LOCUS       NM_001352913            4630 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 2 regulatory subunit B'gamma
            (PPP2R5C), transcript variant 8, mRNA.
ACCESSION   NM_001352913 XM_005267820
VERSION     NM_001352913.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4630)
  AUTHORS   Li,B., Liu,S., Gao,Y., Zheng,L. and Lu,Y.
  TITLE     Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA
            for colorectal cancer screening
  JOURNAL   J Cancer Res Clin Oncol 149 (12), 10241-10253 (2023)
   PUBMED   37270460
  REMARK    GeneRIF: Combined detection of SDC2/ADHFE1/PPP2R5C methylation in
            stool DNA for colorectal cancer screening.
REFERENCE   2  (bases 1 to 4630)
  AUTHORS   Ripamonti,M., Lamarca,A., Davey,N.E., Tonoli,D., Surini,S. and de
            Curtis,I.
  TITLE     A functional interaction between liprin-alpha1 and B56gamma
            regulatory subunit of protein phosphatase 2A supports tumor cell
            motility
  JOURNAL   Commun Biol 5 (1), 1025 (2022)
   PUBMED   36171301
  REMARK    GeneRIF: A functional interaction between liprin-alpha1 and
            B56gamma regulatory subunit of protein phosphatase 2A supports
            tumor cell motility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4630)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4630)
  AUTHORS   McCright,B., Rivers,A.M., Audlin,S. and Virshup,D.M.
  TITLE     The B56 family of protein phosphatase 2A (PP2A) regulatory subunits
            encodes differentiation-induced phosphoproteins that target PP2A to
            both nucleus and cytoplasm
  JOURNAL   J Biol Chem 271 (36), 22081-22089 (1996)
   PUBMED   8703017
REFERENCE   5  (bases 1 to 4630)
  AUTHORS   McCright,B., Brothman,A.R. and Virshup,D.M.
  TITLE     Assignment of human protein phosphatase 2A regulatory subunit genes
            b56alpha, b56beta, b56gamma, b56delta, and b56epsilon
            (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to
            chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12
  JOURNAL   Genomics 36 (1), 168-170 (1996)
   PUBMED   8812429
REFERENCE   6  (bases 1 to 4630)
  AUTHORS   Zolnierowicz,S., Van Hoof,C., Andjelkovic,N., Cron,P., Stevens,I.,
            Merlevede,W., Goris,J. and Hemmings,B.A.
  TITLE     The variable subunit associated with protein phosphatase 2A0
            defines a novel multimember family of regulatory subunits
  JOURNAL   Biochem J 317 (Pt 1) (Pt 1), 187-194 (1996)
   PUBMED   8694763
REFERENCE   7  (bases 1 to 4630)
  AUTHORS   Tehrani,M.A., Mumby,M.C. and Kamibayashi,C.
  TITLE     Identification of a novel protein phosphatase 2A regulatory subunit
            highly expressed in muscle
  JOURNAL   J Biol Chem 271 (9), 5164-5170 (1996)
   PUBMED   8617797
REFERENCE   8  (bases 1 to 4630)
  AUTHORS   McCright,B. and Virshup,D.M.
  TITLE     Identification of a new family of protein phosphatase 2A regulatory
            subunits
  JOURNAL   J Biol Chem 270 (44), 26123-26128 (1995)
   PUBMED   7592815
REFERENCE   9  (bases 1 to 4630)
  AUTHORS   Akiyama,N., Shima,H., Hatano,Y., Osawa,Y., Sugimura,T. and Nagao,M.
  TITLE     cDNA cloning of BR gamma, a novel brain-specific isoform of the B
            regulatory subunit of type-2A protein phosphatase
  JOURNAL   Eur J Biochem 230 (2), 766-772 (1995)
   PUBMED   7607250
REFERENCE   10 (bases 1 to 4630)
  AUTHORS   Ruediger,R., Roeckel,D., Fait,J., Bergqvist,A., Magnusson,G. and
            Walter,G.
