LOCUS       NM_002716               5553 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 2 scaffold subunit Abeta
            (PPP2R1B), transcript variant 1, mRNA.
ACCESSION   NM_002716
VERSION     NM_002716.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5553)
  AUTHORS   Peng,S., He,T., Liu,Y., Zheng,L., Zhong,Y., Niu,Z., Zhang,M. and
            Yang,S.
  TITLE     Lnc-PPP2R1B Mediates the Alternative Splicing of PPP2R1B by
            Interacting and Stabilizing HNRNPLL and Promotes Osteogenesis of
            MSCs
  JOURNAL   Stem Cell Rev Rep 19 (6), 1981-1993 (2023)
   PUBMED   37243830
  REMARK    GeneRIF: Lnc-PPP2R1B Mediates the Alternative Splicing of PPP2R1B
            by Interacting and Stabilizing HNRNPLL and Promotes Osteogenesis of
            MSCs.
REFERENCE   2  (bases 1 to 5553)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5553)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5553)
  AUTHORS   Du,M., Yuan,L., Zhang,Z., Zhang,C., Zhu,M., Zhang,Z., Li,R.,
            Zhao,X., Liang,H., Li,Y., Jiang,H., Qiao,J. and Yin,Y.
  TITLE     PPP2R1B is modulated by ubiquitination and is essential for
            spermatogenesis
  JOURNAL   FASEB J 35 (5), e21564 (2021)
   PUBMED   33913576
  REMARK    GeneRIF: PPP2R1B is modulated by ubiquitination and is essential
            for spermatogenesis.
REFERENCE   5  (bases 1 to 5553)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5553)
  AUTHORS   Adler,H.T., Nallaseth,F.S., Walter,G. and Tkachuk,D.C.
  TITLE     HRX leukemic fusion proteins form a heterocomplex with the
            leukemia-associated protein SET and protein phosphatase 2A
  JOURNAL   J Biol Chem 272 (45), 28407-28414 (1997)
   PUBMED   9353299
REFERENCE   7  (bases 1 to 5553)
  AUTHORS   Tung,H.Y., De Rocquigny,H., Zhao,L.J., Cayla,X., Roques,B.P. and
            Ozon,R.
  TITLE     Direct activation of protein phosphatase-2A0 by HIV-1 encoded
            protein complex NCp7:vpr
  JOURNAL   FEBS Lett 401 (2-3), 197-201 (1997)
   PUBMED   9013886
REFERENCE   8  (bases 1 to 5553)
  AUTHORS   Hendrix,P., Mayer-Jackel,R.E., Cron,P., Goris,J., Hofsteenge,J.,
            Merlevede,W. and Hemmings,B.A.
  TITLE     Structure and expression of a 72-kDa regulatory subunit of protein
            phosphatase 2A. Evidence for different size forms produced by
            alternative splicing
  JOURNAL   J Biol Chem 268 (20), 15267-15276 (1993)
   PUBMED   8392071
REFERENCE   9  (bases 1 to 5553)
  AUTHORS   Kamibayashi,C., Lickteig,R.L., Estes,R., Walter,G. and Mumby,M.C.
  TITLE     Expression of the A subunit of protein phosphatase 2A and
            characterization of its interactions with the catalytic and
            regulatory subunits
  JOURNAL   J Biol Chem 267 (30), 21864-21872 (1992)
   PUBMED   1328247
REFERENCE   10 (bases 1 to 5553)
  AUTHORS   Hemmings,B.A., Adams-Pearson,C., Maurer,F., Muller,P., Goris,J.,
            Merlevede,W., Hofsteenge,J. and Stone,S.R.
  TITLE     alpha- and beta-forms of the 65-kDa subunit of protein phosphatase
            2A have a similar 39 amino acid repeating structure
  JOURNAL   Biochemistry 29 (13), 3166-3173 (1990)
   PUBMED   2159327
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF163473.1, BC027596.2 and
            AP000925.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002716.4.
