LOCUS       NM_181675              10828 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens protein phosphatase 2 regulatory subunit Bbeta
            (PPP2R2B), transcript variant 3, mRNA.
ACCESSION   NM_181675
VERSION     NM_181675.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10828)
  AUTHORS   Shen,D. and Kang,S.
  TITLE     Comprehensive analysis of mitochondria-related genes indicates that
            PPP2R2B is a novel biomarker and promotes the progression of
            bladder cancer via Wnt signaling pathway
  JOURNAL   Biol Direct 19 (1), 17 (2024)
   PUBMED   38409085
  REMARK    GeneRIF: Comprehensive analysis of mitochondria-related genes
            indicates that PPP2R2B is a novel biomarker and promotes the
            progression of bladder cancer via Wnt signaling pathway.
            Erratum:[Biol Direct. 2024 Apr 18;19(1):27. doi:
            10.1186/s13062-024-00474-1.. PMID: 38637864]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10828)
  AUTHORS   Zhou,C., Liu,H.B., Jahanbakhsh,F., Deng,L., Wu,B., Ying,M.,
            Margolis,R.L. and Li,P.P.
  TITLE     Bidirectional Transcription at the PPP2R2B Gene Locus in
            Spinocerebellar Ataxia Type 12
  JOURNAL   Mov Disord 38 (12), 2230-2240 (2023)
   PUBMED   37735923
  REMARK    GeneRIF: Bidirectional Transcription at the PPP2R2B Gene Locus in
            Spinocerebellar Ataxia Type 12.
REFERENCE   3  (bases 1 to 10828)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 10828)
  AUTHORS   Bao,Y., Oguz,G., Lee,W.C., Lee,P.L., Ghosh,K., Li,J., Wang,P.,
            Lobie,P.E., Ehmsen,S., Ditzel,H.J., Wong,A., Tan,E.Y., Lee,S.C. and
            Yu,Q.
  TITLE     EZH2-mediated PP2A inactivation confers resistance to HER2-targeted
            breast cancer therapy
  JOURNAL   Nat Commun 11 (1), 5878 (2020)
   PUBMED   33208750
  REMARK    GeneRIF: EZH2-mediated PP2A inactivation confers resistance to
            HER2-targeted breast cancer therapy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10828)
  AUTHORS   Ruediger,R., Brewis,N., Ohst,K. and Walter,G.
  TITLE     Increasing the ratio of PP2A core enzyme to holoenzyme inhibits
            Tat-stimulated HIV-1 transcription and virus production
  JOURNAL   Virology 238 (2), 432-443 (1997)
   PUBMED   9400615
REFERENCE   6  (bases 1 to 10828)
  AUTHORS   Tung,H.Y., De Rocquigny,H., Zhao,L.J., Cayla,X., Roques,B.P. and
            Ozon,R.
  TITLE     Direct activation of protein phosphatase-2A0 by HIV-1 encoded
            protein complex NCp7:vpr
  JOURNAL   FEBS Lett 401 (2-3), 197-201 (1997)
   PUBMED   9013886
REFERENCE   7  (bases 1 to 10828)
  AUTHORS   Schalling,M., Hudson,T.J., Buetow,K.H. and Housman,D.E.
  TITLE     Direct detection of novel expanded trinucleotide repeats in the
            human genome
  JOURNAL   Nat Genet 4 (2), 135-139 (1993)
   PUBMED   8348150
REFERENCE   8  (bases 1 to 10828)
  AUTHORS   Margolis,R.L., Holmes,S.E., Srivastava,A.K., Mukherji,M. and
            Sinha,K.K.
  TITLE     Spinocerebellar Ataxia Type 12 - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301381
REFERENCE   9  (bases 1 to 10828)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
REFERENCE   10 (bases 1 to 10828)
  AUTHORS   Mayer,R.E., Hendrix,P., Cron,P., Matthies,R., Stone,S.R., Goris,J.,
            Merlevede,W., Hofsteenge,J. and Hemmings,B.A.
