LOCUS       NM_001145115            4147 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 3G (PPP1R3G),
            mRNA.
ACCESSION   NM_001145115 XM_001714573 XM_001718372 XR_018474
VERSION     NM_001145115.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4147)
  AUTHORS   Du,J., Xiang,Y., Liu,H., Liu,S., Kumar,A., Xing,C. and Wang,Z.
  TITLE     RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1gamma
            promote apoptosis and necroptosis
  JOURNAL   Nat Commun 12 (1), 7067 (2021)
   PUBMED   34862394
  REMARK    GeneRIF: RIPK1 dephosphorylation and kinase activation by
            PPP1R3G/PP1gamma promote apoptosis and necroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4147)
  AUTHORS   Zhuo,X., Chen,L., Lai,Z., Liu,J., Li,S., Hu,A. and Lin,Y.
  TITLE     Protein phosphatase 1 regulatory subunit 3G (PPP1R3G) correlates
            with poor prognosis and immune infiltration in lung adenocarcinoma
  JOURNAL   Bioengineered 12 (1), 8336-8346 (2021)
   PUBMED   34592886
  REMARK    GeneRIF: Protein phosphatase 1 regulatory subunit 3G (PPP1R3G)
            correlates with poor prognosis and immune infiltration in lung
            adenocarcinoma.
REFERENCE   3  (bases 1 to 4147)
  AUTHORS   Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Regulator-driven functional diversification of protein
            phosphatase-1 in eukaryotic evolution
  JOURNAL   Bioessays 24 (4), 371-381 (2002)
   PUBMED   11948623
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035653.12 and KF458078.1.
            
            On Aug 5, 2019 this sequence version replaced NM_001145115.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405617.4/ ENSP00000393832.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-611               AL035653.12        12566-13176
            612-671             KF458078.1         1-60                c
            672-4147            AL035653.12        13237-16712
FEATURES             Location/Qualifiers
     source          1..4147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.1"
     gene            1..4147
                     /gene="PPP1R3G"
                     /note="protein phosphatase 1 regulatory subunit 3G"
                     /db_xref="GeneID:648791"
                     /db_xref="HGNC:HGNC:14945"
                     /db_xref="MIM:619541"
     exon            1..4147
                     /gene="PPP1R3G"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1222
                     /gene="PPP1R3G"
                     /note="putative protein phosphatase 1 regulatory inhibitor
                     subunit 3G; protein phosphatase 1, regulatory (inhibitor)
                     subunit 3G"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 3G"
                     /protein_id="NP_001138587.1"
                     /db_xref="CCDS:CCDS47366.1"
                     /db_xref="GeneID:648791"
                     /db_xref="HGNC:HGNC:14945"
                     /db_xref="MIM:619541"
                     /translation="MEPIGARLSLEAPGPAPFREAPPAEELPAPVVPCVQGGGDGGGA
                     SETPSPDAQLGDRPLSPKEEAAPQEQEELLECRRRCRARSFSLPADPILQAAKFLQQQ
