LOCUS       NM_000944               4743 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens protein phosphatase 3 catalytic subunit alpha
            (PPP3CA), transcript variant 1, mRNA.
ACCESSION   NM_000944
VERSION     NM_000944.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4743)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4743)
  AUTHORS   Masaki,T., Habara,M., Shibutani,S., Hanaki,S., Sato,Y., Tomiyasu,H.
            and Shimada,M.
  TITLE     Dephosphorylation of the EGFR protein by calcineurin at serine
            1046/1047 enhances its stability
  JOURNAL   Biochem Biophys Res Commun 641, 84-92 (2023)
   PUBMED   36525928
  REMARK    GeneRIF: Dephosphorylation of the EGFR protein by calcineurin at
            serine 1046/1047 enhances its stability.
REFERENCE   3  (bases 1 to 4743)
  AUTHORS   Wang,Z., Li,H., Wang,H., Li,X., Zhang,Q., Wang,H., Li,K. and Qiu,Y.
  TITLE     TRIM72 exerts antitumor effects in breast cancer and modulates
            lactate production and MCT4 promoter activity by interacting with
            PPP3CA
  JOURNAL   Anticancer Drugs 33 (5), 489-501 (2022)
   PUBMED   35324524
  REMARK    GeneRIF: TRIM72 exerts antitumor effects in breast cancer and
            modulates lactate production and MCT4 promoter activity by
            interacting with PPP3CA.
REFERENCE   4  (bases 1 to 4743)
  AUTHORS   Vymazal,O., Bendickova,K., De Zuani,M., Vlkova,M.,
            Hortova-Kohoutkova,M. and Fric,J.
  TITLE     Immunosuppression Affects Neutrophil Functions: Does
            Calcineurin-NFAT Signaling Matter?
  JOURNAL   Front Immunol 12, 770515 (2021)
   PUBMED   34795676
  REMARK    GeneRIF: Immunosuppression Affects Neutrophil Functions: Does
            Calcineurin-NFAT Signaling Matter?
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4743)
  AUTHORS   Masaki,T., Habara,M., Sato,Y., Goshima,T., Maeda,K., Hanaki,S. and
            Shimada,M.
  TITLE     Calcineurin regulates the stability and activity of estrogen
            receptor alpha
  JOURNAL   Proc Natl Acad Sci U S A 118 (44) (2021)
   PUBMED   34711683
  REMARK    GeneRIF: Calcineurin regulates the stability and activity of
            estrogen receptor alpha.
REFERENCE   6  (bases 1 to 4743)
  AUTHORS   Giri,P.R., Higuchi,S. and Kincaid,R.L.
  TITLE     Chromosomal mapping of the human genes for the calmodulin-dependent
            protein phosphatase (calcineurin) catalytic subunit
  JOURNAL   Biochem Biophys Res Commun 181 (1), 252-258 (1991)
   PUBMED   1659808
REFERENCE   7  (bases 1 to 4743)
  AUTHORS   Kincaid,R.L., Giri,P.R., Higuchi,S., Tamura,J., Dixon,S.C.,
            Marietta,C.A., Amorese,D.A. and Martin,B.M.
  TITLE     Cloning and characterization of molecular isoforms of the catalytic
            subunit of calcineurin using nonisotopic methods
  JOURNAL   J Biol Chem 265 (19), 11312-11319 (1990)
   PUBMED   2162844
REFERENCE   8  (bases 1 to 4743)
  AUTHORS   Guerini,D. and Klee,C.B.
  TITLE     Cloning of human calcineurin A: evidence for two isozymes and
            identification of a polyproline structural domain
  JOURNAL   Proc Natl Acad Sci U S A 86 (23), 9183-9187 (1989)
   PUBMED   2556704
REFERENCE   9  (bases 1 to 4743)
  AUTHORS   Kincaid,R.L., Nightingale,M.S. and Martin,B.M.