  TITLE     Structure of the 55-kDa regulatory subunit of protein phosphatase
            2A: evidence for a neuronal-specific isoform
  JOURNAL   Biochemistry 30 (15), 3589-3597 (1991)
   PUBMED   1849734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011386.6, AC009186.7 and
            AC008728.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 28, 2020 this sequence version replaced NM_181675.3.
            
            Summary: The product of this gene belongs to the phosphatase 2
            regulatory subunit B family. Protein phosphatase 2 is one of the
            four major Ser/Thr phosphatases, and it is implicated in the
            negative control of cell growth and division. It consists of a
            common heteromeric core enzyme, which is composed of a catalytic
            subunit and a constant regulatory subunit, that associates with a
            variety of regulatory subunits. The B regulatory subunit might
            modulate substrate selectivity and catalytic activity. This gene
            encodes a beta isoform of the regulatory subunit B55 subfamily.
            Defects in this gene cause autosomal dominant spinocerebellar
            ataxia 12 (SCA12), a disease caused by degeneration of the
            cerebellum, sometimes involving the brainstem and spinal cord, and
            in resulting in poor coordination of speech and body movements.
            Multiple alternatively spliced variants, which encode different
            isoforms, have been identified for this gene. The 5' UTR of some of
            these variants includes a CAG trinucleotide repeat sequence (7-28
            copies) that can be expanded to 55-78 copies in cases of SCA12.
            [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.3464831.1,
                                           SRR18074967.1774122.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394411.9/ ENSP00000377933.3
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC011386.6         72905-73071
            168-361             AC011386.6         73467-73660
            362-459             AC009186.7         48813-48910         c
            460-625             AC009186.7         45747-45912         c
            626-738             AC009186.7         38896-39008         c
            739-916             AC008728.7         140454-140631       c
            917-1081            AC008728.7         128158-128322       c
            1082-1251           AC008728.7         90198-90367         c
            1252-1343           AC008728.7         82878-82969         c
            1344-10828          AC008728.7         70649-80133         c
FEATURES             Location/Qualifiers
     source          1..10828
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..10828
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /note="protein phosphatase 2 regulatory subunit Bbeta"
                     /db_xref="GeneID:5521"
                     /db_xref="HGNC:HGNC:9305"
                     /db_xref="MIM:604325"
     exon            1..167
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            168..361
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1623
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /EC_number="3.1.3.16"
