LOCUS       NM_005398               2541 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 3C (PPP1R3C),
            mRNA.
ACCESSION   NM_005398
VERSION     NM_005398.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2541)
  AUTHORS   Ardizzoia,A., Jemma,A., Redaelli,S., Silva,M., Bentivegna,A.,
            Lavitrano,M. and Conconi,D.
  TITLE     AhRR and PPP1R3C: Potential Prognostic Biomarkers for Serous
            Ovarian Cancer
  JOURNAL   Int J Mol Sci 24 (14), 11455 (2023)
   PUBMED   37511212
  REMARK    GeneRIF: AhRR and PPP1R3C: Potential Prognostic Biomarkers for
            Serous Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2541)
  AUTHORS   Zhao,Y., Ye,G., Wang,Y. and Luo,D.
  TITLE     MiR-4461 Inhibits Tumorigenesis of Renal Cell Carcinoma by
            Targeting PPP1R3C
  JOURNAL   Cancer Biother Radiopharm 37 (6), 503-514 (2022)
   PUBMED   32915648
  REMARK    GeneRIF: MiR-4461 Inhibits Tumorigenesis of Renal Cell Carcinoma by
            Targeting PPP1R3C.
REFERENCE   3  (bases 1 to 2541)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2541)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2541)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2541)
  AUTHORS   Worby,C.A., Gentry,M.S. and Dixon,J.E.
  TITLE     Malin decreases glycogen accumulation by promoting the degradation
            of protein targeting to glycogen (PTG)
  JOURNAL   J Biol Chem 283 (7), 4069-4076 (2008)
   PUBMED   18070875
REFERENCE   7  (bases 1 to 2541)
  AUTHORS   Fernandez-Sanchez,M.E., Criado-Garcia,O., Heath,K.E.,
            Garcia-Fojeda,B., Medrano-Fernandez,I., Gomez-Garre,P., Sanz,P.,
            Serratosa,J.M. and Rodriguez de Cordoba,S.
  TITLE     Laforin, the dual-phosphatase responsible for Lafora disease,
            interacts with R5 (PTG), a regulatory subunit of protein
            phosphatase-1 that enhances glycogen accumulation
  JOURNAL   Hum Mol Genet 12 (23), 3161-3171 (2003)
   PUBMED   14532330
REFERENCE   8  (bases 1 to 2541)
  AUTHORS   Permana,P.A., Luczy-Bachman,G. and Bogardus,C.
  TITLE     Protein targeting to glycogen/PPP1R5: screening of coding and
            flanking genomic regions for polymorphisms and association analysis
            with insulin action in Pima Indians
  JOURNAL   Biochem Biophys Res Commun 258 (1), 184-186 (1999)
   PUBMED   10222257
REFERENCE   9  (bases 1 to 2541)
  AUTHORS   Armstrong,C.G., Browne,G.J., Cohen,P. and Cohen,P.T.
  TITLE     PPP1R6, a novel member of the family of glycogen-targetting
            subunits of protein phosphatase 1
  JOURNAL   FEBS Lett 418 (1-2), 210-214 (1997)
   PUBMED   9414128
REFERENCE   10 (bases 1 to 2541)
  AUTHORS   Doherty,M.J., Young,P.R. and Cohen,P.T.
  TITLE     Amino acid sequence of a novel protein phosphatase 1 binding
            protein (R5) which is related to the liver- and muscle-specific
            glycogen binding subunits of protein phosphatase 1
  JOURNAL   FEBS Lett 399 (3), 339-343 (1996)
   PUBMED   8985175
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP202053.1, AK313149.1,
            BC012625.1, AI766011.1 and H14591.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005398.6.
            
            Summary: This gene encodes a carbohydrate binding protein that is a
            subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes
            reversible protein phosphorylation, which is important in a wide
            range of cellular activities. The encoded protein affects glycogen
            biosynthesis by activating glycogen synthase and limiting glycogen
            breakdown by reducing glycogen phosphorylase activity. DNA
            hypermethylation of this gene has been found in colorectal cancer
            patients. The encoded protein also interacts with the laforin
            protein, which is a protein tyrosine phosphatase implicated in
            Lafora disease. [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537399.1, SRR1660807.165536.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2155770
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238994.6/ ENSP00000238994.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               BP202053.1         31-415
            386-1056            AK313149.1         386-1056
            1057-2359           BC012625.1         1012-2314
            2360-2539           AI766011.1         8-187               c
            2540-2541           H14591.1           24-25               c
FEATURES             Location/Qualifiers
     source          1..2541
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.32"
     gene            1..2541
                     /gene="PPP1R3C"
                     /gene_synonym="PPP1R5; PTG"
                     /note="protein phosphatase 1 regulatory subunit 3C"
                     /db_xref="GeneID:5507"
                     /db_xref="HGNC:HGNC:9293"
                     /db_xref="MIM:602999"
     exon            1..116
                     /gene="PPP1R3C"
