LOCUS       NM_005605               2194 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens protein phosphatase 3 catalytic subunit gamma
            (PPP3CC), transcript variant 2, mRNA.
ACCESSION   NM_005605
VERSION     NM_005605.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2194)
  AUTHORS   Li,D. and Hu,A.
  TITLE     LINC-PINT suppresses breast cancer cell proliferation and migration
            via MEIS2/PPP3CC/NF-kappaB pathway by sponging miR-576-5p
  JOURNAL   Am J Med Sci 367 (3), 201-211 (2024)
   PUBMED   37660994
  REMARK    GeneRIF: LINC-PINT suppresses breast cancer cell proliferation and
            migration via MEIS2/PPP3CC/NF-kappaB pathway by sponging
            miR-576-5p.
REFERENCE   2  (bases 1 to 2194)
  AUTHORS   Anastasiadou,E., Messina,E., Sanavia,T., Labruna,V., Ceccarelli,S.,
            Megiorni,F., Gerini,G., Pontecorvi,P., Camero,S., Perniola,G.,
            Venneri,M.A., Trivedi,P., Lenzi,A. and Marchese,C.
  TITLE     Calcineurin Gamma Catalytic Subunit PPP3CC Inhibition by
            miR-200c-3p Affects Apoptosis in Epithelial Ovarian Cancer
  JOURNAL   Genes (Basel) 12 (9), 1400 (2021)
   PUBMED   34573382
  REMARK    GeneRIF: Calcineurin Gamma Catalytic Subunit PPP3CC Inhibition by
            miR-200c-3p Affects Apoptosis in Epithelial Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2194)
  AUTHORS   Miyata,H., Oura,S., Morohoshi,A., Shimada,K., Mashiko,D., Oyama,Y.,
            Kaneda,Y., Matsumura,T., Abbasi,F. and Ikawa,M.
  TITLE     SPATA33 localizes calcineurin to the mitochondria and regulates
            sperm motility in mice
  JOURNAL   Proc Natl Acad Sci U S A 118 (35) (2021)
   PUBMED   34446558
REFERENCE   4  (bases 1 to 2194)
  AUTHORS   Chen,H., Zeng,Y., Shao,M., Zhao,H., Fang,Z., Gu,J., Liao,B. and
            Jin,Y.
  TITLE     Calcineurin A gamma and NFATc3/SRPX2 axis contribute to human
            embryonic stem cell differentiation
  JOURNAL   J Cell Physiol 236 (8), 5698-5714 (2021)
   PUBMED   33393109
  REMARK    GeneRIF: Calcineurin A gamma and NFATc3/SRPX2 axis contribute to
            human embryonic stem cell differentiation.
REFERENCE   5  (bases 1 to 2194)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2194)
  AUTHORS   Yang,S.A. and Klee,C.B.
  TITLE     Low affinity Ca2+-binding sites of calcineurin B mediate
            conformational changes in calcineurin A
  JOURNAL   Biochemistry 39 (51), 16147-16154 (2000)
   PUBMED   11123943
REFERENCE   7  (bases 1 to 2194)
  AUTHORS   Wang,H.G., Pathan,N., Ethell,I.M., Krajewski,S., Yamaguchi,Y.,
            Shibasaki,F., McKeon,F., Bobo,T., Franke,T.F. and Reed,J.C.
  TITLE     Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD
  JOURNAL   Science 284 (5412), 339-343 (1999)
   PUBMED   10195903
REFERENCE   8  (bases 1 to 2194)
  AUTHORS   Loh,C., Shaw,K.T., Carew,J., Viola,J.P., Luo,C., Perrino,B.A. and
            Rao,A.
  TITLE     Calcineurin binds the transcription factor NFAT1 and reversibly
            regulates its activity
  JOURNAL   J Biol Chem 271 (18), 10884-10891 (1996)
   PUBMED   8631904
REFERENCE   9  (bases 1 to 2194)
  AUTHORS   Muramatsu,T. and Kincaid,R.L.
  TITLE     Molecular cloning and chromosomal mapping of the human gene for the
            testis-specific catalytic subunit of calmodulin-dependent protein
            phosphatase (calcineurin A)
  JOURNAL   Biochem Biophys Res Commun 188 (1), 265-271 (1992)
   PUBMED   1339277
REFERENCE   10 (bases 1 to 2194)
  AUTHORS   King,M.M., Huang,C.Y., Chock,P.B., Nairn,A.C., Hemmings,H.C. Jr.,
            Chan,K.F. and Greengard,P.
  TITLE     Mammalian brain phosphoproteins as substrates for calcineurin
  JOURNAL   J Biol Chem 259 (13), 8080-8083 (1984)
   PUBMED   6330098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK055013.1, BC004864.2 and
            AY007249.1.
            
            On Feb 27, 2020 this sequence version replaced NM_005605.4.
