgaaaaatg aggcttatat tccaaaacta ctgcaactgt tccacacttg tgaaaatcta
      601 gagaatactg aaggtttaca ccatttgtat gaaattatta agggaatttt gttcctcaac
      661 gaggcatgtc tgtttgagat aatgttttct gacgagtgta tcatggatgt ggtgggatgc
      721 cttgagtatg accctgcttt ggatcagcca aaaaggcata gggacttctt gaccaacgat
      781 gcgaagttca aggaagttat accaataact aactctgaac ttaggcaaaa aatacatcag
      841 acatacagat tacagtacat ttatgacatt cttttgcctg tgccttccat atttgaagat
      901 aattttcttt ctacacttac aacttttatt ttctccaaca aggctgagat agtaagcatg
      961 ctgcagaaag atcacaaatt tttgtatgaa gtttttgcac agttaaagga tgagactaca
     1021 catgatgata gacggtgtga attgctattt tttttcaagg agttatgttc attttctcag
     1081 gcattacagc ctcaaagcaa ggatgcacta tttgaaacgt tgatacagtt gggagttctt
     1141 cctgctctta aaatcgtaat gatcagggat gatttgcaag taaggtcagc tgctgcagtt
     1201 atatgtgctt atctagtgga gtacagtcca tccaggatcc gagaatttat aatttcagaa
     1261 gctcacgtgt gcaaagatag tgaccttttc attaatgtaa taattaaaca aatgatctgt
     1321 gatactgatc ctgagttagg aggtgctgtt catttgatgg tagttctgca tactctactt
     1381 gatccacgca acatgctgac aacacctgag aaaagtgaaa gaagtgaatt tctacatttc
     1441 ttctacaaac attgcatgca taaatttaca gcaccacttt tggctgccac ctcagaacac
     1501 aactgtgagg aggatgatat agctggatat gacaaaagca aaaattgccc caatgataat
     1561 caaacagcac aactgcttgc tttgatatta gagctactta cattttgtat acaacatcat
     1621 acattctaca taagaagcta tatcttgaac aaagacttgc taagaaaggc cttgatattg
     1681 atgaattcaa agcatactca cctgattttg tgtgttcttc gctttatgag aaggatgatt
     1741 tgccttaatg atgaagctta taataattac atcatcaagg gaaatctttt tgagccagtt
     1801 gtaaatgctc ttctagataa tggaactcgg tacaatatgt tgaattcagc tattcttgag
     1861 ctatttgaat acataagagt ggaaaatatc aagcctcttg tttcacatat agttgaaaag
     1921 ttttataaca cacttgaatc gattgaatat gttcagacat tcaaaggatt gaagattaaa
     1981 tatgaaaaag agagagacag acaaagtcaa atacaaaaga atttacattc tgtactgcaa
     2041 aatatagtag ttttcagagg taccatagaa gaaattgggc tggaagaaga aatatgtttt
     2101 atggaagatg caggagaagt agttatgcca ccactggaag atgacgatga atttatggag
     2161 accaaaagaa cccaagaagg agaagcagtt atgccaccac tggaagatga cgataaattt
     2221 acggagacca aaagaaccca ccaagaagga gaagcagtta tgccaccact ggaagatgac
     2281 gatgaattta tggagactaa aagaaaccaa gaacatgaag gcaaggtaga ctctcccaaa
     2341 agaacatctt ctggtgactt caaattctct tcatcttatt ctgcttgtgc tgctattgga
     2401 acaggtagcc caagtggtag cagtgtggtt cgtttagtgg atcatccaga tgatgaagaa
     2461 gaaaaagagg aagatgaaga agaaaaagag gaagataaag aagatgaaac atcccccaag
     2521 aagaaacctc atcttagctc ctaaaatcta tatggggcac cctcaaaatg tggctcaaca
     2581 aaaattctat aaacgtccat aagctaaaaa gactgattcc acaagctttt tcatgtgaac
     2641 ttataatgat aaatcacaga tataacgagt taagagggtt taattctgta aaaacaaaat
     2701 ttctcataat cttaaaaaaa aacagtaacc agaacctggg tgataaactt tttagcaaga
     2761 aagtcttaat ttgtgtcacg atttggggga ggaaaccatc tttgggaagg aaagtcttag
     2821 tttggaatgg ggaagaacca ggtcgataat gttaatgtag ttttgttcta gaggtatata
     2881 ttagaaataa taacagttca gttaaaagcc tacaaattac ttgtataatg gtactagcca
     2941 tggtattctt tccttcagtt acctttttaa cacaaaagtt tatgtttata tgaaaaacaa
     3001 agttaactat aaaaaatgtt agtctcttca gacatttcta taaagatata acaaaattta
     3061 agcttataag taattggaag gaagtagctt tcagagtgta ctttcattca ttaaaaaagc
     3121 aagctggatt tacaa
//
