LOCUS       NM_006246               6655 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 2 regulatory subunit B'epsilon
            (PPP2R5E), transcript variant 1, mRNA.
ACCESSION   NM_006246
VERSION     NM_006246.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6655)
  AUTHORS   Santos,A., Cristobal,I., Carames,C., Luque,M., Sanz-Alvarez,M.,
            Madoz-Gurpide,J., Rojo,F. and Garcia-Foncillas,J.
  TITLE     Deregulation of the miR-19b/PPP2R5E Signaling Axis Shows High
            Functional Impact in Colorectal Cancer Cells
  JOURNAL   Int J Mol Sci 24 (9), 7779 (2023)
   PUBMED   37175484
  REMARK    GeneRIF: Deregulation of the miR-19b/PPP2R5E Signaling Axis Shows
            High Functional Impact in Colorectal Cancer Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6655)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6655)
  AUTHORS   Salamango,D.J., McCann,J.L., Demir,O., Becker,J.T., Wang,J.,
            Lingappa,J.R., Temiz,N.A., Brown,W.L., Amaro,R.E. and Harris,R.S.
  TITLE     Functional and Structural Insights into a Vif/PPP2R5 Complex
            Elucidated Using Patient HIV-1 Isolates and Computational Modeling
  JOURNAL   J Virol 94 (21), e00631-20 (2020)
   PUBMED   32847850
  REMARK    GeneRIF: Functional and Structural Insights into a Vif/PPP2R5
            Complex Elucidated Using Patient HIV-1 Isolates and Computational
            Modeling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6655)
  AUTHORS   Virshup,D.M. and Shenolikar,S.
  TITLE     From promiscuity to precision: protein phosphatases get a makeover
  JOURNAL   Mol Cell 33 (5), 537-545 (2009)
   PUBMED   19285938
  REMARK    Review article
REFERENCE   5  (bases 1 to 6655)
  AUTHORS   Eichhorn,P.J., Creyghton,M.P. and Bernards,R.
  TITLE     Protein phosphatase 2A regulatory subunits and cancer
  JOURNAL   Biochim Biophys Acta 1795 (1), 1-15 (2009)
   PUBMED   18588945
  REMARK    Review article
REFERENCE   6  (bases 1 to 6655)
  AUTHORS   Tung,H.Y., De Rocquigny,H., Zhao,L.J., Cayla,X., Roques,B.P. and
            Ozon,R.
  TITLE     Direct activation of protein phosphatase-2A0 by HIV-1 encoded
            protein complex NCp7:vpr
  JOURNAL   FEBS Lett 401 (2-3), 197-201 (1997)
   PUBMED   9013886
REFERENCE   7  (bases 1 to 6655)
  AUTHORS   McCright,B., Rivers,A.M., Audlin,S. and Virshup,D.M.
  TITLE     The B56 family of protein phosphatase 2A (PP2A) regulatory subunits
            encodes differentiation-induced phosphoproteins that target PP2A to
            both nucleus and cytoplasm
  JOURNAL   J Biol Chem 271 (36), 22081-22089 (1996)
   PUBMED   8703017
REFERENCE   8  (bases 1 to 6655)
  AUTHORS   McCright,B., Brothman,A.R. and Virshup,D.M.
  TITLE     Assignment of human protein phosphatase 2A regulatory subunit genes
            b56alpha, b56beta, b56gamma, b56delta, and b56epsilon
            (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to
            chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12
  JOURNAL   Genomics 36 (1), 168-170 (1996)
   PUBMED   8812429
REFERENCE   9  (bases 1 to 6655)
  AUTHORS   Zolnierowicz,S., Van Hoof,C., Andjelkovic,N., Cron,P., Stevens,I.,
            Merlevede,W., Goris,J. and Hemmings,B.A.
  TITLE     The variable subunit associated with protein phosphatase 2A0
            defines a novel multimember family of regulatory subunits
  JOURNAL   Biochem J 317 (Pt 1) (Pt 1), 187-194 (1996)
   PUBMED   8694763
REFERENCE   10 (bases 1 to 6655)
  AUTHORS   McCright,B. and Virshup,D.M.
