LOCUS       NM_147180               3366 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens protein phosphatase 3 regulatory subunit B, beta
            (PPP3R2), mRNA.
ACCESSION   NM_147180
VERSION     NM_147180.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3366)
  AUTHORS   Miyata,H., Oura,S., Morohoshi,A., Shimada,K., Mashiko,D., Oyama,Y.,
            Kaneda,Y., Matsumura,T., Abbasi,F. and Ikawa,M.
  TITLE     SPATA33 localizes calcineurin to the mitochondria and regulates
            sperm motility in mice
  JOURNAL   Proc Natl Acad Sci U S A 118 (35) (2021)
   PUBMED   34446558
REFERENCE   2  (bases 1 to 3366)
  AUTHORS   Hoffman,A., Taleski,G. and Sontag,E.
  TITLE     The protein serine/threonine phosphatases PP2A, PP1 and
            calcineurin: A triple threat in the regulation of the neuronal
            cytoskeleton
  JOURNAL   Mol Cell Neurosci 84, 119-131 (2017)
   PUBMED   28126489
  REMARK    Review article
REFERENCE   3  (bases 1 to 3366)
  AUTHORS   Miyata,H., Satouh,Y., Mashiko,D., Muto,M., Nozawa,K., Shiba,K.,
            Fujihara,Y., Isotani,A., Inaba,K. and Ikawa,M.
  TITLE     Sperm calcineurin inhibition prevents mouse fertility with
            implications for male contraceptive
  JOURNAL   Science 350 (6259), 442-445 (2015)
   PUBMED   26429887
REFERENCE   4  (bases 1 to 3366)
  AUTHORS   Li,H., Pink,M.D., Murphy,J.G., Stein,A., Dell'Acqua,M.L. and
            Hogan,P.G.
  TITLE     Balanced interactions of calcineurin with AKAP79 regulate
            Ca2+-calcineurin-NFAT signaling
  JOURNAL   Nat Struct Mol Biol 19 (3), 337-345 (2012)
   PUBMED   22343722
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3366)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 3366)
  AUTHORS   Weiwad,M., Edlich,F., Erdmann,F., Jarczowski,F., Kilka,S., Dorn,M.,
            Pechstein,A. and Fischer,G.
  TITLE     A reassessment of the inhibitory capacity of human FKBP38 on
            calcineurin
  JOURNAL   FEBS Lett 579 (7), 1591-1596 (2005)
   PUBMED   15757646
REFERENCE   7  (bases 1 to 3366)
  AUTHORS   Liu,L., Zhang,J., Yuan,J., Dang,Y., Yang,C., Chen,X., Xu,J. and
            Yu,L.
  TITLE     Characterization of a human regulatory subunit of protein
            phosphatase 3 gene (PPP3RL) expressed specifically in testis
  JOURNAL   Mol Biol Rep 32 (1), 41-45 (2005)
   PUBMED   15865209
  REMARK    GeneRIF: PPP3RL gene localizes to human chromosome 9q22 and
            transcripts of PPP3RL gene are specifically expressed in the
            testis.
REFERENCE   8  (bases 1 to 3366)
  AUTHORS   Bennasser,Y., Badou,A., Tkaczuk,J. and Bahraoui,E.
  TITLE     Signaling pathways triggered by HIV-1 Tat in human monocytes to
            induce TNF-alpha
  JOURNAL   Virology 303 (1), 174-180 (2002)
   PUBMED   12482669
REFERENCE   9  (bases 1 to 3366)
  AUTHORS   Yang,S.A. and Klee,C.B.
  TITLE     Low affinity Ca2+-binding sites of calcineurin B mediate
            conformational changes in calcineurin A
  JOURNAL   Biochemistry 39 (51), 16147-16154 (2000)
   PUBMED   11123943
REFERENCE   10 (bases 1 to 3366)
  AUTHORS   Loh,C., Shaw,K.T., Carew,J., Viola,J.P., Luo,C., Perrino,B.A. and
            Rao,A.
  TITLE     Calcineurin binds the transcription factor NFAT1 and reversibly
            regulates its activity
  JOURNAL   J Biol Chem 271 (18), 10884-10891 (1996)
   PUBMED   8631904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030595.2, AL591377.4 and AA904764.1.
