LOCUS       NM_002715               4582 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens protein phosphatase 2 catalytic subunit alpha
            (PPP2CA), transcript variant 1, mRNA.
ACCESSION   NM_002715
VERSION     NM_002715.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4582)
  AUTHORS   Mao,H., Ye,R., Tang,G., Tao,S., Wei,K., Wu,Y., Pang,S., Wang,J.,
            Shi,J., Ji,Y., Xiao,Y., Geng,C., Wang,W., Chen,C. and Yang,Q.
  TITLE     Drug-resistant exosome miR-99b-3p induces macrophage polarization
            and confers chemoresistance on sensitive cells by targeting PPP2CA
  JOURNAL   Int Immunopharmacol 142 (Pt B), 113168 (2024)
   PUBMED   39298813
  REMARK    GeneRIF: Drug-resistant exosome miR-99b-3p induces macrophage
            polarization and confers chemoresistance on sensitive cells by
            targeting PPP2CA.
REFERENCE   2  (bases 1 to 4582)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   3  (bases 1 to 4582)
  AUTHORS   Liang,X., Zhang,H., Shang,W., Wang,M., Li,J., Zhao,Y. and Fang,C.
  TITLE     PPP2CA Inhibition Promotes Ferroptosis Sensitivity Through
            AMPK/SCD1 Pathway in Colorectal Cancer
  JOURNAL   Dig Dis Sci 69 (6), 2083-2095 (2024)
   PUBMED   38637456
  REMARK    GeneRIF: PPP2CA Inhibition Promotes Ferroptosis Sensitivity Through
            AMPK/SCD1 Pathway in Colorectal Cancer.
REFERENCE   4  (bases 1 to 4582)
  AUTHORS   Qian,Y., Jiang,Y., Wang,J., Li,G., Wu,B., Zhou,Y., Xu,X. and
            Wang,H.
  TITLE     Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and
            Genotype-Phenotype Analysis in Neurodevelopmentally Delayed
            Patients
  JOURNAL   Genes (Basel) 14 (9), 1750 (2023)
   PUBMED   37761890
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4582)
  AUTHORS   Mondal,I., Das,O., Sun,R., Gao,J., Yu,B., Diaz,A., Behnan,J.,
            Dubey,A., Meng,Z., Eskandar,E., Xu,B., Lu,R.O. and Ho,W.S.
  TITLE     PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating
            STING-Type I Interferon Signaling in Glioblastoma
  JOURNAL   Cancer Res 83 (15), 2527-2542 (2023)
   PUBMED   37219874
  REMARK    GeneRIF: PP2Ac Deficiency Enhances Tumor Immunogenicity by
            Activating STING-Type I Interferon Signaling in Glioblastoma.
REFERENCE   6  (bases 1 to 4582)
  AUTHORS   Goedert,M., Cohen,E.S., Jakes,R. and Cohen,P.
  TITLE     p42 MAP kinase phosphorylation sites in microtubule-associated
            protein tau are dephosphorylated by protein phosphatase 2A1.
            Implications for Alzheimer's disease [corrected]
  JOURNAL   FEBS Lett 312 (1), 95-99 (1992)
   PUBMED   1330687
  REMARK    Erratum:[FEBS Lett 1992 Nov 23;313(2):203]
REFERENCE   7  (bases 1 to 4582)
  AUTHORS   Ruediger,R., Roeckel,D., Fait,J., Bergqvist,A., Magnusson,G. and
            Walter,G.
  TITLE     Identification of binding sites on the regulatory A subunit of
            protein phosphatase 2A for the catalytic C subunit and for tumor
            antigens of simian virus 40 and polyomavirus
  JOURNAL   Mol Cell Biol 12 (11), 4872-4882 (1992)
   PUBMED   1328865
REFERENCE   8  (bases 1 to 4582)
  AUTHORS   Kamibayashi,C., Lickteig,R.L., Estes,R., Walter,G. and Mumby,M.C.
