LOCUS       NM_014225               5352 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens protein phosphatase 2 scaffold subunit Aalpha
            (PPP2R1A), transcript variant 1, mRNA.
ACCESSION   NM_014225
VERSION     NM_014225.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5352)
  AUTHORS   Remmerie,M., Dok,R., Wang,Z., Omella,J.D., Alen,S., Cokelaere,C.,
            Lenaerts,L., Dreesen,E., Nuyts,S., Derua,R. and Janssens,V.
  TITLE     The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine
            resistance in uterine serous carcinoma cells by a gain-of-function
            mechanism
  JOURNAL   Cell Oncol (Dordr) 47 (5), 1811-1829 (2024)
   PUBMED   38888850
  REMARK    GeneRIF: The PPP2R1A cancer hotspot mutant p.R183W increases
            clofarabine resistance in uterine serous carcinoma cells by a
            gain-of-function mechanism.
REFERENCE   2  (bases 1 to 5352)
  AUTHORS   Kang,Q., Ma,D., Zhao,P., Chai,X., Huang,Y., Gao,R., Zhang,T.,
            Liu,P., Deng,B., Feng,C., Zhang,Y., Lu,Y., Li,Y., Fang,Q. and
            Wang,J.
  TITLE     BRG1 promotes progression of B-cell acute lymphoblastic leukemia by
            disrupting PPP2R1A transcription
  JOURNAL   Cell Death Dis 15 (8), 621 (2024)
   PUBMED   39187513
  REMARK    GeneRIF: BRG1 promotes progression of B-cell acute lymphoblastic
            leukemia by disrupting PPP2R1A transcription.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5352)
  AUTHORS   Qian,Y., Jiang,Y., Wang,J., Li,G., Wu,B., Zhou,Y., Xu,X. and
            Wang,H.
  TITLE     Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and
            Genotype-Phenotype Analysis in Neurodevelopmentally Delayed
            Patients
  JOURNAL   Genes (Basel) 14 (9), 1750 (2023)
   PUBMED   37761890
  REMARK    GeneRIF: Novel Variants of PPP2R1A in Catalytic Subunit Binding
            Domain and Genotype-Phenotype Analysis in Neurodevelopmentally
            Delayed Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5352)
  AUTHORS   Baker,E.K., Solivio,B., Pode-Shakked,B., Cross,L.A., Sullivan,B.,
            Raas-Rothschild,A., Chorin,O., Barel,O., Bar-Yosef,O., Husami,A.,
            Hopkin,R.J., Prada,C.E., Stottmann,R.W. and Weaver,K.N.
  TITLE     PPP2R1A neurodevelopmental disorder is associated with congenital
            heart defects
  JOURNAL   Am J Med Genet A 188 (11), 3262-3277 (2022)
   PUBMED   36209351
  REMARK    GeneRIF: PPP2R1A neurodevelopmental disorder is associated with
            congenital heart defects.
REFERENCE   5  (bases 1 to 5352)
  AUTHORS   Hu,W., Wang,Z., Zhang,H., Mahaman,Y.A.R., Huang,F., Meng,D.,
            Zhou,Y., Wang,S., Jiang,N., Xiong,J., Westermarck,J., Lu,Y.,
            Wang,J., Wang,X., Shentu,Y. and Liu,R.
  TITLE     Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and
            Cognitive Dysfunction Through CIP2A/PP2A Signaling
  JOURNAL   Neurotherapeutics 19 (2), 570-591 (2022)
   PUBMED   35286657
  REMARK    GeneRIF: Chk1 Inhibition Ameliorates Alzheimer's Disease
            Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A
            Signaling.
REFERENCE   6  (bases 1 to 5352)
  AUTHORS   McCright,B. and Virshup,D.M.
  TITLE     Identification of a new family of protein phosphatase 2A regulatory
            subunits
  JOURNAL   J Biol Chem 270 (44), 26123-26128 (1995)
   PUBMED   7592815
REFERENCE   7  (bases 1 to 5352)
  AUTHORS   Douzgou,S., Janssens,V. and Houge,G.
  TITLE     PPP2R1A-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   35593790
REFERENCE   8  (bases 1 to 5352)
  AUTHORS   Hemmings,B.A., Adams-Pearson,C., Maurer,F., Muller,P., Goris,J.,
            Merlevede,W., Hofsteenge,J. and Stone,S.R.
  TITLE     alpha- and beta-forms of the 65-kDa subunit of protein phosphatase
            2A have a similar 39 amino acid repeating structure
  JOURNAL   Biochemistry 29 (13), 3166-3173 (1990)
   PUBMED   2159327
REFERENCE   9  (bases 1 to 5352)
  AUTHORS   Walter,G., Ruediger,R., Slaughter,C. and Mumby,M.