                     QQQAVALGGEGAEDAQLGPGGCCAKCKKRVQFADTLGLSLASVKHFSEAEEPQVPPAV
                     LSRLRSFPMRAEDLEQLGGLLAAAAVAAPLSAPPSRLRPLFQLPGPSAAAERLQRQRV
                     CLERVQCSTASGAEVKGSGRVLSCPGPRAVTVRYTFTEWRSFLDVPAELQPEPLEPQQ
                     PEAPSGASEPGSGDAKKEPGAECFHFSLCLPPGLQPEDEEDADERGVAVHFAVCYRCA
                     QGEYWDNNAGANYTLRYARPADAL"
     regulatory      1860..1865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R3G"
                     /note="hexamer: AGTAAA"
     polyA_site      1881
                     /gene="PPP1R3G"
                     /note="major polyA site"
     regulatory      4074..4079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R3G"
                     /note="hexamer: AATAAA"
     polyA_site      4092
                     /gene="PPP1R3G"
     regulatory      4112..4117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R3G"
                     /note="hexamer: ATTAAA"
     polyA_site      4147
                     /gene="PPP1R3G"
ORIGIN      
        1 cgttgtcttg tcgagcctgg ggcgactcgc ctcggggagg gcgagcctga actgcagccc
       61 tgcgctcctt ccacggcccg aggagttagt taagtctcca gaggggcccg gttcggcccg
      121 agcaagtcca ggggcgaacg gcgtcatgga gcccataggg gcgcggctaa gtttggaggc
      181 gccgggacca gcgcccttcc gagaggcccc gccggccgag gagctgcccg ccccggtggt
      241 cccctgtgtg cagggtggcg gcgacggcgg tggcgcttcg gagaccccga gtcctgacgc
      301 tcagctaggg gataggcccc tgtccccgaa ggaagaggcc gccccccagg agcaggagga
      361 gctgctggaa tgccgccgcc gctgccgcgc gcgctccttt tccttgcccg ccgaccccat
      421 cttgcaggcg gccaagttcc tgcagcagca gcagcaacag gcggtggcac tgggcggcga
      481 gggggcggag gacgcacagc tcggcccggg cggctgctgc gccaagtgca agaagcgggt
      541 gcagttcgcg gacacgctgg ggctaagcct ggccagcgtg aagcacttca gcgaggcgga
      601 ggagccgcag gtgccgcccg ccgtgctctc gcgcctccga agcttcccta tgcgtgccga
      661 ggacctggag cagctcgggg ggctgctggc cgcggcggca gtggccgcgc ccctttcagc
      721 gccgccttcc cggctccggc cgctcttcca gctcccgggg ccgagcgccg cggccgagcg
      781 tctgcagcgg cagcgcgtgt gcctggagcg cgtgcagtgc tcgacggcct cgggcgctga
      841 ggtgaagggc tccggccggg tgctcagctg ccctgggccc agggccgtga ccgtgcgcta
      901 cacctttacc gagtggcgct ccttcctgga cgtgccggct gagctgcagc ccgagccgct
      961 ggagccacag cagccagagg caccgtctgg ggcctccgag ccagggtccg gggatgccaa
     1021 gaaagagcca ggcgccgagt gcttccactt ctcgctgtgc ctgcccccgg gcctgcagcc
     1081 tgaggacgaa gaggacgccg acgagcgcgg cgtcgcggtc cacttcgctg tctgctaccg
     1141 ctgcgcgcag ggcgagtact gggacaacaa cgcgggcgcc aactacacgc tgcgctacgc
     1201 gcgccctgcg gacgcgctct gagcctggag agtttcgaag agccgtgggg cggggttgat
     1261 tagcacgtgg agctcgggct gccgcctcaa ggaacttgct gggacgcttt gctgagcgtg
     1321 gcgagtctgg cgtgaggggc gcgtggaggg aaaggaggga gactttgaac cgtcgactcg
     1381 cacccccgca gacaagtgag cgagcttaga gagcccgggc aatgctccga aagcctctga
     1441 cctcagtctt ctcgtccgtt tgaccttcct acaaggcctc tagaattccc agcctgcgtc
     1501 agaataggaa gaaacttcca aggcccggag cagctgcctc caagaaaaag gctcccaact
     1561 cccgggcatg gttctaaggc cttgggattg gtttttaact ctaaatatca tattgtagcc
     1621 cttgcagttt gctggagacc cctagggaaa gaacaaagcg tcctgccacg gtgcaccaga
