LOCUS       NM_002717               3923 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens protein phosphatase 2 regulatory subunit Balpha
            (PPP2R2A), transcript variant 1, mRNA.
ACCESSION   NM_002717
VERSION     NM_002717.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3923)
  AUTHORS   Wasserman,J.S., Faezov,B., Patel,K.R., Kurimchak,A.M.,
            Palacio,S.M., Glass,D.J., Fowle,H., McEwan,B.C., Xu,Q., Zhao,Z.,
            Cressey,L., Johnson,N., Duncan,J.S., Kettenbach,A.N., Dunbrack,R.L.
            Jr. and Grana,X.
  TITLE     FAM122A ensures cell cycle interphase progression and checkpoint
            control by inhibiting B55alpha/PP2A through helical motifs
  JOURNAL   Nat Commun 15 (1), 5776 (2024)
   PUBMED   38982062
  REMARK    GeneRIF: FAM122A ensures cell cycle interphase progression and
            checkpoint control by inhibiting B55alpha/PP2A through helical
            motifs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3923)
  AUTHORS   Palanivel,C., Madduri,L.S.V., Hein,A.L., Jenkins,C.B., Graff,B.T.,
            Camero,A.L., Zhou,S., Enke,C.A., Ouellette,M.M. and Yan,Y.
  TITLE     PR55alpha-controlled protein phosphatase 2A inhibits p16 expression
            and blocks cellular senescence induction by gamma-irradiation
  JOURNAL   Aging (Albany NY) 16 (5), 4116-4137 (2024)
   PUBMED   38441530
  REMARK    GeneRIF: PR55alpha-controlled protein phosphatase 2A inhibits p16
            expression and blocks cellular senescence induction by
            gamma-irradiation.
REFERENCE   3  (bases 1 to 3923)
  AUTHORS   Perl,A.L., Koetsier,J.L. and Green,K.J.
  TITLE     PP2A-B55alpha controls keratinocyte adhesion through
            dephosphorylation of the Desmoplakin C-terminus
  JOURNAL   Sci Rep 13 (1), 12720 (2023)
   PUBMED   37543698
  REMARK    GeneRIF: PP2A-B55alpha controls keratinocyte adhesion through
            dephosphorylation of the Desmoplakin C-terminus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3923)
  AUTHORS   Madduri,L.S.V., Brandquist,N.D., Palanivel,C., Talmon,G.A.,
            Baine,M.J., Zhou,S., Enke,C.A., Johnson,K.R., Ouellette,M.M. and
            Yan,Y.
  TITLE     p53/FBXL20 axis negatively regulates the protein stability of
            PR55alpha, a regulatory subunit of PP2A Ser/Thr phosphatase
  JOURNAL   Neoplasia 23 (12), 1192-1203 (2021)
   PUBMED   34731788
REFERENCE   5  (bases 1 to 3923)
  AUTHORS   Fowle,H., Zhao,Z., Xu,Q., Wasserman,J.S., Wang,X., Adeyemi,M.,
            Feiser,F., Kurimchak,A.N., Atar,D., McEwan,B.C., Kettenbach,A.N.,
            Page,R., Peti,W., Dunbrack,R.L. and Grana,X.
  TITLE     PP2A/B55alpha substrate recruitment as defined by the
            retinoblastoma-related protein p107
  JOURNAL   Elife 10, e63181 (2021)
   PUBMED   34661528
  REMARK    GeneRIF: PP2A/B55alpha substrate recruitment as defined by the
            retinoblastoma-related protein p107.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3923)
  AUTHORS   Xing,Y., Xu,Y., Chen,Y., Jeffrey,P.D., Chao,Y., Lin,Z., Li,Z.,
            Strack,S., Stock,J.B. and Shi,Y.
  TITLE     Structure of protein phosphatase 2A core enzyme bound to
            tumor-inducing toxins
  JOURNAL   Cell 127 (2), 341-353 (2006)
   PUBMED   17055435
  REMARK    GeneRIF: The scaffolding subunit exhibits considerable
            conformational flexibility, which is proposed to play an essential
            role in PP2A function.