            
            Summary: This gene encodes a constant regulatory subunit of protein
            phosphatase 2. Protein phosphatase 2 is one of the four major
            Ser/Thr phosphatases, and it is implicated in the negative control
            of cell growth and division. It consists of a common heteromeric
            core enzyme, which is composed of a catalytic subunit and a
            constant regulatory subunit, that associates with a variety of
            regulatory subunits. The constant regulatory subunit A serves as a
            scaffolding molecule to coordinate the assembly of the catalytic
            subunit and a variable regulatory B subunit. This gene encodes a
            beta isoform of the constant regulatory subunit A. Mutations in
            this gene have been associated with some lung and colon cancers.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.89530.1,
                                           SRR1660805.204435.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000527614.6/ ENSP00000437193.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               AF163473.1         39-598
            561-963             BC027596.2         554-956
            964-2022            AF163473.1         1002-2060
            2023-5549           AP000925.6         167704-171230       c
            5550-5553           AP000925.6         167700-167703       c
FEATURES             Location/Qualifiers
     source          1..5553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..5553
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /note="protein phosphatase 2 scaffold subunit Abeta"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
     exon            1..142
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1834
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /EC_number="3.1.3.16"
                     /note="isoform a is encoded by transcript variant 1;
                     protein phosphatase 2, structural/regulatory subunit A,
                     beta; protein phosphatase 2, regulatory subunit A, beta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform a"
                     /protein_id="NP_002707.3"
                     /db_xref="CCDS:CCDS8349.1"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
                     /translation="MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSI
                     KKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLL
                     PPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSAC
                     GLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIV
                     PLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVA
                     DRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETII
                     MNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPDV
                     RLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEF
                     FDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYL
                     HRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTN
                     ALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLALA"
     exon            143..233
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            234..334
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            335..567
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            568..715
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            716..871
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            872..986
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1057
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1192
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1366
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1427