  TITLE     Expression of the A subunit of protein phosphatase 2A and
            characterization of its interactions with the catalytic and
            regulatory subunits
  JOURNAL   J Biol Chem 267 (30), 21864-21872 (1992)
   PUBMED   1328247
REFERENCE   9  (bases 1 to 4582)
  AUTHORS   Scheidtmann,K.H., Virshup,D.M. and Kelly,T.J.
  TITLE     Protein phosphatase 2A dephosphorylates simian virus 40 large T
            antigen specifically at residues involved in regulation of
            DNA-binding activity
  JOURNAL   J Virol 65 (4), 2098-2101 (1991)
   PUBMED   1848320
REFERENCE   10 (bases 1 to 4582)
  AUTHORS   Khew-Goodall,Y., Mayer,R.E., Maurer,F., Stone,S.R. and
            Hemmings,B.A.
  TITLE     Structure and transcriptional regulation of protein phosphatase 2A
            catalytic subunit genes
  JOURNAL   Biochemistry 30 (1), 89-97 (1991)
   PUBMED   1846293
  REMARK    Erratum:[Biochemistry 1991 May 28;30(21):5328]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104109.3 and AK097599.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002715.3.
            
            Summary: This gene encodes the phosphatase 2A catalytic subunit.
            Protein phosphatase 2A is one of the four major Ser/Thr
            phosphatases, and it is implicated in the negative control of cell
            growth and division. It consists of a common heteromeric core
            enzyme, which is composed of a catalytic subunit and a constant
            regulatory subunit, that associates with a variety of regulatory
            subunits. This gene encodes an alpha isoform of the catalytic
            subunit. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.26971.1,
                                           SRR11853559.26465.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267764 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000481195.6/ ENSP00000418447.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC104109.3         97096-97271
            177-2364            AK097599.1         175-2362
            2365-4582           AC104109.3         126620-128837
FEATURES             Location/Qualifiers
     source          1..4582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..4582
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /note="protein phosphatase 2 catalytic subunit alpha"
                     /db_xref="GeneID:5515"
                     /db_xref="HGNC:HGNC:9299"
                     /db_xref="MIM:176915"
     exon            1..314
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1142
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PP2A-alpha; replication protein C; protein phosphatase 2,
                     catalytic subunit, alpha isozyme"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     catalytic subunit alpha isoform isoform 1"
                     /protein_id="NP_002706.1"
                     /db_xref="CCDS:CCDS4173.1"
                     /db_xref="GeneID:5515"
                     /db_xref="HGNC:HGNC:9299"
                     /db_xref="MIM:176915"
                     /translation="MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESN
                     VQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVA
                     LKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVD
                     GQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGY
                     TFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIM
                     ELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL"
     exon            315..524
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            525..698
