LOCUS       NM_001366432            4416 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 4 regulatory subunit 3A (PPP4R3A),
            transcript variant 5, mRNA.
ACCESSION   NM_001366432
VERSION     NM_001366432.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4416)
  AUTHORS   Qadri,O., Bashir,S., Banday,M., Hilal,N., Majeed,Y., Fatima,N.I.,
            Pal,D. and Fazili,K.M.
  TITLE     Tumour suppressor protein sMEK1 links to IRE1 signalling pathway to
            modulate its activity during ER stress
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119774 (2024)
   PUBMED   38838857
  REMARK    GeneRIF: Tumour suppressor protein sMEK1 links to IRE1 signalling
            pathway to modulate its activity during ER stress.
REFERENCE   2  (bases 1 to 4416)
  AUTHORS   Kavousi,N., Tonge,D.P. and Mourtada-Maarabouni,M.
  TITLE     New insights into the functional role of protein phosphatase 4
            regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell
            fate
  JOURNAL   Int J Biol Macromol 233, 123467 (2023)
   PUBMED   36731689
  REMARK    GeneRIF: New insights into the functional role of protein
            phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of
            leukemic cell fate.
REFERENCE   3  (bases 1 to 4416)
  AUTHORS   Christopher,L., Napolioni,V., Khan,R.R., Han,S.S. and Greicius,M.D.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     A variant in PPP4R3A protects against alzheimer-related metabolic
            decline
  JOURNAL   Ann Neurol 82 (6), 900-911 (2017)
   PUBMED   29130521
  REMARK    GeneRIF: A variant in PPP4R3A was associated with reduced metabolic
            decline in Alzheimer's disease patients.
REFERENCE   4  (bases 1 to 4416)
  AUTHORS   Kim,B.R., Kwon,Y. and Rho,S.B.
  TITLE     BMI-1 interacts with sMEK1 and inactivates sMEK1-induced apoptotic
            cell death
  JOURNAL   Oncol Rep 37 (1), 579-586 (2017)
   PUBMED   27878292
  REMARK    GeneRIF: sMEK1 significantly inhibited BMI-1-stimulated
            oncogenesis.
REFERENCE   5  (bases 1 to 4416)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (bases 1 to 4416)
  AUTHORS   Chen,G.I., Tisayakorn,S., Jorgensen,C., D'Ambrosio,L.M.,
            Goudreault,M. and Gingras,A.C.
  TITLE     PP4R4/KIAA1622 forms a novel stable cytosolic complex with
            phosphoprotein phosphatase 4
  JOURNAL   J Biol Chem 283 (43), 29273-29284 (2008)
   PUBMED   18715871
REFERENCE   7  (bases 1 to 4416)
  AUTHORS   Chowdhury,D., Xu,X., Zhong,X., Ahmed,F., Zhong,J., Liao,J.,
            Dykxhoorn,D.M., Weinstock,D.M., Pfeifer,G.P. and Lieberman,J.
  TITLE     A PP4-phosphatase complex dephosphorylates gamma-H2AX generated
            during DNA replication
  JOURNAL   Mol Cell 31 (1), 33-46 (2008)
   PUBMED   18614045
REFERENCE   8  (bases 1 to 4416)
  AUTHORS   Martin-Granados,C., Philp,A., Oxenham,S.K., Prescott,A.R. and
            Cohen,P.T.
  TITLE     Depletion of protein phosphatase 4 in human cells reveals essential
            roles in centrosome maturation, cell migration and the regulation
            of Rho GTPases
  JOURNAL   Int J Biochem Cell Biol 40 (10), 2315-2332 (2008)
   PUBMED   18487071
REFERENCE   9  (bases 1 to 4416)
  AUTHORS   Gingras,A.C., Caballero,M., Zarske,M., Sanchez,A., Hazbun,T.R.,
            Fields,S., Sonenberg,N., Hafen,E., Raught,B. and Aebersold,R.
  TITLE     A novel, evolutionarily conserved protein phosphatase complex
            involved in cisplatin sensitivity
  JOURNAL   Mol Cell Proteomics 4 (11), 1725-1740 (2005)
   PUBMED   16085932
REFERENCE   10 (bases 1 to 4416)
  AUTHORS   Mendoza,M.C., Du,F., Iranfar,N., Tang,N., Ma,H., Loomis,W.F. and
            Firtel,R.A.
