LOCUS       NM_018461               5374 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens protein phosphatase 2 regulatory subunit Bdelta
            (PPP2R2D), transcript variant 1, mRNA.
ACCESSION   NM_018461 XM_495852
VERSION     NM_018461.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5374)
  AUTHORS   Choi,S., Sarker,M.K., Yu,M.R., Lee,H., Kwon,S.H., Jeon,J.S., Noh,H.
            and Kim,H.
  TITLE     MicroRNA-5010-5p ameliorates high-glucose induced inflammation in
            renal tubular epithelial cells by modulating the expression of
            PPP2R2D
  JOURNAL   BMJ Open Diabetes Res Care 12 (2), e003784 (2024)
   PUBMED   38442987
  REMARK    GeneRIF: MicroRNA-5010-5p ameliorates high-glucose induced
            inflammation in renal tubular epithelial cells by modulating the
            expression of PPP2R2D.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5374)
  AUTHORS   Pan,W., Sharabi,A., Ferretti,A., Zhang,Y., Burbano,C., Yoshida,N.,
            Tsokos,M.G. and Tsokos,G.C.
  TITLE     PPP2R2D suppresses IL-2 production and Treg function
  JOURNAL   JCI Insight 5 (19), 138215 (2020)
   PUBMED   32897879
  REMARK    GeneRIF: PPP2R2D suppresses IL-2 production and Treg function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5374)
  AUTHORS   Yu,S., Li,L., Wu,Q., Dou,N., Li,Y. and Gao,Y.
  TITLE     PPP2R2D, a regulatory subunit of protein phosphatase 2A, promotes
            gastric cancer growth and metastasis via mechanistic target of
            rapamycin activation
  JOURNAL   Int J Oncol 52 (6), 2011-2020 (2018)
   PUBMED   29568966
  REMARK    GeneRIF: Results show that PPP2R2D expression was significantly
            upregulated at the mRNA and protein levels in gastric cancer (GC)
            tissues and correlated with poor prognosis. Further evidence
            demonstrates an oncogenic role of PPP2R2D in GC progression and
            development through regulation of mTOR.
REFERENCE   4  (bases 1 to 5374)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   5  (bases 1 to 5374)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5374)
  AUTHORS   .
  TITLE     An in vivo screen implicates PPP2R2D as an inhibitor of T-cell
            function
  JOURNAL   Cancer Discov 4 (3), OF13 (2014)
   PUBMED   24596207
  REMARK    GeneRIF: The PP2A regulatory subunit PPP2R2D inhibits T-cell
            proliferation and survival within tumors.
REFERENCE   7  (bases 1 to 5374)
  AUTHORS   Chen,H.F., Lin,L.N., Chen,Y.X., Wan,J.X., Luo,J., Zhang,C.Z.,
            Li,X.J., Hu,Y.M., Mai,J.R., Chen,W., Lin,Z.N. and Lin,Y.C.
  TITLE     Identification and functional analysis of variant haplotypes in the
            5'-flanking region of protein phosphatase 2A-Bdelta gene
  JOURNAL   PLoS One 7 (4), e35524 (2012)
   PUBMED   22539979
  REMARK    GeneRIF: The -462 G>A variant of PPP2R2D affects NF1 binding to the
            proximal promoter of PPP2R2D.
REFERENCE   8  (bases 1 to 5374)
  AUTHORS   Goudreault,M., D'Ambrosio,L.M., Kean,M.J., Mullin,M.J.,
            Larsen,B.G., Sanchez,A., Chaudhry,S., Chen,G.I., Sicheri,F.,
            Nesvizhskii,A.I., Aebersold,R., Raught,B. and Gingras,A.C.
  TITLE     A PP2A phosphatase high density interaction network identifies a
            novel striatin-interacting phosphatase and kinase complex linked to
            the cerebral cavernous malformation 3 (CCM3) protein
  JOURNAL   Mol Cell Proteomics 8 (1), 157-171 (2009)
   PUBMED   18782753
REFERENCE   9  (bases 1 to 5374)
  AUTHORS   Glatter,T., Wepf,A., Aebersold,R. and Gstaiger,M.
  TITLE     An integrated workflow for charting the human interaction proteome:
            insights into the PP2A system
  JOURNAL   Mol Syst Biol 5, 237 (2009)
   PUBMED   19156129
REFERENCE   10 (bases 1 to 5374)
  AUTHORS   Batut,J., Schmierer,B., Cao,J., Raftery,L.A., Hill,C.S. and
            Howell,M.
