LOCUS       NM_001276318            4775 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 3E (PPP1R3E),
            mRNA.
ACCESSION   NM_001276318
VERSION     NM_001276318.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4775)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 4775)
  AUTHORS   Munro,S., Ceulemans,H., Bollen,M., Diplexcito,J. and Cohen,P.T.
  TITLE     A novel glycogen-targeting subunit of protein phosphatase 1 that is
            regulated by insulin and shows differential tissue distribution in
            humans and rodents
  JOURNAL   FEBS J 272 (6), 1478-1489 (2005)
   PUBMED   15752363
  REMARK    Erratum:[FEBS J. 2024 Feb;291(3):609. doi: 10.1111/febs.16963..
            PMID: 37766503]
REFERENCE   3  (bases 1 to 4775)
  AUTHORS   Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Regulator-driven functional diversification of protein
            phosphatase-1 in eukaryotic evolution
  JOURNAL   Bioessays 24 (4), 371-381 (2002)
   PUBMED   11948623
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049829.4 and AK024489.1.
            
            On May 17, 2019 this sequence version replaced NM_001276318.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024489.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000452015.9/ ENSP00000408288.3
            NMD candidate          :: PMID: 15752363
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL049829.4         84907-84917         c
            12-4506             AK024489.1         1-4495
            4507-4775           AL049829.4         77710-77978         c
FEATURES             Location/Qualifiers
     source          1..4775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..4775
                     /gene="PPP1R3E"
                     /note="protein phosphatase 1 regulatory subunit 3E"
                     /db_xref="GeneID:90673"
                     /db_xref="HGNC:HGNC:14943"
                     /db_xref="MIM:619540"
     exon            1..700
                     /gene="PPP1R3E"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1123
                     /gene="PPP1R3E"
                     /note="protein phosphatase 1, regulatory (inhibitor)
                     subunit 3E"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 3E"
                     /protein_id="NP_001263247.1"
                     /db_xref="CCDS:CCDS61403.1"
                     /db_xref="GeneID:90673"
                     /db_xref="HGNC:HGNC:14943"
                     /db_xref="MIM:619540"
                     /translation="MSRERPPGTDIPRNLSFIAALTERAYYRSQRPSLEEEPEEEPGE
                     GGTRFGARSRAHAPSRGRRARSAPAGGGGARAPRSRSPDTRKRVRFADALGLELAVVR
                     RFRPGELPRVPRHVQIQLQRDALRHFAPCQPRARGLQEARAALEPASEPGFAARLLTQ
                     RICLERAEAGPLGVAGSARVVDLAYEKRVSVRWSADGWRSQREAPAAYAGPAPPPPRA
                     DRFAFRLPAPPIGGALLFALRYRVTGHEFWDNNGGRDYALRGPEHPGSGGAPEPQGWI
                     HFI"
     exon            701..1261
                     /gene="PPP1R3E"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1368
                     /gene="PPP1R3E"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1509
                     /gene="PPP1R3E"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..4775
                     /gene="PPP1R3E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2110..2115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R3E"
                     /note="hexamer: AACAAA"
     polyA_site      2127
