LOCUS       NM_002718               6743 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens protein phosphatase 2 regulatory subunit B''alpha
            (PPP2R3A), transcript variant 1, mRNA.
ACCESSION   NM_002718
VERSION     NM_002718.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6743)
  AUTHORS   Jiao,N., Ji,W.S., Zhang,B., Shang,Y.K., Zhang,Y.C., Yu,W.Q.,
            Jin,H.L., Li,C., Zhang,C.Y., Yan,C., Yue,W. and Zhang,Q.
  TITLE     Overexpression of Protein Phosphatase 2 Regulatory Subunit B'Alpha
            Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular
            Carcinoma
  JOURNAL   Biomed Environ Sci 35 (7), 622-632 (2022)
   PUBMED   35945177
  REMARK    GeneRIF: Overexpression of Protein Phosphatase 2 Regulatory Subunit
            B''Alpha Promotes Glycolysis by Regulating Hexokinase 1 in
            Hepatocellular Carcinoma.
REFERENCE   2  (bases 1 to 6743)
  AUTHORS   Zheng,J., Tian,N., Liu,F., Zhang,Y., Su,J., Gao,Y., Deng,M.,
            Wei,L., Ye,J., Li,H. and Wang,J.Z.
  TITLE     A novel dephosphorylation targeting chimera selectively promoting
            tau removal in tauopathies
  JOURNAL   Signal Transduct Target Ther 6 (1), 269 (2021)
   PUBMED   34262014
  REMARK    GeneRIF: A novel dephosphorylation targeting chimera selectively
            promoting tau removal in tauopathies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6743)
  AUTHORS   Dzulko,M., Pons,M., Henke,A., Schneider,G. and Kramer,O.H.
  TITLE     The PP2A subunit PR130 is a key regulator of cell development and
            oncogenic transformation
  JOURNAL   Biochim Biophys Acta Rev Cancer 1874 (2), 188453 (2020)
   PUBMED   33068647
  REMARK    GeneRIF: The PP2A subunit PR130 is a key regulator of cell
            development and oncogenic transformation.
            Review article
REFERENCE   4  (bases 1 to 6743)
  AUTHORS   Dmitriev,A.A., Beniaminov,A.D., Melnikova,N.V., Pushkova,E.N.,
            Gerashchenko,G.V., Kudryavtseva,A.V. and Kashuba,V.I.
  TITLE     [Functional Hypermethylation of ALDH1L1, PLCL2, and PPP2R3A in
            Colon Cancer]
  JOURNAL   Mol Biol (Mosk) 54 (2), 204-211 (2020)
   PUBMED   32392189
  REMARK    GeneRIF: [Functional Hypermethylation of ALDH1L1, PLCL2, and
            PPP2R3A in Colon Cancer].
REFERENCE   5  (bases 1 to 6743)
  AUTHORS   Reynhout,S., Jansen,S., Haesen,D., van Belle,S., de Munnik,S.A.,
            Bongers,E.M.H.F., Schieving,J.H., Marcelis,C., Amiel,J., Rio,M.,
            Mclaughlin,H., Ladda,R., Sell,S., Kriek,M.,
            Peeters-Scholte,C.M.P.C.D., Terhal,P.A., van Gassen,K.L.,
            Verbeek,N., Henry,S., Scott Schwoerer,J., Malik,S., Revencu,N.,
            Ferreira,C.R., Macnamara,E., Braakman,H.M.H., Brimble,E.,
            Ruzhnikov,M.R.Z., Wagner,M., Harrer,P., Wieczorek,D., Kuechler,A.,
            Tziperman,B., Barel,O., de Vries,B.B.A., Gordon,C.T., Janssens,V.
            and Vissers,L.E.L.M.
  TITLE     De Novo Mutations Affecting the Catalytic Calpha Subunit of PP2A,
            PPP2CA, Cause Syndromic Intellectual Disability Resembling Other
            PP2A-Related Neurodevelopmental Disorders
  JOURNAL   Am J Hum Genet 104 (1), 139-156 (2019)
   PUBMED   30595372
  REMARK    Erratum:[Am J Hum Genet. 2019 Feb 7;104(2):357. doi:
            10.1016/j.ajhg.2019.01.003.. PMID: 30735662]
REFERENCE   6  (bases 1 to 6743)
  AUTHORS   Ruediger,R., Fields,K. and Walter,G.