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1582
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1725
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1817
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..5553
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4235..4240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /note="hexamer: AATAAA"
     polyA_site      4255
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /note="major polyA site"
     regulatory      4565..4570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /note="hexamer: AATAAA"
     polyA_site      4595
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
ORIGIN      
        1 ggtgaccagc agcaggagga gaaagaacat ggcgggcgca tcagagctcg ggaccggccc
       61 aggagcagcg ggtggagatg gagatgattc gctatacccg atcgcggttt taatcgacga
      121 gctccgcaat gaagacgtgc agctccgact caacagtatt aagaagttat caacaattgc
      181 cctagcactt ggagtagaaa ggacccgaag tgaattgttg ccatttctta cagatacaat
      241 ttatgatgaa gatgaggtac tattagctct tgctgagcag ctgggaaatt tcactggcct
      301 agtgggaggt cctgactttg cccactgtct gctgcctcct ttggaaaatc tggcaactgt
      361 ggaagagact gttgttcgtg acaaggctgt ggagtccctg agacagatct cccaggagca
      421 tactcctgtt gctctggaag cttattttgt acctctggtg aaacgcttag caagtgggga
      481 ttggttcacc tctcgcacat ctgcatgtgg tttgttcagc gtttgctatc ccagggcatc
      541 aaatgctgtt aaagcagaaa tcagacagca attccgttcc ttgtgctcag atgacacacc
      601 aatggtacga cgtgctgctg cttccaaatt gggtgaattt gcaaaagttt tggaattaga
      661 cagtgtgaaa agtgaaattg ttccactgtt cactagtcta gcttcagatg aacaggattc
      721 agtgcgcctc cttgctgtgg aagcttgtgt cagtattgcc cagttattgt ctcaggatga
      781 ccttgagact ttggtgatgc ctacacttcg acaagcagca gaagataaat cttggcgcgt
      841 tcgctatatg gtggctgaca gattttcaga gctccagaaa gccatgggtc ctaaaatcac
      901 cctaaatgac ctcatccccg cctttcagaa cctacttaaa gactgtgaag ctgaagtccg
      961 ggcagctgct gcccacaaag taaaagaact tggtgagaac ttgcccattg aagatagaga
     1021 gaccataatt atgaatcaaa ttctgcctta tataaaggaa ttagtatccg ataccaatca
     1081 acatgtcaaa tcggctctag cttctgtaat tatgggattg tctactattt tgggcaaaga
     1141 aaataccatt gaacatcttc tacctctttt cttagctcag ttaaaggatg agtgtcctga
     1201 cgttcgtttg aatatcatct ccaatttgga ttgtgtaaat gaagtgattg gaatccgtca
     1261 gctctctcag tctctccttc ctgccatagt ggagctggca gaagatgcca aatggagggt
     1321 ccgcctggcc atcattgagt atatgccgct gctggcaggc cagctgggtg tggaattctt
     1381 tgatgaaaag ctgaattctt tatgtatggc ttggctcgtg gaccatgtat acgccatccg
     1441 agaagctgcc accaacaacc tcatgaaact agttcagaag tttggtacag agtgggccca
     1501 aaatactatt gttcccaaag tgttagtaat ggcaaatgat cctaattact tgcatagaat
     1561 gaccacttta ttctgcatta atgcactgtc tgaggcctgt ggtcaggaaa taactactaa
     1621 gcaaatgctg cccatcgtat taaaaatggc aggagaccaa gtagcaaatg ttcgcttcaa
     1681 tgtggccaaa tctctacaaa agattggacc aattctagat accaatgctt tacagggaga
     1741 agtgaagcca gtactacaga agttaggtca agatgaagac atggatgtca aatactttgc
     1801 acaggaagct ataagtgttc ttgcattggc ataatgagga gcaggaggga aaaggccttt
     1861 actagattct tgtcacaaat ttctagtcaa tgtgttctta actgggtgga gaaagaatgg
     1921 aaaaccttca agatctcatc caagcaaatg gcaacaactt agaagaaatc atttagtgac
     1981 ttaattcttt ctaaagatga aatgggattg ttttttactc gtcttccttg ttaaatcatt
     2041 atttaagccg ttcttattga ccaattcctg acacttgatt gtctcctaat gctttatcca
     2101 tcaccacctg ggctcctgca tcctcactgt ggaatcaggc accagccaca taatgttcca
     2161 gacaaagcct ggaagggtgt ggacccagac gtggagtgga gtgattctct tgacgtttac
     2221 atatatctct gtgtctctcc atcattccaa agctaaatgt acatgtttag aataacttat
     2281 tttataaact cttcgggaga catgttgaga tttgaccgta atgaaagcca cattttcctg
     2341 aattatgatg gtctgcatta gtctcatgtg aaaggggaat gtggaagctc agggttaatg
     2401 tagtggttgt tttggttttt atttgctcaa ttttgtctgt actcatgtca ttcagaaacc
     2461 tgaagtgtgg ctgcatcttg ctgctaatgt gtgatgttga cgcctaactg aatttgaaca