REFERENCE   7  (bases 1 to 3923)
  AUTHORS   Ruediger,R., Brewis,N., Ohst,K. and Walter,G.
  TITLE     Increasing the ratio of PP2A core enzyme to holoenzyme inhibits
            Tat-stimulated HIV-1 transcription and virus production
  JOURNAL   Virology 238 (2), 432-443 (1997)
   PUBMED   9400615
REFERENCE   8  (bases 1 to 3923)
  AUTHORS   Tung,H.Y., De Rocquigny,H., Zhao,L.J., Cayla,X., Roques,B.P. and
            Ozon,R.
  TITLE     Direct activation of protein phosphatase-2A0 by HIV-1 encoded
            protein complex NCp7:vpr
  JOURNAL   FEBS Lett 401 (2-3), 197-201 (1997)
   PUBMED   9013886
REFERENCE   9  (bases 1 to 3923)
  AUTHORS   Kamibayashi,C., Lickteig,R.L., Estes,R., Walter,G. and Mumby,M.C.
  TITLE     Expression of the A subunit of protein phosphatase 2A and
            characterization of its interactions with the catalytic and
            regulatory subunits
  JOURNAL   J Biol Chem 267 (30), 21864-21872 (1992)
   PUBMED   1328247
REFERENCE   10 (bases 1 to 3923)
  AUTHORS   Mayer,R.E., Hendrix,P., Cron,P., Matthies,R., Stone,S.R., Goris,J.,
            Merlevede,W., Hofsteenge,J. and Hemmings,B.A.
  TITLE     Structure of the 55-kDa regulatory subunit of protein phosphatase
            2A: evidence for a neuronal-specific isoform
  JOURNAL   Biochemistry 30 (15), 3589-3597 (1991)
   PUBMED   1849734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB451813.1, AK314823.1,
            BC041071.1, AC022911.6 and AI814790.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002717.3.
            
            Summary: The product of this gene belongs to the phosphatase 2
            regulatory subunit B family. Protein phosphatase 2 is one of the
            four major Ser/Thr phosphatases, and it is implicated in the
            negative control of cell growth and division. It consists of a
            common heteromeric core enzyme, which is composed of a catalytic
            subunit and a constant regulatory subunit, that associates with a
            variety of regulatory subunits. The B regulatory subunit might
            modulate substrate selectivity and catalytic activity. This gene
            encodes an alpha isoform of the regulatory subunit B55 subfamily.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.200855.1,
                                           SRR1803611.15646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380737.8/ ENSP00000370113.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DB451813.1         18-37
            21-1656             AK314823.1         1-1636
            1657-2373           BC041071.1         1624-2340
            2374-3430           AC022911.6         29957-31013         c
            3431-3923           AI814790.1         6-498               c
FEATURES             Location/Qualifiers
     source          1..3923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..3923
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /note="protein phosphatase 2 regulatory subunit Balpha"
                     /db_xref="GeneID:5520"
                     /db_xref="HGNC:HGNC:9304"
                     /db_xref="MIM:604941"
     exon            1..319
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1656
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein phosphatase 2, regulatory subunit B, alpha"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 55 kDa
                     regulatory subunit B alpha isoform isoform 1"
                     /protein_id="NP_002708.1"
                     /db_xref="CCDS:CCDS34867.1"