  TITLE     Two highly related regulatory subunits of PP2A exert opposite
            effects on TGF-beta/Activin/Nodal signalling
  JOURNAL   Development 135 (17), 2927-2937 (2008)
   PUBMED   18697906
  REMARK    GeneRIF: These highly related members of the same subfamily of PP2A
            regulatory subunits differentially regulate TGF-beta/Activin/Nodal
            signalling to elicit opposing biological outcomes.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC047379.1, AB040974.1 and BQ023669.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018461.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.234973.1,
                                           SRR1803615.117155.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455566.6/ ENSP00000399970.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1517              BC047379.1         365-1881
            1518-5367           AB040974.1         2357-6206
            5368-5374           BQ023669.1         17-23               c
FEATURES             Location/Qualifiers
     source          1..5374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..5374
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /note="protein phosphatase 2 regulatory subunit Bdelta"
                     /db_xref="GeneID:55844"
                     /db_xref="HGNC:HGNC:23732"
                     /db_xref="MIM:613992"
     exon            1..148
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1503
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /note="isoform a is encoded by transcript variant 1;
                     protein phosphatase 2 regulatory subunit B, delta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 55 kDa
                     regulatory subunit B delta isoform isoform a"
                     /protein_id="NP_060931.2"
                     /db_xref="CCDS:CCDS73224.1"
                     /db_xref="GeneID:55844"
                     /db_xref="HGNC:HGNC:23732"
                     /db_xref="MIM:613992"
                     /translation="MAGAGGGGCPAGGNDFQWCFSQVKGAIDEDVAEADIISTVEFNY
                     SGDLLATGDKGGRVVIFQREQENKSRPHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKI
                     NKIRWLPQQNAAHFLLSTNDKTIKLWKISERDKRAEGYNLKDEDGRLRDPFRITALRV
                     PILKPMDLMVEASPRRIFANAHTYHINSISVNSDHETYLSADDLRINLWHLEITDRSF
                     NIVDIKPANMEELTEVITAAEFHPHQCNVFVYSSSKGTIRLCDMRSSALCDRHSKFFE
                     EPEDPSSRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMESRPVETHQVHEY
                     LRSKLCSLYENDCIFDKFECCWNGSDSAIMTGSYNNFFRMFDRDTRRDVTLEASRESS
                     KPRASLKPRKVCTGGKRRKDEISVDSLDFNKKILHTAWHPVDNVIAVAATNNLYIFQD
                     KIN"
     exon            149..241
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            242..339
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            340..505
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            506..618
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            619..796
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            797..961
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1223
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..5374
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2068..2073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /note="hexamer: TATAAA"
     polyA_site      2090
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /note="major polyA site"
     regulatory      5350..5355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
