LOCUS       NM_020416               4450 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 2 regulatory subunit Bgamma
            (PPP2R2C), transcript variant 1, mRNA.
ACCESSION   NM_020416 XM_005247977
VERSION     NM_020416.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4450)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4450)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   3  (bases 1 to 4450)
  AUTHORS   Daily,J.W., Liu,M. and Park,S.
  TITLE     High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants
            increased insulin resistance and interacted with coffee and
            caffeine consumption in middle-aged adults
  JOURNAL   Nutr Metab Cardiovasc Dis 29 (1), 79-89 (2019)
   PUBMED   30454882
  REMARK    GeneRIF: High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C
            variants increase susceptibility to increased insulin resistance by
            50% and its risk may be exacerbated by consuming more than 10 cups
            coffee/week or 220 mg caffeine/day.
REFERENCE   4  (bases 1 to 4450)
  AUTHORS   Serguienko,A., Hanes,R., Grad,I., Wang,M.Y., Myklebost,O. and
            Munthe,E.
  TITLE     PP2A Regulatory Subunit B55gamma is a Gatekeeper of Osteoblast
            Maturation and Lineage Maintenance
  JOURNAL   Stem Cells Dev 26 (19), 1375-1383 (2017)
   PUBMED   28805158
  REMARK    GeneRIF: B55gamma is induced by glucocorticoid receptor in human
            primary BM-MSCs during differentiation to osteoblast and is
            required for osteoblast morphogenesis.
REFERENCE   5  (bases 1 to 4450)
  AUTHORS   Bi,D., Ning,H., Liu,S., Que,X. and Ding,K.
  TITLE     miR-1301 promotes prostate cancer proliferation through directly
            targeting PPP2R2C
  JOURNAL   Biomed Pharmacother 81, 25-30 (2016)
   PUBMED   27261573
  REMARK    GeneRIF: miR-1301 promoted prostate cancer proliferation by
            inhibiting PPP2R2C.
REFERENCE   6  (bases 1 to 4450)
  AUTHORS   Hu,P., Yu,L., Zhang,M., Zheng,L., Zhao,Y., Fu,Q. and Zhao,S.
  TITLE     Molecular cloning and mapping of the brain-abundant B1gamma subunit
            of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16
  JOURNAL   Genomics 67 (1), 83-86 (2000)
   PUBMED   10945473
REFERENCE   7  (bases 1 to 4450)
  AUTHORS   Torres,R., Ide,S.E., Dehejia,A., Baras,A. and Polymeropoulos,M.H.
  TITLE     Genomic structure and localization of the human protein phosphatase
            2A BRgamma regulatory subunit
  JOURNAL   DNA Res 6 (5), 323-327 (1999)
   PUBMED   10574460
REFERENCE   8  (bases 1 to 4450)
  AUTHORS   Strack,S., Zaucha,J.A., Ebner,F.F., Colbran,R.J. and Wadzinski,B.E.
  TITLE     Brain protein phosphatase 2A: developmental regulation and distinct
            cellular and subcellular localization by B subunits
  JOURNAL   J Comp Neurol 392 (4), 515-527 (1998)
   PUBMED   9514514
REFERENCE   9  (bases 1 to 4450)
  AUTHORS   Ruediger,R., Brewis,N., Ohst,K. and Walter,G.
  TITLE     Increasing the ratio of PP2A core enzyme to holoenzyme inhibits
            Tat-stimulated HIV-1 transcription and virus production
  JOURNAL   Virology 238 (2), 432-443 (1997)
   PUBMED   9400615
REFERENCE   10 (bases 1 to 4450)
  AUTHORS   Tung,H.Y., De Rocquigny,H., Zhao,L.J., Cayla,X., Roques,B.P. and
            Ozon,R.
  TITLE     Direct activation of protein phosphatase-2A0 by HIV-1 encoded
            protein complex NCp7:vpr
  JOURNAL   FEBS Lett 401 (2-3), 197-201 (1997)
   PUBMED   9013886
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114815.5, BM551976.1,
            AK093115.1 and AC116317.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020416.3.