  TITLE     Characterization of a cDNA clone encoding the calmodulin-binding
            domain of mouse brain calcineurin
  JOURNAL   Proc Natl Acad Sci U S A 85 (23), 8983-8987 (1988)
   PUBMED   2848250
REFERENCE   10 (bases 1 to 4743)
  AUTHORS   King,M.M., Huang,C.Y., Chock,P.B., Nairn,A.C., Hemmings,H.C. Jr.,
            Chan,K.F. and Greengard,P.
  TITLE     Mammalian brain phosphoproteins as substrates for calcineurin
  JOURNAL   J Biol Chem 259 (13), 8080-8083 (1984)
   PUBMED   6330098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001816.2, EU192652.1, AL353950.1, AW973358.1 and AP001870.2.
            
            On Nov 22, 2018 this sequence version replaced NM_000944.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL353950.1, L14778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394854.8/ ENSP00000378323.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AP001816.2         109831-109885       c
            56-649              EU192652.1         1-594
            650-2337            AL353950.1         326-2013
            2338-4648           EU192652.1         2127-4437
            4649-4731           AW973358.1         1-83                c
            4732-4743           AP001870.2         14631-14642
FEATURES             Location/Qualifiers
     source          1..4743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24"
     gene            1..4743
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /note="protein phosphatase 3 catalytic subunit alpha"
                     /db_xref="GeneID:5530"
                     /db_xref="HGNC:HGNC:9314"
                     /db_xref="MIM:114105"
     exon            1..788
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             731..2296
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcineurin A alpha; CAM-PRP catalytic subunit; protein
                     phosphatase 3 catalytic subunit alpha isozyme; CNA alpha"
                     /codon_start=1
                     /product="protein phosphatase 3 catalytic subunit alpha
                     isoform 1"
                     /protein_id="NP_000935.1"
                     /db_xref="CCDS:CCDS34037.1"
                     /db_xref="GeneID:5530"
                     /db_xref="HGNC:HGNC:9314"
                     /db_xref="MIM:114105"
                     /translation="MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVD
                     ILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLF
                     EVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYF
                     TFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRF
                     KEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLS
                     ILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF
                     NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAAR
                     KEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVE
                     AIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALTSETN
                     GTDSNGSNSSNIQ"
     exon            789..989
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1114
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1226
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1372
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1512
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1590
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1685
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1811