                     /note="isoform e is encoded by transcript variant 3;
                     protein phosphatase 2, regulatory subunit B, beta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 55 kDa
                     regulatory subunit B beta isoform isoform e"
                     /protein_id="NP_858061.3"
                     /db_xref="CCDS:CCDS93800.1"
                     /db_xref="GeneID:5521"
                     /db_xref="HGNC:HGNC:9305"
                     /db_xref="MIM:604325"
                     /translation="MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDK
                     GGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQN
                     AAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMV
                     EATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANM
                     EELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSF
                     FSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYE
                     NDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRK
                     VCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN"
     exon            362..459
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            460..625
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            626..738
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            739..916
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1081
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1251
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1343
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..10828
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2040..2045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /note="hexamer: AATAAA"
     polyA_site      2041
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /note="major polyA site"
     polyA_site      2066
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /note="major polyA site"
     regulatory      10405..10410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /note="hexamer: ATTAAA"
     polyA_site      10430
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
     regulatory      10808..10813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
                     /note="hexamer: AATAAA"
     polyA_site      10828
                     /gene="PPP2R2B"
                     /gene_synonym="B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B;
                     PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B;
                     PR55-BETA; PR55BETA; SCA12"
ORIGIN      
        1 agcagcagca gcagcagcag cagcagcagc tgcgagtgcg cgcgtgtggg tgtgagggtg
       61 agtgcgctgg cgccggctgc agcgccctgc ccagctcccc gccagcttcc ctacccccgc
      121 ctgccggagc cgccctcccg tgggaccagc accctcattc cggccaggct cggaccatgg
      181 tgcagtccca ctggctcccc tgcccccctc tcctgtgaga ctggctgcgg ggagggatca
      241 tggatacttg tctgccggct tctggttccc acgcaagtaa gcctgctgtc aatggaggag
      301 gacattgata cccgcaaaat caacaacagt ttcctgcgcg accacagcta tgcgaccgaa
      361 gctgacatta tctctacggt agaattcaac cacacgggag aattactagc gacaggggac
      421 aaggggggtc gggttgtaat atttcaacga gagcaggaga gtaaaaatca ggttcatcgt
      481 aggggtgaat acaatgttta cagcacattc cagagccatg aacccgagtt cgattacctg