                     /gene="PPP1R3E"
                     /note="major polyA site"
     regulatory      4485..4490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R3E"
                     /note="hexamer: AATAAA"
     regulatory      4504..4509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R3E"
                     /note="hexamer: AAGAAA"
     polyA_site      4509
                     /gene="PPP1R3E"
                     /note="major polyA site"
     polyA_site      4522
                     /gene="PPP1R3E"
     regulatory      4662..4667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R3E"
                     /note="hexamer: TATAAA"
     polyA_site      4694
                     /gene="PPP1R3E"
     regulatory      4739..4744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R3E"
                     /note="hexamer: ATTAAA"
     polyA_site      4775
                     /gene="PPP1R3E"
ORIGIN      
        1 gcagttgagc gcacgctcag agcagaccgc tagcaggagg caggatgtga tagtctaaga
       61 ccctggaagc tgacggccag agggagggaa gggtggtcac agaggagagg caaagcaacg
      121 ggaggtggag gatcctggag gtgtctgcaa ggagaataca cagcagcgag gggctgcaga
      181 agcggaccca gcgacttctg cgctgacgcg gggcgggcgg gagagaggaa gagaggggag
      241 cgcggtggcg ctgcgagctg gccccgccgg ggaaggggct gccatgtccc gtgagcggcc
      301 cccgggcacc gacattcccc gcaacctgag cttcatcgcc gcgctaacgg agcgcgccta
      361 ctaccgtagc cagcggccca gcctcgagga ggagccggag gaggagccag gcgagggcgg
      421 gacgcggttc ggggcccgat cccgcgctca cgcaccgagt cggggccgcc gggcccgatc
      481 tgcaccagcc ggaggcggcg gggcccgggc gccccgcagc cgtagcccag acacccgcaa
      541 gagagtgcgt ttcgccgacg cactggggtt ggagctggct gtcgtgcgcc gcttccgtcc
      601 cggtgagctg ccccgggtgc cccgccacgt gcagatccaa ttgcagaggg acgccctccg
      661 ccacttcgcg ccctgccagc cccgcgcccg cggcctccag gaggcgcgcg ccgccctgga
      721 gccggccagc gagcccggct tcgccgcccg cttgctgacg cagcgcatct gcctggaacg
      781 cgccgaggcg ggcccgctgg gcgtggccgg gagcgcgcgc gtggtggacc tggcctacga
      841 gaagcgcgtg agcgtgcgct ggagcgccga cggctggcgg agccaacgcg aggcgccagc
      901 cgcctacgcc ggtccggccc cgcccccgcc gcgcgccgac cgcttcgcct tccgcctgcc
      961 cgcgccgccg attgggggcg ccctgctctt cgccttgcgc taccgtgtga caggtcacga
     1021 gttctgggac aacaacggcg gccgtgacta tgctctacgt gggcccgagc acccgggcag
     1081 tggcggagct ccggagccgc agggctggat ccactttatc tgagacgagg cgcctgcggc
     1141 cgacggcgga aaacaccaaa ggcacccggg ggcggggcga cccgatgtgg cggggaggag
     1201 taggagagac caggattggc gggagcggtc caagggagtc aagccgggga gggcgaaaag
     1261 ggaacctggc cactgctcct tggtccttgg cattatgacg ggattccctt gtcacctctg
     1321 acagttcctg gctgcggtgt ccgcggactg gctggggagt gatgacagaa gggatggaaa
     1381 ccctattttc ttttctccaa gaccatggtt ggtctgcttc cctcactcgg gctccttgac
     1441 agtcttctag aagagagaag gaggaaaaga agcagttcct gatgttacaa atgaacaagg
     1501 atctcccagc cttagtcttt gagaaaagat ggctgaaaga gaggaactct ccaagtcatt
     1561 ccgcaaacaa atgcccattt aaacatcatc cttgtcttgt gaagaaaaca ggaagaatgt
     1621 catgtaccat gtggatcacc ttcagttcaa agttgcagca aagtgaagaa agaaactact
     1681 ggaagccacc cagcaatgca ctgtttagtc atcaattagg agcccatggg aggataatag
     1741 ggagactggg tggaggctca gtgtgtaata atctcttgtc taatgtatgt gtgtcactgc
     1801 catgttgtat gaacaatagt gagggctcac atttacttaa cacttgtgtg cgcaaatctg
     1861 ggtttttctt cctttccaga actatgactc gatcataaaa tctgttttgt ttgcatgcat
     1921 gcccaaaaca accctgtaag tagaacattg tcattatctc tgttttagag atgaggaaac
     1981 aggctcagag aagctcagaa atttgttcaa gatcgcacag ctagtaaatg gcagaagtag
