LOCUS       NM_013239               2378 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens protein phosphatase 2 regulatory subunit B''beta
            (PPP2R3B), mRNA.
ACCESSION   NM_013239
VERSION     NM_013239.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2378)
  AUTHORS   Polubothu,S., Zecchin,D., Al-Olabi,L., Lionarons,D.A., Harland,M.,
            Horswell,S., Thomas,A.C., Hunt,L., Wlodarchak,N., Aguilera,P.,
            Brand,S., Bryant,D., Carrera,C., Chen,H., Elgar,G., Harwood,C.A.,
            Howell,M., Larue,L., Loughlin,S., MacDonald,J., Malvehy,J.,
            Barberan,S.M., da Silva,V.M., Molina,M., Morrogh,D., Moulding,D.,
            Nsengimana,J., Pittman,A., Puig-Butille,J.A., Parmar,K.,
            Sebire,N.J., Scherer,S., Stadnik,P., Stanier,P., Tell,G.,
            Waelchli,R., Zarrei,M., Puig,S., Bataille,V., Xing,Y., Healy,E.,
            Moore,G.E., Di,W.L., Newton-Bishop,J., Downward,J. and Kinsler,V.A.
  TITLE     Inherited duplications of PPP2R3B predispose to nevi and melanoma
            via a C21orf91-driven proliferative phenotype
  JOURNAL   Genet Med 23 (9), 1636-1647 (2021)
   PUBMED   34145395
REFERENCE   2  (bases 1 to 2378)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2378)
  AUTHORS   van Kempen,L.C., Redpath,M., Elchebly,M., Klein,K.O.,
            Papadakis,A.I., Wilmott,J.S., Scolyer,R.A., Edqvist,P.H.,
            Ponten,F., Schadendorf,D., van Rijk,A.F., Michiels,S., Dumay,A.,
            Helbling-Leclerc,A., Dessen,P., Wouters,J., Stass,M.,
            Greenwood,C.M., Ghanem,G.E., van den Oord,J., Feunteun,J. and
            Spatz,A.
  TITLE     The protein phosphatase 2A regulatory subunit PR70 is a gonosomal
            melanoma tumor suppressor gene
  JOURNAL   Sci Transl Med 8 (369), 369ra177 (2016)
   PUBMED   27974665
  REMARK    GeneRIF: PPP2R3B codes for the PR70 protein, a regulatory
            substrate-recognizing subunit of protein phosphatase 2A. PR70
            decreased melanoma growth by negatively interfering with DNA
            replication and cell cycle progression through its role in
            stabilizing CDC6-chromatin licensing and CDT1 interaction
REFERENCE   4  (bases 1 to 2378)
  AUTHORS   Thiebaut,R., Esmiol,S., Lecine,P., Mahfouz,B., Hermant,A.,
            Nicoletti,C., Parnis,S., Perroy,J., Borg,J.P., Pascoe,L.,
            Hugot,J.P. and Ollendorff,V.
  TITLE     Characterization and Genetic Analyses of New Genes Coding for NOD2
            Interacting Proteins
  JOURNAL   PLoS One 11 (11), e0165420 (2016)
   PUBMED   27812135
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2378)
  AUTHORS   Dovega,R., Tsutakawa,S., Quistgaard,E.M., Anandapadamanaban,M.,
            Low,C. and Nordlund,P.
  TITLE     Structural and biochemical characterization of human PR70 in
            isolation and in complex with the scaffolding subunit of protein
            phosphatase 2A
  JOURNAL   PLoS One 9 (7), e101846 (2014)
   PUBMED   25007185
  REMARK    GeneRIF: Results show the crystal structure of PR48/PR70, at 2.0 A
            degrees resolution with two domain elongated structure and two Ca2+
            binding EF-hands Scattering data.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2378)
  AUTHORS   Yokoyama,N. and Miller,W.T.
  TITLE     Protein phosphatase 2A interacts with the Src kinase substrate
            p130(CAS)
  JOURNAL   Oncogene 20 (42), 6057-6065 (2001)
   PUBMED   11593413
REFERENCE   7  (bases 1 to 2378)
  AUTHORS   Yan,Z., Fedorov,S.A., Mumby,M.C. and Williams,R.S.
  TITLE     PR48, a novel regulatory subunit of protein phosphatase 2A,
            interacts with Cdc6 and modulates DNA replication in human cells
  JOURNAL   Mol Cell Biol 20 (3), 1021-1029 (2000)
   PUBMED   10629059
REFERENCE   8  (bases 1 to 2378)
  AUTHORS   Schiebel,K., Meder,J., Rump,A., Rosenthal,A., Winkelmann,M.,
            Fischer,C., Bonk,T., Humeny,A. and Rappold,G.