      541 aagagtttag aaatagaaga aaaaatcaat aaaataagat ggctccccca gcagaatgca
      601 gcttactttc ttctgtctac taatgataaa actgtgaagc tgtggaaagt cagcgagcgt
      661 gataagaggc cagaaggcta caatctgaaa gatgaggagg gccggctccg ggatcctgcc
      721 accatcacaa ccctgcgggt gcctgtcctg agacccatgg acctgatggt ggaggccacc
      781 ccacgaagag tatttgccaa cgcacacaca tatcacatca actccatatc tgtcaacagc
      841 gactatgaaa cctacatgtc cgctgatgac ctgaggatta acctatggaa ctttgaaata
      901 accaatcaaa gttttaatat tgtggacatt aagccagcca acatggagga gctcacggag
      961 gtgatcacag cagccgagtt ccacccccat cattgcaaca ccttcgtgta cagcagcagc
     1021 aaagggacaa tccggctgtg tgacatgcgg gcatctgccc tgtgtgacag gcacaccaaa
     1081 ttttttgaag agccggaaga tccaagcaac agatcatttt tctctgaaat tatctcttcg
     1141 atttcggatg tgaagttcag ccacagtggg aggtatatca tgaccaggga ctacttgacc
     1201 gtcaaagtct gggatctcaa catggaaaac cgccccatcg agacttacca ggttcatgac
     1261 tacctccgca gcaagctgtg ttccctctat gaaaatgact gcatttttga taaatttgag
     1321 tgtgtgtgga atgggtcaga cagtgtcatc atgacaggct cctacaacaa cttcttcagg
     1381 atgttcgaca gaaacaccaa gcgtgatgtg acccttgagg cttcgaggga aaacagcaag
     1441 ccccgggcta tcctcaaacc ccgaaaagtg tgtgtggggg gcaagcggag aaaagacgag
     1501 atcagtgtcg acagtctgga ctttagcaaa aagatcttgc atacagcttg gcatccttca
     1561 gaaaatatta tagcagtggc ggctacaaat aacctatata tattccagga caaggttaac
     1621 taggtggaca agttattact taataatctc acatactgaa tactagtcaa acaagttttt
     1681 aaatgtttct ttgggtcttc atttgatgca ttgactttaa tttccctata caggaaatga
     1741 ttggaataga attaaaagga gtccaacatt cccagctccc cagttctaag aaacttttgt
     1801 caaacccaat aggtttggga cacttctgtt tagaattgaa agctgccagc taacagtaat
     1861 tcttccatag ttgacttgaa cttctgatgc ttttattgcc cagttttctc tggtgggtcc
     1921 agtgttttgt tcctaggtgt ctgctgcgat aaaatgaggt tgtctgtagt atttaaggag
     1981 aaaagagata agtttttttt aattaagcaa ttccatttga ttgaaaaaaa tcaacaaaaa
     2041 ataaacaccg tttactctta gacaaattct tcttgttttg tgaaaaacca gaactagtca
     2101 gtatctcctg cccctccacc attttttttt ccattttcca ttttcctttg aacaatttca
     2161 tttaagccag agatttattg catgaagctg agaagaggat gcagaatgac aaggaaaggg
     2221 cacatcaacc ctgctatgct ctttttttgt aagctccata gaaacagcct gagaatttgg
     2281 ctagggaact tgaatgcttc aggggacaga aagagagcac tttcgacaca gtgcttccca
     2341 gagtgagctt ggcagggcca ggcggggcca aattccatct gctgccttgt tactcttgct
     2401 ttttgtgctc ttaaatggct ccatataatc ttctacttac atgttccttg gcttttttct
     2461 cttcaacctt ttccagctta tttattccat tgacttctaa aggccgagtc ctgggtgctt
     2521 attatctggt gttctaaatg aagcagtaag ttggaagcag tgccaccacc cctgagtccc
     2581 tgagaaaggc tggtctgttc tttttgggtg tttctcctaa gcagcaccct cccctcctcc
     2641 tggttttggt aaccaaaagt aacaatccat caacctccat tgtacctaga acaaaaatag
     2701 ccaataaaaa cgctgagttg tgaagtccaa tcaggcactt ctaactcacc ccaagctcgc
     2761 catctggaaa aacagaccag aaggctctct tctacagaaa tgaactgtgg ggaaatcaag
     2821 cagctgtgac atgaagtgaa tgaagtccac ttgaagctgt ggaagatggt tcatcctttt
     2881 ccccagttga ggatccagat ttataacttc tagaaagcca tttccagaag gttctatgtg
     2941 gcacacccct aggaaaggca ctaaatgcat gcaaaggatt tataaactta ggaaagtaga
     3001 tgggtggagt ccagaaaact ggttctgggt taatatctct acatctgtct tgatgactca
     3061 tttctcctaa ctcccattta gtgcagggta aatggtttga gatgagagtt tttcaatgaa
