LOCUS       NM_002720               1402 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens protein phosphatase 4 catalytic subunit (PPP4C),
            transcript variant 2, mRNA.
ACCESSION   NM_002720
VERSION     NM_002720.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1402)
  AUTHORS   Wang,K., Peng,B., Xu,R., Lu,T., Chang,X., Shen,Z., Shi,J., Li,M.,
            Wang,C., Zhou,X., Xu,C., Chang,H. and Zhang,L.
  TITLE     Comprehensive analysis of PPP4C's impact on prognosis, immune
            microenvironment, and immunotherapy response in lung adenocarcinoma
            using single-cell sequencing and multi-omics
  JOURNAL   Front Immunol 15, 1416632 (2024)
   PUBMED   39026674
  REMARK    GeneRIF: Comprehensive analysis of PPP4C's impact on prognosis,
            immune microenvironment, and immunotherapy response in lung
            adenocarcinoma using single-cell sequencing and multi-omics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1402)
  AUTHORS   Xu,W., Hua,Z., Wang,Y., Tang,W., Ou,W., Liu,F., Yang,Y., Ding,W.,
            Wang,Z., Cui,L., Ge,W., Gu,Y., Wang,X., Chen,Y., Liu,C.Y. and Du,P.
  TITLE     AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c
            mediated IKK dephosphorylation in an autophagy-independent manner
  JOURNAL   Cell Death Differ 31 (5), 618-634 (2024)
   PUBMED   38424148
  REMARK    GeneRIF: AMBRA1 promotes intestinal inflammation by antagonizing
            PP4R1/PP4c mediated IKK dephosphorylation in an
            autophagy-independent manner.
REFERENCE   3  (bases 1 to 1402)
  AUTHORS   Loh,J.T., Teo,J.K.H., Kannan,S., Verma,C.S., Andiappan,A.K.,
            Lim,H.H. and Lam,K.P.
  TITLE     DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to
            inhibit the T cell signaling mediator CARD11
  JOURNAL   Sci Signal 16 (809), eadg5171 (2023)
   PUBMED   37906628
  REMARK    GeneRIF: DOK3 promotes atopic dermatitis by enabling the
            phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
REFERENCE   4  (bases 1 to 1402)
  AUTHORS   Rethi-Nagy,Z., Abraham,E., Sinka,R., Juhasz,S. and Lipinszki,Z.
  TITLE     Protein Phosphatase 4 Is Required for Centrobin Function in DNA
            Damage Repair
  JOURNAL   Cells 12 (18), 2219 (2023)
   PUBMED   37759442
  REMARK    GeneRIF: Protein Phosphatase 4 Is Required for Centrobin Function
            in DNA Damage Repair.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1402)
  AUTHORS   Rasti,G., Becker,M., Vazquez,B.N., Espinosa-Alcantud,M.,
            Fernandez-Duran,I., Gamez-Garcia,A., Ianni,A., Gonzalez,J.,
            Bosch-Presegue,L., Marazuela-Duque,A., Guitart-Solanes,A.,
            Segura-Bayona,S., Bech-Serra,J.J., Scher,M., Serrano,L.,
            Shankavaram,U., Erdjument-Bromage,H., Tempst,P., Reinberg,D.,
            Olivella,M., Stracker,T.H., de la Torre,C. and Vaquero,A.
  TITLE     SIRT1 regulates DNA damage signaling through the PP4 phosphatase
            complex
  JOURNAL   Nucleic Acids Res 51 (13), 6754-6769 (2023)
   PUBMED   37309898
  REMARK    GeneRIF: SIRT1 regulates DNA damage signaling through the PP4
            phosphatase complex.
REFERENCE   6  (bases 1 to 1402)
  AUTHORS   Chen,J., Peterson,R.T. and Schreiber,S.L.
  TITLE     Alpha 4 associates with protein phosphatases 2A, 4, and 6
  JOURNAL   Biochem Biophys Res Commun 247 (3), 827-832 (1998)
   PUBMED   9647778
REFERENCE   7  (bases 1 to 1402)
  AUTHORS   Kloeker,S., Bryant,J.C., Strack,S., Colbran,R.J. and Wadzinski,B.E.
  TITLE     Carboxymethylation of nuclear protein serine/threonine phosphatase
            X
  JOURNAL   Biochem J 327 (Pt 2) (Pt 2), 481-486 (1997)
   PUBMED   9359419
REFERENCE   8  (bases 1 to 1402)
  AUTHORS   Bastians,H., Krebber,H., Hoheisel,J., Ohl,S., Lichter,P.,
            Ponstingl,H. and Joos,S.
  TITLE     Assignment of the human serine/threonine protein phosphatase 4 gene
            (PPP4C) to chromosome 16p11-p12 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 42 (1), 181-182 (1997)
   PUBMED   9177794
REFERENCE   9  (bases 1 to 1402)
  AUTHORS   Brewis,N.D., Street,A.J., Prescott,A.R. and Cohen,P.T.