            
            Summary: The product of this gene belongs to the phosphatase 2
            regulatory subunit B family. Protein phosphatase 2 is one of the
            four major Ser/Thr phosphatases, and it is implicated in the
            negative control of cell growth and division. It consists of a
            common heteromeric core enzyme, which is composed of a catalytic
            subunit and a constant regulatory subunit, that associates with a
            variety of regulatory subunits. The B regulatory subunit might
            modulate substrate selectivity and catalytic activity. This gene
            encodes a gamma isoform of the regulatory subunit B55 subfamily.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.179732.1,
                                           SRR1660803.89891.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382599.9/ ENSP00000372042.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC114815.5         62925-62939         c
            16-763              BM551976.1         1-748
            764-1981            AK093115.1         403-1620
            1982-4450           AC116317.4         82068-84536         c
FEATURES             Location/Qualifiers
     source          1..4450
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..4450
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /note="protein phosphatase 2 regulatory subunit Bgamma"
                     /db_xref="GeneID:5522"
                     /db_xref="HGNC:HGNC:9306"
                     /db_xref="MIM:605997"
     exon            1..455
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..1729
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /EC_number="3.1.3.16"
                     /note="isoform a is encoded by transcript variant 1;
                     protein phosphatase 2A1 B gamma subunit; phosphoprotein
                     phosphatase 2A BR gamma regulatory chain; protein
                     phosphatase 2, regulatory subunit B, gamma"
                     /codon_start=1
                     /product="protein phosphatase 2, regulatory subunit B,
                     gamma isoform a"
                     /protein_id="NP_065149.2"
                     /db_xref="CCDS:CCDS3387.1"
                     /db_xref="GeneID:5522"
                     /db_xref="HGNC:HGNC:9306"
                     /db_xref="MIM:605997"
                     /translation="MGEDTDTRKINHSFLRDHSYVTEADIISTVEFNHTGELLATGDK
                     GGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQN
                     AAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMV
                     EVSPRRIFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANM
                     EDLTEVITASEFHPHHCNLFVYSSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSF
                     FSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYE
                     NDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRR
                     VCVGGKRRRDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH"
     exon            456..553
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /inference="alignment:Splign:2.1.0"
     exon            554..719
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /inference="alignment:Splign:2.1.0"
     exon            720..832
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1010
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1175
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1345
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1437
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..4450
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4431..4436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /note="hexamer: AACAAA"
     polyA_site      4450
                     /gene="PPP2R2C"
                     /gene_synonym="B55-GAMMA; B55gamma; IMYPNO; IMYPNO1; PR52;
                     PR55G"
                     /note="major polyA site"
ORIGIN      
        1 agcccggctc ggccccggct tggtcggcgc agcgcagcgc cgcgcgcgtc ccctcgccgc
       61 cgtcgccgca gccaggcgca ccggcaccag gccccgccgc cgggcgcacg gacgcagcgc
      121 gcacgggccg gccgggatgc gcgcctgggc cccggcccgc ccgaacccgc ggccgccgcc
      181 cgcccaccgc gcgctcgctt gaccgcggcg cccgcccccg gccgcccccg cccgtccccc
      241 tgccgcgatg ccctcccttc ggggccccgg cggcccgcgc ccctgctagg ctgcggcggc
      301 atggcccgcg cgcccggcgc gacctctgcg gattgcatcg gtgtgtggcg gcggggcatg
      361 cccagagcac cgggcacggc cttcaatggg cgaggacacg gacacgcgga aaattaacca
      421 cagcttcctg cgggaccaca gctatgtgac tgaagctgac atcatctcta ccgttgagtt
      481 caaccacacg ggagagctgc tggccacagg tgacaagggc ggccgggtcg tcatcttcca
      541 gcgggaacca gagagtaaaa atgcgcccca cagccagggc gaatacgacg tgtacagcac
      601 tttccagagc cacgagccgg agtttgacta tctcaagagc ctggagatag aggagaagat