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            699..788
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            789..950
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1069
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..4582
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1800..1805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /note="hexamer: AATAAA"
     polyA_site      1824
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /note="major polyA site"
     regulatory      2158..2163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /note="hexamer: AATAAA"
     polyA_site      2195
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
     regulatory      2407..2412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /note="hexamer: AATAGA"
     polyA_site      2432
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
     regulatory      2630..2635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /note="hexamer: AATAAA"
     polyA_site      2648
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
     regulatory      3789..3794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /note="hexamer: ATTAAA"
     polyA_site      3809
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
     regulatory      4562..4567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
                     /note="hexamer: ATTAAA"
     polyA_site      4582
                     /gene="PPP2CA"
                     /gene_synonym="HJS3; NEDLBA; PP2Ac; PP2CA; PP2Calpha;
                     RP-C"
ORIGIN      
        1 acagagagcc gagctctgga gcctcagcga gcggaggagg aggcgcagcg gccgacggcc
       61 gagtactgcg gtgagagcca gcgggccagc gccagcctca acagccgcca gaagtacacg
      121 aggaaccggc ggcggcgtgt gcgtgtaggc ccgtgtgcgg gcggcggcgc gggagcagcg
      181 cggagcggca gccggctggg gcgggtggca tcatggacga gaaggtgttc accaaggagc
      241 tggaccagtg gatcgagcag ctgaacgagt gcaagcagct gtccgagtcc caggtcaaga
      301 gcctctgcga gaaggctaaa gaaatcctga caaaagaatc caacgtgcaa gaggttcgat
      361 gtccagttac tgtctgtgga gatgtgcatg ggcaatttca tgatctcatg gaactgttta
      421 gaattggtgg caaatcacca gatacaaatt acttgtttat gggagattat gttgacagag
      481 gatattattc agttgaaaca gttacactgc ttgtagctct taaggttcgt taccgtgaac
      541 gcatcaccat tcttcgaggg aatcatgaga gcagacagat cacacaagtt tatggtttct
      601 atgatgaatg tttaagaaaa tatggaaatg caaatgtttg gaaatatttt acagatcttt
      661 ttgactatct tcctctcact gccttggtgg atgggcagat cttctgtcta catggtggtc
      721 tctcgccatc tatagataca ctggatcata tcagagcact tgatcgccta caagaagttc
      781 cccatgaggg tccaatgtgt gacttgctgt ggtcagatcc agatgaccgt ggtggttggg
      841 gtatatctcc tcgaggagct ggttacacct ttgggcaaga tatttctgag acatttaatc
      901 atgccaatgg cctcacgttg gtgtctagag ctcaccagct agtgatggag ggatataact
      961 ggtgccatga ccggaatgta gtaacgattt tcagtgctcc aaactattgt tatcgttgtg
     1021 gtaaccaagc tgcaatcatg gaacttgacg atactctaaa atactctttc ttgcagtttg
     1081 acccagcacc tcgtagaggc gagccacatg ttactcgtcg taccccagac tacttcctgt
     1141 aatgaaattt taaacttgta cagtattgcc atgaaccata tatcgaccta atggaaatgg
     1201 gaagagcaac agtaactcca aagtgtcaga aaatagttaa cattcaaaaa acttgttttc
     1261 acatggacca aaagatgtgc catataaaaa tacaaagcct cttgtcatca acagccgtga
     1321 ccactttaga atgaaccagt tcattgcatg ctgaagcgac attgttggtc aagaaaccag
     1381 tttctggcat agcgctattt gtagttactt ttgctttctc tgagagactg cagataataa
     1441 gatgtaaaca ttaacacctc gtgaatacaa tttaacttcc atttagctat agctttactc
     1501 agcatgactg tagataagga tagcagcaaa caatcattgg agcttaatga acatttttaa
     1561 aaataattac caaggcctcc cttctacttg tgagttttga aattgttctt tttattttca
     1621 gggataccgt ttaatttaat tatatgattt gtctgcactc agtttattcc ctactcaaat