  TITLE     Identification of binding sites on the regulatory A subunit of
            protein phosphatase 2A for the catalytic C subunit and for tumor
            antigens of simian virus 40 and polyomavirus
  JOURNAL   Mol Cell Biol 12 (11), 4872-4882 (1992)
   PUBMED   1328865
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137779.6 and AL118558.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001352913.1.
            
            Summary: The product of this gene belongs to the phosphatase 2A
            regulatory subunit B family. Protein phosphatase 2A is one of the
            four major Ser/Thr phosphatases, and it is implicated in the
            negative control of cell growth and division. It consists of a
            common heteromeric core enzyme, which is composed of a catalytic
            subunit and a constant regulatory subunit, that associates with a
            variety of regulatory subunits. The B regulatory subunit might
            modulate substrate selectivity and catalytic activity. This gene
            encodes a gamma isoform of the regulatory subunit B56 subfamily.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1453405.1,
                                           SRR14038197.1430629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000694906.1/ ENSP00000511581.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AL137779.6         117134-117345       c
            213-278             AL137779.6         116084-116149       c
            279-444             AL137779.6         92871-93036         c
            445-644             AL137779.6         22169-22368         c
            645-755             AL118558.6         9992-10102
            756-848             AL118558.6         11088-11180
            849-979             AL118558.6         11263-11393
            980-1039            AL118558.6         18068-18127
            1040-1148           AL118558.6         20831-20939
            1149-1202           AL118558.6         22338-22391
            1203-1373           AL118558.6         29550-29720
            1374-1501           AL118558.6         34233-34360
            1502-1603           AL118558.6         37420-37521
            1604-1676           AL118558.6         40232-40304
            1677-1793           AL118558.6         45662-45778
            1794-4630           AL118558.6         52972-55808
FEATURES             Location/Qualifiers
     source          1..4630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.31"
     gene            1..4630
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /note="protein phosphatase 2 regulatory subunit B'gamma"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
     exon            1..212
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1925
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /note="isoform g is encoded by transcript variant 8; B'
                     alpha regulatory subunit; renal carcinoma antigen
                     NY-REN-29; protein phosphatase 2 regulatory subunit B',
                     gamma"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform g"
                     /protein_id="NP_001339842.1"
                     /db_xref="CCDS:CCDS91934.1"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
                     /translation="MPNKNKKEKESPKAGKSGKSSKEGQDTVESEQISVRKNSLVAVP
                     STVSAKIKVPVSQPIVKKDKRQNSSRFSASNNRELQKLPSLKDVPPADQEKLFIQKLR
                     QCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFR
                     TLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKF
                     VLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGI
                     AELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDS
                     TLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSS
                     PHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALK
                     LFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYTVYSQASTMS
                     IPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEA
                     HCRADELASQDGR"
     exon            213..278
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            279..444
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            445..644
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            645..755
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            756..848
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            849..979
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1039
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1148
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1202
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1373
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1501
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1603
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1676
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1793
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..4630
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4146..4151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /note="hexamer: AATAAA"
     polyA_site      4175
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /note="major polyA site"
     regulatory      4321..4326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /note="hexamer: AATAAA"
     polyA_site      4339
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /note="major polyA site"
     regulatory      4368..4373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /note="hexamer: AATAAA"
     polyA_site      4394
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /note="major polyA site"
     regulatory      4609..4614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /note="hexamer: AATAAA"
     polyA_site      4630
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; PR61G"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgtgg ctgccgcagc ctctgggagt ctggaaaagg ggaagcgaga gcaagcgaaa
       61 gactcagtcc ccgggcggcg gcggcggcgg cggccgcggg ggcgcgacgg ccggggcggg
      121 ggcgctgctg ctgcgggggc aggcggcggc aggggcggcg gcggcggcgg cggcccgctc
      181 cagccatgcc gaataaaaac aagaaggaga aagaatcacc aaaagcaggg aagagtggaa
      241 aaagttcaaa agaaggacaa gacacagtag aatcagagca aatttccgtc aggaaaaaca
      301 gccttgttgc tgtcccgtct acagtatctg ctaaaataaa agtaccagtc tctcagccca
      361 tagtgaagaa agacaaacgg caaaattctt caaggtttag cgcaagcaat aatagagaac
      421 ttcaaaaact accatcctta aaagatgttc ctcctgctga tcaagagaag ctttttatcc
      481 agaagttacg tcagtgttgc gtcctctttg actttgtttc tgatccacta agtgacctaa
      541 agtggaagga agtaaaacga gctgctttaa gtgaaatggt agaatatatc acccataatc
      601 ggaatgtgat cacagagcct atttacccag aagtagtcca tatgtttgca gttaacatgt
      661 ttcgaacatt accaccttcc tccaatccta cgggagcgga atttgacccg gaggaagatg
      721 aaccaacgtt agaagcagcc tggcctcatc tacagcttgt ttatgaattt ttcttaagat
      781 ttttagagtc tccagatttc caacctaata tagcgaagaa atatattgat cagaagtttg
      841 tattgcagct tttagagctc tttgacagtg aagatcctcg ggagagagat tttcttaaaa
      901 ccacccttca cagaatctat gggaaattcc taggcttgag agcttacatc agaaaacaga
      961 taaataatat attttatagg tttatttatg aaacagagca tcataatggc atagcagagt
     1021 tactggaaat attgggaagt ataattaatg gatttgcctt accactaaaa gaagagcaca
     1081 agattttctt attgaaggtg ttactacctt tgcacaaagt gaaatctctg agtgtctacc
     1141 atccccagct ggcatactgt gtagtgcagt ttttagaaaa ggacagcacc ctcacggaac
     1201 cagtggtgat ggcacttctc aaatactggc caaagactca cagtccaaaa gaagtaatgt
     1261 tcttaaacga attagaagag attttagatg tcattgaacc atcagaattt gtgaagatca
     1321 tggaacccct cttccggcag ttggccaaat gtgtctccag cccacacttc caggtggcag
     1381 agcgagctct ctattactgg aataatgaat acatcatgag tttaatcagt gacaacgcag
     1441 cgaagattct gcccatcatg tttccttcct tgtaccgcaa ctcaaagacc cattggaaca
