LOCUS       NM_024607               5510 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein phosphatase 1 regulatory subunit 3B (PPP1R3B),
            transcript variant 2, mRNA.
ACCESSION   NM_024607
VERSION     NM_024607.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5510)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5510)
  AUTHORS   Kahali,B., Chen,Y., Feitosa,M.F., Bielak,L.F., O'Connell,J.R.,
            Musani,S.K., Hegde,Y., Chen,Y., Stetson,L.C., Guo,X., Fu,Y.P.,
            Smith,A.V., Ryan,K.A., Eiriksdottir,G., Cohain,A.T., Allison,M.,
            Bakshi,A., Bowden,D.W., Budoff,M.J., Carr,J.J., Carskadon,S.,
            Chen,Y.I., Correa,A., Crudup,B.F., Du,X., Harris,T.B., Yang,J.,
            Kardia,S.L.R., Launer,L.J., Liu,J., Mosley,T.H., Norris,J.M.,
            Terry,J.G., Palanisamy,N., Schadt,E.E., O'Donnell,C.J.,
            Yerges-Armstrong,L.M., Rotter,J.I., Wagenknecht,L.E.,
            Handelman,S.K., Gudnason,V., Province,M.A., Peyser,P.A.,
            Halligan,B., Palmer,N.D. and Speliotes,E.K.
  TITLE     A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage
            and MetS, but Protects Against Myocardial Infarction
  JOURNAL   J Clin Endocrinol Metab 106 (2), 372-387 (2021)
   PUBMED   33231259
  REMARK    GeneRIF: A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen
            Storage and MetS, but Protects Against Myocardial Infarction.
REFERENCE   3  (bases 1 to 5510)
  AUTHORS   Mannisto,V., Kaminska,D., Kakela,P., Neuvonen,M., Niemi,M.,
            Alvarez,M., Pajukanta,P., Romeo,S., Nieuwdorp,M., Groen,A.K. and
            Pihlajamaki,J.
  TITLE     Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624
            Has a Major Effect on Gallbladder Bile Composition
  JOURNAL   Hepatol Commun 5 (2), 244-257 (2020)
   PUBMED   33553972
  REMARK    GeneRIF: Protein Phosphatase 1 Regulatory Subunit 3B Genotype at
            rs4240624 Has a Major Effect on Gallbladder Bile Composition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5510)
  AUTHORS   Seidelin,A.S., Nordestgaard,B.G., Tybjaerg-Hansen,A. and Stender,S.
  TITLE     Genetic Variation at PPP1R3B Increases Hepatic CT Attenuation and
            Interacts With Prandial Status on Plasma Glucose
  JOURNAL   J Clin Endocrinol Metab 105 (6) (2020)
   PUBMED   32219298
  REMARK    GeneRIF: Genetic Variation at PPP1R3B Increases Hepatic CT
            Attenuation and Interacts With Prandial Status on Plasma Glucose.
REFERENCE   5  (bases 1 to 5510)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5510)
  AUTHORS   Montori-Grau,M., Guitart,M., Lerin,C., Andreu,A.L., Newgard,C.B.,
            Garcia-Martinez,C. and Gomez-Foix,A.M.
  TITLE     Expression and glycogenic effect of glycogen-targeting protein
            phosphatase 1 regulatory subunit GL in cultured human muscle
  JOURNAL   Biochem J 405 (1), 107-113 (2007)
   PUBMED   17555403
  REMARK    GeneRIF: Results suggest that in cultured human myotubes,
            glycogen-targeting PP1 (protein phosphatase 1) subunit G(L) (coded
            for by the PPP1R3B gene) is expressed as in muscle tissue and is
            unresponsive to glucose or insulin, as are G(M) and PTG genes.
            Erratum:[Biochem J. 2007 Aug 1;405(3):625]
REFERENCE   7  (bases 1 to 5510)
  AUTHORS   Dunn,J.S., Mlynarski,W.M., Pezzolesi,M.G., Borowiec,M., Powers,C.,
            Krolewski,A.S. and Doria,A.
  TITLE     Examination of PPP1R3B as a candidate gene for the type 2 diabetes
            and MODY loci on chromosome 8p23
  JOURNAL   Ann Hum Genet 70 (Pt 5), 587-593 (2006)
   PUBMED   16907705
REFERENCE   8  (bases 1 to 5510)
  AUTHORS   Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Regulator-driven functional diversification of protein
            phosphatase-1 in eukaryotic evolution
  JOURNAL   Bioessays 24 (4), 371-381 (2002)
   PUBMED   11948623
  REMARK    Review article
REFERENCE   9  (bases 1 to 5510)
  AUTHORS   Munro,S., Cuthbertson,D.J., Cunningham,J., Sales,M. and Cohen,P.T.