     3121 agggaaattt tctttcagtt tacagatgta ttagaagtcc tgactttcaa gtgtaatttg
     3181 ctttggagga ggaaaaaata gtgaaagaat cattttatct caattctaag ctactatcca
     3241 tttactaata gctttttggc aaggaaataa ctgtcacctt aggtaaaaac agtcttgtta
     3301 gatgcagccc aatttcagga acattaaaat gtaaaaaagt acgtctcaga attgagggag
     3361 catgggaaca aagacgagac tttctcagta tttctcattt ttcctgcaag gaaagcctcg
     3421 ccttaggcat ctcaagtaaa gtggctaagg tgtaaactct ctgggcaaga tttctgtcct
     3481 gactgggaca gtgttcttgg aggagacatg agagagtcag aaacttctgc cagtcataga
     3541 gagtgatgat tttgcagaag gccactgggt tattggccta catttaccac cgacttcctt
     3601 tatggccttt tctccacttc tccggactca gctcctctgt ctgtaccacg tcgggggttg
     3661 ggaccaatca ttgtatctca aacttaagaa tcaactcaca tttgtactat tactcatgta
     3721 acattttttt aagtcacctt ttcttaaaag caagacttag cctcctccaa agaaataata
     3781 tgcatgaaat ttcaactctg atatgctagg tttttcccta acattaatca cataattatc
     3841 aatgtaacaa acatgcaccc acataccacc tgaaatcatt ttgtgaacca ccaggagcat
     3901 gtgtatcaaa ctttgggacc ctgagtaact gatatgacag aagatttatg cccttagggg
     3961 catcaaagat ggtggttctt cacatattag agtcagcagg gctgcccata acacacacag
     4021 gaataatttt tgtcatggtt taaggagttc ataggcccct ttgcagttta tctgcgaact
     4081 ccaaataaaa gcccctacac tagtccaaca cccttagcat atagatgtac aaactgggat
     4141 ccagagtagg atgagtttgc cagagaagaa agagcagagg gcagccatcc tctcctccat
     4201 cccctgcaaa ggatgcatta gagcaaacac ccaagactcc tggacgggaa caggagggga
     4261 aagccctaga gattaggcct cagggagcaa taaccaccac gatgtttcac aaattaactg
     4321 ttctttacca ggtactgaac taggtatttt acatgtgtga tctttcagcc ccagtactgg
     4381 caatatttct tagttagtgg cacatagaag tcagtctgtt ttcctgctga cactaaaaac
     4441 tacttgaagg ctgatttgct accttgcaac agttggttcg attctaaggg ccctatacta
     4501 ctttacccca caaggcctgc tgcttggtaa gagccatcag attacaactg gagggtgtca
     4561 gttgaatgaa ggaaaatgga agccacgcca tccctggctt ttacaaaaac catccttgcg
     4621 caacattcag ttcctgacgt taaaaacaag taatgcaaaa agctgaactt tggtagacat
     4681 tcgtactctt ctgtcaggag gaggaagatt agttagaaaa aacaaaaaag gaagatacta
     4741 gccagcatca agaagtggga tatataaagg cagatgggca gtgggaatca agttgcttct
     4801 taactccttc aagtttggct cctgccttta ctcttccatt gaaaaaaaag cacctttaaa
     4861 cctctcattg atcttgtaat taattcaacc aaatcaactt ctattaggca accagcatat
     4921 ataagatgga acaattgcaa ggtggaataa agatgaagct aaaattctgc tagctcagtg
     4981 gcccaatgaa ataagtcagc tatctccact aaacttcctt tgaatattct agggtccatt
     5041 ataataaaag gtacacactc aaatgcccaa tttctaagga cttgaaaagc cataatttcc
     5101 ctcccttcaa gcctacagag caactgccta aagcttccct ccccagacaa ccccaggcct
     5161 catttctttt tcagtccctt tgctagctgc ctgcagggct caagaaagcc ctggtaggcc
     5221 tcataatgag gatttaggga tgacactata gtccacagcc tgaatggtgg aacccttact
     5281 aattttccct cttccgtgat gaatgtgtgg atgaagccgg tgtgttttta ataatgccac
     5341 cccacttcca aaacaaatcc cctgacacag tctttggaca taccaccctg aatgcacccg
     5401 atctcatctg atcttggaag tgaaatggag tcaggcctgg ttagtctttg gatgggggaa
     5461 gtctagacac accactgaga aacattcaca ctgcaacctg attcactgtg catccaacat
     5521 gccttcatcc acctcttccc cctgaacttc taagtcaact ctcagggact gctttccaag
     5581 ggagcaacca acctggtcag tggaaaaagg atgagactgg gagacaggaa acgtgggtcc
     5641 tgctcctggt aaccatggaa cttaagctac ccactcagtc cctatgtcag tgtcatcacc