  TITLE     Binding specificity of protein phosphatase 2A core enzyme for
            regulatory B subunits and T antigens
  JOURNAL   J Virol 73 (1), 839-842 (1999)
   PUBMED   9847399
REFERENCE   7  (bases 1 to 6743)
  AUTHORS   Ruediger,R., Brewis,N., Ohst,K. and Walter,G.
  TITLE     Increasing the ratio of PP2A core enzyme to holoenzyme inhibits
            Tat-stimulated HIV-1 transcription and virus production
  JOURNAL   Virology 238 (2), 432-443 (1997)
   PUBMED   9400615
REFERENCE   8  (bases 1 to 6743)
  AUTHORS   Tung,H.Y., De Rocquigny,H., Zhao,L.J., Cayla,X., Roques,B.P. and
            Ozon,R.
  TITLE     Direct activation of protein phosphatase-2A0 by HIV-1 encoded
            protein complex NCp7:vpr
  JOURNAL   FEBS Lett 401 (2-3), 197-201 (1997)
   PUBMED   9013886
REFERENCE   9  (bases 1 to 6743)
  AUTHORS   Hendrix,P., Mayer-Jackel,R.E., Cron,P., Goris,J., Hofsteenge,J.,
            Merlevede,W. and Hemmings,B.A.
  TITLE     Structure and expression of a 72-kDa regulatory subunit of protein
            phosphatase 2A. Evidence for different size forms produced by
            alternative splicing
  JOURNAL   J Biol Chem 268 (20), 15267-15276 (1993)
   PUBMED   8392071
REFERENCE   10 (bases 1 to 6743)
  AUTHORS   Mayer,R.E., Hendrix,P., Cron,P., Matthies,R., Stone,S.R., Goris,J.,
            Merlevede,W., Hofsteenge,J. and Hemmings,B.A.
  TITLE     Structure of the 55-kDa regulatory subunit of protein phosphatase
            2A: evidence for a neuronal-specific isoform
  JOURNAL   Biochemistry 30 (15), 3589-3597 (1991)
   PUBMED   1849734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK293012.1, AL389975.1 and
            DB378665.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002718.4.
            
            Summary: This gene encodes one of the regulatory subunits of the
            protein phosphatase 2. Protein phosphatase 2 (formerly named type
            2A) is one of the four major Ser/Thr phosphatases and is implicated
            in the negative control of cell growth and division. Protein
            phosphatase 2 holoenzymes are heterotrimeric proteins composed of a
            structural subunit A, a catalytic subunit C, and a regulatory
            subunit B. The regulatory subunit is encoded by a diverse set of
            genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72
            families. These different regulatory subunits confer distinct
            enzymatic specificities and intracellular localizations to the
            holozenzyme. The product of this gene belongs to the B'' family.