     1501 agacaataca tggcttgata tacaacgccc tgaagctctt catggagatg aaccaaaagc
     1561 tatttgatga ctgtacacaa cagttcaaag cagagaaact aaaagagaag ctaaaaatga
     1621 aagaacggga agaagcatgg gttaaaatag aaaatctagc caaagccaat ccccagtaca
     1681 cagtgtatag tcaagccagc accatgagca ttccggttgc aatggagaca gatgggcctt
     1741 tatttgaaga tgtgcagatg ctgagaaaga cagtgaagga cgaggctcat caggcacaga
     1801 aagatccgaa gaaggaccgt cctcttgcac gccgcaagtc cgagctgcct caggaccccc
     1861 acaccaagaa agccttggaa gctcactgca gggccgatga gctggcctcc caggacggcc
     1921 gctagcctcc ggggcgccgc gtcggggccg ggcccgccag ttcttttccg gattctgtag
     1981 aaaatacata cttcctgtgc cataccaatc agttacactc aaagctttct tggaccccgt
     2041 tccgtaggca ataacgtgcg tccgcctcag cgcgagatta ggagttcaaa caatggtgac
     2101 ttcccagagc ccgctggcag agccgcgggt tgacgacggt gtcctcgcag tgtcgccgcc
     2161 accccagcgt agtccaagtc agactatttc acaaagtcag agcgatagga aagcaccctg
     2221 cccttcatct tcatgttctc ccaaatggaa cttaggatct tttaacatag gtggttctgt
     2281 gataacatca gtgttttcca aatcaaagga acgctttaaa aaataggacc tattttttaa
     2341 gactttacag cctttgaaat ggtttccacg tgattgttac gccagcagtt ctcgttttgt
     2401 ttgtttttca atctcagtga aatggctctt tgctttcgag ttctcacgca acgtactggg
     2461 caaatgacaa tcctcagccg ctggtatttt ctaaggggtc tcttcacttt gatgagtgac
     2521 atgaacaccg tgtctccttc tcttgtgtgt acctaaagcc atatttccaa gtctgtggta
     2581 ctccaggatt ccaggagtaa gcctgtagaa gagatttatt ttaaaagaga ttgctctgaa
     2641 atttatctta aaagagcttg ctctgtctac cttgacagaa attggagttt taaaattatg
     2701 tgttaatatt tttatttgca gatttcgttt ccgtcaactt aaacattgtt gcccttcaac
     2761 aaggctcttg aattaataaa attatagtct ctaagaattc cacattttat ggaaagttag
     2821 agcaaaatca ttttgagtta agccagttct tagcctaatg caaactgcag cgcctttaag
     2881 cataaagtaa cacaacagca ttgcacgggg ccggcactgc cgctgccttc actgaaggct
     2941 gcagtgctgt tctgagagct tggaggaggc accagcgagg atgacgttta gtggagctct
     3001 ttctgttgaa aagagctcac gttatcaaca ccttgtaagg aaaatacagt gtctgagttt
     3061 tcatcggtct tcacatgctg ctatatattc cacagagttc cttgcatgta ctgagctttt
     3121 gttttagatg gaatagcaca aggagaaaaa tctttaaact tagtgctttg tctattcttt
     3181 atttctctca gggtggccag tattttgact tatttatcct gcttgaaagc tacttgagat
     3241 gtgtactgct attctaaaca cgtgatctag tttctttcat ctctggcata agattatata
     3301 acttaatgtt aagtgtcttg aggcataaaa gacaaaatgt ggcttatttt aggatctgtt
     3361 ttttcatcga ggtctcgggt atcctttcaa agatagtgag aagcagacac tgctccttgt
     3421 gcagctctgg tacctcctgc ccactgctgt cacttcaagc cactggcaat gcttctgtcc
     3481 tcgtgtcttg gaggaaaatc acctgggggg aggggacttc ttgtggtaag agcaagtgca
     3541 ggtatgaaat gcgaagattg ccccagctaa aagtggacaa gtccgctttg tgagatgaat
     3601 acttcctgag aaacttgaca agtatctctc cattttacca ttatgaaaac tatcattaaa
     3661 aaaaacagtt tagatgcctt ctccttttga gggaaaaagg gtgcttttta ttgtataaag
     3721 cagcgtctta tgtattttga tataccattg tttgaacttc cgtctttagc tgatagattc
     3781 tcaaatatcc ttgattttgg atgttcagta tgtttgtgag agaggtttct gggaagactc
     3841 tctttttgcc ctcgggaaaa agcaaaatat caatgtttgg gtgactgtgt aaagctcagt
     3901 gtgtaagaac atctttttgt ctaggttttc tttctgctct ttattgaaga caaacactca
     3961 ccaaaaagaa aaataaaagt tttcagagaa actaattttc tttggcaaga gtattactta
     4021 atattttggc ctcctaaagt ttccctagtt agtactcgga ctcctgtgct aattgtcagc
     4081 ttacatatca ttgtatagag actgtttatt ctgtaccaaa ctgatttcaa aagtactaca
     4141 ttgaaaataa accggtgact gtttttcttc ataaagttct gcgtttggca tcttcactct
     4201 ttccaaaatg tatctgtaca tcagaaatgt cactattcca agtgtctttt tagtgtggct
     4261 ttagtatggc ttccttttaa tattgtacat acattgtatc tttgttttat ggtaataagt
     4321 aataaaaatg tagacttcat attttgtaca aaatgtccta tgtacagaat aaaaaagttc
     4381 atagaaacag caaatatagg taagtggcac aattattttt ctttagaaaa tatctgtaac
     4441 tttatgcatt agtgaaatgt taagtaccga catatttttt aacattttgt aattcaaaac
     4501 tttttgtttt gacattgttt atgaagagaa acttcataca cttgccattt aatatgctct
     4561 tttatctaat tttcaaaaac tctaaaaaac ggtgtatcat atggactaaa taaagaacat
     4621 gtgaatttta
//