                     /note="hexamer: AATAAA"
     polyA_site      5374
                     /gene="PPP2R2D"
                     /gene_synonym="B55D; B55delta; MDS026"
ORIGIN      
        1 aaaaatccct ccccggcggc ggcggcggcg gcggcggcgc cggcggtggt ggcggccccg
       61 gggctgagcg ctcggctgca gcggcgcgga ggccgtctcc ctggtctgcc gcggtccccg
      121 cccgtcccgc cgccggctgc catggcagga gccggaggcg gcggctgccc cgcgggcggc
      181 aacgacttcc agtggtgctt ctcgcaggtc aagggggcca tcgacgagga cgtggccgaa
      241 gcggacatca tttccaccgt tgagtttaat tactctggag atcttcttgc aacaggagac
      301 aagggcggca gagttgttat ttttcagcgt gaacaagaga ataaaagccg ccctcattct
      361 aggggagaat ataatgttta cagcaccttt caaagtcatg aaccggagtt tgactatttg
      421 aaaagtctag aaattgagga aaaaattaat aaaattaggt ggttaccaca acagaatgct
      481 gctcattttc tactgtctac aaatgataaa actataaaat tatggaaaat aagtgaacgg
      541 gataaaagag cagaaggtta taacctgaaa gacgaagatg gaagacttcg agacccattt
      601 aggatcacgg cgctacgggt cccaatattg aagcccatgg atcttatggt agaagcgagt
      661 ccacggcgaa tttttgcaaa tgctcacaca tatcatataa attccatttc agtaaatagt
      721 gatcatgaaa catatctttc tgcagatgac ctgagaatta atttatggca cttagaaatc
      781 acagatagaa gctttaacat cgtggacatc aagcctgcta acatggagga gctgaccgaa
      841 gtcatcactg cagccgagtt ccacccgcac cagtgcaacg tgttcgtcta cagcagtagc
      901 aaagggacca tccgcctgtg tgacatgcgc tcctcggccc tgtgcgacag acactccaag
      961 ttttttgaag agcctgaaga tcccagcagt aggtccttct tctcagaaat aatttcatcc
     1021 atatccgatg taaaattcag tcatagtggg cggtacatga tgaccagaga ctacctgtcg
     1081 gtgaaggtgt gggacctcaa catggagagc aggccggtgg agacccacca ggtccacgag
     1141 tacctgcgca gcaagctctg ctctctctat gagaacgact gcatctttga caagtttgag
     1201 tgttgctgga acggttcgga tagcgccatc atgaccgggt cctataacaa cttcttcagg
     1261 atgtttgata gagacacgcg gagggatgtg accctggagg cctcgagaga gagcagcaaa
     1321 ccgcgcgcca gcctcaaacc ccggaaggtg tgtacggggg gtaagcggag gaaagacgag
     1381 atcagtgtgg acagtctgga cttcaacaag aagatcctgc acacagcctg gcaccccgtg
     1441 gacaatgtca ttgccgtggc tgccaccaat aacttgtaca tattccagga caaaatcaac
     1501 tagagacgcg aacgtgagga ccaagtcttg tcttgcatag ttaagccgga catttttctg
     1561 tcagagaaaa ggcatcattg tccgctccat taagaacagt gacgcacctg ctacttccct
     1621 tcacagacac aggagaaagc cgcctccgct ggaggcccgg tgtggttccg cctcggcgag
     1681 gcgcgagaca ggcgctgctg ctcacgtgga gacgctctcg aagcagagtt gacggacact
     1741 gctcccaaaa ggtcattact cagaataaat gtatttattt cagtccgagc cttcctttcc
     1801 aatttataga ccaaaaaatt aacatccaag agaaaagtta ttgtcagata ccgctctttc
     1861 tccaactttc cctctttctc tgccatcaca cttgggcctt cactgcagcg tggtgtggcc
     1921 accgtccgtg tcctctcggc cttcctccga gtccaggtgg actctgtgga tgtgtggatg
     1981 tggcccgagc aggctcaggc ggccccactc acccacagca tccgccgcca ccccttcggg
     2041 tgtgagcgct caataaaaac aacacactat aaagtgtttt taaatccaaa cagaagtatt
     2101 gtctttttat ttaattttat tgcatagaat gaagttatgc agggttcttc tttggaacta
     2161 actgtttgag aaatgtgtgt ccttctttgg cagcgtgggg gtatgtgtgc agcatttctg
     2221 tccccaagct gctgcccgct gtgtttctgt agaagtagcc catcagatac accaggtaag
     2281 gtctgggaaa agccagaacc gaggccacct ctgagaaaga aaattgcaag gaagaaccaa
     2341 aattgctgcc atccagtaag cctggtttaa agtagcttca aattcactac agttgaagaa
     2401 atacgtgctt gctttctaag gcttttgaaa aagcactttg gggaaagtat actttttaaa
     2461 cattgctaaa attacatgca tgctaaattt catcctgcat ttcaagccag caaaattaag
     2521 caattttaat tacacgatgc caccagtacg ttggtttatt ttcaaagtag gatctttgat