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1886
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1971
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2069
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2099
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..4743
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3813..3818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /note="hexamer: AATAAA"
     polyA_site      3833
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
     regulatory      4707..4712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /note="hexamer: AATAAA"
     regulatory      4721..4726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /note="hexamer: ATTAAA"
     polyA_site      4730
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
                     /note="major polyA site"
     polyA_site      4743
                     /gene="PPP3CA"
                     /gene_synonym="ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1;
                     DEE91; IECEE; IECEE1; PPP2B"
ORIGIN      
        1 aggttgtgcc cgggactgtg tctgccgagc tcggcggctg tgccttggtg agtggaggag
       61 cggcgcgggg aggcagaggc gagcgcgggc gatcgcggcg gcgggacgtc tccggcggcc
      121 gcggcaccag cggcggcgct ctgtgtggag aagcaggggc agcggcagca gcaacagcgg
      181 cagcggcagc agcagcggca gcagcggcgg ccgcctctcc gccgccgggg acgccaaggt
      241 gcggctggtg gcactgacat cggcggccct gcctctcctc cctcgccccc ggccttcccc
      301 atgtgatcgg tcttaatcct ggccgtgtgt gcgcgcgtgg ggctccattc cgcggtgctg
      361 ggtctccgtg ccggggtggg tgctcgtgtg tgcgcttctc ctccccatcc cccttccccc
      421 aagaataaaa gaagaaccgg gaggcgtgct cagaaaataa ataaataacc accacacacg
      481 cgcagcccgg agcgagtcgg cggggctggc ggcagcggcg gaggaggagt gaaggcggcg
      541 gcggcggagg agggacgcgc ggaaaaggca gcaactttaa agccagctca gagcctagac
      601 ctccagccga gcggtttgca gcgcggcggc ggcggcggcg gcggcggcgt tgagtgtctg
      661 gcccgccggt ccggtcgggg tgtgcagtcg gacggacgag cagcgcgtcg ctgtcctccg
      721 gcagctggag atgtccgagc ccaaggcaat tgatcccaag ttgtcgacga ccgacagggt
      781 ggtgaaagct gttccatttc ctccaagtca ccggcttaca gcaaaagaag tgtttgataa
      841 tgatggaaaa cctcgtgtgg atatcttaaa ggcgcatctt atgaaggagg gaaggctgga
      901 agagagtgtt gcattgagaa taataacaga gggtgcatca attcttcgac aggaaaaaaa
      961 tttgctggat attgatgcgc cagtcactgt ttgtggggac attcatggac aattctttga
     1021 tttgatgaag ctctttgaag tcgggggatc tcctgccaac actcgctacc tcttcttagg
     1081 ggactatgtt gacagagggt acttcagtat tgaatgtgtg ctgtatttgt gggccttgaa
     1141 aattctctac cccaaaacac tgtttttact tcgtggaaat catgaatgta gacatctaac
     1201 agagtatttc acatttaaac aagaatgtaa aataaagtat tcagaacgcg tatatgatgc
     1261 ctgtatggat gcctttgact gccttcccct ggctgccctg atgaaccaac agttcctgtg
     1321 tgtgcatggt ggtttgtctc cagagattaa cactttagat gatatcagaa aattagaccg
     1381 attcaaagaa ccacctgcat atggacctat gtgtgatatc ctgtggtcag accccctgga
     1441 agattttgga aatgagaaga ctcaggaaca tttcactcac aacacagtca gggggtgttc
     1501 atacttctac agttacccgg ctgtatgtga attcttacag cacaataact tgttatctat
     1561 actccgagcc cacgaagccc aagatgcagg gtaccgcatg tacaggaaaa gccaaacaac
     1621 aggcttccct tctctaatta caattttttc agcaccaaat tacttagatg tatacaataa
     1681 caaagctgca gtattgaagt atgagaacaa tgttatgaat atcaggcaat tcaactgttc
     1741 tcctcatcca tactggcttc caaatttcat ggatgttttt acttggtccc ttccatttgt
     1801 tggggaaaaa gtgactgaga tgctggtaaa tgtcctcaac atctgctcag atgatgaact
     1861 agggtcagaa gaagatggat ttgatggtgc aacagctgca gcccggaaag aggtgataag
     1921 gaacaagatc cgagcaatag gcaaaatggc cagagtgttc tcagtgctca gagaagagag
