LOCUS       NM_001009552            1946 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 2 catalytic subunit beta (PPP2CB),
            mRNA.
ACCESSION   NM_001009552
VERSION     NM_001009552.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Jun,G.R., You,Y., Zhu,C., Meng,G., Chung,J., Panitch,R., Hu,J.,
            Xia,W., Bennett,D.A., Foroud,T.M., Wang,L.S., Haines,J.L.,
            Mayeux,R., Pericak-Vance,M.A., Schellenberg,G.D., Au,R.,
            Lunetta,K.L., Ikezu,T., Stein,T.D. and Farrer,L.A.
  CONSRTM   Alzheimer's Disease Genetics Consortium
  TITLE     Protein phosphatase 2A and complement component 4 are linked to the
            protective effect of APOE varepsilon2 for Alzheimer's disease
  JOURNAL   Alzheimers Dement 18 (11), 2042-2054 (2022)
   PUBMED   35142023
  REMARK    GeneRIF: Protein phosphatase 2A and complement component 4 are
            linked to the protective effect of APOE varepsilon2 for Alzheimer's
            disease.
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Sergienko,N.M., Donner,D.G., Delbridge,L.M.D., McMullen,J.R. and
            Weeks,K.L.
  TITLE     Protein phosphatase 2A in the healthy and failing heart: New
            insights and therapeutic opportunities
  JOURNAL   Cell Signal 91, 110213 (2022)
   PUBMED   34902541
  REMARK    GeneRIF: Protein phosphatase 2A in the healthy and failing heart:
            New insights and therapeutic opportunities.
            Review article
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   Goedert,M., Cohen,E.S., Jakes,R. and Cohen,P.
  TITLE     p42 MAP kinase phosphorylation sites in microtubule-associated
            protein tau are dephosphorylated by protein phosphatase 2A1.
            Implications for Alzheimer's disease [corrected]
  JOURNAL   FEBS Lett 312 (1), 95-99 (1992)
   PUBMED   1330687
  REMARK    Erratum:[FEBS Lett 1992 Nov 23;313(2):203]
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Khew-Goodall,Y., Mayer,R.E., Maurer,F., Stone,S.R. and
            Hemmings,B.A.
  TITLE     Structure and transcriptional regulation of protein phosphatase 2A
            catalytic subunit genes
  JOURNAL   Biochemistry 30 (1), 89-97 (1991)
   PUBMED   1846293
  REMARK    Erratum:[Biochemistry 1991 May 28;30(21):5328]
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Pallas,D.C., Shahrik,L.K., Martin,B.L., Jaspers,S., Miller,T.B.,
            Brautigan,D.L. and Roberts,T.M.
  TITLE     Polyoma small and middle T antigens and SV40 small t antigen form
            stable complexes with protein phosphatase 2A
  JOURNAL   Cell 60 (1), 167-176 (1990)
   PUBMED   2153055
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Virshup,D.M., Kauffman,M.G. and Kelly,T.J.
  TITLE     Activation of SV40 DNA replication in vitro by cellular protein
            phosphatase 2A
  JOURNAL   EMBO J 8 (12), 3891-3898 (1989)
   PUBMED   2555176
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Arino,J., Woon,C.W., Brautigan,D.L., Miller,T.B. Jr. and
            Johnson,G.L.
  TITLE     Human liver phosphatase 2A: cDNA and amino acid sequence of two
            catalytic subunit isotypes
  JOURNAL   Proc Natl Acad Sci U S A 85 (12), 4252-4256 (1988)
   PUBMED   2837763
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG716837.1, CF594136.1,
            AC009314.4, BC012022.1 and CA419001.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001009552.1.
            
            Summary: This gene encodes the phosphatase 2A catalytic subunit.
            Protein phosphatase 2A is one of the four major Ser/Thr
            phosphatases, and it is implicated in the negative control of cell
            growth and division. It consists of a common heteromeric core
            enzyme, which is composed of a catalytic subunit and a constant
            regulatory subunit, that associates with a variety of regulatory
            subunits. This gene encodes a beta isoform of the catalytic
            subunit. [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012022.1, X12656.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221138.9/ ENSP00000221138.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               BG716837.1         56-374
            320-321             CF594136.1         365-366
            322-347             BG716837.1         377-402
            348-499             AC009314.4         26814-26965
            500-709             AC009314.4         39530-39739
            710-883             AC009314.4         41531-41704
            884-973             AC009314.4         45004-45093
            974-1135            AC009314.4         45207-45368
            1136-1254           AC009314.4         47970-48088
            1255-1911           AC009314.4         52978-53634
            1912-1941           BC012022.1         1546-1575
            1942-1946           CA419001.1         24-28               c
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..1946
                     /gene="PPP2CB"
                     /gene_synonym="PP2Abeta; PP2CB"
                     /note="protein phosphatase 2 catalytic subunit beta"
                     /db_xref="GeneID:5516"