  TITLE     Elevated DNA sequence diversity in the genomic region of the
            phosphatase PPP2R3L gene in the human pseudoautosomal region
  JOURNAL   Cytogenet Cell Genet 91 (1-4), 224-230 (2000)
   PUBMED   11173861
REFERENCE   9  (bases 1 to 2378)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   10 (bases 1 to 2378)
  AUTHORS   Ruediger,R., Fields,K. and Walter,G.
  TITLE     Binding specificity of protein phosphatase 2A core enzyme for
            regulatory B subunits and T antigens
  JOURNAL   J Virol 73 (1), 839-842 (1999)
   PUBMED   9847399
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA061573.1, BK000521.1,
            BM715684.1, AL954664.18 and BM666129.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_013239.4.
            
            Summary: Protein phosphatase 2 (formerly named type 2A) is one of
            the four major Ser/Thr phosphatases and is implicated in the
            negative control of cell growth and division. Protein phosphatase 2
            holoenzymes are heterotrimeric proteins composed of a structural
            subunit A, a catalytic subunit C, and a regulatory subunit B. The
            regulatory subunit is encoded by a diverse set of genes that have
            been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These
            different regulatory subunits confer distinct enzymatic
            specificities and intracellular localizations to the holozenzyme.
            The product of this gene belongs to the B'' family. The B'' family
            has been further divided into subfamilies. The product of this gene
            belongs to the beta subfamily of regulatory subunit B''. [provided
            by RefSeq, Apr 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000521.1, SRR14038195.1837774.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000390665.9/ ENSP00000375080.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DA061573.1         49-73
            26-1607             BK000521.1         1-1582
            1608-1919           BM715684.1         396-707
            1920-2246           AL954664.18        17163-17489
            2247-2378           BM666129.1         18-149              c
FEATURES             Location/Qualifiers
     source          1..2378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="X"
                     /map="Y"
     gene            1..2378
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /note="protein phosphatase 2 regulatory subunit B''beta"
                     /db_xref="GeneID:28227"
                     /db_xref="HGNC:HGNC:13417"
                     /db_xref="MIM:300339"
     exon            1..540
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1944
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /note="protein phosphatase 2 (formerly 2A), regulatory
                     subunit B'', beta; NY-REN-8 antigen; serine/threonine
                     protein phosphatase 2A, 48kDa regulatory subunit B;
                     protein phosphatase 2, regulatory subunit B'', beta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     regulatory subunit B'' subunit beta"
                     /protein_id="NP_037371.2"
                     /db_xref="CCDS:CCDS14104.1"
                     /db_xref="GeneID:28227"
                     /db_xref="HGNC:HGNC:13417"
                     /db_xref="MIM:300339"
                     /translation="MPPGKVLQPVLKMKVDELFLYWLSEASTQRMLQDCLRRIKAPGR
                     DQPTPGDGEQPGAWPTAPLAAPRPSGLEPPGTPGPGPALPLGAASSPRNAPHVRGTRR
                     SAGTRVVQTRKEEPLPPATSQSIPTFYFPRGRPQDSVNVDAVISKIESTFARFPHERA
                     TMDDMGLVAKACGCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQNCHDDAAKFV
                     HLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRS
                     WSGRITCAELRRSSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLI
                     DADDLARHNDHALSTKMIDRIFSGAVTRGRKVQKEGKISYADFVWFLISEEDKKTPTS
                     IEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQMLDLVKPRTE
                     GKITLQDLKRCKLANVFFDTFFNIEKYLDHEQKEQISLLRDGDSGGPELSDWEKYAAE
                     EYDILVAEETAGEPWEDGFEAELSPVEQKLSALRSPLAQRPFFEAPSPLGAVDLYEYA