            
            Summary: Calcineurin is a calcium-dependent, calmodulin-stimulated
            protein phosphatase involved in the downstream regulation of
            dopaminergic signal transduction. Calcineurin is composed of a
            regulatory subunit and a catalytic subunit. The protein encoded by
            this gene represents one of the regulatory subunits that has been
            found for calcineurin. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2011].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004864.2, SRR1660805.225482.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240139.10/ ENSP00000240139.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AK055013.1         260-326
            68-1969             BC004864.2         63-1964
            1970-2194           AY007249.1         1654-1878
FEATURES             Location/Qualifiers
     source          1..2194
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..2194
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /note="protein phosphatase 3 catalytic subunit gamma"
                     /db_xref="GeneID:5533"
                     /db_xref="HGNC:HGNC:9316"
                     /db_xref="MIM:114107"
     exon            1..381
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..1871
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /EC_number="3.1.3.16"
                     /note="isoform 2 is encoded by transcript variant 2;
                     CAM-PRP catalytic subunit; calcineurin, testis-specific
                     catalytic subunit; protein phosphatase 3, catalytic
                     subunit, gamma isozyme"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2B
                     catalytic subunit gamma isoform isoform 2"
                     /protein_id="NP_005596.2"
                     /db_xref="CCDS:CCDS34859.1"
                     /db_xref="GeneID:5533"
                     /db_xref="HGNC:HGNC:9316"
                     /db_xref="MIM:114107"
                     /translation="MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKN
                     HLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGG
                     SPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQ
                     ECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPP
                     AFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRA
                     HEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSP
                     HPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELISDDEAEGSTTVRKEIIRN
                     KIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQTIETATVEAVEARE
                     AIRGFSLQHKIRSFEEARGLDRINERMPPRKDSIHAGGPMKSVTSAHSHAAHRSDQGK
                     KAHS"
     exon            382..579
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            580..704
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            705..816
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            817..962
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1102
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1180
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1275
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1401
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1473
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1555
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1653
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1683
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..2194
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2169..2174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /note="hexamer: AATAAA"
     polyA_site      2194
                     /gene="PPP3CC"
                     /gene_synonym="CALNA3; CNA3; PP2Bgamma"
                     /note="major polyA site"
ORIGIN      
        1 gcgtgcacga gggcccgggc cgcgagcagc cgcggccgtc ccggtcgcca cccttagcag
       61 cggtcgcggt cggtgccgaa gcggtgttcc ccgccttagc cgctggcgcc tcccaagaga
      121 gcggccggtg ggccctcgtc ctgtcagtgg cgtcggaggc cggcgctgcg gtggccgcgc
      181 ccttctggtg ctcggacacc gctgaggagc cggggccggg cacggctggc tgacggctcc
      241 gggcagctaa ggctgcccga ggagaaggcg gcggccgcgg cgtaggcgca cgtccggcgg
      301 gctcctggag cctggaggag gccgagggga ccatgtccgg gaggcgcttc cacctctcca
      361 ccaccgaccg cgtcatcaaa gctgtcccct ttcctccaac ccaacggctt actttcaagg
      421 aagtatttga gaatgggaaa cctaaagttg atgttttaaa aaaccatttg gtaaaggaag
      481 gacgactgga agaggaagta gccttaaaga taatcaatga tggggctgcc atcctgaggc
      541 aagagaagac tatgatagaa gtagatgctc caatcacagt atgtggtgat attcatggac
      601 aattctttga cctaatgaag ttatttgaag ttggaggatc acctagtaac acacgctacc
      661 tctttctggg tgactatgtg gacagaggct atttcagtat agagtgtgtg ctgtatttat
      721 ggagtttaaa gattaatcat cccaaaacat tgtttctgct tcggggaaat catgaatgca
      781 ggcatcttac agactatttc accttcaaac aggaatgtcg aatcaaatat tcggaacagg
      841 tgtatgatgc ctgtatggag acatttgact gtcttcctct tgctgccctc ttaaaccagc
      901 agtttctctg tgtacatgga ggaatgtcac ctgaaattac ttctttagat gacattagga
      961 aattagacag gtttacggaa cctcccgcct ttggacctgt gtgtgacctg ctttggtctg
     1021 atccctcaga ggattatggc aatgagaaga ccttggagca ctatacccac aacactgtcc
     1081 gagggtgctc ttatttctac agttaccctg cagtttgtga atttttgcag aacaataatt
     1141 tactatcaat tatcagagcc catgaagccc aagatgctgg gtatcgaatg tacaggaaga
     1201 gccaagccac aggctttcca tcacttatta caattttctc tgcccccaat tacctagatg
     1261 tctataacaa taaagctgct gtgttgaaat atgaaaacaa tgtcatgaat atcaggcagt
     1321 ttaactgttc tccacacccc tactggcttc caaactttat ggatgttttc acatggtctt
     1381 tgccttttgt tggggaaaaa gtcacagaga tgctggtaaa tgtgctcaac atatgctctg
     1441 atgacgaact gatttctgat gatgaagcag aaggaagcac tacagttcgt aaggagatca
     1501 tcaggaataa gatcagagcc attgggaaga tggcacgggt cttttcaatt cttcggcaag
     1561 aaagtgagag tgtgctgact ctcaagggcc tgactcccac aggcacactc cctctgggcg
     1621 tcctctcagg aggcaagcag actatcgaga cagccacagt agaagcggta gaggcccggg
     1681 aagccatcag agggttctcg cttcagcaca agatccggag ttttgaagaa gcgcgaggtc
     1741 tggaccgaat taatgagcga atgccacccc gaaaggatag catacacgct ggtgggccaa
     1801 tgaaatctgt aacctcagca cactcacatg ctgcgcacag gagcgaccaa gggaagaaag
     1861 cccattcatg acttagagtc ctgccgtggc tcaggtggat ctaaaactca agaacaaatt
     1921 ctatttattt attattggaa aatgaaaagc aactcaaaac aacttcaacg tggaggtgca
     1981 tttataattc agtctgcatt tattctgtaa aaaggtggct gttttataaa ttcttttaat
     2041 ttatgttcaa tatatataaa aagtgcatct gttttgtttt tccctttttt ctccataatt
     2101 ttaagaaatg aatctgattg ttgtcaacac atttgtgaag tcttgtgcta taaaggggaa
     2161 cttcccctaa taaaagggcc ttggaaacct caaa
//