  TITLE     Identification of a new family of protein phosphatase 2A regulatory
            subunits
  JOURNAL   J Biol Chem 270 (44), 26123-26128 (1995)
   PUBMED   7592815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136038.5, CB989123.1,
            BC093766.1, L76703.1, AW134792.1, CK820060.1, AA782601.1 and
            AL118555.6.
            
            On Nov 22, 2018 this sequence version replaced NM_006246.4.
            
            Summary: The protein encoded by this gene belongs to the
            phosphatase 2A regulatory subunit B family. Protein phosphatase 2A
            is one of the four major Ser/Thr phosphatases, and it is implicated
            in the negative control of cell growth and division. It consists of
            a common heteromeric core enzyme, which is composed of a catalytic
            subunit and a constant regulatory subunit, that associates with a
            variety of regulatory subunits. The B regulatory subunit might
            modulate substrate selectivity and catalytic activity. This gene
            encodes an epsilon isoform of the regulatory subunit B56 subfamily.
            Multiple transcript variants encoding several different isoforms
            have been found for this gene. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.4272.1, L76703.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337537.8/ ENSP00000337641.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL136038.5         121397-121412
            17-548              CB989123.1         28-559
            549-2094            BC093766.1         1-1546
            2095-2269           L76703.1           2056-2230
            2270-3308           L76703.1           2232-3270
            3309-3950           AW134792.1         7-648               c
            3951-4047           CK820060.1         83-179              c
            4048-4127           AA782601.1         13-92               c
            4128-6655           AL118555.6         56874-59401
FEATURES             Location/Qualifiers
     source          1..6655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.2"
     gene            1..6655
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /note="protein phosphatase 2 regulatory subunit B'epsilon"
                     /db_xref="GeneID:5529"
                     /db_xref="HGNC:HGNC:9313"
                     /db_xref="MIM:601647"
     exon            1..599
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            600..763
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     CDS             607..2010
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /note="isoform a is encoded by transcript variant 1; PP2A,
                     B subunit, B' epsilon; PP2A, B subunit, B56 epsilon; PP2A,
                     B subunit, PR61 epsilon; PP2A, B subunit, R5 epsilon;
                     serine/threonine protein phosphatase 2A, 56 kDa regulatory
                     subunit, epsilon; protein phosphatase 2 regulatory subunit
                     B', epsilon"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit epsilon isoform isoform a"
                     /protein_id="NP_006237.1"
                     /db_xref="CCDS:CCDS9758.1"
                     /db_xref="GeneID:5529"
                     /db_xref="HGNC:HGNC:9313"
                     /db_xref="MIM:601647"
                     /translation="MSSAPTTPPSVDKVDGFSRKSVRKARQKRSQSSSQFRSQGKPIE
                     LTPLPLLKDVPSSEQPELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITI
                     SRGCLTEQTYPEVVRMVSCNIFRTLPPSDSNEFDPEEDEPTLEASWPHLQLVYEFFIR
                     FLESQEFQPSIAKKYIDQKFVLQLLELFDSEDPRERDYLKTVLHRIYGKFLGLRAFIR
                     KQINNIFLRFVYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLVKVLIPLHTVRS
                     LSLFHAQLAYCIVQFLEKDPSLTEPVIRGLMKFWPKTCSQKEVMFLGELEEILDVIEP
                     SQFVKIQEPLFKQIAKCVSSPHFQVAERALYYWNNEYIMSLIEENSNVILPIMFSSLY
                     RISKEHWNPAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQREKKKEKEREELWKKL
                     EDLELKRGLRRDGIIPT"
     exon            764..960
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1062
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1155
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1286
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1346
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1455
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1509
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1560
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1680
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1808
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1910
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..6655
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4107..4112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /note="hexamer: AATAAA"
     polyA_site      4128
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /note="major polyA site"
     regulatory      6634..6639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /note="hexamer: AATAAA"
     polyA_site      6655
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /note="major polyA site"
ORIGIN      
        1 gctggccaga aggttcggtt gcgcgtgtgc catggactca gccgcccggt gatattgaca
       61 ataggagaga gaaaggggca ttgactggga cccaccgcgg gtagcgaaag gtggctctgg
      121 cagcggcggc tccagctcct gcggctcctc ctccttattc tgtccccttc tcttgctgcc
      181 gctgcagatc cagtcttcct ccctcccttc cccccctccc cacgtcgtcg ccgccgccgc
      241 cgggtccggg gcaacgagct gaggcgccgc ccgccaggaa tgtgagcgag gagccaccgg
      301 cggagccgca acggggtcgg tgccgatttg atgggacggg cccgcggggg aggatcgtga
      361 ggccgccgcc gccaccggaa cgctgaggtt cgggtccggc cgtgaggcct agaggctccg
      421 ccgccgcgga accggaggga ccccgtaccg gacagccgtc gccccaggct ccccgcagct
      481 gcccggacct ccccctgcac gtcccggtcc cgccgcccgc ccccgctgcg gccacctcgc
      541 ccgtctcccg cccctccaag ccacagatca tctttggatt cttccccaga agcttcaagt
      601 agggatatgt cctcagcacc aactactcct ccatcagtgg ataaagtaga cggattttct
      661 cggaagtccg tcagaaaagc cagacagaag aggtcgcaaa gttcctcaca gtttaggtct
      721 caaggcaagc ctattgagtt aacacctctg ccgctgctaa aagacgttcc atcctcagag
      781 cagcctgaac tgttcctaaa gaaacttcag cagtgctgtg tcatttttga cttcatggac
      841 acgctatctg atcttaaaat gaaagaatac aagcgctcca ctcttaatga actggtggac
      901 tacattacaa taagcagagg ctgtttgaca gagcagactt accctgaagt agttagaatg
      961 gtatcttgca atatattcag aactctccct cctagtgaca gcaatgaatt tgatccagaa
     1021 gaagatgaac ctacccttga ggcatcgtgg ccacacttac agcttgtata tgaatttttc
     1081 atacgatttt tggaaagcca agaattccaa cccagcattg ccaaaaaata tatagatcag
     1141 aaatttgtat tacagcttct ggagctattt gacagcgaag accctcggga acgggactac
     1201 ttaaaaacag tcttacacag aatttatggc aagtttcttg gtcttagagc atttatccga