            
            On Oct 19, 2018 this sequence version replaced NM_147180.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC030595.2, AK057524.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000374806.2/
                                                ENSP00000363939.2
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2832              BC030595.2         33-2864
            2833-2833           AL591377.4         53731-53731         c
            2834-3355           BC030595.2         2866-3387
            3356-3366           AA904764.1         4-14                c
FEATURES             Location/Qualifiers
     source          1..3366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..3366
                     /gene="PPP3R2"
                     /gene_synonym="PPP3RL"
                     /note="protein phosphatase 3 regulatory subunit B, beta"
                     /db_xref="GeneID:5535"
                     /db_xref="HGNC:HGNC:9318"
                     /db_xref="MIM:613821"
     exon            1..3366
                     /gene="PPP3R2"
                     /gene_synonym="PPP3RL"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..561
                     /gene="PPP3R2"
                     /gene_synonym="PPP3RL"
                     /EC_number="3.1.3.16"
                     /note="calcineurin B, type II (19kDa); calcineurin B-like
                     protein; CBLP; CNBII; calcineurin BII; protein phosphatase
                     2B regulatory subunit 2"
                     /codon_start=1
                     /product="calcineurin subunit B type 2"
                     /protein_id="NP_671709.2"
                     /db_xref="CCDS:CCDS6759.2"
                     /db_xref="GeneID:5535"
                     /db_xref="HGNC:HGNC:9318"
                     /db_xref="MIM:613821"
                     /translation="MGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFM
                     SLPELRHNPLVRRVIDVFDTDGDGEVDFKEFILGTSQFSVKGDEEQKLRFAFSIYDMD
                     KDGYISNGELFQVLKMMVGNNLTDWQLQQLVDKTIIILDKDGDGKISFEEFSAVVRDL
                     EIHKKLVLIV"
     regulatory      875..880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP3R2"
                     /gene_synonym="PPP3RL"
                     /note="hexamer: AAGAAA"
     polyA_site      899
                     /gene="PPP3R2"
                     /gene_synonym="PPP3RL"
                     /note="major polyA site"
     regulatory      1025..1030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP3R2"
                     /gene_synonym="PPP3RL"
                     /note="hexamer: AATATA"
     polyA_site      1047
                     /gene="PPP3R2"
                     /gene_synonym="PPP3RL"
                     /note="major polyA site"
     regulatory      3336..3341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP3R2"
                     /gene_synonym="PPP3RL"
                     /note="hexamer: AATAAA"
     polyA_site      3366
                     /gene="PPP3R2"
                     /gene_synonym="PPP3RL"
ORIGIN      
        1 gctcccctct ccgacccttt gagccgtggc cgttgccaga tgtccacaat gggaaacgag
       61 gccagttacc cggcggagat gtgctcccac tttgacaatg atgaaattaa aaggctgggc
      121 aggaggttta agaagttgga cttggacaaa tcagggtctc tgagcgtgga ggagttcatg
      181 tccctgccgg agctgcgcca caacccgttg gtgcggcgag tgatcgacgt cttcgacacc
      241 gacggtgatg gagaagtgga cttcaaggaa ttcatcctgg ggacctccca gttcagcgtc
      301 aagggcgacg aggagcagaa gttgaggttt gcgttcagca tttacgacat ggataaagat
      361 ggctacattt ccaacgggga gctcttccag gtgctgaaga tgatggtggg caacaacctg
      421 acggactggc agctccagca gctggtcgac aaaaccatca tcatcctgga caaggatggc