  TITLE     Human skeletal muscle expresses a glycogen-targeting subunit of PP1
            that is identical to the insulin-sensitive glycogen-targeting
            subunit G(L) of liver
  JOURNAL   Diabetes 51 (3), 591-598 (2002)
   PUBMED   11872655
REFERENCE   10 (bases 1 to 5510)
  AUTHORS   Doherty,M.J., Moorhead,G., Morrice,N., Cohen,P. and Cohen,P.T.
  TITLE     Amino acid sequence and expression of the hepatic glycogen-binding
            (GL)-subunit of protein phosphatase-1
  JOURNAL   FEBS Lett 375 (3), 294-298 (1995)
   PUBMED   7498521
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA100998.1, BQ431880.1,
            AC022784.7 and AI263711.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024607.3.
            
            Summary: This gene encodes the catalytic subunit of the
            serine/theonine phosphatase, protein phosphatase-1. The encoded
            protein is expressed in liver and skeletal muscle tissue and may be
            involved in regulating glycogen synthesis in these tissues. This
            gene may be a involved in type 2 diabetes and maturity-onset
            diabetes of the young. Alternate splicing results in multiple
            transcript variants that encode the same protein.[provided by
            RefSeq, Jan 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP233331.1, AK024067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMN03267757
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310455.4/ ENSP00000308318.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               DA100998.1         53-592
            541-780             BQ431880.1         525-764
            781-5500            AC022784.7         178652-183371
            5501-5510           AI263711.1         13-22               c
FEATURES             Location/Qualifiers
     source          1..5510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..5510
                     /gene="PPP1R3B"
                     /gene_synonym="GL; PPP1R4; PTG"
                     /note="protein phosphatase 1 regulatory subunit 3B"
                     /db_xref="GeneID:79660"
                     /db_xref="HGNC:HGNC:14942"
                     /db_xref="MIM:610541"
     exon            1..96
                     /gene="PPP1R3B"
                     /gene_synonym="GL; PPP1R4; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            97..5510
                     /gene="PPP1R3B"
                     /gene_synonym="GL; PPP1R4; PTG"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..971
                     /gene="PPP1R3B"
                     /gene_synonym="GL; PPP1R4; PTG"
                     /note="PP1 subunit R4; protein phosphatase 1, regulatory
                     (inhibitor) subunit 3B; protein phosphatase 1 regulatory
                     subunit 4; hepatic glycogen-targeting protein phosphatase
                     1 regulatory subunit GL; hepatic glycogen-targeting
                     subunit, G(L)"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 3B"
                     /protein_id="NP_078883.2"
                     /db_xref="CCDS:CCDS5973.1"
                     /db_xref="GeneID:79660"
                     /db_xref="HGNC:HGNC:14942"
                     /db_xref="MIM:610541"
                     /translation="MMAVDIEYRYNCMAPSLRQERFAFKISPKPSKPLRPCIQLSSKN
                     EASGMVAPAVQEKKVKKRVSFADNQGLALTMVKVFSEFDDPLDMPFNITELLDNIVSL
                     TTAESESFVLDFSQPSADYLDFRNRLQADHVCLENCVLKDKAIAGTVKVQNLAFEKTV
                     KIRMTFDTWKSYTDFPCQYVKDTYAGSDRDTFSFDISLPEKIQSYERMEFAVYYECNG
                     QTYWDSNRGKNYRIIRAELKSTQGMTKPHSGPDLGISFDQFGSPRCSYGLFPEWPSYL