     2521 gctcaccact gtgcctacat ttaaaaatac ttctctctct tttctaaaaa gctttaactg
     2581 tagtgcctcc taataagcag tatgtttgtt tcattgtgag attgcagttc tgtatttcga
     2641 atgagtctaa gaaccacagg gataatactg tgcagatttc ctgttcttta cctggctctg
     2701 cttccagcag tattgacacc tagtccttgc tgcattgtac agtagctttt caaactgcag
     2761 ttttattgct aagtttttag tatgggtgat actggagtct tatcatttga agtgtttgct
     2821 tttctacttt tacagtaaaa cctcattaat tctgaaattt aagataatga gttaagctga
     2881 agagtttact gaagcaaatt aatagtgagg aagcctattt gaactactta aacagtatta
     2941 aagccctttt taaaaagcac ctatttggga tcatttgagg tcaagaattc gagatcagcc
     3001 tgaccaacat ggtgaaaccc catctctact aaaaatacaa aaaagttagc tgggcgtggt
     3061 ggcacacacc tgtagtccca gctactcagg aggctgaggc aggagaattg cttgaacctg
     3121 ggaggtagag gttgcactga gccgagatcg cgccactgca ctctagcctg ggccatagag
     3181 cgagagtcca tctcaaaaaa aaacaactat ttttcacata atcaaactca ccttgtctca
     3241 tgacttttgg ttaagggggt tttcccatag tttatttttc tctcagtgca tcttgctatg
     3301 aggtttgctt gttacccttt tggtttttga attgttgatt ttgttcacaa cctcttttaa
     3361 atctaacaag tcctgttctg tttagtgaag gcccaaagac tcctctaaga ctttgtatat
     3421 ttgttacata aaaccaagtt ttactaaata ctttaaaatt tgtcctacat tcgaaaaata
     3481 gaaattgtaa atcagaggtt atctgtctgc attttaaact gccaaattac cttatagtaa
     3541 gtttctattt tatgactttg ggccaagaat taagtatttt cctaagcaca aatctttttc
     3601 tatattctca ttttaatatc ttatgctatt attctgtaaa cattttaatt ttagtttcat
     3661 gagtctttat tttttgttac ctgcaagtta tgttcttctt cattgaattt catatttgag
     3721 agacatttgt cttcatgaag cagatttgca ctggaaccat tgctttactc tggttggaaa
     3781 tgccattgtt ttggggacag acttttaaaa tgcccttgtg tctcccagtg aggagcccta
     3841 agcattgact tctctaccct aaaactgttt gagagaggga gagtgggccc tggctttctc
     3901 aagcatgggt cgggggttca gcggggcctc tgtcttttgt ggtgacccct caggggtttc
     3961 attgtttcct tctgacttaa gcaatagaga gagaatttgt tttggtactc ttcagaggaa
     4021 ttgtgctttg gctcataact tggccatgtt ctccatgaat tagttctcct attttttttt
     4081 ttaactacct taaacttaag ggaaaagttc tcctatcttg atttcactgg aatataggct
     4141 ttaggagctc tgtaaggctg gtatttttgt ctgttttatc ttctactgta tcgccagtgc
     4201 ctggaacagt gtctggtgca cataataggt gctcaataaa aatgtgttca atggatgaat
     4261 ttctaaaata tcctccaatg tgtgcatgga acaaataatc aaaagaacca gactgtgtct
     4321 tattctccca ctgacagaaa gattttcctg ctttcaggaa acaagcttta tgtggccctt
     4381 ttctggtccc ctggcttaga ctacagttct gtgtggattt gtctgattgc ttcagacatg
     4441 taatgttgtt tttcatcctt ggcagcttac atcagttgtt tgtttgatta gaaaaatgaa
     4501 gcagacacac acacacacac acacacacac acacacacac acacacaaac atataaccta
     4561 tgccaataaa aatgtctcag caacagtgga attcaccttg gtgtttctct ctgtaatttg
     4621 tgtggggttt acccctcaca ggtttaagag accaggtctt gtttctctct ctgtgctacc
     4681 aagaagatgt gaacctgagg atgcatcttg tttcataaga aggaaggcag gtgaatatgt
     4741 ggtttctaac gaggtcttgt tgaaataacg ggctgccctc agctcacaga aataccacag
     4801 ctcagccact gtgatgcaga gccccagggg tctttgccag acaacttgtc ctgactcaac
     4861 agagacggca gcctgacctt tgagctggct tgtccaggca ttcaggttgc ttgcgtagac
     4921 ttccagggaa gcaagcctgt ccttcctgac ccggcggtta acctggtgca cttttgttcc
     4981 tttgttaact gttgtgttgt cactaaactg aaaggctggg gcttgccctt agacgtcaca
     5041 ttggctctgt ccctgtggcg atggcagggc agggtggcca aacaggtcag gtgcttgttc
     5101 tgtcctcttg ccttttactt aaattcctct gacttttaaa aatggtgaca ctcttatcgt
     5161 aaagcttctt atttttctcc actgcttgga tatgaaactg tagagggaga ggccctgttg
     5221 cccagtgttc tcctggttta gcagctgagg tgactgcagt ctgatgtgat gtaactgttt
     5281 ccctttgatt ctccagtatt cctgtttcca tccagttcct tactctcctc tttcctcttc
     5341 cctcgcatgt ctccctccag tcctctgtac ctagaatagt ctcactgtcc cccgtttgcc
     5401 tccacgagcc tgctgtttcc aggaaattac ataacgttca gttgggatgg aaatcttccg
     5461 gaggacgaat agagtttaat tactcattgc gtcggaaagc caagccattt ctgtctccag
     5521 agttgttctc ttaaactgat atgagttctg aaa
//