     2581 accagaaatc aagattttcc aagacaaata atacagagct gtaccaatgc tgagtgacca
     2641 gagcttgctt ccgtgggatt taacacacgc ccactacgtg tccccgaggg gagtggggag
     2701 tcgggctccc gtgcccctgt ggagatggag gtgtgtgctg atcccccgtc cgcctgtgga
     2761 gatgaaggtg tgtgttgatt cctcctgctg ctgtggagat ggaggtgtgt gctgatcgcc
     2821 cgtcaccctg tctagatgaa ggtatgtgct gattgcctgt gcccctgtgg agaaggaggt
     2881 gtgtgctgat cccctgtgcc ctgtggagat ggaggtgtgt gctgctccct cgtgcccctg
     2941 tggagatgga ggtgtgtgct gatcccccat cccatccccc tgtctagatg aaggtgtgtg
     3001 ctgattcctc atgcccctgt ctggatgaag gtgtgtgctg atcccccgtc cccctgtgga
     3061 gatgaaggtg tgtgctgatc ccccgtgccc ctgtggagat gaaggtgcgt gctgatcccc
     3121 catctccctg tggagatgaa ggtgtgtgct gatccccatc cccctgtgga gatgaaggga
     3181 tatgctgatc ccctgtccca ctgtggagat gaaggggtgt gctgatcccc cgtccccctg
     3241 tggagatgaa ggtgtgtgct gatcccccat ctccctgtgg agatgaaggg gtgtgccaat
     3301 cccccgcgcc cctgtggaga tggaggcgtg tgctgatccc catccccctg tggagatgaa
     3361 ggtgtgtgct gatcccccat ccccatgtgg agatgaaggg gtgtgttgat cccctgtccc
     3421 cctgtggaga tggtgtgtgc tgatccccgt ccccctgtgg agatgaaggt gtgtgctgat
     3481 cccccatctc cctgtgaaga tgaaggggtg tgctgatccc ccgtgcccct gtggacatgg
     3541 aggcgtgtgc tgatcccccg tccccctgtg gagatgaagg tgtgtgctga tcccccatcc
     3601 ccatgtggag atgaaggggt gtgttgatcc cccgtccccc tgtggagatg aaggtgtgtg
     3661 ctgatccccg tccccctgtg gagatgaagg ggtgtgctga tcccccatgc cctgtggaga
     3721 tggaggtgtg tgctgatccc tcgtgcccct gtggagatag aggtgtgtac tgatcccctg
     3781 ttcccctatc tagatgaagg tgtgtactgc tgatcccccg tccccctgtg gagatgaagg
     3841 tgtgtgctga tcccccatcc ccctgtggag atgaaggggt gtgctgatcc cccgtcttcc
     3901 tgtggagatg aaggtgtgtg ctgattcctc atgcccctgt ggagatggag gtgtgtgctg
     3961 atcccccatc cccctgtggg gatgaaggtg tgtgctgatc ccccatcccc ctgtggagat
     4021 gaaggggtat gctgatcccc cgtccccctg tggagatgaa ggtgtgtgct gatcccccat
     4081 ccccctgtgg agatgaaggg gtatgctgat cccctgtccc cctgtgggga tgaaggtgtg
     4141 tgctgatctc ttgtccccct gtggagatgg aggtgtgtgc tgatccccca tccccctgtg
     4201 gagatgaaga tgtgtgctga tcccccgtcc tcctgtggag atgaaggtgt gtgctgcttc
     4261 ctcgtgcccc tgtggagatg gaggtgtgtg ctggtccccc gtccccctgt ggagatggag
     4321 gtgtgtgctg atcccccgtc cccctgtgga gatggaggcg tgtgctgatc ccccatcccc
     4381 ctgtggagat gaaggcgtgt gctgatccgc catcccactg tggagatgaa ggcgtgtgct
     4441 gatcccccat ccccctgtgg agataaaggt gtgtgctgat cccccatccc cctgtggaga
     4501 tgaaggcgtg tgctgatccg ccatcccact gtggagatga aggcgtgtgc tgatccccca
     4561 tccccctgtg gagatgaagg cgtgtgctca tcccccatcc ccctgtggag atgaaggcgt
     4621 gtgctgatcc gccatcccac tgtggagatg aaggtgtgtg ctgatccccc atccccctgt
     4681 ggagatgaag gtgtgtgctg atccccggtc cccctgtgga gatgaaggtg tgtgctgatc
     4741 ccccgtcctc ctgtggagat gaaggcgtgt gctgatcccc cgtccccctg tggagatgaa
     4801 ggcgtgtgct gatccgccgt ccccctgtgg agatgaaggc gtgtgctgat ccgccatccc
     4861 cctgtggaga tgaaggcgtg tgctcatccc ccatccccct gtggagatga aggcgtgtgc
     4921 tgatccgcca tcccactgtg gagatgaagg tgtgtgctga tcccccatcc ccctgtggag
     4981 atgaaggcgt gtgctgatcc ccggtccccc tgtggagatg aaggtgtgtg ttgatccccc
     5041 atccccctgt ggaggtgaag gtgtgtgctg attactaatc cacatgggca agaacaggat
     5101 gtccgtcatt accctgaatc aatgctaaca cagtgccact tgagttcaca ttaagttaga
     5161 aattgagaat ctaaaggtac ctttatttta actaaaaaat aatttatata ctgtatattg
     5221 attgtgacac aatttacaaa gtctgaggtg tggaacagtt atttaagcat tagtcaaccc
     5281 tggtccttaa gacagttcta gtaaaatggg attgtatata tttgttcaac tattttgacc
     5341 aaaaagttca ataaatttta aatgtttaac tgga
//