  TITLE     Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell
            polarity, chemotaxis, and gene expression defects
  JOURNAL   Mol Cell Biol 25 (17), 7839-7853 (2005)
   PUBMED   16107728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133153.3.
            
            On Jun 16, 2020 this sequence version replaced NM_001366432.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.10547.1,
                                           SRR14038197.2535513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000554943.6/ ENSP00000450883.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-805               AL133153.3         205132-205936       c
            806-861             AL133153.3         186373-186428       c
            862-960             AL133153.3         181258-181356       c
            961-1578            AL133153.3         177202-177819       c
            1579-1656           AL133153.3         172535-172612       c
            1657-1773           AL133153.3         172034-172150       c
            1774-1929           AL133153.3         171437-171592       c
            1930-2061           AL133153.3         168865-168996       c
            2062-2164           AL133153.3         168659-168761       c
            2165-2323           AL133153.3         166463-166621       c
            2324-2493           AL133153.3         160876-161045       c
            2494-2636           AL133153.3         158361-158503       c
            2637-2827           AL133153.3         157675-157865       c
            2828-3054           AL133153.3         157007-157233       c
            3055-4416           AL133153.3         153134-154495       c
FEATURES             Location/Qualifiers
     source          1..4416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..4416
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /note="protein phosphatase 4 regulatory subunit 3A"
                     /db_xref="GeneID:55671"
                     /db_xref="HGNC:HGNC:20219"
                     /db_xref="MIM:610351"
     exon            1..805
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             664..3165
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /note="isoform 4 is encoded by transcript variant 5;
                     serine/threonine-protein phosphatase 4 regulatory subunit
                     3A; SMEK homolog 1, suppressor of mek1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 3A isoform 4"
                     /protein_id="NP_001353361.1"
                     /db_xref="CCDS:CCDS91918.1"
                     /db_xref="GeneID:55671"
                     /db_xref="HGNC:HGNC:20219"
                     /db_xref="MIM:610351"
                     /translation="MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRA
                     ESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQG
                     KDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAELVASSLPSPLRREKL
                     ALALENEGYIKKLLELFHVCEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIM
                     DVIGCLEYDPALSQPRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQYIQDMVLP
                     TPSVFEENMLSTLHSFIFFNKVEIVGMLQEDEKFLTDLFAQLTDEATDEEKRQELVNF
                     LKEFCAFSQTLQPQNRDAFFKTLSNMGILPALEVILGMDDTQVRSAATDIFSYLVEYN
                     PSMVREFVMQEAQQNDDVSKKLTEQKITSKDILLINLIIEHMICDTDPELGGAVQLMG
                     LLRTLVDPENMLATANKTEKTEFLGFFYKHCMHVLTAPLLANTTEDKPSKDDFQTAQL
                     LALVLELLTFCVEHHTYHIKNYIINKDILRRVLVLMASKHAFLALCALRFKRKIIGLK
                     DEFYNRYIMKSFLFEPVVKAFLNNGSRYNLMNSAIIEMFEFIRVEDIKSLTAHVIENY
                     WKALEDVDYVQTFKGLKLRFEQQRERQDNPKLDSMRSILRNHRYRRDARTLEDEEEMW