            The B'' family has been further divided into subfamilies. The
            product of this gene belongs to the alpha subfamily of regulatory
            subunit B''. Alternative splicing results in multiple transcript
            variants encoding different isoforms.[provided by RefSeq, Jun
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1), also known as
            isoform beta or isoform PR130.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.163327.1,
                                           SRR1803612.161424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264977.8/ ENSP00000264977.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4029              AK293012.1         36-4064
            4030-6740           AL389975.1         1168-3878
            6741-6743           DB378665.1         17-19               c
FEATURES             Location/Qualifiers
     source          1..6743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.2-q22.3"
     gene            1..6743
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /note="protein phosphatase 2 regulatory subunit B''alpha"
                     /db_xref="GeneID:5523"
                     /db_xref="HGNC:HGNC:9307"
                     /db_xref="MIM:604944"
     exon            1..122
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            123..2557
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     CDS             563..4015
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein phosphatase 2A 72/130 kDa
                     regulatory subunit B; protein phosphatase 2, regulatory
                     subunit B'', alpha; PR130/B''alpha1 subunit;
                     PR72/B''alpha2 subuit"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     regulatory subunit B'' subunit alpha isoform 1"
                     /protein_id="NP_002709.2"
                     /db_xref="CCDS:CCDS3087.1"
                     /db_xref="GeneID:5523"
                     /db_xref="HGNC:HGNC:9307"
                     /db_xref="MIM:604944"
                     /translation="MAATYRLVVSTVNHYSSVVIDRRFEQAIHYCTGTCHTFTHGIDC
                     IVVHHSVCADLLHIPVSQFKDADLNSMFLPHENGLSSAEGDYPQQAFTGIPRVKRGST
                     FQNTYNLKDIAGEAISFASGKIKEFSFEKLKNSNHAAYRKGRKVKSDSFNRRSVDLDL
                     LCGHYNNDGNAPSFGLLRSSSVEEKPLSHRNSLDTNLTSMFLQNFSEEDLVTQILEKH
                     KIDNFSSGTDIKMCLDILLKCSEDLKKCTDIIKQCIKKKSGSSISEGSGNDTISSSET
                     VYMNVMTRLASYLKKLPFEFMQSGNNEALDLTELISNMPSLQLTPFSPVFGTEQPPKY
                     EDVVQLSASDSGRFQTIELQNDKPNSRKMDTVQSIPNNSTNSLYNLEVNDPRTLKAVQ
                     VQSQSLTMNPLENVSSDDLMETLYIEEESDGKKALDKGQKTENGPSHELLKVNEHRAE
                     FPEHATHLKKCPTPMQNEIGKIFEKSFVNLPKEDCKSKVSKFEEGDQRDFTNSSSQEE
                     IDKLLMDLESFSQKMETSLREPLAKGKNSNFLNSHSQLTGQTLVDLEPKSKVSSPIEK
                     VSPSCLTRIIETNGHKIEEEDRALLLRILESIEDFAQELVECKSSRGSLSQEKEMMQI
                     LQETLTTSSQANLSVCRSPVGDKAKDTTSAVLIQQTPEVIKIQNKPEKKPGTPLPPPA
                     TSPSSPRPLSPVPHVNNVVNAPLSINIPRFYFPEGLPDTCSNHEQTLSRIETAFMDIE
                     EQKADIYEMGKIAKVCGCPLYWKAPMFRAAGGEKTGFVTAQSFIAMWRKLLNNHHDDA
                     SKFICLLAKPNCSSLEQEDFIPLLQDVVDTHPGLTFLKDAPEFHSRYITTVIQRIFYT
                     VNRSWSGKITSTEIRKSNFLQTLALLEEEEDINQITDYFSYEHFYVIYCKFWELDTDH