  TITLE     Association of protein phosphatase 2A with polyoma virus medium
            tumor antigen
  JOURNAL   Proc Natl Acad Sci U S A 87 (7), 2521-2525 (1990)
   PUBMED   2157202
REFERENCE   10 (bases 1 to 5352)
  AUTHORS   Walter,G., Ferre,F., Espiritu,O. and Carbone-Wiley,A.
  TITLE     Molecular cloning and sequence of cDNA encoding polyoma medium
            tumor antigen-associated 61-kDa protein
  JOURNAL   Proc Natl Acad Sci U S A 86 (22), 8669-8672 (1989)
   PUBMED   2554323
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC026733.1, CA426613.1 and
            AC010320.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014225.5.
            
            Summary: This gene encodes a constant regulatory subunit of protein
            phosphatase 2. Protein phosphatase 2 is one of the four major
            Ser/Thr phosphatases, and it is implicated in the negative control
            of cell growth and division. It consists of a common heteromeric
            core enzyme, which is composed of a catalytic subunit and a
            constant regulatory subunit, that associates with a variety of
            regulatory subunits. The constant regulatory subunit A serves as a
            scaffolding molecule to coordinate the assembly of the catalytic
            subunit and a variable regulatory B subunit. This gene encodes an
            alpha isoform of the constant regulatory subunit A. Alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.57023.1,
                                           SRR1803611.188780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322088.11/ ENSP00000324804.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2252              BC026733.1         14-2265
            2253-2259           CA426613.1         19-25               c
            2260-5352           AC010320.10        69853-72945
FEATURES             Location/Qualifiers
     source          1..5352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..5352
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /note="protein phosphatase 2 scaffold subunit Aalpha"
                     /db_xref="GeneID:5518"
                     /db_xref="HGNC:HGNC:9302"
                     /db_xref="MIM:605983"
     exon            1..123
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1815
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     medium tumor antigen-associated 61 KDA protein; protein
                     phosphatase 2, regulatory subunit A, alpha; testicular
                     secretory protein Li 1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A alpha isoform isoform 1"
                     /protein_id="NP_055040.2"
                     /db_xref="CCDS:CCDS12849.1"
                     /db_xref="GeneID:5518"
                     /db_xref="HGNC:HGNC:9302"
                     /db_xref="MIM:605983"
                     /translation="MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGV
                     ERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEET
                     VVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSS
                     AVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQD
                     SVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGP
                     EITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELV
                     SDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVN
                     EVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAW
                     LVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVL
                     SEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEK
                     LTQDQDVDVKYFAQEALTVLSLA"
     exon            124..214
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            215..315
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            316..548
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            549..696
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            697..852