                     FNTDEDDMEDGEAVVSPSDKTKNDDDIMDPISKFMERKKLKESEEKEVLLKTNLSGRQ
                     SPSFKLSLSSGTKTNLTSQSSTTNLPGSPGSPGSPGSPGSPGSVPKNTSQTAAITTKG
                     GLVGLVDYPDDDEDDDEDEDKEDTLPLSKKAKFDS"
     exon            806..861
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..960
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1578
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1656
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1773
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1929
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2061
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2164
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2323
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2493
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2636
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2827
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3054
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..4416
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3763..3768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /note="hexamer: ATTAAA"
     polyA_site      3785
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /note="major polyA site"
     regulatory      3890..3895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /note="hexamer: ATTAAA"
     polyA_site      3916
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /note="major polyA site"
     regulatory      4290..4295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /note="hexamer: AAGAAA"
     polyA_site      4307
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /note="major polyA site"
     regulatory      4396..4401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /note="hexamer: AATAAA"
     polyA_site      4416
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
ORIGIN      
        1 gcgccgcttt tgaggggcga accaagatgg cggcggtttt ggctgtgtga ggaagacgga
       61 agagacggcg gcggagggaa accgacttcc actagtccgg gtcgcttggg cggccggggg
      121 ccctcagagt ctcccgggca gtggtagcag ttgcagcagg atcaggcgcc tgtcggcttc
      181 tgacgtttaa aacaggggga gcggaaggga gccactggcc gcggtggcag ggccaggtat
      241 aaggaaggaa aatatggcgg cggcggcggc ggcctgagga ggcggcggcg gcgcgggaag
      301 ctgcttcgcg gagatcatgg cggaggcggg agcagggcag tgacgggagc cccgagttcc
      361 tagcgctgcg gggcgggagg ctacgaagcg ctgcgcggcc ccctcggggc tgccgggcgc
      421 cgggctcgcc aggcctggac aatagcgccg gggagccgga ggcgaggaaa ggcggcggcc
      481 cagagctcgg tccctggagc gggccatgca ggcggcggcg cggccccgcg gcgcccagcg
      541 gcggcagtga ggccggggag ccctccgctc gcgggcgccc tcacgcctcg cccctcgcct
      601 ctccagggcc cctttcctgg gcgtctactg gcggggcccc cgccccggtt cccgggcggc
      661 acgatgaccg acacccggcg gcgggtgaag gtgtacacgc tcaacgagga ccggcagtgg
      721 gacgaccggg gcaccgggca tgtgtcgtct ggctacgtgg agcggctgaa gggcatgtcc
      781 ctgcttgtca gggctgagag cgacggttct ctacttttag agtcgaaaat aaatcctaac
      841 actgcatacc agaaacaaca ggacactctg attgtgtggt ctgaagcaga aaattatgac
      901 ttggccctta gctttcaaga aaaagctgga tgtgatgaaa tttgggagaa aatatgtcag
      961 gttcaaggaa aggacccttc cgtggacatc actcaggacc ttgtggatga atctgaagag
     1021 gagcgttttg atgatatgtc atcgccaggc ttagaattgc catcttgtga attaagtcgc
     1081 cttgaagaaa ttgcagaact tgtggcatca tctttacctt cacctcttcg tcgtgaaaaa
     1141 cttgcactgg cactagaaaa tgagggttat attaaaaagc tcctggagct ttttcatgtg
     1201 tgtgaagatt tggaaaatat tgaaggactg caccacttgt atgaaattat caaaggcatc
     1261 tttctcttga atcgaactgc tctttttgaa gttatgttct ctgaagaatg tataatggac
     1321 gtcattggat gtttagaata tgatcctgct ttatcacaac cacgaaaaca cagggaattt
     1381 ctaacaaaaa cagccaagtt taaagaagtg attcccatat cagatcctga gctgaaacaa
     1441 aaaattcatc agacatacag agttcagtat atacaagata tggttctacc aactccttcg
