LOCUS       NM_006244               2729 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens protein phosphatase 2 regulatory subunit B'beta
            (PPP2R5B), mRNA.
ACCESSION   NM_006244
VERSION     NM_006244.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2729)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2729)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2729)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2729)
  AUTHORS   Reynhout,S., Jansen,S., Haesen,D., van Belle,S., de Munnik,S.A.,
            Bongers,E.M.H.F., Schieving,J.H., Marcelis,C., Amiel,J., Rio,M.,
            Mclaughlin,H., Ladda,R., Sell,S., Kriek,M.,
            Peeters-Scholte,C.M.P.C.D., Terhal,P.A., van Gassen,K.L.,
            Verbeek,N., Henry,S., Scott Schwoerer,J., Malik,S., Revencu,N.,
            Ferreira,C.R., Macnamara,E., Braakman,H.M.H., Brimble,E.,
            Ruzhnikov,M.R.Z., Wagner,M., Harrer,P., Wieczorek,D., Kuechler,A.,
            Tziperman,B., Barel,O., de Vries,B.B.A., Gordon,C.T., Janssens,V.
            and Vissers,L.E.L.M.
  TITLE     De Novo Mutations Affecting the Catalytic Calpha Subunit of PP2A,
            PPP2CA, Cause Syndromic Intellectual Disability Resembling Other
            PP2A-Related Neurodevelopmental Disorders
  JOURNAL   Am J Hum Genet 104 (1), 139-156 (2019)
   PUBMED   30595372
  REMARK    Erratum:[Am J Hum Genet. 2019 Feb 7;104(2):357. doi:
            10.1016/j.ajhg.2019.01.003.. PMID: 30735662]
REFERENCE   5  (bases 1 to 2729)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   6  (bases 1 to 2729)
  AUTHORS   McCright,B., Rivers,A.M., Audlin,S. and Virshup,D.M.
  TITLE     The B56 family of protein phosphatase 2A (PP2A) regulatory subunits
            encodes differentiation-induced phosphoproteins that target PP2A to
            both nucleus and cytoplasm
  JOURNAL   J Biol Chem 271 (36), 22081-22089 (1996)
   PUBMED   8703017
REFERENCE   7  (bases 1 to 2729)
  AUTHORS   McCright,B., Brothman,A.R. and Virshup,D.M.
  TITLE     Assignment of human protein phosphatase 2A regulatory subunit genes
            b56alpha, b56beta, b56gamma, b56delta, and b56epsilon
            (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to
            chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12
  JOURNAL   Genomics 36 (1), 168-170 (1996)
   PUBMED   8812429
REFERENCE   8  (bases 1 to 2729)
  AUTHORS   Zolnierowicz,S., Van Hoof,C., Andjelkovic,N., Cron,P., Stevens,I.,
            Merlevede,W., Goris,J. and Hemmings,B.A.
  TITLE     The variable subunit associated with protein phosphatase 2A0
            defines a novel multimember family of regulatory subunits
  JOURNAL   Biochem J 317 (Pt 1) (Pt 1), 187-194 (1996)
   PUBMED   8694763
REFERENCE   9  (bases 1 to 2729)
  AUTHORS   McCright,B. and Virshup,D.M.
  TITLE     Identification of a new family of protein phosphatase 2A regulatory
            subunits
  JOURNAL   J Biol Chem 270 (44), 26123-26128 (1995)
   PUBMED   7592815
REFERENCE   10 (bases 1 to 2729)
  AUTHORS   Cross,S.H., Charlton,J.A., Nan,X. and Bird,A.P.
  TITLE     Purification of CpG islands using a methylated DNA binding column
  JOURNAL   Nat Genet 6 (3), 236-244 (1994)
   PUBMED   8012384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE883575.1, L42374.1,
            AP001187.5 and BM665417.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_006244.3.
            
            Summary: The product of this gene belongs to the phosphatase 2A
            regulatory subunit B family. Protein phosphatase 2A is one of the
            four major Ser/Thr phosphatases, and it is implicated in the
            negative control of cell growth and division. It consists of a
            common heteromeric core enzyme, which is composed of a catalytic
            subunit and a constant regulatory subunit, that associates with a
            variety of regulatory subunits. The B regulatory subunit might
            modulate substrate selectivity and catalytic activity. This gene
            encodes a beta isoform of the regulatory subunit B56 subfamily.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.888844.1,
                                           SRR3476690.697029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000164133.7/ ENSP00000164133.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               BE883575.1         19-297
            280-2224            L42374.1           1-1945
            2225-2225           AP001187.5         139771-139771
            2226-2727           L42374.1           1947-2448
            2728-2729           BM665417.1         20-21               c
FEATURES             Location/Qualifiers
     source          1..2729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2729
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /note="protein phosphatase 2 regulatory subunit B'beta"
                     /db_xref="GeneID:5526"
                     /db_xref="HGNC:HGNC:9310"
                     /db_xref="MIM:601644"
     exon            1..340
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            341..803
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     CDS             605..2098
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /note="protein phosphatase 2 regulatory subunit B', beta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit beta isoform"