     5701 tgtaaaatgg ccagaaagac atctatccta gctcagagaa ttgttattgg gagaacaaga
     5761 aatccattta cttacaacta ttttgatagg tttaaagcac cataaactaa taatagcaac
     5821 aacagtgatg ggtaatatac tattgctttc catgcctcat ctcattatct cctctcccag
     5881 accccatggt ggcattagta tttccatttt gcaaatgaga aaatagactc aagttgtcaa
     5941 cctagccaag ggcacaaagc ccgagagaga tggaaccagg actccaactc aaggtatctg
     6001 actctaaagc cagagctgtt aaaatacagc tctaacatac aatagttgct aacatttatt
     6061 gagcacttat tataagccag gctttgttct acaaatttca catgtattga cttatttacc
     6121 cctaaaactc cagatgcaga tactattgtt gttctcattt tatagataca gaaacagatg
     6181 aatgacaacc aaatttacac agttcacaag tgacaaagcc aggcagtttt agttaaagtt
     6241 cttatccact atccccatca tacattatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     6301 gtgtgtgtgt atgcatgtag atggaagtta ctgatcagaa aacaagcccc agtaatgacc
     6361 cataagctca atgaattaaa gattcattgg ttgcctggga tgtgtcaggc agccaggttc
     6421 tagacaaggg gctggagtta ctaagatatt taaaccactg gcccctgccc tccaagagat
     6481 gacactcaca taggagaaag tgcatatttg catactgtaa acatttttac aatgagatat
     6541 ctatgaaggg cagaagtcat acagaggaag aaatagttaa tcaatgagtg ataagaaaag
     6601 gttctcagaa tgtgtcatct aagcagaatt ttaactaaat ttgctcaaca aagcatgata
     6661 cagcgtttcc aataggtaga ccaacatata ccagaatatg aagcaaaatc catatggcat
     6721 ggaaacagaa agccaatgtt tctctccttc cattagaaac acattttcga catactagaa
     6781 ctagcctacc cctttttcct tttgttcatc caataacaaa tatttattaa accttatttt
     6841 aagcactgta tttaagtgta aagtagacgg aaagaataaa aggaaaccaa tatttcctga
     6901 gtagttattg caatgacagg cattgggaga ggcactgttt taaatcattg ttaatcacct
     6961 gataggtaga tgtattattc catttttata gcgagaaaca gactcaaaag ggttagatga
     7021 cgtagcagga agttttatct agatctatcc tgttccagat cctatacttc ttccatcaca
     7081 gttattggta atgcagagtt accttggctt gattattttc cctagcgtgg atactcacaa
     7141 acacgccatt tctctgtgac taaatattgc ctgacagctg accaagaata caaatttggt
     7201 ctgtcatcaa agcagagagt gaagtcaagt ggctcacagg tctccaactt ctgactttga
     7261 ccttattatg actgattaac tgtcccccaa tttagatatt ccatgcccca ttggttaaac
     7321 tgctggtggc agaaccatca tgatctgcca tctccgctga tccctgcctc agctgcaatc
     7381 aaagcaatga tcactgtcag gccagaagaa ggggcttagc cactgccaag acagatccca
     7441 gtccactccc agccttcccg cccctgctgc tcattcccca aaaagtcaac ctgggttttc
     7501 ctgggtgaac agtgcccact gaacagctcc tgcttgccca tctcaagccc tctcagttgc
     7561 cactccaatc attttggctg ctgtatttgg tttgagaaag agtggagagg acacttcttc
     7621 ataactcata tttgacagaa acccagaaat tgtaggaaca agccatgatt gctgtgattc
     7681 ttgctctggt tggctaggga tgccctccct tccagccaga gtaatacata cttgtgggag
     7741 tcatggaaga ctgaggaagc tggagtagaa gggaacaggg gctttcctca gtggtaaaag
     7801 gaaaagcaac attttggaac tctaaacagt tgctcagttg ggcgaatttc atgcattcat
     7861 tcattcattt actaaatggt taatgattgt tcatgtactg cctgccaagc ccatgccagg
     7921 gtggtctgtg gaagcagcag tgacagctcc atcttcacac agctcacaga tagcgggagg
     7981 tgcagacaaa ctcacaggca atggtggcag tggaatgtca agagcccagg ataccgagcc
     8041 tgccagcctg cctgcctggg ttaaaatctg agctccacca tgtaaaagct gagcaaccta
     8101 gaaaaatgac aacctctctg tgcctcgatt ttctcattat gagataagga taaaaacgac
     8161 atctatctca taaaattgct gtgaagattg catgatttaa tatgcacaaa gctcttagaa
     8221 ggatgcctgg cccacaaata tgcattcagt gcacatttct tgctacagtt ctgctaatcc