     1501 gtctttgaag aaaacatgtt atcaacactt cactctttta tctttttcaa taaggtagag
     1561 attgttggca tgttgcagga agatgaaaaa tttctgacag atttgtttgc acaactaaca
     1621 gatgaagcaa cagatgagga aaaaagacag gaattggtta actttttaaa agaattttgt
     1681 gcgttttccc aaacgctaca gcctcaaaac agagatgctt ttttcaagac tttgtcaaac
     1741 atgggcatat taccagcttt agaagtcatc cttggcatgg atgatacaca ggtgcgaagt
     1801 gctgctactg atatattctc atacttggtt gaatataatc catccatggt acgagagttt
     1861 gtcatgcagg aggcacaaca gaatgatgat gtaagtaaga agttaacaga gcaaaaaata
     1921 accagcaagg atattttgct catcaacctc attatagaac atatgatttg tgatacagat
     1981 cctgaacttg gaggagcagt ccagcttatg ggcctgcttc gaactttagt tgacccagag
     2041 aacatgctag ccactgccaa taaaacagaa aagactgaat ttctgggttt cttctacaag
     2101 cactgtatgc atgttctcac tgctccttta ctagcaaata caacagaaga caaacctagt
     2161 aaagatgatt ttcagactgc ccaactattg gcacttgtat tggaattgtt aacattttgt
     2221 gtggagcacc atacctacca cataaagaac tacattatta ataaggatat cctccggaga
     2281 gtgctagttc ttatggcctc gaagcatgct ttcttggcat tatgtgccct tcgttttaaa
     2341 agaaagatta ttggattaaa agatgagttt tacaaccgct acataatgaa aagttttttg
     2401 tttgaaccag tagtgaaagc atttctcaac aatggatccc gctacaatct gatgaactct
     2461 gccataatag agatgtttga atttattaga gtggaagata taaaatcatt aactgctcat
     2521 gtaattgaaa attactggaa agcactggaa gatgtagatt atgtacagac atttaaagga
     2581 ttaaaactga gatttgaaca acaaagagaa aggcaagata atcccaaact tgacagtatg
     2641 cgttccattt tgaggaatca cagatatcga agagatgcca gaacactaga agatgaagaa
     2701 gagatgtggt ttaacacaga tgaagatgac atggaagatg gagaagctgt agtgtctcca
     2761 tctgacaaaa ctaaaaatga tgatgatatt atggatccaa taagtaaatt catggaaagg
     2821 aagaaattaa aagaaagtga ggaaaaggaa gtgcttctga aaacaaacct ttctggacgg
     2881 cagagcccaa gtttcaagct ttccctgtcc agtggaacga agactaacct caccagccag
     2941 tcatctacaa caaatctgcc tggttctccg ggatcacctg gatccccagg atctccaggc
     3001 tctcctggat ccgtacctaa aaatacatct cagacggcag ctattactac aaagggaggc
     3061 ctcgtgggtc tggtagatta tcctgatgat gatgaagatg atgatgagga tgaagataag
     3121 gaagatacgt taccattgtc aaagaaagca aaatttgatt cataataatg gcaacggcct
     3181 aggatcagta cctgttgaaa aaaactggtt ctccacccct cccccataca aaatccacaa
     3241 caaagcgcag tggtctcttg tgaatgactg acacagatca gcctcttaca cttgacttct
     3301 gctcatcaag tgccaattca atggagcagg aggaggggat atcatatatt taggggaaag
     3361 acttaagcct ttgagctctc cagcttggac cacacattgc ccttttctca gggaaggaaa
     3421 tggaaacaaa aagccaacag ggcaggggtt ttgtaagtgg aactctggat tgactggtca
     3481 gttgctacaa tcagaatatg ctttcttgga ccatgtttga gactcagaag aatgggcctt
     3541 tctgccataa ttcttcacta gtcaagaatg ccagcagttt ctttgtataa agagacctgc
     3601 ctttaaaatc atacattctg aacattttag tcaagctaca acaggtttgg aaaacctctg
     3661 tgggggaggg gcgagtataa agttttcctc ttttttaact gttccctttg cccttcaaac
     3721 tgcagatatt ttttttttta agtggggact tctccctact tgattaaaga ttgagtggaa
     3781 ttctagatgt ggtcatttgt gtcataattt ttttgtttta ttttgttttt gatttttttt
     3841 ttcctcccct gagtgtatgc ttagttgttg agtatatata tttgggacca ttaaaacttt
     3901 ttttgatgta atataaccta acgttgtgct ggtacctgtt ttaccatgtg taatttttgt
     3961 tctacatcac agttcttaat ttgtttagag ttttatgaaa gatggtatag tttttattga
     4021 caaaagcaaa gtaatcttac aactatgtgc atacaaaagc aatactattt tgtgactaaa
     4081 tattttatat taaaatttac atcagcaact gtcttgagaa ttcagggaaa tagaatggaa
     4141 tttaaaactt caacagtttt gttaaatcta gaaacatgaa attagtattc caaagagatt
     4201 ctgaaatttc ttttcttggg gaaatgacgg tacattaaat caaaattgag gatggatgat
     4261 ttaaaaacat ttgacttttg aataataaaa agaaaagtga agagtaagag aaattgtatt
     4321 agttgtatgt ttcttgtttt tgtttttaac tactcccttt ggaataccag tttgacttgt
     4381 aagtggtggt ttctaaataa atacctggcc agagga
//