                     GYEKLGPYY"
     regulatory      5489..5494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PPP1R3B"
                     /gene_synonym="GL; PPP1R4; PTG"
                     /note="hexamer: AATAAA"
     polyA_site      5510
                     /gene="PPP1R3B"
                     /gene_synonym="GL; PPP1R4; PTG"
                     /note="major polyA site"
ORIGIN      
        1 acacaccgac gctcacgtag tcgcgcttgc cacaaccctg cgggctctcc gatgcggcga
       61 gcgagctggg gagggggctt ctccgcggcc caaaagcctg ttcatctagc cccatgatgg
      121 ctgtggacat cgagtacaga tacaactgca tggctccttc cttgcgccaa gagaggtttg
      181 cctttaagat ctcaccaaag cccagcaaac cactgaggcc ttgtattcag ctgagcagca
      241 agaatgaagc cagtggaatg gtggccccgg ctgtccagga gaagaaggtg aaaaagcggg
      301 tgtccttcgc agacaaccag gggctggccc tgacaatggt caaagtgttc tcggaattcg
      361 atgacccgct agatatgcca ttcaacatca ccgagctcct agacaacatt gtgagcttga
      421 cgacagcaga gagcgagagc tttgttctgg atttttccca gccctctgca gattacttag
      481 actttagaaa tcgacttcag gccgaccacg tctgccttga gaactgtgtg ctcaaggaca
      541 aggccattgc aggcactgtg aaggttcaga acctcgcatt tgagaagacc gtgaaaataa
      601 ggatgacgtt cgacacctgg aagagctaca cagactttcc ttgtcagtac gtgaaggaca
      661 cttatgccgg ttcagacagg gacacgttct ccttcgacat cagcttgccc gagaagattc
      721 agtcttatga aagaatggag tttgctgtgt actacgagtg caatggacag acgtactggg
      781 acagcaacag aggcaagaac tataggatca tccgggctga gttaaaatct acccagggaa
      841 tgaccaagcc ccacagtgga ccggatttgg gaatatcctt tgaccagttc ggaagccctc
      901 ggtgttccta tggtctgttt ccagagtggc caagttactt aggatatgaa aagctagggc
      961 cctactacta gtgactgcag gtgacagggc gtggcggagc tgccacagac aagcctagct
     1021 ctgctcactg tgcagtggag atggaaggcc agggaggagc aacgtggaac ttccatgagg
     1081 ccccgtttgg gaaaataaaa ggatcctctt cacttctttc ttaaacagca aatccagcca
     1141 ggttcagatt acacaaccag tgtctcactc aaaggagcag tggtggctgg cgcgctttcg
     1201 cactgtggca gccacgagag tctgtgcacg tctgtgctgg aaagggtatg gatgggaatc
     1261 aagcctatgc cagtgctgat gaagctggag gagtctctcc tctgctctcc actcagatgt
     1321 gggacatcag tcgccaaaag ccactcagcc ccagccacct cgcgtgagac cctcactgtt
     1381 cattgtgttc atctttgggt gctctctgcc agccaggcct ttcctgcaag ctgctgtgct
     1441 tccccgtcca cgtgtatctc tgctgtgaca cactgagctg acgcacattt ccagtgcagc
     1501 tgcagaagag aaatgggatt ggctcttgtt ttctgcaagt tcatgttttg cattttatgt
     1561 tcttccacaa ttgatctgat gttcaggaaa agataataaa ggcaaattag ttagtggttg
     1621 agacaggcat ttcctcctcc cgcttcttga ccccacagat gtattccagc agagagcaac
     1681 acaccagtca tcaaaaccca ctggctcctg tgcggtgtca cagattgcag ggttctgaca
     1741 aggcaggaca gtcaagagtg gggacacttt cagcttctac ttttgccttc tagggggagc
     1801 tttctaagtc cccacattta ccccgagtca ccggaaaaat ctgatttttc ccccgaaagc
     1861 tcaatgactt taacgtgctt ggctggtttg tctcattctt tatgaaagaa ttttggggcc
     1921 gggcgcggtg gcttatgcct gtaatcccag cactttggga ggccgaggca ggtggatcac
     1981 gaggtcagga gatcgagacc atcctggcta acacggtgaa accctgtctc tactaaaaat
     2041 acaaaaaaat tagccaggcg tggtggcggg cgcctgtagt cccagctact tgggaggctg
     2101 aggcaggaga atggcgggaa cctgggaggc ggagcttaca gtgaaccgag atcacaccac
     2161 tgcattcccg cctgggcagc agagcgagac tccgtctcaa acagaaaaaa aaagagaatt
     2221 ttgaatctcc tttcccaaag agtcatcttt tctgctgtgt ttaggacatt tgatttgcat
     2281 atccaatatc tcctcgaaac cttcagaaaa tggttttatc gtgactgtga ttcacactat
     2341 ctagaacact ttaccagcac ccagggacat ggacttgggt gttcttattt atggtgtgta
     2401 tgtaaagaga taggggagaa aaacctcacc caagttctta tacgttattt taaacgtttg
     2461 ccaactctga aatttcagag attcattgtt cttaaccata ttggactaaa gtctgttggt