  TITLE     PPX, a novel protein serine/threonine phosphatase localized to
            centrosomes
  JOURNAL   EMBO J 12 (3), 987-996 (1993)
   PUBMED   8384557
REFERENCE   10 (bases 1 to 1402)
  AUTHORS   Brewis,N.D. and Cohen,P.T.
  TITLE     Protein phosphatase X has been highly conserved during mammalian
            evolution
  JOURNAL   Biochim Biophys Acta 1171 (2), 231-233 (1992)
   PUBMED   1336397
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG705710.1, AF097996.1 and AA765831.1.
            
            On Nov 24, 2018 this sequence version replaced NM_002720.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.570602.1,
                                           SRR3476690.309638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279387.12/ ENSP00000279387.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BG705710.1         24-93
            71-1399             AF097996.1         11-1339
            1400-1402           AA765831.1         10-12               c
FEATURES             Location/Qualifiers
     source          1..1402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1402
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /note="protein phosphatase 4 catalytic subunit"
                     /db_xref="GeneID:5531"
                     /db_xref="HGNC:HGNC:9319"
                     /db_xref="MIM:602035"
     exon            1..101
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /inference="alignment:Splign:2.1.0"
     exon            102..262
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1088
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 2;
                     protein phosphatase X, catalytic subunit; protein
                     phosphatase 4 (formerly X), catalytic subunit;
                     serine/threonine-protein phosphatase 4 catalytic subunit;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 4 catalytic
                     subunit isoform 1"
                     /protein_id="NP_002711.1"
                     /db_xref="CCDS:CCDS10669.1"
                     /db_xref="GeneID:5531"
                     /db_xref="HGNC:HGNC:9319"
                     /db_xref="MIM:602035"
                     /translation="MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQR
                     VDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKV
                     RYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKI
                     FCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFG
                     SDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELD
                     EHLQKDFIIFEAAPQETRGIPSKKPVADYFL"
     exon            263..314
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /inference="alignment:Splign:2.1.0"
     exon            315..365
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /inference="alignment:Splign:2.1.0"
     exon            366..467
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /inference="alignment:Splign:2.1.0"
     exon            468..641
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /inference="alignment:Splign:2.1.0"
     exon            642..768
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /inference="alignment:Splign:2.1.0"
     exon            769..958
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1402
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1383..1388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /note="hexamer: AATAAA"
     polyA_site      1402
                     /gene="PPP4C"
                     /gene_synonym="PP-X; PP4; PP4C; PPH3; PPP4; PPX"
                     /note="major polyA site"
ORIGIN      
        1 gccggaagta ggagcggcgg cggcggcggc ggcggcggtc gaaagcggag tgaaagaggg
       61 aggcagggag ccggagagcc ggaaccggag tcgcagcggc ggagacccct gtgcggtgcg
      121 gagggggcgg cggccccgac tctgacccgc gccgggggtg ggccatggcg gagatcagcg
      181 acctggaccg gcagatcgag cagctgcgtc gctgcgagct catcaaggag agcgaagtca
      241 aggccctgtg cgctaaggcc agagagatct tggtagagga gagcaacgtg cagagggtgg
      301 actcgccagt cacagtgtgc ggcgacatcc atggacaatt ctatgacctc aaagagctgt
      361 tcagagtagg tggcgacgtc cctgagacca actacctctt catgggggac tttgtggacc
      421 gtggcttcta tagcgtcgaa acgttcctcc tgctgctggc acttaaggtt cgctatcctg
      481 atcgcatcac actgatccgg ggcaaccatg agagtcgcca gatcacgcag gtctatggct
      541 tctacgatga gtgcctgcgc aagtacggct cggtgactgt gtggcgctac tgcactgaga
      601 tctttgacta cctcagcctg tcagccatca tcgatggcaa gatcttctgc gtgcacgggg
      661 gcctctcccc ctccatccag accctggatc agattcggac aatcgaccga aagcaagagg
      721 tgcctcatga tgggcccatg tgtgacctcc tctggtctga cccagaagac accacaggct
      781 ggggcgtgag cccccgagga gccggctacc tatttggcag tgacgtggtg gcccagttca
      841 acgcagccaa tgacattgac atgatctgcc gtgcccacca actggtgatg gaaggttaca
      901 agtggcactt caatgagacg gtgctcactg tgtggtcggc acccaactac tgctaccgct
      961 gtgggaatgt ggcagccatc ttggagctgg acgagcatct ccagaaagat ttcatcatct
     1021 ttgaggctgc tccccaagag acacggggca tcccctccaa gaagcccgtg gccgactact
     1081 tcctgtgacc ccgcccggcc cctgccccct ccaacccttc tggccctcgc accactgtga
     1141 ctctgccatc ttcctcagac ggaggctggg cgtggggggg gctgtcctgg ctctgctgtc
     1201 ccccaagagg gtgcttcgag ggtgaggact tctctggaga ggcctggaga cctagctcca
     1261 tgttcctcct cctctctccc cacttgaacc atgaagtttc caataatttt tttttctttt
     1321 tttccttctt ttttctgttt gtttttagat aaaaattttg agaaaaaaaa tgaaaaaatt
     1381 ctaataaaag aagaaaaatg gt
//
