LOCUS       NM_002712               1941 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 7 (PPP1R7),
            transcript variant 1, mRNA.
ACCESSION   NM_002712
VERSION     NM_002712.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1941)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1941)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1941)
  AUTHORS   Jiang,Y., Scott,K.L., Kwak,S.J., Chen,R. and Mardon,G.
  TITLE     Sds22/PP1 links epithelial integrity and tumor suppression via
            regulation of myosin II and JNK signaling
  JOURNAL   Oncogene 30 (29), 3248-3260 (2011)
   PUBMED   21399659
  REMARK    GeneRIF: human Sds22 is focally deleted and downregulated in
            multiple carcinomas, and this downregulation correlates with tumor
            progression, suggesting that sds22 inactivation may contribute to
            tumorigenesis and metastatic potential
REFERENCE   4  (bases 1 to 1941)
  AUTHORS   Posch,M., Khoudoli,G.A., Swift,S., King,E.M., Deluca,J.G. and
            Swedlow,J.R.
  TITLE     Sds22 regulates aurora B activity and microtubule-kinetochore
            interactions at mitosis
  JOURNAL   J Cell Biol 191 (1), 61-74 (2010)
   PUBMED   20921135
  REMARK    GeneRIF: Sds22 specifically defines protein phosphatase 1 function
            and localization in mitosis.
REFERENCE   5  (bases 1 to 1941)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1941)
  AUTHORS   Lesage,B., Beullens,M., Pedelini,L., Garcia-Gimeno,M.A.,
            Waelkens,E., Sanz,P. and Bollen,M.
  TITLE     A complex of catalytically inactive protein phosphatase-1
            sandwiched between Sds22 and inhibitor-3
  JOURNAL   Biochemistry 46 (31), 8909-8919 (2007)
   PUBMED   17630778
  REMARK    GeneRIF: Sds22 and Inhibitor-3 form a heterotrimeric complex with
            PP1, both in cell lysates and after purification. A pool of PP1 is
            complexly controlled by both Sds22 and Inhibitor-3.
REFERENCE   7  (bases 1 to 1941)
  AUTHORS   Ceulemans,H., Vulsteke,V., De Maeyer,M., Tatchell,K., Stalmans,W.
            and Bollen,M.
  TITLE     Binding of the concave surface of the Sds22 superhelix to the alpha
            4/alpha 5/alpha 6-triangle of protein phosphatase-1
  JOURNAL   J Biol Chem 277 (49), 47331-47337 (2002)
   PUBMED   12226088
REFERENCE   8  (bases 1 to 1941)
  AUTHORS   Ceulemans,H., Van Eynde,A., Perez-Callejon,E., Beullens,M.,
            Stalmans,W. and Bollen,M.
  TITLE     Structure and splice products of the human gene encoding sds22, a
            putative mitotic regulator of protein phosphatase-1
  JOURNAL   Eur J Biochem 262 (1), 36-42 (1999)
   PUBMED   10231361
REFERENCE   9  (bases 1 to 1941)
  AUTHORS   Renouf,S., Beullens,M., Wera,S., Van Eynde,A., Sikela,J.,
            Stalmans,W. and Bollen,M.
  TITLE     Molecular cloning of a human polypeptide related to yeast sds22, a
            regulator of protein phosphatase-1
  JOURNAL   FEBS Lett 375 (1-2), 75-78 (1995)
   PUBMED   7498485
REFERENCE   10 (bases 1 to 1941)
  AUTHORS   Berry,R., Stevens,T.J., Walter,N.A., Wilcox,A.S., Rubano,T.,
            Hopkins,J.A., Weber,J., Goold,R., Soares,M.B. and Sikela,J.M.
  TITLE     Gene-based sequence-tagged-sites (STSs) as the basis for a human
            gene map
  JOURNAL   Nat Genet 10 (4), 415-423 (1995)
   PUBMED   7670491
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC051689.1, BC000910.2,
            AC005237.2 and BM676947.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002712.2.