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            853..967
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1038
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1173
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1347
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1408
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1563
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1706
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1798
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..5352
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2235..2240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /note="hexamer: AATAAA"
     polyA_site      2252
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /note="major polyA site"
     regulatory      3250..3255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /note="hexamer: ATTAAA"
     polyA_site      3268
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
     regulatory      5322..5327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
                     /note="hexamer: AATAAA"
     polyA_site      5352
                     /gene="PPP2R1A"
                     /gene_synonym="HJS2; MRD36; PP2A-Aalpha; PP2AA;
                     PP2AAALPHA; PR65A"
ORIGIN      
        1 agcacagcgc tggccgcagt ctgacaggaa agggacggag ccaagatggc ggcggccgac
       61 ggcgacgact cgctgtaccc catcgcggtg ctcatagacg aactccgcaa tgaggacgtt
      121 cagcttcgcc tcaacagcat caagaagctg tccaccatcg ccttggccct tggggttgaa
      181 aggacccgaa gtgagcttct gcctttcctt acagatacca tctatgatga agatgaggtc
      241 ctcctggccc tggcagaaca gctgggaacc ttcactaccc tggtgggagg cccagagtac
      301 gtgcactgcc tgctgccacc gctggagtcg ctggccacag tggaggagac agtggtgcgg
      361 gacaaggcag tggagtcctt acgggccatc tcacacgagc actcgccctc tgacctggag
      421 gcgcactttg tgccgctagt gaagcggctg gcgggcggcg actggttcac ctcccgcacc
      481 tcggcctgcg gcctcttctc cgtctgctac ccccgagtgt ccagtgctgt gaaggcggaa
      541 cttcgacagt acttccggaa cctgtgctca gatgacaccc ccatggtgcg gcgggccgca
      601 gcctccaagc tgggggagtt tgccaaggtg ctggagctgg acaacgtcaa gagtgagatc
      661 atccccatgt tctccaacct ggcctctgac gagcaggact cggtgcggct gctggcggtg
      721 gaggcgtgcg tgaacatcgc ccagcttctg ccccaggagg atctggaggc cctggtgatg
      781 cccactctgc gccaggccgc tgaagacaag tcctggcgcg tccgctacat ggtggctgac
      841 aagttcacag agctccagaa agcagtgggg cctgagatca ccaagacaga cctggtccct
      901 gccttccaga acctgatgaa agactgtgag gccgaggtga gggccgcagc ctcccacaag
      961 gtcaaagagt tctgtgaaaa cctctcagct gactgtcggg agaatgtgat catgtcccag
     1021 atcttgccct gcatcaagga gctggtgtcc gatgccaacc aacatgtcaa gtctgccctg
     1081 gcctcagtca tcatgggtct ctctcccatc ttgggcaaag acaacaccat cgagcacctc
     1141 ttgcccctct tcctggctca gctgaaggat gagtgccctg aggtacggct gaacatcatc
     1201 tctaacctgg actgtgtgaa cgaggtgatt ggcatccggc agctgtccca gtccctgctc
     1261 cctgccattg tggagctggc tgaggacgcc aagtggcggg tgcggctggc catcattgag
     1321 tacatgcccc tcctggctgg acagctggga gtggagttct ttgatgagaa acttaactcc
     1381 ttgtgcatgg cctggcttgt ggatcatgta tatgccatcc gcgaggcagc caccagcaac
     1441 ctgaagaagc tagtggaaaa gtttgggaag gagtgggccc atgccacaat catccccaag
     1501 gtcttggcca tgtccggaga ccccaactac ctgcaccgca tgactacgct cttctgcatc
     1561 aatgtgctgt ctgaggtctg tgggcaggac atcaccacca agcacatgct acccacggtt
     1621 ctgcgcatgg ctggggaccc ggttgccaat gtccgcttca atgtggccaa gtctctgcag
     1681 aagatagggc ccatcctgga caacagcacc ttgcagagtg aagtcaagcc catcctagag
     1741 aagctgaccc aggaccagga tgtggacgtc aaatactttg cccaggaggc tctgactgtt
     1801 ctgtctctcg cctgatgctg gaagaggagc aaacactggc ctctggtgtc caccctccaa
     1861 cccccacaag tccctctttg gggagacact ggggggcctt tggctgtcac tccctgtgca
     1921 tggtctgacc ccaggcccct tcccccagca cggttcctcc tctccccagc ctgggaagat
     1981 gtctcactgt ccacctccca acgggctagg ggagcacggg gttggacagg acagtgacct
     2041 tgggaggaag gggctactcc gcccacgtca gggagagatg tgagcatccc gggtcactgg
     2101 atcctgctgc tgtaatggga acccctcccc catttacttc tccacctccc gtcctcccca