                     /protein_id="NP_006235.1"
                     /db_xref="CCDS:CCDS8085.1"
                     /db_xref="GeneID:5526"
                     /db_xref="HGNC:HGNC:9310"
                     /db_xref="MIM:601644"
                     /translation="METKLPPASTPTSPSSPGLSPVPPPDKVDGFSRRSLRRARPRRS
                     HSSSQFRYQSNQQELTPLPLLKDVPASELHELLSRKLAQCGVMFDFLDCVADLKGKEV
                     KRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRTLPPSENPEFDPEEDEPNLEP
                     SWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILH
                     RVYGKFLGLRAYIRKQCNHIFLRFIYEFEHFNGVAELLEILGSIINGFALPLKTEHKQ
                     FLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWPKTCTQKEVM
                     FLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLIED
                     NCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQE
                     QQKAQERQELWQGLEELRLRRLQGTQGAKEAPLQRLTPQVAASGGQS"
     exon            804..1000
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1102
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1195
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1326
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1386
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1495
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1549
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1600
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1720
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1848
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1950
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2729
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2711..2716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /note="hexamer: AATAAA"
     polyA_site      2729
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /note="major polyA site"
ORIGIN      
        1 gatgtcatcc tgagcagctg ggcggcgggt gccggtgcgc acggagccga gccggggctc
       61 ccgttgcgct gcaccgcgtt gggtcggagt cccaggactt cagcggagat ccgcgcgctg
      121 cgacggccgg tgcagagccc gccgagcgcc cagtcccggc ccggggctga gttgggggca
      181 tgctctagcc gcccccccgg agcccgggag agaacccagg agcgccgccg cccagcccca
      241 gcgccccgag cggaaccgct gcgaaggggc cctgaacggc cgtcgccctc cctacgggca
      301 gcccccgggg gttggcgacc gaagtctagg ttttcgagaa agccagggtg ggaaccctaa
      361 ctggactctt cgggaccccc aggaaggatc tgaggcctga gccatcctcc tttctaccct
      421 gtctgccccc caggactggg cagttgcagg aggccctggg ggggggccca ggactgtggt
      481 tgtgcccccc ccccaaaggc cggacaggat gggaccaagt tagtctgtcc agtctcaccc
      541 agcacctccc aggcccagag agaacccccg gggctctgaa agcttgccct gccgcctgac
      601 cgccatggag acgaagctgc cccctgcaag cacccccact agcccctcct cccccgggct
      661 gtcgcctgtg cccccacccg acaaggtgga cggcttctcc cgccgttccc tccgcagagc
      721 ccggccccgc cgctcccaca gctcctctca gttccgctat cagagcaacc agcaagagct
      781 cacaccgctg cccctgctca aagatgtgcc ggcttccgag ctgcacgagc tgctgagccg
      841 gaagctggcc cagtgtgggg tgatgtttga cttcttggac tgtgtggccg acctcaaggg
      901 gaaggaggtg aagcgggcag ccctcaacga gctggtggag tgtgtgggga gcacccgggg
      961 tgtcctcatc gagcccgtct acccagacat catccgcatg atctcagtga atatcttccg
     1021 gactctgccg cccagtgaga accctgaatt tgaccctgaa gaggatgagc ccaatcttga
     1081 gccttcgtgg ccacacctgc agctggtata tgagtttttc ctgcgtttct tggagagccc
     1141 agacttccag ccctccgtgg ccaagagata tgtggatcaa aagtttgtcc tgatgctcct
     1201 ggagctattt gatagtgagg atccccggga gcgtgagtac ctcaagacca tcctgcaccg
     1261 ggtctatggc aagttcctgg gtctccgggc ctacatccgc aaacagtgca accacatctt
     1321 cctccggttc atctatgaat tcgagcactt caatggtgtg gctgagctgc tggagatcct
     1381 aggaagcatc atcaatggct ttgcgctgcc cctgaagacg gagcacaagc agttcctggt
     1441 tcgcgtcctg atccccctgc actctgtcaa gtcgctgtct gtcttccatg cccagctggc
     1501 atactgtgtg gtgcagttcc tggagaagga tgccactctg acagagcacg tgatccgggg
     1561 gctgctcaaa tactggccaa aaacctgcac ccagaaggag gtgatgtttc tgggggagat
     1621 ggaagagatt cttgatgtca tcgagccctc ccagtttgtg aagatccagg agcccctttt
     1681 taagcaggtg gctcgctgtg tttccagccc ccatttccag gttgcagagc gggctctgta
     1741 tttctggaac aatgagtata tcctaagcct cattgaggac aactgccaca ctgtgctgcc
     1801 tgctgtgttt gggaccctct accaagtctc caaggagcac tggaaccaaa ccatcgtatc
     1861 actgatctac aatgtgctca agaccttcat ggagatgaat gggaagctgt ttgatgagct
     1921 cacagcctcc tacaagctgg aaaagcagca ggagcagcag aaggcccagg agcgtcagga
     1981 gttatggcaa ggtctggagg agctgcggct acgccggcta caggggaccc agggggccaa
     2041 ggaggccccc ctccagcggc ttacacccca ggtggccgcc agtgggggtc agagctagac
     2101 agcacctcag aaggggaaaa gctaaaccca gagctgtcag tccctctatc ccttctcctg
     2161 tccaggggcc cagagagaaa cacacctacc cctggccttg ccagagtggc ttctgaggac
     2221 tccctgccca gcccagcttt cactgggggg agacgaggag aggcaatggt ggtcttggca
     2281 acagaatgct cagcccctcg tggcaggact tgacaagggc aagcttgacc aggaagctgc
     2341 catcagggat cttcccctgc cccgcaaagc taggctccag ctgcaggcgg gctcccaccc
     2401 tctgctcctg gccttgggca agggcactca gcgcctcgcc tgcccctgcc ttggccaatg
     2461 cgaggtcctt ccttatcccc accatggggt ccatggtcta tttattctcg cccagctcac
     2521 cctctacaca gacactgtcc tgggtgcaca ctcctccctt ccctcgctgt gtacttcctt
     2581 gtcccctttt tatttattgg gcagggggag ggggagggca caggcaagaa gagattcaca
     2641 gtgtcctggg gtaagggggg gttcacagta atcatggtct actcctcttt ccgtggctgg
     2701 gggtagactt aataaagaga gaaattcaa
//