                     DLYISQADLSRYNDQASSSRIIERIFSGAVTRGKTIQKEGRMSYADFVWFLISEEDKR
                     NPTSIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHDLLCQMLDLVK
                     PAVDGKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPFAVQKDVENDGPEPSDWDR
                     FAAEEYETLVAEESAQAQFQEGFEDYETDEPASPSEFGNKSNKILSASLPEKCGKLQS
                     VDEE"
     exon            2558..2824
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2928
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3031
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3106
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3193
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3350
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3399
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3489
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3665
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..3784
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3891
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     exon            3892..6743
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6723..6728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /note="hexamer: AATAAA"
     polyA_site      6743
                     /gene="PPP2R3A"
                     /gene_synonym="PPP2R3; PR130; PR72"
                     /note="major polyA site"
ORIGIN      
        1 gcgctcgggc ctccgctctt cacgcgccgc attcgtagcc cgagagtccg cgccgcgggg
       61 aggcttggag gcaagcgctg cccgcgagct gagccgccgg aggaggagcc gcgggcaacg
      121 aggtttctct gtcattcaca gaaaaatgaa tcatttaaac ctttggagga ctcagttatc
      181 acaatacttc tctactacca actaagattt atgatagtaa atttatgaga gcaaatttcc
      241 atgttataga actgttgaag aactaaaaga ggatattctt tcatcaaaat aattctgcag
      301 tatcataata ttactaaata aaattaaaaa gcacaattat taaattatta aatttgccac
      361 acatgtgcag cagctactgt atcctgatag tgaccaaacc tcaaatataa atggtttccc
      421 ttcatgggaa aagccattat atttggaaga aaccactgaa cattgttatt aaatatattt
      481 tcagctaact gtcatttagg agaattttca tgaaacaagt tctagaaagt tccaagtccc
      541 accagtaagt ggatttgata ttatggcagc aacttacaga cttgtggtta gtactgtgaa
      601 ccactacagc agcgtggtga tagaccggcg ttttgaacaa gctatacatt attgcactgg
      661 aacctgccac accttcacac atggaattga ctgcattgtg gtacaccata gtgtttgtgc
      721 agacctcttg cacatccctg tgtctcagtt caaagatgca gatctgaact ctatgtttct
      781 accccatgaa aatgggcttt cttcggctga aggagactat ccccaacagg ccttcacagg
      841 catacccagg gtcaagagag gatctacatt tcagaatacc tacaacttaa aggatattgc
      901 aggagaagca atcagttttg ccagtgggaa aataaaagaa ttttcctttg aaaaactcaa
      961 aaactctaac catgcagctt acagaaaggg aaggaaagtt aagtctgact catttaatag
     1021 gaggtcagtt gatttggact tgctttgtgg ccattataac aacgatggga acgccccatc
     1081 ctttggttta ctgcggagtt cctcagttga ggaaaaacct ttgtctcata gaaactcact
     1141 ggatacgaac ctgacttcca tgtttcttca aaacttttct gaagaagact tggttactca
     1201 gattttggaa aaacataaaa tagataattt ttcttctggg acagacataa agatgtgctt
     1261 ggacatctta ttgaaatgct ccgaggattt aaaaaaatgc acagacatca taaaacaatg
     1321 cataaagaaa aaatcaggga gtagcatcag tgaaggaagt ggtaatgata caatttctag
     1381 ctctgaaact gtctatatga atgtaatgac caggttagca tcctatctga aaaagttacc
     1441 atttgaattc atgcagtctg ggaataatga ggctctagat ttaacagaac tgatcagtaa