     1681 ggaaggtgcc acggactgtg ggtgcacgcg tgggaccttt acaccccaac ctatttctca
     1741 gagaaaaccc ttcggggctg ggccaggcca cccttttctt ttgactgaga tgtgggtaat
     1801 gtgtgcccag acttgacgtt gtttattgtg cgacattgtg tacaaatgtc ctttataaaa
     1861 gtaaaggcca ctcgcacccc cttttacgct gtactctgaa ttttggcttt cgtgagtttg
     1921 gggaggcatt ggcagtcggc cgatctttgt cagctgatga tgtgcgcact ttaacaatcc
     1981 ttaaacaaca gcctacaaat tcctcccctt cgttccttcc tctctactgc gaaagggccc
     2041 aaacttccca tgtgctttaa aatgttctgt agaaagtgtt ccgtccccct ccgaattaag
     2101 acgtttggtg aattgaaatg ccagtcctcg ggcaggccct ggctgtgatc tgcgagagcc
     2161 gggcacgcac gccccggcgc cctttgtgta ggcagagcac actgttagga gacttgccgg
     2221 gccattagca gtcagagaag ctgggccctt ttagtcgctg gactgccagc gcaggggatg
     2281 ggggatggga aagtggcttt ctgttcctct cagagccaca gtggggagtg gtgacttgat
     2341 ggaagaggag gcatgcccag cgagtcagtg ctgcgcagac gcagatggcc acctctgcag
     2401 gcccgttggg tggggtatgg acggccttgg tcgctgtgct ggctgtggat gccaggatga
     2461 tgtggccctc tgtgcatggg tgggcaggag ggcatcccga gtaaggtctg tcgccccttg
     2521 actctgcctc agtgatttcc ctttttttaa gtcttcccat tttccagcac atggcgagta
     2581 cagtcagtcg ttttagggat ggtagtctct aaggagggac agtttcactg ttgcttgata
     2641 gaacagggct gggcatacgt acatttggcc catgggccaa atttggcaca cagcttattc
     2701 ttgtagggcc tgtgacctaa gaatagtttt tacattttta tttttaattt aattttctta
     2761 ttattatttt tcgagacgga gtttcactct tgtcgcccag gctggagtgc aatgtgcgat
     2821 cttggctcat tgcaacctcc gcctcccagg ttcaagcgat tctcctgcct cagcctccag
     2881 agtagttggg agtacaggca tctgccacca cacctggcta atttttgtat ttttggtaga
     2941 gacagggttt caccatgttg gccaggctag tcttgaactc ctgacctcag gtgatccacc
     3001 cgccttggcc tcccaaagtg ctaggattat aggcgtgagc cacctcacct ggccttacat
     3061 ttttaaattg ttgaaaaaaa ttcaaaagaa agtactattt ggtggcacgt gagaattata
     3121 taaaatatat atttcagtgt tcacaaatca ggttttactg gaacacagcc gtgcacactc
     3181 atttctgtct tctctgtgct gcttccatgc taccgcagca gagtggagta gacacagcag
     3241 agaccagatg gcaaagtgta aaatatttac tatctggccc ttttacaaaa ggctggccaa
     3301 cccctgctct agggaagtag tgttttttaa acacaatatg ctgacaatta tagttaataa
     3361 agcatttaga ctttagtgag cttttgccac ttgaaataaa ccccctttgg gtaaaggtaa
     3421 agctttatat gactctcagt aatcttgttt agaataaaca cgaaaatgtg aaaagtgcgg
     3481 ttatcattgt gtcaggcagg ggaatctacc tgttgccttc tttcacctaa aaaaatagta
     3541 acacatcagt gcaactgaaa catagcaccc gtttgaattg gcttcaaact acaaagctgc
     3601 cagatatttc tctgtgcttc aaaatgtggc atcttacaca atggaagtat ttagtttgaa
     3661 ctttgggttg gagatatccc tttgactatg gcagtgtttc ccaaagtaaa ctgatcatag
     3721 gaaaaaaata atttattgac agcaagccat caggagttaa catattacaa tttagacttt
     3781 taaaaatggt caatggtcat atcaatgaac taatgaatac ttaattcata tatgcttata
     3841 aaaactttga cgaaaaataa atgataaaat gaaacaattt ttctgttact aaatataaaa
     3901 gctatgaagc cttctgatgc atcatcaggt aatcttggtc tgatatacca tttcttaaaa
     3961 gtacattatt gcataaccat atttttccga tatatttata aatacattaa tttttaagat
     4021 attgacagta tacatatgct ataacattgt ttgaaaatgc ttgtttgtgg ggcaataaag
     4081 caacattttg aattgttttg aattacttaa aattaaatga ggagcccaat ataatgattc
     4141 aaacaga
//