                     CGDEDLEPL"
     exon            541..726
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     exon            727..830
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     exon            831..933
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1008
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1095
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1252
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1301
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1391
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1567
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1686
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1793
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..2378
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2052..2057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /note="hexamer: GATAAA"
     polyA_site      2073
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
                     /note="major polyA site"
     polyA_site      2359
                     /gene="PPP2R3B"
                     /gene_synonym="NYREN8; PPP2R3L; PPP2R3LY; PR48; PR70"
ORIGIN      
        1 gaagctgccc tgagcagcgc gggccggacc gcgccccctc ctcggtcccc gcgccccgcg
       61 agtccgcgca gttcccgagg cgcgggccct gttccctgcg ccgcgccccc tcagcgggcc
      121 gtgctcgcat caccgaggtc ggtccggggc ggaccgaagc ccccggggcg gggcggggcg
      181 cgggcgtccg ggggcgccgc gggcccagcc cccgccatgc cgcccggcaa agtgctgcag
      241 ccggtcctga agatgaaggt ggacgagctg ttcctgtact ggctcagcga ggccagcacg
      301 cagcggatgc tgcaggactg cctgcgccgg atcaaggcgc ccgggcggga ccagccgacc
      361 ccgggggacg gggagcagcc cggggcctgg cccacagccc cgctcgccgc cccccggccc
      421 agcgggctcg aacccccggg aacccccggg ccgggccctg cgctgcccct gggcgccgcc
      481 tccagcccca ggaacgcgcc ccacgttcga ggcacccgta gatccgcagg gacgagagta
      541 gttcagacac ggaaagaaga gcctctgccc ccggccacga gccaaagcat tccgaccttc
      601 tacttcccca gaggacgccc gcaggactcc gtcaacgtgg atgccgtcat cagcaagatc
      661 gagagcacct tcgcccggtt cccccacgag agggccacca tggatgacat gggcctggtg
      721 gccaaggcct gcggctgccc cctctactgg aaggggccgc tcttctatgg cgccggcggg
      781 gagcgcacgg gctccgtgtc cgtccacaag ttcgtcgcca tgtggagaaa aatcctccag
      841 aactgccacg acgacgcggc caagttcgtc catctgctca tgagccccgg ctgcaactac
      901 ctggtgcagg aggactttgt ccccttcttg caggacgtgg tgaacacgca cccggggctg
      961 tcgttcctga aggaggcgtc cgagttccac tcgcgctaca tcaccacggt catccagcgg
     1021 atcttctacg ccgtgaaccg gtcctggtcc ggcaggatca cctgcgccga gctgcggagg
     1081 agctccttcc tgcagaatgt ggcgctgctg gaggaggagg cggacatcaa ccagctgacc
     1141 gaattcttct cgtacgagca tttctacgtc atctactgca agttctggga gctggacacg
     1201 gaccacgacc tgctcatcga cgcggacgac ctggcgcggc acaatgacca cgccctttct
     1261 accaagatga tagacaggat cttctcagga gcagtcacac gaggcagaaa agtgcagaag
     1321 gaagggaaga tcagctatgc cgactttgtc tggtttttga tctctgagga agacaaaaaa
     1381 acaccgacca gcatcgagta ctggttccgc tgcatggacc tggacgggga cggcgccctg
     1441 tccatgttcg agctcgagta cttctacgag gagcagtgcc gaaggctgga cagcatggcc
     1501 atcgaggccc tgcccttcca ggactgcctc tgccagatgc tggacctggt caagccgagg
     1561 actgaaggga agatcacgct gcaggacctg aagcgctgca agctggctaa cgtcttcttc
     1621 gacaccttct tcaacatcga gaagtacctc gaccacgagc agaaagagca gatctccctg
     1681 ctcagggacg gtgacagcgg cggccccgag ctctcggact gggagaagta cgcggccgag
     1741 gagtacgaca tcctggtggc cgaggagact gcgggagagc cctgggagga cgggttcgag
     1801 gccgagctca gccctgtgga gcagaagctg agtgcgctgc gctccccgct ggcccagagg
     1861 cccttcttcg aggcgccctc accgctgggc gccgtggacc tgtacgagta cgcatgcggg
     1921 gacgaggacc tggagccgct gtgacgccgc ccgcgagaac gccgccgcgg ggccgctccc
     1981 cacgtgccac caccgggcca ccgcggctcg tgtaaaaact gttgtggaaa atgagtgcgt
     2041 ttgtacggaa tgataaactt ttatttattc acagaagcgt gttgattgcc gctgtgggtt
     2101 cgtggctgga cctgcccaga gctctgtgcc agggggacac gtagggccgc gcgtgaatgg
     2161 gacgggttcc cacacggaca ccctctggcg cttgccgttc ccgacccagc ctgggttccg
     2221 gggcctgcgt ctgtggaaag ggtccgtgtg cgcacaacgg tgaccggcgg ctcccgggcg
     2281 cctcagtcct ggacaggagc ctccaccaca ggctgtgtga atgttttgtg taaacgtaca
     2341 aaaccgtttc tggcgatcac gcttgtacgt ttggagga
//