                     /gene_synonym="PPP1R5; PTG"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1056
                     /gene="PPP1R3C"
                     /gene_synonym="PPP1R5; PTG"
                     /note="Phosphatase 1, regulatory inhibitor subunit 5;
                     protein targeting to glycogen; PP1 subunit R5; protein
                     phosphatase 1 regulatory subunit 5; protein phosphatase 1,
                     regulatory (inhibitor) subunit 3C"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 3C"
                     /protein_id="NP_005389.1"
                     /db_xref="CCDS:CCDS7416.1"
                     /db_xref="GeneID:5507"
                     /db_xref="HGNC:HGNC:9293"
                     /db_xref="MIM:602999"
                     /translation="MSCTRMIQVLDPRPLTSSVMPVDVAMRLCLAHSPPVKSFLGPYD
                     EFQRRHFVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHVFS
                     DLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRSHFQKNFVCLE
                     NCSLQERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVDCVYMKNVYGGTDSDTFSF
                     AIDLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRIVHVQWKPDGVQTQMAPQDCA
                     FHQTSPKTELESTIFGSPRLASGLFPEWQSWGRMENLASYR"
     exon            117..2541
                     /gene="PPP1R3C"
                     /gene_synonym="PPP1R5; PTG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2522..2527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R3C"
                     /gene_synonym="PPP1R5; PTG"
                     /note="hexamer: AATAAA"
     polyA_site      2541
                     /gene="PPP1R3C"
                     /gene_synonym="PPP1R5; PTG"
                     /note="major polyA site"
ORIGIN      
        1 agtctctccc agcgaccgcc gcgggggcaa ggcctggagc tgtggttcga atttgtgcag
       61 gcagcgggtg ctggctttta gggtccgccg cctctctgcc taatgagctg caccagaatg
      121 atccaggttt tagatccacg tcctttgaca agttcggtca tgcccgtgga tgtggccatg
      181 aggctttgct tggcacattc accacctgtg aagagtttcc tgggcccgta cgatgaattt
      241 caacgacgac attttgtgaa taaattaaag cccctgaaat catgtctcaa tataaaacac
      301 aaagccaaat cacagaatga ctggaagtgc tcacacaacc aagccaagaa gcgcgttgtg
      361 tttgctgact ccaagggcct ctctctcact gcgatccatg tcttctccga cctcccagaa
      421 gaaccagcgt gggatctgca gtttgatctc ttggacctta atgatatctc ctctgcctta
      481 aaacaccacg aggagaaaaa cttgatttta gatttccctc agccttcaac cgattactta
      541 agtttccgga gccactttca gaagaacttt gtctgtctgg agaactgctc gttgcaagag
      601 cgaacagtga cagggactgt taaagtcaaa aatgtgagtt ttgagaagaa agttcagatc
      661 cgtatcactt tcgattcttg gaaaaactac actgacgtag actgtgtcta tatgaaaaat
      721 gtgtatggtg gcacagatag tgataccttc tcatttgcca ttgacttacc ccctgtcatt
      781 ccaactgagc agaaaattga gttctgcatt tcttaccatg ctaatgggca agtcttttgg
      841 gacaacaatg atggtcagaa ttatagaatt gttcatgttc aatggaagcc tgatggggtg
      901 cagacacaga tggcacccca ggactgtgca ttccaccaga cgtctcctaa gacagagtta
      961 gagtcaacaa tctttggcag tccgaggctg gctagtgggc tcttcccaga gtggcagagc
     1021 tgggggagaa tggagaactt ggcctcttat cgatgaatta agcaacaatg taactggtct
     1081 tgacttgtca tattccccca tgcaatccta ggtctgtatt gctcaatttt aggaagcctt
     1141 tgctactcca tcagtaggtt tagatttgag cttttgagac ctggctatgg aaaagaaaga
     1201 cacttgagaa tttagtgttg gggtctgtac agatgatgct acccaatttg gctttgaagg
     1261 atcaagtaac aggttgaaaa ctatttttat aaaggtaata ctttttcagt tcccttcttc
     1321 cttccctctc aatccactag ctttcatgtt gggcaaggaa aagttgagga aggatggctg
     1381 atggtgatgg aaagctgtgt taatggtatg aggaatgtgt gaaaagtata cacaaagggc
     1441 tctgaagctc aagtcagagg agtgggaggt ctgatcattg ttggtggaaa aacgtaaggt
     1501 tattttgtgt ttttaagttg gttttacaat tctttcctgg ggaaattatt tctggagggg
     1561 aaaaagatcc attctacgta tccttgtgga gaaaagctaa ataaccttta agaatgtggg
     1621 tggtattgga gaaagaagat gaattatagc tccggagaat caagatctta agtgaagcct
     1681 ttctgttcag atgtgatcta taaaaaatca taatttgggg aaagtttaag caaatctggc
     1741 tttgtagtcc tgatgttata agtgactttg tgatcaaact gtcaggcttg ggttcttgtt
     1801 atagaatgct tggtatagaa aaaccatgcc atcattaatg gctaacaaca cgtagggact
     1861 tcatgtcatg tcaaagatag ctctttgcaa gtgccttgat taaaccagaa aactgtcatc
     1921 gtttaaccca aatatctgaa tggtcatctg gtaactcatg ggtttttggc ctcataagat
     1981 ggtccactct gtacacaggc attcctcctg caataatgtt gtatctttga gaccgttgtc
     2041 agtgtacaca actcacatcc ttcatattga aggtgactca tttttctgca cacttttttg
     2101 atgtgatgct tgacgtgagg cccgacacta ggattctcaa tgcaagaatc cagtaccttg
     2161 cacatagaag tagcaaccca tcccttgcct attttcatct tgctgttttc ttttttttaa
     2221 aaaaatggat gtgacttgtt ttgaatgttt tgtattatac ttgtttttgt gtgtgcataa
     2281 attcattctg taggatctta agaaaaagag tcccagaatg ttgcttctat tattgtgcac
     2341 aaccattgag aggtgttaca agaatgcagt taattttaac atgtgtgatg tgccatggtg
     2401 gaaaagtact atcggaataa ctctgcagtg acagaatttg aagtttggct agcatccata
     2461 cttttctact gtaaatattt cactctcctc tagctatcct tgatgagctt ctcactttaa
     2521 gaataaatgt gtttgatata a
//