     1981 tgagagtgtg ctgacgctga aaggcttgac cccaactggc atgctcccca gcggagtact
     2041 ttctggaggg aagcaaaccc tgcaaagcgc tactgttgag gctattgagg ctgatgaagc
     2101 tatcaaagga ttttcaccac aacataagat cactagcttc gaggaagcca agggcttaga
     2161 ccgaattaat gagaggatgc cgcctcgcag agatgccatg ccctctgacg ccaaccttaa
     2221 ctccatcaac aaggctctca cctcagagac taacggcacg gacagcaatg gcagtaatag
     2281 cagcaatatt cagtgaccac ttcctgttca cttttttttt tttttttttt tttttttttt
     2341 gagctgcggg gcatgatggg gattgctgca tatcagcagt tggatgttct tgcctctgac
     2401 agtagcttat ttgctctggg ggccaggaat tggattcagt ttacactatc attaaaaaag
     2461 agggagagag ataataaact atattttggt ggggatggtg attaaacacc tcttttgggt
     2521 atgcctttta aaaatgctta tagagaaaaa aaattttaaa aagaaagcta atgctagtat
     2581 atactgcaat gttaggggaa tgaacatgtt ttcctactgc attggggact tctagatagg
     2641 ttaatgaaag gccttttatt ctgttactgg acatgaaaac tttgtctaat ttcttactct
     2701 attgtacgtt tacagtcgca gcactaaaaa tggatgacat caaacatttt taacaaaatg
     2761 atgtacaaac taaggactat ttattgataa tgttttgcta ctcttgtcag acaatggcta
     2821 taaactgaat taggcagtct taaaaaaaaa aaaaaacaga aaaagaaaaa aaagaacgtt
     2881 gcaaatttgt taaaatgcca aaaaggacag tttaattttg tacagattat gcttacctca
     2941 ggtttcttta gtgtgcttga atgcccttct ttccatataa cacttatctt cttcttaatt
     3001 cggcaatgga atatctttta agttttaaaa aaactggaat aattatatct atcttttttg
     3061 ccgtttatat ttaggggttt ttgttgataa aatcaagtct tggttgtggc ttgctgaatt
     3121 aaatatttat gagtggtgca tttttaagta tagtgaacaa gacaccatat taagtacagt
     3181 gataaagcat ctatattctg taaaaaaaaa aaaaatctgc ctatgcatgt tttttaagaa
     3241 aaaaaaaatg gctgtatcgg cctgtatggg actgtaatgc gcttagtggt ctgacatata
     3301 ctggaaatgt atgtatactg gcgtacttta tattctctaa aatgcttaat gcctttgaaa
     3361 ttttgtaatc aaaaaaaagc tttgaaaaaa tctaaagggg agagtattct ttaaagtttt
     3421 taacataagc ttgtcaatgc acatgtagat ggttagcatg tttagcaaac cttgtgaaat
     3481 tataataagt ttgtagttac atgtgaaact ctaaatgcat ggcaactgtt aatgtcataa
     3541 cagtttagtt attttgttct gttctgtcat gtgccacaaa atatgtactt ttttcacttt
     3601 tttccctttg tatatcagtt acgggttaca actggttcat tctgaaaaca acaacaacaa
     3661 aagtccattc atatttttta acaattgtat aagtgcccaa gtaattcact acagcctaaa
     3721 gccttgcctt tgtaatttga cttctgacat gttggcaatc aaagcatgca cttgtaacaa
     3781 tgaaaaagaa aaagcatttt atattactac tcaataaaat gtgcatgaac ttacagaatt
     3841 ctcatccttc cactgagtcc gctgaaggga tttatgtgca caaccaccat gtgtcttcta
     3901 ggtgctggcc caccaccaca catcacaggc tgatttccac aggcttcttc ctaggggcct
     3961 cgtgatctga ggggtggtgc ctacttccac tgtaagaaag aatcttggtg gatttgtgtc
     4021 tcaaatcaga taagagaagc ctgtttaaag agcagatgcc atcttctggc ttcctcaagg
     4081 agccagttaa aaaaccagag cattcctttt tattgaaaaa taaaattaat ttgttatcag
     4141 gttgtttcag ttgtattgga tgccctatct atctgctaaa gcaaaaagta ctaggctact
     4201 aagtgcattt tcatcacaga aaagagttgc atttgtatta acaagaaatt tgtataccca
     4261 cgcttcagct actatctaat catcacccga agatttaaga tacaccaaat ttcagtttgt
     4321 ttgtaacatt gttcatcttt agtgcacttt gttttatata ataaagtatg cctgttatat
     4381 taaataataa gaatatggca attagcgata tagcataccc aaacaaagat gttctcgata
     4441 cagtctggca aagactatcc caaggttatt ttaatgaatt cagacatttt ttcctgtgga
     4501 tatttctcca tcctaaaaaa agtggcaacc aaggaaaata tttagatgca acttactaga
     4561 gtgatgatgt gaaagaaatg gtgattctgg tatcatggtg tttattttct ttcttataac
     4621 tgcagagaaa atatcctgac taaaaaaaat tcattttttt ggattccttt cttttacaaa
     4681 ttgtgctgag gcaactatgg catagaaata aacatttgac attaaaataa gcagttgatg
     4741 tga
//