     1681 ctcagcccca tgttgttctt tgttattgtc agaacctggt gagttgtttt gaacagaact
     1741 gttttttccc cttcctgtaa gacgatgtga ctgcacaaga gcactgcagt gtttttcata
     1801 ataaacttgt gaactaagaa ctgagaaggt caaattttaa ttgtatcaat gggcaagact
     1861 ggtgctgttt attaaaaaag ttaaatcaat tgagtaaatt ttagaatttg tagacttgta
     1921 ggtaaaataa aaatcaaggg cactacataa cctctctggt aactccttga cattcttcag
     1981 attaacttca ggatttattt gtatttcaca tattacaatt tgtcacattg ttggtgtgca
     2041 ctttgtgggt tcttcctgca tattaacttg tttgtaagaa aggaaatctg tgctgcttca
     2101 gtaagactta attgtaaaac catataactt gagatttaag tctttgggtt ttgttttaat
     2161 aaaacagcat gttttcaggt agagcttaaa ctaaatgatg tgtttactta gtgcagtttc
     2221 tggttatgaa tattatattg ctatgtgtat attatatgga ctctttaaaa tgattgacag
     2281 attggcaaat tcttaaatct ttgtacattg ttgagtcata tgttcttaga gttaaatttg
     2341 tctcagataa gaaagtgtta aagcattagc ctgtgtcaag ttctttgagt gatactagtg
     2401 aaaccaaata gaaaactatt gttggatcat gatttagtct tatgtacatt cacccgaaga
     2461 caaaaatggt acttaaagtg gcagtgttca acatttaatg agtttttccc cttttatcct
     2521 tcgaatagga ttagatgttt aaaaaaaagt tcttctgtgg gaactaatat ttgatatttt
     2581 aacctaccag agtaaacagg aacacttaat catacttgtg agtgtagtaa ataaaagttt
     2641 tcttgctttg tgctgtgttg aatctggaac caacagggaa gttatagcat atcccctttc
     2701 taaaatgctt gaggaacaca tacataccga atgtcttttc tgatctaatt gatagtattt
     2761 ttagtggctt gtggagttaa ttttccaaag caaaaggcca ttagggtttc tacatttcat
     2821 ttcatttcat tcttttcttt cacaagaaat acattctctg tgtgtctttt tgttgctctg
     2881 tcactctatg ccctttctct ccgactgaac aaatagctta tccatgtgca gtggttttaa
     2941 tacccaaaca atctagacac caagcagcta ttttttccgg tcctgtgata tcagaattga
     3001 ccaaggaata cgtatattgt aattgacacg tggtggtatc ttccaggtac aaattctcta
     3061 aattttgtgg ttagcagaat gggacttgtg ataagaatag cttggtttta gcataactag
     3121 ggtttaaaat aattgtttaa ttatagagac tgaccgggct ttggccatct aaactggaaa
     3181 gtgttagtac cctaccttct tttgaaaatg gctatggtaa ggaaaatgtg ttagtaaatt
     3241 atgtattttc ttgaaaaata cataattatg gttggatggg aatcactaag ttgggtgtta
     3301 actgatgtct caattagtaa cattaggatt ttcattaata aacctaaaaa gctttcccta
     3361 agaacaggcc tggcacagtg gctcatgcct gtaatcccag cactttggga gaccagggtg
     3421 ggtggatccc ttgaggtcag gagttgaaga gcagcctggc caacatggca aaaccccatc
     3481 tctacaaaaa atatgaaaat cagccgggct tggtggcata ccatagtccc agctacttgg
     3541 gaggctgagg tgagaggatc gcctgagccc aggagatgga ggttgcagtg ggctgagatt
     3601 gtgccactgt actccagtct gggtgacaga gccagaccct gtctcaaaaa taaagaggat
     3661 tctgagtttg tatagtgagg gcttgcagaa attttgaaac ttattttgta agtttacaat
     3721 gaatttgtac atgatgtgct catgtcttgg gttgagtatc ctagacatga ttttttcatt
     3781 tgctgcatat taaacatttg ttggttgtag tcggtatttc ttaaatagaa gtttgtcaat
     3841 attagattag tttcaagaag gacttagctc aggaaaagga tagttatttc tgtggttctc
     3901 agctttgatg cctacagaga ttctgattta aattgctgga ggagggccca ggcatacatt
     3961 ttttaagttt cccaagtgat tctaatttac atctagggtt aaaaacagcc aggcgcggtg
     4021 gctcatgcct gtaatcccag cacttgggga ggccggggtg ggtggatcac ctgatgtcag
     4081 gagatcgaga ccagcctggc cagcgtggtg aaaccccatc tctattaaaa atacaaaact
     4141 gaccggtgtg gtggcaggag cctgtaatcc cagctacttg ggaggctgag gcaggagaat
     4201 cacttgaact caggaggagg aggttacagt gagcccagat cgtgccattg cactccagcc
     4261 tgggcaaaaa gagcaaaact ccatctcaaa aaacaaaaac acctcactgc tgtttcctaa
     4321 gtacatactt aagaaaattg ggatacatgg tggtggttca tggatgttga taaggaatta
     4381 aaatgtaccg tgcgactctc tgtttcagtg gtgactttta cctgtttagt ataaatattc
     4441 ctttgcttcc aaccataaat gtgttcttag aaatgggcct atagtttagt aacctatagt
     4501 ttggtaatag gcttgtttgt tttcagatgg attttggttc tgtgagctaa agctattttg
     4561 cattaaagcc ttcgtcctca ca
//