     1261 aaacagatta acaatatttt tctaaggttt gtttatgaaa cagaacactt caatggtgta
     1321 gctgaactgc tggaaatatt aggaagtatt atcaatggct ttgctttacc tcttaaggca
     1381 gaacacaaac agtttctggt gaaagtattg atccctttac acactgtcag gagcttatca
     1441 ctcttccatg cacagctggc atattgtata gtacagtttc tggagaaaga tccttcactc
     1501 acagaaccag ttattagggg gttaatgaaa ttttggccta aaacatgtag tcaaaaagag
     1561 gtcatgttcc ttggggaact ggaagaaata ttggatgtga ttgaaccttc acaatttgtt
     1621 aaaatccaag aacctttgtt taaacaaatc gccaagtgtg tatctagccc ccattttcag
     1681 gtggcagaaa gagcactcta ttattggaat aatgaataca tcatgagttt gatagaagaa
     1741 aactctaacg tcatccttcc catcatgttt tccagccttt ataggatttc aaaagaacat
     1801 tggaatccgg ctattgtggc gttggtgtac aatgtgttga aggcatttat ggaaatgaac
     1861 agcaccatgt ttgacgagct gacagccaca tacaagtcag atcgtcagcg tgagaaaaag
     1921 aaagaaaagg agcgtgaaga attgtggaaa aaattggagg atctggagtt aaagagaggt
     1981 cttagacgtg atggaataat tccaacttaa caaaaacaat gacaacaaca ttactaacct
     2041 gtggagtcac acgtttatgt agtagaagat ggagcaacag ttttctgtat tgtgcaactt
     2101 tacagtagat ttcacctttg tttcattatt acagcagcac tgtatatacc tgtctctaag
     2161 taaaggaaaa aacaaaataa ggacttcaat ccaaagtttg gacagtagat ggacttctca
     2221 gaactttgca aacataatca ttgttctcac cctcttttaa aaaaaaaaat cggtcttcaa
     2281 agatctgttg atgaaattgc tatgttaaaa ttccattatc gggagttcct tatttatcac
     2341 tagcagagag tatgatacaa ttttcaaatg tgaacaatct taaatttagc ttgtctttct
     2401 gctaagctgt taaatgtatt tatagtaaag gaagaaaaaa agactgtcat ttccttataa
     2461 gtttgtgtaa catcctcctc tggataactt gactgtaatt taacatcttt ttcttttgca
     2521 catcttcctg agttgaatgt ccacgtggaa tggggtcatg aattataaaa gtccctgata
     2581 aaagttttgt ttactggggt gaacatcttt ccagtaacca ggtagtcctg gtactccttt
     2641 agttttaaaa ttaggagtta agagagaaga ggtgataaac atagtaggga agggaatatc
     2701 ggattcatgc atcagtttat ggtgaatcca aatcaatgtc ttgaatcctt tgaaaacagg
     2761 cactgggaca tcacaggctt cagtacctga ccagtattag ttgcatatat cattgaacac
     2821 acataccaga gatgttttag aaatgtgaga aaaacatcct tttggaccat ttgaaataag
     2881 aaagacaaac actaaacaat acaaccatga aattgatcac cgggattgca aatctaattg
     2941 ggaaaagagt tgagcaaaca gcttggactg tttggagttg ttgccttact ttttaatatg
     3001 tatttataaa gtattccagc aaaagaggat gtagcctctg ggaaaaaaca aacatgttac
     3061 agtgtttttt gtagattctc gttctatatc tcatcacagc gccagccctg tttttagccg
     3121 gaaaggattc aggataaaca ttattatgca ttctgaattg gatgcatatt cctaactact
     3181 gtatttgtta ccaaaagtgg ttctacaaat gctactgaaa aaaatctgga aattcctaat
     3241 gtcctgagta ttaataataa agtttaaaaa tgcttttata tcaaaggtgc atcgtgacca
     3301 aattgtttaa gaaaaaaaaa caaaaaaaac aaaatctagg gctgtatttt atatatatat
     3361 atatatatat atatatatat atatcttatt ggctctctgc tttgtattta aatgaagaat
     3421 cttacatctt gggtaggtaa actgctgata aaatttgtgt acagtatgta cttacctaat
     3481 gcagttgcat tattacgtac tgaaagatat gtgtttggag gtttatttcc aggatgcatt
     3541 tgcttgtttt ggtcatggca gcagtgagtt ggtaatccta aaccatcact tccagcagta
     3601 ttcatggtat agagctgatc tgtgttcata tgttgaattg tgatagtagc aaacatgaac
     3661 atatgaacta ttgttgctct taatagaaat acaatataaa tatgggcttg tatattttct
     3721 tccttacatt taaatataaa gtagaatacg cagttttatt attttcaaga aaaagaaaga
     3781 gaagctgctg acctttctcc cccataaagt ttttcaggat gatcaggtca cagtgtgtac
     3841 gtaagagtca gctaattatg gatattgtca tctcggtaac tttgtaaaaa aacaaacaaa
     3901 actggcattg ttaattccaa aaagaaaaaa aaaagcagta aaaaaaaaaa gtcatatgca