     2161 tcattggttt ttttttgtgt gtcaactgtg ccgtttttat tttattcctt ttattttccc
     2221 ccttttcaca gagaaataaa ggtctagaag tagttggtcc tctggcctta gtcatcagct
     2281 tggaggaggg ggcaccaccc cagagccaca acatctgcgc ttttctctgg agaagatctt
     2341 gttacaggac ccattatacc cctatgtccc gaaagaatac tctggggatc cccccaggag
     2401 tgctgctggc ctttggggta gagggtccat gaggtgctct gggtggtgtc ctgtagtgca
     2461 gttcagattc atagatgtcg gccgagtatt tggggggtta agagcaggtg ccttggaacc
     2521 agactgcctg ggtccaaatt gtggctcctt cagttaatag acgtgtgact aggagtagct
     2581 tgttaagtct ttatgagctc agttttgtat tgtgtaaaat gagagttaca gtaataccta
     2641 gattgcaggg tgggtggcga ggaccaagtg aattagtacc tggaaagtgt gtaacagttt
     2701 caacatgaga agtacacaac atgagaagca gagttagctg tacattgcca gagaaccccc
     2761 tgtgggccat ttcctgtgtt cttgaagaag acttgggctt ggaccctgtc cccaggaggt
     2821 ctcagagtaa tcaggacggt actagggaga gaactgtggc aagatagatc agttatctcg
     2881 gtatctattc tccccttcct aatgtagaag ctctgatttt taactgggca gatgactaca
     2941 tggattcaag gtattttcct agtgtctctt gaaattaggt gtggtattgt gaccaaattc
     3001 tagccaaaaa gatgttgaac agaagtggta tatgcagctt ctaggaagtg ttcttaaggg
     3061 ggaaggcgtc atcccccacc tttcctcctt cctgcactct ggaatgtgga ccagatggct
     3121 ggagtaggag ctgccacctg gggccagaaa atgatcttag gcgtgaaggt caagtaaggc
     3181 aggacaagag agaaggagcc tgcctccccg aggctgtgaa gagccatgcc agtactgtca
     3241 cctgggagaa ttaaactggt caagtgcctg ttcgtttagg gtttcatcac ttgaaggtga
     3301 ccggaattct aactgatgga gggaggggcc cagagcaccc tggagaaagg agcaagggac
     3361 gtatggctgg tggtgtctgc atggaagggt ttcacagagg aaatgatgct tgagcacatt
     3421 ttgacccagg tggtggaagg gaaatgtggc tttgagtgac aaggtgattt caccagctca
     3481 gccttcatat taccacatcc ctaccctttg ttagacttta ttgtgcccta ggggatgagg
     3541 ctgaaggaga ccaaaaagca tctttagaaa tttccattta tgccctgggc gataaactct
     3601 ctcccagttg agaactactg ctctagaaat gtgaacacac gtgtaaccaa acgtcaaagt
     3661 ctgacattaa actttgactt tccccatggt taacgctgct ggtccattgt aacaagagtg
     3721 cagtggacca gcagcctttg cattctcagg agcttgttag aaatgcagag cctctcgtcc
     3781 ctgccccgac ctgctcaggc agagccttca ttttaacaag atgcccaggt tcatctgcac
     3841 actgaagtta gagaagtcct gccttaaata ctaacccagt ttttctctct tgagagtgag
     3901 gttaatgcta cgtgggtcta gggctgagga tgtgctatgg ctcagaggtg gggtctacaa
     3961 ttggacatgt gtatgtagac aaggctcagg gatatgttga ggctgctaga ttgggcaagt
     4021 gatggaatgg gattattaca ggaggtggag gtgcgatgga tacccaggat gtgctgggta
     4081 atgaggtgat actcagcgac cacaggagtg agtatgagag acgagggtga aggatagctt
     4141 gagttattga acgctggcag agtcctgagt taaccaggag ttgcctggtg tcttgggtca
     4201 tgtgctctag aagcagagcc cgagtggaga ctcgttcaag tgtgttactg agggagtgct
     4261 ctcaggagaa cggactgagg taactcacct tctgtgagct tcatgttgga agaatccaat
     4321 caggtgatga atgtgatgtt attaagtcca ttgttaggag tggttcctaa tctcccaggc
     4381 tgcaggcttt gtttgctcca tacacctggc cttctctgta gcagctgaag tttgatgctg
     4441 gagctgggtc agggtggaga gactgtgtgg agccaggact catgaccctg gcctgtttct
     4501 cccgctctct aggcctaaat cccagcagtc acactggcca tctctaatgg ttccttccac
     4561 agcactgttc ttcagagccc acacacaaat tttgtctcct tttgtgatga ctgcacttct
     4621 ttggctgttt ttgccaacag cctcttcact gaccccttcc ttccactgca ttgacccaga
     4681 catctggatg tggatgaggt cgagtcactt gttgcctttg gctaatgcat aggggcacga
     4741 gtagagctct agaatcacca tgcccttgac tcagggtgca gaatctgcct atggtgcttg
     4801 agctgtggtt gtcgctagag gagaattacc atggctcccc cgggcagatg aagatgacga
     4861 ggtggtgcct cagccccgag gagtgaactg cagggcaccg acaagattct gcctgtggcc
     4921 atcagggctg gagggaagga ggccaggttc atctacccaa gctggtggca tgaggcataa
     4981 atttaaaaaa attggtgtgg gcacagtggc tcgcacctgt aatcccagcg ctttgggagg
     5041 ccgaggtggg cggatcacct gaggccggga gttcgagacc atcctgacca attcagtgaa
     5101 accctgtctt tactaaaaat atgaaaaaat tagctgggcg tggtggaggg cgcctgtaat
     5161 cccagctact caggaggctg aggcgggagg attgcttgaa cctgggaggc agaggttgca
     5221 gtgagcctag attgggccat tgcactccag ccagggtgac agagcaagac cccatatgaa
     5281 aaaaaataat aattcaggaa cttgtcaaaa agagaaaatc caataaagat ttagtgccag
     5341 gccttgactc ca
//