      481 gatgggaaga tatcctttga ggaattcagt gctgtggtca gagacctgga gatccacaag
      541 aagctggtcc tcatcgtatg agcctttttc ttacaagcac cacccaacaa cttctgcttt
      601 cttccctatc tctttcaaga tttgctcaag acgtccaact gtctctctga cttatctgga
      661 agtatttctt tttgtgaagc catatgtcct aacaggagct tcatcaccaa ctcagtgcta
      721 ttaattctcc ttctctgaat gactcagggt accctatagg gggaagagca agtcaaatga
      781 gcatagtggg gaaagaaaag gaaatggctt ttataaacat cttttacttt gttttgattc
      841 aaagaccaaa ctagaacttt aaaagttcaa aaataagaaa gtatacattt ttgctgttat
      901 ttctcatcat tttgtatatg ggaggaaatt tataatttgc atgggtgtta ggtgaactgt
      961 tttcatttgc ttgtgttcag atatcttgcc agattgttaa cttcctattg tagcaacagg
     1021 gacaaatata tttgtctttg ctgggcatct cgtaatcact tttcttaggg gacagaatcc
     1081 catcttttcc ttcggcagat tgcagcccca ttccccacaa tgcatccaga aatcgctgtg
     1141 catgtttgag gggtaggagt tcatttggcc tcctcctgac ttgttgctcc agctcctgaa
     1201 cagaaactag cttcagggct cttataggaa atgctaagcc tggactaagt gcccagctca
     1261 gccatcatcc tcattagcag tgggtttcca gggttggcag cccacaccag cattaatttc
     1321 aatgaagggg acctccagct aaatagggca agcaaagtgt tctcccagaa agtgctctca
     1381 cctccgacac tggtccctac ccccaggtgg agacaatgag acatttagtt agttgtccta
     1441 cggaggagag gcagtagagt caggctgcag tggaatctcc ctaggatgcc aaagtggcat
     1501 tatgtctgtt gctcacagat gcagagactg acaattgtgt ctccacagca gaggtggatg
     1561 ctagctacac cagctatgct gattttgaaa atcagatctg aggcctagaa gagaaactga
     1621 gagctctctc attccaggaa gccttttccc tagtggaaca ttcagtgcag aagtcctcac
     1681 acactaacag atctccacca ttgggtgagc cggagcctgt ggttccaggg gagatccaga
     1741 atgcatgtgt ctcttcccac gcatttatgt catgttggta gctttagatc agccatggtg
     1801 agaaaagaac aaaagctttt agttgttttt gttttgtttt ggagaatttg tttaccagta
     1861 aatacatcac tgcctgtacc ccaaatgtta ccagctccct gaggtgtccc acatactatt
     1921 gtgagttctc agagcatgaa ctgtcctcag aagagcaggg ctaggacttg tcccagcatc
     1981 tgtgcctcca taccaatcct ctttctcaca gagaaccact tcccatataa gatgcttaag
     2041 gctctcaaaa cagcagaaca atgaaacata ctctccctac acttgcttag ccaagagata
     2101 ccactcaggt aacttttttc aggacatgga agatctgttt caaggagatt tactgctatt
     2161 ttatttggaa gaagctggca actggtcttg accaaaatag aaaaaaaaaa aaaaagtcca
     2221 caaatttaat cacttgtagg gaacccatct atcaaggtac cctaccatat acttttgtat
     2281 ttaatagatt acttagaaac cacaaaaata ggaatcctta ccccttcaat tcctgttcaa
     2341 ccctaaaaac tgtgataaac gctcccaacc ctgtggtgat cagggttatg taatgttcaa
     2401 agattcagac acacctgggt ttggattcag ttgcaactgg gttgttatca cactcacttc
     2461 tttttagctg tgtgagcatg aataatttac ttagcctctc tgtgtctttc cacctaatta
     2521 aagaggatcc accccagggt tattttgagg attcaaaaag gcatgcaaca cacctggagc
     2581 acaattccac tttcattcaa ctaattccct tcccttcccc cttcttcccc ttctacaaga
     2641 tcaatatgta aaggagacat gaggcttact ggttgctttt gaacacttac ttagttctta
     2701 gctacaccca ctctaaaatt aactggacat tagtgtacag cccatgtcca agcccagaga
     2761 gaaaacaatg ggaacaattt caaggtcctc accactcctt catttgcaga ggggacaaca
     2821 gactttctga cctgagaact ggagaatttt taaaacaaaa tctctcattc cagcccaacc
     2881 tatttaactt tttgtggagg aattttacat ggaggaagtg agcacatgtc atgctagcca
     2941 agaggacatt attgtcatta aagagaggca ttatttatac accctgcaat gtgcacatta
     3001 aaatatggaa attttaaaat tatgaccaag ggcttgaaac atattggatt acatgctcac
     3061 atttaacaaa gagaggaaat gtgtttcagt ttctggagtg gctggaattt acaagctaat
     3121 tgttcaataa atctactcaa gatagttacc taaggctttg tggcaatgac cttgaactga
     3181 gagcctgtat ctggatttag cacttgaaag atctaactgg atatttgggt taaaagaatc
     3241 acatttattc ccaaatcgga atgctttgtt tttcctgtca gttaattgcc agttgccaac
     3301 aaatctagtt ctatacagtt tcttgggatg atgataataa acatttattg agcaattgtc
     3361 ccataa
//
