LOCUS       NM_001364910            1182 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 42 (PPP1R42),
            transcript variant 3, mRNA.
ACCESSION   NM_001364910
VERSION     NM_001364910.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1182)
  AUTHORS   DeVaul,N., Wang,R. and Sperry,A.O.
  TITLE     PPP1R42, a PP1 binding protein, regulates centrosome dynamics in
            ARPE-19 cells
  JOURNAL   Biol Cell 105 (8), 359-371 (2013)
   PUBMED   23718219
  REMARK    GeneRIF: PPP1R42 regulation of PP1 function in centrosome
            separation.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110998.4.
            
            Summary: The protein encoded by this gene can interact with
            gamma-tubulin and PP1 phosphatase, a regulator of centrosome
            separation. The encoded protein is a positive regulator of PP1
            phosphatase and thus plays a role in the control of centrosome
            integrity. [provided by RefSeq, Feb 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000685739.1/ ENSP00000508980.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC110998.4         129782-129845       c
            65-277              AC110998.4         118910-119122       c
            278-444             AC110998.4         115717-115883       c
            445-583             AC110998.4         114249-114387       c
            584-700             AC110998.4         112006-112122       c
            701-818             AC110998.4         89691-89808         c
            819-950             AC110998.4         83340-83471         c
            951-1182            AC110998.4         65394-65625         c
FEATURES             Location/Qualifiers
     source          1..1182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..1182
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /note="protein phosphatase 1 regulatory subunit 42"
                     /db_xref="GeneID:286187"
                     /db_xref="HGNC:HGNC:33732"
                     /db_xref="MIM:617720"
     exon            1..64
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            65..277
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..964
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /note="isoform 3 is encoded by transcript variant 3;
                     leucine-rich repeat-containing protein 67; leucine rich
                     repeat containing 67; testis leucine-rich repeat"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 42
                     isoform 3"
                     /protein_id="NP_001351839.1"
                     /db_xref="CCDS:CCDS94299.1"
                     /db_xref="GeneID:286187"
                     /db_xref="HGNC:HGNC:33732"
                     /db_xref="MIM:617720"
                     /translation="MVRLTLDLIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIE
                     DLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLG
                     GNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDD
                     ITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLIL
                     VSKSLEFLDGKEIKNIERQFLMNWKASKDAKKISKKRSSKNEDASNSLIRISL"
     exon            278..444
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            445..583
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            584..700
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            701..818
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            819..950
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1182
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1162..1167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /note="hexamer: AATATA"
     polyA_site      1182
                     /gene="PPP1R42"
                     /gene_synonym="dtr; LRRC67; TLLR; TLRR"
                     /note="major polyA site"
ORIGIN      
        1 gtagggaccc ggcgccgatg aaaccgacca aactggagtt agctaccgga ctgtcccgcg
       61 agcgaaagtt ggaaataata cctaaaccta cttcttgaca tggtgtcaaa acagagcttt
      121 tgctgagagt ttgatttata aagaaattat ggttcgactg accttggatc taattgccag
      181 aaacagcaat cttaaacccc gaaaagaaga aaccatttca cagtgcctga agaaaataac
      241 tcatataaat ttttcagaca aaaatataga tgcaattgaa gacctctctc tttgcaaaaa
      301 tcttagtgtt ttatatttat atgataattg tattagtcaa atcactaacc tgaattatgc
      361 cacaaatctg acccacttgt acctacaaaa caattgtatt tcatgtatag agaacctcag
      421 gtcattaaag aaactggaaa aactgtatct gggaggcaat tacattgctg tcatagaagg
      481 tttagaagga ttaggagaac taagagagct tcatgttgag aatcagaggc ttccccttgg
      541 ggaaaagctt ctgtttgatc caagaactct tcattctctg gcaaaatccc tctgtatatt
      601 gaatatcagc aataataata ttgatgacat tacagactta gaactactag agaatcttaa
      661 tcagctcata gccgttgaca accaacttct gcatgtgaag gatttggagt ttttactgaa
      721 caagttgatg aagctgtgga aaattgatct aaatggaaat cctgtttgtc tcaaaccaaa
      781 atacagggac agactgatat tggtgtccaa atcactggaa tttcttgatg gaaaagaaat
      841 taaaaatata gaaagacaat tcctaatgaa ttggaaagca tccaaagatg ccaagaaaat
      901 cagcaaaaaa aggagcagta aaaatgagga tgcaagcaat tcactcataa gaatctctct
      961 ttgaagcaat ctgaaagctt gctgacaaaa aatgatgtgc atgaacctca cctcttccat
     1021 aacccagaag aaaaagaaaa tttgtttgtg gaaaatgagt aaattcagcc tcaagtgaca
     1081 ggaaacgttt gattttgttt ttaaccttat atgactaggc aacaatatct tttgtgggtt
     1141 tgtagcttta tggtatctca taatataagg aaaaactttt aa
//