                     /db_xref="GeneID:5520"
                     /db_xref="HGNC:HGNC:9304"
                     /db_xref="MIM:604941"
                     /translation="MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLA
                     TGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWL
                     PQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPM
                     DLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIK
                     PANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPS
                     NRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLC
                     SLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVL
                     KPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN"
     exon            320..394
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            395..492
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            493..658
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            659..771
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            772..949
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1114
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1284
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1376
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..3923
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2327..2332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /note="hexamer: AATAAG"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /note="hexamer: AATAAA"
     polyA_site      2366
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /note="major polyA site"
     polyA_site      2373
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /note="major polyA site"
     regulatory      3918..3923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /note="hexamer: AATAAA"
     polyA_site      3923
                     /gene="PPP2R2A"
                     /gene_synonym="B55; B55A; B55ALPHA; PR52A; PR55A;
                     PR55alpha"
                     /note="major polyA site"
ORIGIN      
        1 aggccagccg gcgccatttt gaaagtggag tcgcctgccc ctgccgctgc cgccgccgcc
       61 gtcgctgtcg tagtcgccgc cgccgctgcc ggagaaagag cacgagcggg gaagccccag
      121 agtgaaatct agcatcctgc cggctggtct gcccgcccct ccttcctttt ccccccggcc
      181 cccgtcccct ccccccgcag gtgccatccg ccgccatccg ccctctctac ccccccatcc
      241 ccaggtgagg ggggtgagtt caggaagcgg agaccccgag gaacccagca gggtcaccat
      301 ttgcagcgca acatggcagg agctggagga gggaatgata ttcagtggtg tttttctcag
      361 gtgaaaggag cagtagatga tgatgtagca gaagcagata taatttctac agtagaattt
      421 aatcattctg gagaattact agcaacagga gataaaggtg gtagagttgt catctttcaa
      481 caggagcagg agaacaaaat ccagtctcat agcagaggag aatataatgt ttacagcacc
      541 ttccagagcc atgaaccaga gtttgactac ttgaaaagtt tagaaataga agaaaagatc
      601 aacaaaatta ggtggttacc ccagaaaaat gctgctcagt ttttattgtc taccaatgat
      661 aaaacaataa aattatggaa aatcagtgaa agggacaaaa gaccagaagg gtataacttg
      721 aaagaggagg atggaaggta tagagatcct actacagtta ctacactacg agtgccagtc
      781 tttaggccta tggatctaat ggttgaggcc agtccacgaa gaatatttgc caatgctcat
      841 acatatcaca tcaactcaat ttctattaat agtgattatg aaacatattt atctgcagat
      901 gatttgcgga ttaatctttg gcatctggaa attacagaca ggagttttaa cattgtggat
      961 atcaagcctg ccaatatgga agagctaaca gaggtgatta cagcagcaga atttcatcca
     1021 aacagctgta acacatttgt atacagcagc agtaaaggaa ctattcggct atgtgacatg
     1081 agggcatctg ccctctgtga tagacattct aaattgtttg aagaacctga agatcccagt