            
            Summary: This gene encodes a protein subunit that regulates the
            activity of the serine/threonine phosphatase, protein
            phosphatase-1. The encoded protein is required for completion of
            the mitotic cycle and for targeting protein phosphatase-1 to
            mitotic kinetochores. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as
            sds22alpha1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.87173.1, BC000910.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234038.11/ ENSP00000234038.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BC051689.1         810-827
            19-1259             BC000910.2         1-1241
            1260-1265           AC005237.2         150938-150943
            1266-1298           BC000910.2         1248-1280
            1299-1475           BM676947.1         479-655             c
            1476-1896           AC005237.2         151154-151574
            1897-1939           BM676947.1         14-56               c
            1940-1941           AC005237.2         151618-151619
FEATURES             Location/Qualifiers
     source          1..1941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..1941
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /note="protein phosphatase 1 regulatory subunit 7"
                     /db_xref="GeneID:5510"
                     /db_xref="HGNC:HGNC:9295"
                     /db_xref="MIM:602877"
     exon            1..81
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1112
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein phosphatase 1 regulatory subunit 22; protein
                     phosphatase 1, regulatory (inhibitor) subunit 7; testis
                     secretory sperm-binding protein Li 210a"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 7
                     isoform 1"
                     /protein_id="NP_002703.1"
                     /db_xref="CCDS:CCDS2546.1"
                     /db_xref="GeneID:5510"
                     /db_xref="HGNC:HGNC:9295"
                     /db_xref="MIM:602877"
                     /translation="MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLS
                     EQSLKDGEERGEEDPEEEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKT
                     LCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGV
                     DKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKN
                     KITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKL
                     TMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQ
                     KDPQYRRKVMLALPSVRQIDATFVRF"
     exon            82..210
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            211..266
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            267..332
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            333..463
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            464..626
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            627..743
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            744..848
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            849..935
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1941
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1293..1298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /note="hexamer: ATTAAA"
     polyA_site      1313
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /note="major polyA site"
     regulatory      1919..1924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
                     /note="hexamer: TATAAA"
     polyA_site      1941
                     /gene="PPP1R7"
                     /gene_synonym="SDS22"
ORIGIN      
        1 agattccgga aaggggaaga gcagccaaca tggcggcgga acgcggcgcg gggcagcaac
       61 agtcgcagga gatgatggag gttgacaggc gggtcgagtc tgaagaatcc ggcgatgaag
      121 aagggaagaa acacagcagt ggcatcgtgg ccgacctcag tgaacagagc ctgaaggatg
      181 gggaggagcg gggggaggag gacccagaag aagaacatga gctgcctgtg gacatggaaa
      241 ccatcaacct ggacagagat gcagaggatg ttgatttgaa tcactatcgc atagggaaga
      301 ttgaaggatt tgaggtactg aagaaagtga agactctctg cctccgccaa aatttaatta
      361 aatgcattga gaatctggag gagctacaga gtcttcgaga gctggatctt tacgacaacc
      421 agatcaagaa gattgagaat ctggaggcgc taacagagct ggagattcta gatatttctt
      481 ttaatctgct gagaaacatc gaaggggttg acaagttgac acgactgaaa aaactcttct
      541 tggtcaacaa taaaatcagt aaaattgaga acttaagcaa cttacatcaa ctacagatgc
      601 tagagctggg atctaaccgc atccgggcaa tcgaaaatat cgacacctta accaacctgg
      661 agagtttgtt tttggggaaa aacaaaatta ctaaacttca gaacctggat gcgctcacca
      721 acctgacagt cctcagtatg cagagcaacc ggctgaccaa gatcgagggt ctgcagaacc
      781 tggtgaacct gcgggagctg taccttagcc acaatggcat cgaggtcatc gagggcctgg
      841 agaacaataa caaactcacg atgttggaca ttgcatcaaa tagaatcaaa aagattgaaa
      901 atatcagcca tctaacagag ctgcaagagt tctggatgaa cgacaatctc cttgagagct
      961 ggagcgacct cgacgagctg aagggagcca ggagcctgga gacagtgtac ctggagcgga
     1021 accccttgca gaaggacccc cagtaccggc ggaaggtcat gctcgccctc ccctccgtgc
     1081 ggcagatcga tgccacgttc gtcaggttct gagtccttct tggctcctca tgtggtccct
     1141 ctcctcggaa gaactgccca gccacgggtt tttaacccac ctgttgctcc tgaggtcgtc
     1201 actatatcaa cagtcacaaa cccaatggca ataaaggcac tgacgatagc tggcgcgcgc
     1261 gacgtcacac accattttca gatgccgttg caattaaatc ttgccacact gtcctcctgg
     1321 gtgattgttg acagttattg tagccacaga gagaacataa gacacgttgc gttcattcgc
     1381 tagaaatccc tgtttccttc tctcagaagg cagtcacagt ccctacctga gtcgtgtgaa
     1441 acacagggcc tgagagtgct ttacaggcat tcacgtgctg tccgagtggc attcgggggc
     1501 tggcctagct ggccctagtc ctggtgtgca gggttcaggc agtcttgacc tgcaacaacc
     1561 gaggtttttt agtcttttaa cccagccatt ttcaattttt taaaaattag gtaagttaaa
     1621 aaagctgggt aaaagctgac tcagccctgt gtgcttgtgt tccttagagc tctccttcaa
     1681 agagcgccgg gcagggctga ctgttttcac gtgtgcccgt cagttctcgc cacatccctt
     1741 gcctgtgggt gaaagctcag gtgtggggag ggtgtcctgt gtcccacacg gtgctgtgct
     1801 gctgccagaa tacgagtccc attgagcctc tccaaagacg gcctccaagg atctgaactc
     1861 ttggccactg gtatagtggc ctcctgttct caccccattg ttattttggc ttttttaata
     1921 taaaatgtac attgacagac a
//