     1501 tatgcctagc ttacaactga ctcccttctc cccagtgttt ggcactgaac aaccccctaa
     1561 atatgaagat gttgtccagc tctcagcttc tgactctgga cgatttcaaa ctattgaatt
     1621 gcaaaatgac aagcctaatt ctaggaagat ggacactgta caatccattc caaacaactc
     1681 cacaaattcc ttatataact tagaggtaaa tgatcctaga actctaaaag ctgtccaggt
     1741 ccaatcacag tcattaacca tgaatccttt agaaaatgtt tcttctgacg acttaatgga
     1801 aactctttat attgaagaag agtcagatgg aaagaaagca ttagataaag gacaaaagac
     1861 agagaatgga cctagtcatg agttattaaa ggtaaatgaa catagagcag aatttccaga
     1921 acatgctact catcttaaaa aatgccccac cccaatgcaa aatgaaattg gtaagatatt
     1981 tgagaaatca tttgttaatc tacctaagga agactgtaaa tcaaaagttt ctaaatttga
     2041 agagggagac cagagagatt ttacaaattc cagtagccag gaagagatag ataaattgtt
     2101 aatggatttg gaatcttttt cacagaagat ggagacctct ctaagagagc cacttgcgaa
     2161 gggtaaaaac tctaattttt taaatagtca cagtcagttg accggtcaga cccttgtaga
     2221 tcttgagcct aaatctaaag tctcttcacc catagaaaaa gtctcacctt cctgtctaac
     2281 aaggattatt gaaaccaatg gacacaaaat agaggaagag gatcgagccc tcttactgcg
     2341 aatcctggaa agcattgaag actttgctca agaactagtt gaatgcaaat caagcagagg
     2401 gagcctatca caagaaaagg aaatgatgca aattctacag gaaaccttga caacttcctc
     2461 ccaggccaat ttatcagtct gtagaagtcc tgttggtgat aaagccaaag atactacttc
     2521 agcagttttg attcagcaga ctccagaggt gatcaagatt caaaataaac cagaaaagaa
     2581 acctggaaca ccactcccac ctccagccac ctctccaagt agtccccgac ctctctcccc
     2641 ggttccccat gtgaataatg ttgtgaatgc gccattgtcc ataaacattc cacggttcta
     2701 ctttcctgaa ggactcccag atacctgtag taatcatgaa caaactctaa gcagaattga
     2761 aactgctttc atggatattg aagaacagaa agcagacatt tatgaaatgg ggaaaattgc
     2821 aaaggtctgt ggctgtcctc tctattggaa agcccccatg ttcagggctg cagggggaga
     2881 gaagacagga tttgtgacag cacagtcatt cattgccatg tggagaaagt tgctgaataa
     2941 ccatcatgat gatgcctcta aattcatctg tcttctagca aagcccaact gcagctctct
     3001 agaacaggag gatttcatcc ctctacttca ggatgtggtg gatacccacc ctggtctcac
     3061 gttcctgaaa gatgctccag aattccactc ccgctacatc accacggtta ttcagagaat
     3121 attctacaca gtcaacagat cttggagtgg aaaaattact tcgacagaga taagaaaaag
     3181 caactttttg caaaccctag cacttttgga agaagaggaa gatataaacc aaattacaga
     3241 ttacttctcc tatgaacatt tctatgttat ttattgtaaa ttctgggaac tagatactga
     3301 tcacgacctc tacatcagcc aggccgatct gtctcgatac aatgaccagg cttcatcaag
     3361 caggattatt gaaaggatat tctctggtgc agtaacaagg ggaaaaacaa tacagaaaga
     3421 gggaagaatg agctatgcag attttgtttg gtttttgatc tctgaagaag acaaaaggaa
     3481 tcctaccagc attgagtatt ggttccgctg catggatgtg gatggagacg gtgtactctc
     3541 catgtatgag ctggagtact tctatgagga gcagtgtgaa cggatggaag ccatgggaat
     3601 tgagcccttg ccattccatg atttactgtg ccagatgctt gacctagtga agccagctgt
     3661 tgatggcaaa ataactctaa gagatctgaa gaggtgcaga atggctcaca tcttctatga
     3721 cactttcttt aatctggaga aatacttaga ccatgaacag agagatccct ttgcggtcca
     3781 gaaggatgtt gagaacgatg ggcctgagcc ctcagactgg gaccggtttg ccgctgagga
     3841 gtatgagacg cttgttgcag aggaatctgc ccaagcacaa ttccaggaag gctttgaaga
     3901 ttatgaaaca gatgaacctg cctctccctc tgaatttgga aacaaaagca ataaaatatt
     3961 aagtgcaagc cttccagaga aatgtggaaa gcttcaatca gtggatgaag aatagctgcc
     4021 ggtgtctaca atgaaacgaa gatgtgtatt ttaaatgttt ctttcttgtg aagagatgtt
     4081 ctcgtttgca tactgctttt taaagacttt gatttctcca agtgtgtatc atctgcacta