      661 caacaagatc aagtggctcc cacagcagaa cgccgcccac tcactcctgt ccaccaacga
      721 taaaactatc aaattatgga agattaccga acgagataaa aggcccgaag gatacaacct
      781 gaaggatgaa gaggggaaac ttaaggacct gtccacggtg acgtcactgc aggtgccagt
      841 gctgaagccc atggatctga tggtggaggt gagccctcgg aggatctttg ccaatggcca
      901 cacctaccac atcaactcca tctccgtcaa cagtgactgc gagacctaca tgtcggcgga
      961 tgacctgcgc atcaacctct ggcacctggc catcaccgac aggagcttca acatcgtgga
     1021 catcaagccg gccaacatgg aggaccttac ggaggtgatc acagcatctg agttccatcc
     1081 gcaccactgc aacctcttcg tctacagcag cagcaagggc tccctgcggc tctgcgacat
     1141 gcgggcagct gccctgtgtg acaagcattc caagctcttt gaagagcctg aggaccccag
     1201 taaccgctca ttcttctcgg aaatcatctc ctccgtgtcc gacgtgaagt tcagccacag
     1261 cggccgctac atgctcaccc gggactacct tacagtcaag gtctgggacc tgaacatgga
     1321 ggcaagaccc atagagacct accaggtcca tgactacctt cggagcaagc tctgttccct
     1381 gtacgagaac gactgcattt tcgacaagtt tgaatgtgcc tggaacggga gcgacagcgt
     1441 catcatgacc ggggcctaca acaacttctt ccgcatgttc gatcggaaca ccaagcggga
     1501 cgtgaccctg gaggcctcga gggaaagcag caagccccgg gctgtgctca agccacggcg
     1561 cgtgtgcgtg gggggcaagc gccggcgtga tgacatcagt gtggacagct tggacttcac
     1621 caagaagatc ctgcacacgg cctggcaccc ggctgagaac atcattgcca tcgccgccac
     1681 caacaacctg tacatcttcc aggacaaggt aaactctgac atgcactagg tatgtgcagt
     1741 tcccggcccc tgccacccag cctcatgcaa gtcatccccg acatgacctt cacgaccgca
     1801 atgcaaggag gggaagaaag tcacagcact gatgaggaca gctgcagagg tggcagtgtg
     1861 tggacacagg aagtttgggc cccctccctg ccccagcttt cctaggccag aattgtgttt
     1921 ggcagtaatt gtctgtttaa aaaaataaaa aggaaaggaa gcgttcaccg ccacaaatca
     1981 taaaatggac atgactgtgg agtcttacag ttcagggttc tttcattcac gtcccttcct
     2041 gtctcggtct gcggtcttta ccacatcaat aggacttttt atgcgtccgg gttaattttt
     2101 cactccagtg cgtcctgttg cagggaccgg agctgatggg agctgcttct cccccatgcc
     2161 tcactggtcc cagatcaggg ctccagggac agatgatgag tctcaaacga gccagccagg
     2221 ggttcttttg gttataaatg gggcaattcg ccctgtctca gagctgatga cctcaccgtt
     2281 gttttttgga tggtgaattc atgctgagaa tttgcagatg caagctcctc tcctaggtct
     2341 tctgaatgtc ttgaaacatc ccaggtccca ggtctggtgc ggtttcccga gaggagcgga
     2401 gtggggtttg tcttctgtgt gcctgtgtcc tcatctgatt cacctgccat ttgctgagcc
     2461 tctgctgtgt accaggcgtg gtgctcagcc ctagaggcag ttgacttacc ctctgcagcc
     2521 ctccctgccg cctcaccctt cagcattcac tgggcacctt cccggagcgg acactgactc
     2581 ccatgcacga ttttttggaa tcttcctcct gactgtgagg tgggtgttca ttcatttcct
     2641 ccataaacac caacttctcg aagcgtgcca ggctctgggc tggatgctgg ggataagcgg
     2701 gaacccttag gatcccctct gtccacgaga agaagctgag gctctgagcg gatgcacagg
     2761 tcacccatgg caggtgccgt gcagtggtgt caggaacccg tccgggtctt cacacaaggt
     2821 tctctccagt ccatctcgtg ggcggctcat gttagagcga cattcaaatg gaaggtttgg
     2881 aaaggaatgc ctctgtcttg tgaagtagga catggcagac ttggcgacga caagggtcca
     2941 ggagaactga gacgcaggat ggaagacaga gaagaccccc cggagctcct cgctctgctt
     3001 ggtggcttca ggagtgtggc cctccccagg actccacttc atcctgggct tgcaccctcc
     3061 ttgagccaat gcactgaact gcctttgaaa ggaaattgca tgttctgacc attttaggat
     3121 acctttactt taaggaccac acagtcccag aggacacatc cctcgggaac tctgcccctc
     3181 tgacaatgag ggccacagag aaggtggtgt ttccatggta gatgctcctg ttctggtgat
     3241 accaaacctg cccacccctc tgagtcgtct ttgctcatgg acttgcagca gagccacgta
     3301 gtttggcatt ttgattcaga aagtggggag cagagaccca gccaaatcca aacttttttt
     3361 ttggttttgt tttgttttgt tttttacaag atataacata acccaggaaa cagacccagc
     3421 tgaggttatt ctcagtggat tacagtatac ttttgtgtgt gtaaaagcac aaagtgcatg
     3481 tgtactcact tctggccata taacatttac acagggaaat ggatcattga ttttttttta
     3541 atcaacgtga atgaagaatg tttgtttata tatcactata aaatccagtt gacctggaca
     3601 gtattatatg tacatatcta ttctaattaa atttaacaat caaaggattg gattactttt
     3661 ttcccccttg taaagaggtt cgagaatgtg gtcaattgta tagatagcgt gttaaagcca
     3721 aaacccagct ctgagggcct tacccattac ttggatattt gctacgatcc atctcccttt
     3781 gtgagtcaaa tgttaagaga agaaacttgt atttgcagct agaggttact gtcacatcat
     3841 agatttaaca tttaccatct tcaaagtaca aatcttacat gtccttcaaa aggaggtctt
     3901 aatacagttc ctagttcctt acttctgttt taaactttgg gtaccaaacc aaaaagaaga
     3961 aaaaagaaag gaaaagatct tctttgaaga aaagtatgtc tctggatccc tggaaaataa
     4021 tgatgtccaa agcaaattgt gaagatcaaa tgtgtgttaa gaaaaggtgt cgaggggagg
     4081 gacaaaacca gaaacggtgg aaggaccagt gtaatagtca cagacttgca tcctggctct
     4141 gcttacattt cctggtactc tcgaatgtac gggcgttcac atagtcattg tgaagttgtt
     4201 ggggtttttt tggttttgtt tttaatttag ctcttctctg aggacgaagc tgttggtggt
     4261 ggtggtggtg ggggtggtgg tgtgggatac atggtggtca agttgtcagc cctgatcagt
     4321 ttggactctg taactcatag gtgcattctt tttttctttg gtgtctcaca aattacccaa
     4381 ttgttgaata aaactataaa tatgttaata ccagcttttt ccaataaaat aacaaatgtt
     4441 acatcaaaaa
//