     8281 tataaaacat atgcactatg atggatgtgt ctgggtgcca ggaggacaca aaggagcact
     8341 aactcatcca gaccagaagc ttcccagagg aggtgattcc caaggtgaaa tccgaaagat
     8401 aaagggagtg agttatccag gagaagagaa aggaaaagca tattccagac atcaggatag
     8461 gacagtggag gcaaaacagc atatgctata tatatatgga attcacaaca ctctggtatg
     8521 actgattagt aaaaagtagg aaggcagacc aagagaaata aggagacatg gtaaggtgag
     8581 tgggcaataa tgcatgatct gaaaaataat aatgcatgga cttagtgtgg ttcacatatc
     8641 aggagcttct ccaatagcca ggctatgagg cactaaaatg aggaaatatg gtttccaaac
     8701 ttcgcaaata cttatagtcc agccacaggg gatatactga taaactcagc tcaaatgtca
     8761 cctcctcaga gatgctttct caaccaccct tagttccatg aggactgcat cattgtttag
     8821 gccactcctg tatccccaga gcacagaaca ttgtctggct catagtaggt gctcaaaagt
     8881 tttgttgaat gaatgaacaa ataaacgtgt aaggaagtca ggcacagcac ttgcccacag
     8941 gaagcttata agatgagcgg catgccattg ggagtttgaa tgatatatgg agatccaaac
     9001 agggcatcag aggactgctc agaggagtca gggaattaag aaaaaattgg gagccagtga
     9061 gccaagatgt gttaaaagca agtgatcaag cttagattgc agtgttagtt aatagagcat
     9121 atgtgtccct gcctgatgca ttaccttccc tgcagtagtt agccttctgg gaccctgaaa
     9181 agcatgcaga aaggttgaca gcttacaatc aataccatgt tcactgatgc aggaagcaac
     9241 attatcacat ccaagatatt gcccccacac ccaggctgca gcactaaata ttccccataa
     9301 caaggcaaag ggaagtgaca agagctatta ttctcaaccc tcccacttgg aaacaagagg
     9361 tgagacaaac cttcccctag atgttcttag ggaaaggcaa gacccccaaa gaaatctttc
     9421 agagctgagc acatgcctaa tacagcaaga cagggatggg agaagattgg cattttcatt
     9481 tgcctgggtg tccacaatat tgcaggggaa gctctgtggg cagctgggaa atacaacaat
     9541 aaattggagg gggatgaaca atagggtcag tggggctgtg tgctgagtga atgctggatt
     9601 ttattctaca tgcccaattc actccaataa gataaacttg acttcctcca gtgtggcttt
     9661 cttatttcag cttctctgac tgtggcataa ttgaaagtca tatttcatct agaccattgg
     9721 ttttcaactc caaatgcagg tggcttatga agactcagcc tgaatatata aagagaacag
     9781 caaacaatca tagttgcata ttaaagacaa tctatttctc cgtaaaggaa agtaaagtga
     9841 gtcatattac atacaagcca caatacagaa ctgatctgaa atacactgcg gaatggcctt
     9901 tcagtctatg ctggactcta acaggaaaaa ggcagaaggt ggtcaatggt gcatttattt
     9961 aaacccctca tttcctccct gacgagaaga aggacaacag ttcttatttt tcatattatt
    10021 tttgaaaagg cagaaaggtt aattatatat tgacatgatt tggatctgtg tcctcaccat
    10081 aatctcatgt caaattgtaa tccccagtgt ttgaggtggg gccaggtggg aggtgattgg
    10141 atcgtggagg tggatttctc atgcatggtt tagcaccatc ttcttggtgc tattctcgtg
    10201 atagtgagta agttctcacg agatctggtt gtttaaaggt gtgaagaacc tcccctctgt
    10261 ctctcttgct cctgttcctg ccatgtaaga tatgctggct ccccctttgc cttctgccat
    10321 gattgtaagt atccagaggc ctctccagaa gctgagcaga tgtcagcacc atgcttcctg
    10381 tacagcctgt ggaaccatga gccaattaaa cctcattcct ttacaaatta cccagtctcg
    10441 ggtttttctt tatagcaatg caagaacaga ctaatagagg taatttgtga tgtttcttga
    10501 tgaaagaatc agctgaaact cgagaattaa tacattcatt gaagatcaga caaatatcat
    10561 agaaaccgag aaagtatcca tcatggaaca agaaagttca gctcaaaaag ctgatttttt
    10621 caaagtacaa aatgaaatac catttcaggc atggatcatg actcaaagaa gctcttcact
    10681 ttgaccagca cggggttgat tcattaactc cattgttctc aaatgaatcc cacggtgtcc
    10741 caagagaaac tctggagagg cttcaccaag aacagtaatt atagcttttc catgttatct
    10801 agcattcaat aaattcttcc taatgtga
//