     3961 acaccagacg caacatggtt taatggaatt aatagttttt tttttttttt ttttaaagaa
     4021 cattgatggg gattcactgt aaagttggca gaggctgcca aagacgaaac aactgacttt
     4081 aaaaatgctg gaacaatgtg ataaaaaata aatttgtaac aaatcttctc ctttttagcc
     4141 cttgtcattt tagcccttta gtttcaactc tgcattatat ttagtttata tagtgtaaac
     4201 ttttgtttgc cattaattca tctttttagg tagaagacat taaaatcaca ggtttatgaa
     4261 gaatctctgc tcattggaat gaaatgcagt catttgaaat gagaaaggcc aggatccttt
     4321 tttgtacctt accctgtctt caagagtaaa ggtgaacact tacagctctc ctccttgatg
     4381 tcaattttgt atgttgatca ttccaaactg agaagaataa agccacattt tagacatatt
     4441 tatagaatca attaaagcta tatgtctaaa attcgtaggg caacttctga gaagaaacac
     4501 cgtctttttc ttttttaatg gaaagtgaca atgtgacatt agtcatgttg tgtgcggtga
     4561 cgcagagtaa ctgaggtaat ctgactgttg cactatgtga catatttcag gacgtacttg
     4621 ctgcatttgc agcagccctc tctctctgtc ccttcccaca attctgctgt tgctgcaact
     4681 tgagttaatt gtgacaaatg catctttgtg ttatattttg tttgcttcat aatttccaga
     4741 actatatata aatatatttt ttaaatagca aatattgtag ttagtgagtg atgatcactc
     4801 caaccttatc cttaccatat tggtttcagg gataggatta agagtgtctt tggaagagaa
     4861 aaatacacac aaccctgtgg tttagaatga cgctgaggcc ttaggctgtg ggcctagaac
     4921 aactatgtga gtgaattcac ccatctcata ctttgaatca agcatgcatt cctgtttctc
     4981 attgtgaagt atccccagtt gttttccttc agtgttgagt ttttgtcctt ttaaatttta
     5041 ttatattttg ctctccctaa catttgactg ttttttataa aagaaaagaa aaaaaaagaa
     5101 ataaataata ccctcgatgc cactggatac tcacaagcag ggttatgctc cttcatcttg
     5161 ggcttgtttg cctaaatgaa agggtttaat ttattttgta cctcctatgc gtgggatagt
     5221 ccagggtgca gagccaggac ttgcttgtaa ttgcacctgc tatacttaaa tgtatagccc
     5281 taggctcaat cacactatgg aaagaaacaa aaaaagtata tttagagctt taaaagcttt
     5341 tttatttttt tgtggggatg agggtgggat gggaaaggga tgtatggatg ttattggcat
     5401 ttttaagtgt ttagagtttt ttggggtttg gggtggtttt ttttccttgt tttccttttt
     5461 tccttttaat tggatgcact gacctggccc aggaaatgaa gagattctct tttgatgcta
     5521 ttaccaatgt tatcataaag tgacagtcac ctgtaacaaa aaggtggcac cagacatgat
     5581 cactgatgtt ttatttgcac atcaatattt ttatttttgt attctggctc agctgcttct
     5641 ctgagtggag ttaaggaatg agccacaaag atttttgtag taggtatatt ggcattgcat
     5701 tttatattcc tctatattta attttgaaaa cctaaaagaa ggattgtgca tcttgagaga
     5761 aagttgagca aattgtgatc tagcggaatg ttaatttgtg ctgcttcttg tgcacgatag
     5821 cagcagtagt atctctcttg gaaataaaca tcccatatta tgatgtctat gaatataggt
     5881 ttccttttct tccttccctc cctccttccc ccacctttct cttttttttt tctctctcag
     5941 cttctctttt cctccttccc tcttcccttc ctctttcttt actttttttg aaatcactta
     6001 ttgtaaataa gttgtaatcc aaacctcatg tatcaatggg gaattttcaa atataaatat
     6061 taccaatgca ttttctggtt gttgtctgat ttttgattga agtataatga gaatgacatg
     6121 tctgttgctt ttggtttgag gacttcgctt tagcttcata aatcttttgg tattttagta
     6181 tttcattgtt ttagcaggag agggcagcaa aagttcattt tccctgttag taatgctgtg
     6241 gttcatgatc ggttttaaat ttagctgtgt gtgtgttttt ttaaacagca tctctttgtg
     6301 agtagaggta aaaatgaaac atttttgata tgaaaagttg catatgaaaa ttatagactg
     6361 gttcaaccag acagtgaaga cttctgatcc acatcaaact taaaatgcca caaaacaatc
     6421 ttccacctct ggctaaaaca tgctacttcc ttttcaaaca ccacaaaata caagctgagt
     6481 cttaaacact tggaatttaa aatgtttttc tttggaaatg atttgctttc ttcaaagtgg
     6541 taacagaaac aaaaatgaag gtgctcccca aaaagaaatg taaccttccc ctttcacaga
     6601 tgtgtgagag gttctgtact gtgggtgcat cataataaag aagcagtgaa gagtt
//