                     /db_xref="HGNC:HGNC:9300"
                     /db_xref="MIM:176916"
     exon            1..499
                     /gene="PPP2CB"
                     /gene_synonym="PP2Abeta; PP2CB"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..1327
                     /gene="PPP2CB"
                     /gene_synonym="PP2Abeta; PP2CB"
                     /EC_number="3.1.3.16"
                     /note="PP2A-beta; protein phosphatase type 2A catalytic
                     subunit; protein phosphatase 2, catalytic subunit, beta
                     isozyme; testicular tissue protein Li 146"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     catalytic subunit beta isoform"
                     /protein_id="NP_001009552.1"
                     /db_xref="CCDS:CCDS6079.1"
                     /db_xref="GeneID:5516"
                     /db_xref="HGNC:HGNC:9300"
                     /db_xref="MIM:176916"
                     /translation="MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESN
                     VQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVA
                     LKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVD
                     GQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGY
                     TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIM
                     ELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL"
     exon            500..709
                     /gene="PPP2CB"
                     /gene_synonym="PP2Abeta; PP2CB"
                     /inference="alignment:Splign:2.1.0"
     exon            710..883
                     /gene="PPP2CB"
                     /gene_synonym="PP2Abeta; PP2CB"
                     /inference="alignment:Splign:2.1.0"
     exon            884..973
                     /gene="PPP2CB"
                     /gene_synonym="PP2Abeta; PP2CB"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1135
                     /gene="PPP2CB"
                     /gene_synonym="PP2Abeta; PP2CB"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1254
                     /gene="PPP2CB"
                     /gene_synonym="PP2Abeta; PP2CB"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1946
                     /gene="PPP2CB"
                     /gene_synonym="PP2Abeta; PP2CB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2CB"
                     /gene_synonym="PP2Abeta; PP2CB"
                     /note="hexamer: AATAAA"
     polyA_site      1946
                     /gene="PPP2CB"
                     /gene_synonym="PP2Abeta; PP2CB"
                     /note="major polyA site"
ORIGIN      
        1 gagagaaggg gaaagacaag tcgggagagg ccggtaggcg tgaggcgggc ctgaagcggc
       61 agcgggcggc cttcgtccgg cgagagctag gccgaggacc cgcgccgcgc tccccggcac
      121 ctcaccgcgt ccttcaccga ctcccgcggc gcgcggccgg gcggggaagg gcgggcgggg
      181 gtctcctcca ggctgcgcgc tcggagccgc ctgctgggct tgggcggggc gcggggcccg
      241 cggccgccct acccggctca gtcctccccc tgtgggacct ggcgacggcg gcggagggag
      301 aggggagcgg cgcccgggcc ggggccgggg gcgggtgggg aggggggagg gcggcggccg
      361 ggctggggct cgggatccgc atcgggatcg ggccgccatg gacgacaagg cgttcaccaa
      421 ggagctggac cagtgggtcg agcagctgaa cgagtgtaag cagctgaacg agaaccaagt
      481 gcggacgctg tgcgagaagg caaaggaaat tttaacaaaa gaatcaaatg tgcaagaggt
      541 tcgttgccct gttactgtct gtggagatgt gcatggtcaa tttcatgatc ttatggaact
      601 ctttagaatt ggtggaaaat caccggatac aaactactta ttcatgggtg actatgtaga
      661 cagaggatat tattcagtgg agactgtgac tcttcttgta gcattaaagg tgcgttatcc
      721 agaacgcatt acaatattga gaggaaatca cgaaagccga caaattaccc aagtatatgg
      781 cttttatgat gaatgtctgc gaaagtatgg gaatgccaac gtttggaaat attttacaga
      841 tctctttgat tatcttccac ttacagcttt agtagatgga cagatattct gcctccatgg
      901 tggcctctct ccatccatag acacactgga tcatataaga gccctggatc gtttacagga
      961 agttccacat gagggcccaa tgtgtgatct gttatggtca gatccagatg atcgtggtgg
     1021 atggggtatt tcaccacgtg gtgctggcta cacatttgga caagacattt ctgaaacctt
     1081 taaccatgcc aatggtctca cactggtttc tcgtgcccac cagcttgtaa tggagggata
     1141 caattggtgt catgatcgga atgtggttac cattttcagt gcacccaatt actgttatcg
     1201 ttgtgggaac caggctgcta tcatggaatt agatgacact ttaaaatatt ccttccttca
     1261 atttgaccca gcgcctcgtc gtggtgagcc tcatgttaca cggcgcaccc cagactactt
     1321 cctataaatt tctcctggga aacctgcctt tgtatgtgga agtatacctg gctttttaaa
     1381 atatatgtat ttaaaaacaa aaagcaacag taatctatgt gtttctgtaa caaattggga
     1441 tctgtcttgg cattaaacca catcatggac caaatgtgcc atactaatga tgagcattta
     1501 gcacaatttg agactgaaat ttagtacact atgttctagg tcagtctaac agtttgcctg
     1561 ctgtatttat agtaaccatt ttcctttgga ctgttcaagc aaaaaaggta actaactgct
     1621 tcatctcctt ttgcgcttat ttggaaattt tagttatagt gtttaactgg catggattaa
     1681 tagagttgga gttttatttt taagaaaaat tcacaagcta acttccacta atccattatc
     1741 ctttatttta ttgaaatgta taattaactt aactgaagaa aaggttcttc ttgggagtat
     1801 gttgtcataa catttaaaga gatttccctt catttaaact aaattactgt tttatgttga
     1861 tctgcatatt tctgtatatt tgtcatgaca gtgcttgcat cctatttggt gtactcagca
     1921 aataaacttt tcattttaaa caaaaa
//