     1141 aacaggtcat ttttttccga aatcatctcc tctatttcgg atgtaaaatt cagccatagt
     1201 ggtcgatata tgatgactag agactatttg tcagtcaaaa tttgggactt aaatatggaa
     1261 aacaggcctg tggaaacata ccaggtgcat gaatacctca gaagtaaact ctgttcactg
     1321 tatgaaaatg actgcatatt tgacaaattt gaatgttgtt ggaatggatc tgacagtgtt
     1381 gtcatgactg gatcttacaa taatttcttc agaatgtttg acagaaacac aaagcgagac
     1441 ataaccctag aagcatcgcg ggaaaacaat aagcctcgca cagttctgaa gcctcgcaaa
     1501 gtctgtgcaa gtggcaagcg aaagaaagat gaaataagtg ttgacagcct agacttcaat
     1561 aagaaaatcc ttcacacagc ctggcacccc aaggaaaata tcattgccgt agctactaca
     1621 aacaatctgt atatatttca agacaaagtg aattagggtt ggcattccta gcagaagaac
     1681 ccacttcctg cttagttgag atagttgaat ctagcattcg ttcctataaa agagagaggt
     1741 ccattgtggc gcccctttcc agtgtttgac agtgtgccat tcgacaacac attgttatag
     1801 ctacatggag aaagctctgt ggattcatca ctgtggtgtt ctccatgtct gctagccatt
     1861 taggtaaggg tagggcactt ttaatttaaa tgacttcttg caccatcttg cctaatggac
     1921 tagattggac tgtatcaaca ttgatttact ccacttttta tgccttccat tgtgatgacg
     1981 tcaaacacag tgaaagcctt cagtcatgct atgggattta attgtgtatc ctcattactg
     2041 tatcatttgt ggggtacacc ccttccccct ttttttaaat taaatacagc tcattcttac
     2101 tgtggcttgt agcattcctc ctcttctggc ctcctggact gctccccttc atctcttacc
     2161 cttgccccct ccacccggtc ttggtggtgg tatattaaaa aaagaaagaa tgaaagcaca
     2221 caaaatgagt cagtttgggg tcagtggtat aaagggggta tatgttgcaa acaaatgttt
     2281 tagtaacagt tggctgtaat cactcctcgc cgtgtctggc actgaaaata aggaaaaaaa
     2341 acctactact gaataaaagt gacaaagaat ggagaatctg gttttctttt tctttttaac
     2401 ctacctcttg tagccaatat tttgtgtcat acctttgggc acagtgaaac aaaatgggtt
     2461 ttcattgttt attggtattt ttgttaatta tttttaacaa gtgttctttt acatgcagga
     2521 ggagaggtat tggttctcta tgaacatatt ttgaatatag gttttattaa ggatttcaca
     2581 atctataaat gctactagtt tttttttttt tttttaccat catgagggta ttggatacat
     2641 tgtgtctcta tttaactcat tatgtgttaa tgaaattgtt gtaaatggga accaaatttg
     2701 tagaacttaa tttctacttt ttagagtgct taatttcatt tttgccttac taaatagtca
     2761 aagacttata aaacattttt aacaagttag aacttttttg ttattcagtc atataaaata
     2821 gcagaaaact aacatcaagt gacactgcac taaatacttt ttttgtattt tactgctatc
     2881 aaatcagaat gaaatatact ttaccataga tatttttctt ctatttttgg ttttccaaag
     2941 ctatatgaaa gacaaatttt taaaggtaca gcgttcaaaa agtgcttaat gaactccaac
     3001 agctgcctca aataaaaatc tgtatatgaa tacattttcc ctaagcggtg atacattatc
     3061 caaagatgaa gagtgctcct atttttaata ggtagaatgt acctttgtca gtcttgcaga
     3121 aactttaatg gagaagaaat ggactttatt tttgaaaggt gaaatgaaca ggcatttata
     3181 ttattagaga atggtagtct tattttggtg gaacataatg taacaacctt gaatttcaga
     3241 ggactctgag tgcttctatg tccactacct attgttctat tcttcaataa tgaaaaagaa
     3301 ttcaacgagc cgaccgtgat tccctctact acaaatatta tgtcttgtaa gttagcattt
     3361 ttagcacaca ggagaaattt tatgtaataa aattactgta tcttttggat ttaacaaatt
     3421 tgtatttgaa acacattcta tgtctgataa ttcttaatgg cacttttact aatttatttg
     3481 gggatcttgg gtacattctt aatttgtgtt tattcttcac gcttgacttg caagtgggat
     3541 attcccctgc cacaagtgtc aaacagtgat attcttcctg tgttgtgact ggacagtttt
     3601 ccagatcttt tttgggagat tttcctacag cttggttgta tgtcttgaga taacaccacc
     3661 aaacagctct cagaaattct tttttgattg atcagtagct atgatgattc tcctccatga
     3721 cactaaggat tagtttatat atttaagaga aataattgct aaaattaaaa tgcctctatc
     3781 aaggaatgct attataaatt attgttaaca ttctcaagta ttaatttttt aatttcattg
     3841 gtgtagcaaa ctctaagccc agccactcat tttacatggc catggttaat ctttttatta
     3901 ataaaaatta tacttagaat aaa
//