     4141 ggaactttgt ttttaagcaa taggtctgga tacacattta acttaggagg ctcctccaat
     4201 ttgcctcaaa cctcttacgg agcttctcct cagaagtggt accatcgcct tccaaagtca
     4261 gcactctaca ctcttgaatg taccaaggat ctcttggcga cagtaccaag cacggttctc
     4321 tacacaggtg actgaagttg cctctgtgtt ggctggcatc cctgagtccc ctccgggctc
     4381 ctatggagcc tagaagaaac cttcacttgc agaaaacttg agtcagaaaa ttctggaact
     4441 tgaaaaagta gtaagggcct ccagaattga cttagcccta gtaataaaag cactgccaaa
     4501 acatctcaga gacttctttt atgtatactg gagttcaaag atctttaact tacctggctt
     4561 aatgtaattt cacagttacc tgccaaacta ctagtcactt tacatcctca ggtattgtaa
     4621 ccactgggcc ttccaacttt gctggcaagc tctggtaacc tccctgactg tggatcttat
     4681 ataaaatctc aagataaaaa aacacttctt aaatgaagta tagaatttga ctcatacttg
     4741 gaaaaagccc ttttaacttt tatcttttat tcattgaact attgaatgat gtatttaata
     4801 tccaaattag ttgataactg ttttcacttc ctatcagaag gcctgcttga agacataaag
     4861 gaataatgat acattaaaat tcttactaga tagatatatt ccttcctccc aggagtatta
     4921 gactagctaa tagtaaaggc ctcaacgtta ttctttactt catgttgaaa acaattacta
     4981 cagatatttc atccacctca gtatttatca aggaaatgga aaatgataca gctataaaag
     5041 aaagctgtta tttactgtag ttgtagatgt attcactaca gaatcctaca tttttcagca
     5101 ggccacagtc cagccaaatc ctataatatc cttgaaaaga aactattaaa aaggatagac
     5161 atttctgatg taagtaaaac ccccaagcaa cttaatatcc atctgtcagt catcaacttt
     5221 tcccctagat ttttttttta actagttctg aaagtgtcaa gaatagcttc cctttccacc
     5281 ctacctaggt tccctccttg ctggcataaa ggccaagcag tgaaatgaac cttgggttag
     5341 agttatggta ggcaaaaaga aaaggagaat ttaggaaata aatatgctat aaacaaggta
     5401 cagtacagtg agagttaaca atcctaggaa tcctgcctgt cacaagctcc cagttccctg
     5461 tcattttatc ttcatgatta gaactgatct tccatttaac tattacagaa agcagtaact
     5521 attgcaacta tctaatagtt cacacaaaag aattaaaagc ttaaaaataa tttttaggaa
     5581 acacaatatt caaaatctaa acacactgat aaattattaa gattaagatt atttatgtga
     5641 taaatgaaat ctcctaccaa tccatccagc ctttaccagg gaagaaaagc aattatttca
     5701 tttcagatag aaatacaaaa aaaaaaaaaa tacttttctt agaagccaga tatggtttaa
     5761 atgttttatt atccataatg atctaaacta ataagattca ccaaaaagta aaaattcaat
     5821 tttacaatat acattttttt ttttaactat ttggctttac ctttttacct tggttctcct
     5881 tactgaagtc ctcttgcttt cactttgatc tggtttttga agtctcttaa ttattggctg
     5941 ggcatggtga ctcatgcctg taatcccggc actttgggag gccaagggag gtgatcactt
     6001 gagcccagga gtaaagacca gcctgggcaa catagtgaga ctccgtctct acaaaaaata
     6061 aatttagctg ggcatggtgg tgcacatctg tagtcctacc aacttgggag gctgaggcag
     6121 gagaatcgct tgagccccag gcttcgaggc tgcagtgagc tatgattacg acactgcact
     6181 ccagcctagg cgacagagca agaccccatt ctcttacaaa gtctctatta taaaagtaca
     6241 tccatcaata ccattccatt taaaatgggc tattgtaatt tacccacatt atcacatttt
     6301 caggaattat aagaatgtgt tttattgtac tccttccttg gagctgaatg caaggaatgt
     6361 gaattctgag gaattaaggt agaatatatt tgactttctg gtaaagatca tggttaagta
     6421 taatcattac tgccaaactg gaattttcaa gttattataa tatcccaggc cccttgataa
     6481 aagctgaggg ttatcatgac cttaatgcta attcaatgag aaatgagttt aatagcataa
     6541 cattaccaag gtaatcaaac taataaaatt ccatatatct tccctgcatc ttgtcactgt
     6601 gtaccattca aagtgtttat aaaactctag attcatcaaa tgagatttgc tcagcttttt
     6661 gaaatgttaa gatgtgtttg gagaaggctg catgactttg tttttccctt ttagcaaaac
     6721 taaataaagt tgtcaaatat gaa
//