     2041 gattgtgaac ccagggaatc tccagagcct ctgtgtaacc atgatgttat attttttttc
     2101 ctctttaaaa acaaaattta aaaccttgct ataatctctt attaggaaat gatcatagtt
     2161 tctgactgtg ctctgccttc ccatcctgcc aatctcctgg actggcttgg agaagacagg
     2221 gggcccccga gcttcatctg tgactcgaag gagtttgctg ctgtctcctg tgtcagtgtc
     2281 ccatctatgc aggatcagca caggaccccc ctcaccttcc cacttacact ctagcctttc
     2341 catacattgg aattctctcc tggccctagc cagcgctcca cacctgttgg tgtgccacct
     2401 ccctccctct tcccccactg gccttgaaca ggcaaacccc ctaatgtcgc cactaggttg
     2461 ggtccgtgac taggacacct gctagagggt ctgtgcttgg gccttttcta ggaatcccga
     2521 tgttactggg taagtgccaa ctctgtgggc agaatgctaa tgataatcct gttccctgac
     2581 ctctttctca gaagtaccct ggctcactct ccccaatctc agctttatag aacaacattt
     2641 tggtcttgat tattcccata tcaagctgcc ccagggcttc ggtaagctgt tagttgcccc
     2701 actgcctcaa ggctgggtct ggctgagcta cttcttaggc acacaaatag tgggtgtctc
     2761 cttggaacct gacacaaaac tatcagtgct accaagcctt gtaaaatagg gaggaaacta
     2821 atatttcttg agtggcttct gagtgcctgg tgctttcgcg gctctctgga gagattcctt
     2881 gccctgatgg ctttggtgtg tactcctctc ccaggacttc agcactgaga ttttcccaac
     2941 cccctggctt ttcctcacct tgggttgagt tgatccggca ctaccacaaa ccccaccatc
     3001 tgcaaaccaa ccaagattag gcagtatgcc ctttccgtct tgcactgctc ttccaaaact
     3061 tccatctgta tttctcacac cctcagtaag caaagctgag tgtgcatgga cagagctgca
     3121 tccactgctt tctcccagcg ggtgcagtct aatctgacac ggggaacact aggagtttag
     3181 cggaatcttc agccacccta ttaatgtgtt acgcattagg cattgtagtg gaaactcctc
     3241 tgatggctca tgactatatg aacaggagca atttggaata taacatgtca gctgtggact
     3301 gggaagtgcc gtgagagaaa acactacctg ggtcataggc ttgggtccct gaggcaaccc
     3361 agcagggaca ctgttgccca ttcctctcat ccagactgca ggtgtcttcc tacacctccc
     3421 tgtcccatag cctccgtcct gttttttgtt tgtttgtttt tctttgtgaa tgtagaaaaa
     3481 catttcatca tgagccctag ctcctcagtt ttccacctaa cacccacatt cccttgtttc
     3541 taactgccgt gtttttctgg agcctgctgg gatctttgca gtttgcaggt catagaatca
     3601 gacatgaaaa ggcttctctt ccgacgtcat tggttcctgg ctcctttaca gatgagaaca
     3661 caggtccaga ggtgagaaat gactctagca gggtcataga atttgttagt gcagctcaag
     3721 atgggactta aactcaggcc tcctgatcac ccattcccag gctaggaaac aggtctctgc
     3781 tcggtgtggt ggttcatacc tgtaatcgca acactttggg aggctgaggc aggagcattg
     3841 cttgagccca ggagttcgag accagtctga gcaacatagt gggaccctgt ctctacaaaa
     3901 acttttaaaa ttagctgggc atggtggcac acatctgtat tcccagctac tcaggaagct
     3961 gagacaggag gatcgcttga gcccaggagt tggaggttac tgagctatga tcgcaccact
     4021 gcactccagc ttggtgacag tgagaccctc aaaaaaaaaa agaaaagaaa gaggtctcta
     4081 cacaagcccg tgattcttca tggcaaggga taacatcaga aatgtttcat tttctgctat
     4141 tagtttccat tcctttcccc atccaggcat aaagagaaac aaaagacaat gatggtattc
     4201 tctgtgtcct cagctttggc acttttgttg atgttgctaa ggagcagtga ccttgctaaa
     4261 aagactgaat aatccaccca ctgaatagct aacctgggga ggaaatgaaa atttcctttg
     4321 tggatctccc caaatccatt gttgtcacca ggccctccca gaacctcctc agttccttca
     4381 cagtgcaacc ctgtgtactt ggcccgcaac ccaatagtat tgtgcctcac ttcaccttcc
     4441 atgggcaact gccctccctt ctggacataa aacctcatat tttaaataaa gttgaaatat
     4501 gaaaagaaag tatgtcataa gatattcaga agtattgtgt gttttgggct aagggcagca
     4561 agagactcag aggcaagatt ccctccttga ctcaatttct tggtcacctt gttttttgtg
     4621 tgtgtgtgtc cagaaaaatt taataagttt gcttaaatta ttataaagtt gaaccactga
     4681 aatgttcact gaaacatttt gacttgcatt aatgctttac ttccccacct acatttacat
     4741 taaaaattca cacacaaatg aaaattgaaa actga
//