     2521 tagtgctgtt gtaaaagaga cctctggggc cgagtgtggt ggcttatgcc tgtaatccct
     2581 gcactttggg aagccaaggc gggcagctca cctgaggtca ggcgttcaag accagcctgg
     2641 ccaacatggt gaaacctcgt ctgtactaaa aatacaaaat ttagctgagt gtggtggcag
     2701 gcgcctgtaa tccagctact cgggaggctg aggcaggaga atcacttgaa cccaggaggt
     2761 ggaggttgca gtgagccgag atcacgtcac tgcatttcag cctgagcgac agagtgaaac
     2821 tgtctcaaaa aagagagact tccgggacag tcattatcag ataggcccca aacctgtgat
     2881 ttttcttggg caagattggt gtttacttag gggtgcttta aaaatatatt tttacaagta
     2941 tacttgtagg aagttggttt tttattttct atttttgttt gtttttggag tttggttaaa
     3001 cgactctttt attttctgtt ttgccttatc ttactaaagt gaagttttcc taaggcaagc
     3061 aagaagagga gtggaagcac agttgcctgg atttggaggc agagttgtca ggcttttcaa
     3121 gctaagagtc ttgtgcttgg attttccaga ttaatttgaa aagacctccc atttgtggct
     3181 ttgtacataa ccaacaggca gatactgagt gccttggctc ctagagtttt gtggttgggt
     3241 taggttgttt ttgttgttgt tttgttttgg ttttgttttc atttctgaag tttaagatgc
     3301 cttgactttt taaatgctct taaggctatt cgatgtaatt cttactccta aaactggctg
     3361 ttcttagcct gaaatctaat gctttgtttt ttgtacctct cccaggtggg taacactcta
     3421 ggatgacatg atgttataat tttaggggaa atcacatttt taccttatgc tgttactggg
     3481 cagaaccacg ttttatgtaa acataccaga catcgggtaa cagacagtac tttaaatgtt
     3541 ataaatttgg tgatcagaac tattaatagc ataaatcgaa ctcaaatgga agcaaaactg
     3601 atttcatgca ggtcctgaat tttactttgc cttaagaagt gccctcccca caatgcagga
     3661 gaggcacaga gtgcactgtc attgacatgt tacccgacta aggatcactc tgttcataag
     3721 aaaaaggcct gaagtgactc tgtttaataa agtcagttta attttatcta ataatgatct
     3781 taagacattc ccatgtcaaa atttgaaata tggtaattca gtgataacta tctcttctaa
     3841 agcagccgta aaccctcccc actacccgtc tttctcccag ctcaccctgg ctttttttgc
     3901 tgggggtgct ggatgcaagc ccccagccag cacacctggg atgctcaccc tgccgcacag
     3961 ttcagaaggc aagtcctcac ctgctcgcaa agacccttct tctccaataa aagactctac
     4021 ttgcctgagt ttcctcatca gggctgtcat tcagtgatgt atgggggtct gaagaatact
     4081 gccttctatc tgtcttctgt ttaccacttg ctcctctgct accctcctgc cgcaaacagt
     4141 cttcttcctt ttggcccagt tctgtcccgt gaaattctca gaaggcctcg ggagctgcgc
     4201 tgatgtattc tctccttgtt tgatagctca tcatcagtag ataagcctac acacttcaga
     4261 gggtgacagg tttcttactt ggagacttca ctgcaccttg acttgtagat ttgccttcag
     4321 acagctcttg gttatggtta caagtggccc ccgagtccca gaatctttcc caggttgccc
     4381 cagaaagacc agccacctgt cacaggtgca gttgtccggc aatagggaag caacttcatt
     4441 tttgttttat atttattccc tcaagtgccc tgaggagcat ttgcaaactg ggtacaataa
     4501 ataagctgga ttatacaaag atatttaata aataagcttt cagtatctat tggaagacat
     4561 gaagcatttg agtgggtttc tttatttaaa aaattattct actggagctg gtgagaaata
     4621 atgaagctgt acagttctcc agaaattaaa acaatgtcag agtcaatggg agaatttaat
     4681 ttacctttaa gatttcattt taatggtggc aaaattatac attcttagaa gatgtaaatt
     4741 tggaactgtt aggagattgc tctgtggttt tgatcttttc aaaccatttt ctttttgaaa
     4801 aaaggcatta gttgtagtca tggacattaa atgggccata tatgcttatc aatcaaaaaa
     4861 gtgttccttt tttggaactg cccattttct ggatcttccc tctcaatgga taggggatga
     4921 aaaccttggt tgccttttat ttgtttcctc ttctaaaatt tctcacctga atgtagtcct
     4981 gggagagtcc cgatcacgtc tctcctgaca tgttcactga aatcggagac aagaagttac
     5041 atggatgatg ggatcttata gggtcacaca aagacaattt ggcagcttat cttaatttcc
     5101 tgcagtgaga caacacatgt ggaactggga aggacagctg ttgttacgag cagtttttcc
     5161 tggtcatggt tgtaaagctc tgtaacccac attgtaaagc cgtgaatgtt tttagtcttg
     5221 ttgacgagtt tttagagact gctggacctc tgagggcttt gagagtgcag ctgtgatgat
     5281 gtttcactat tacttcagtg tgaatgtaga accaaggact catcttcatt ttatacctaa
     5341 aagtgccttg tcaagaaatt tttgcatgtt ttaaaagata aatatttttg tacacagagt
     5401 tcaaggggaa atgcacttta aaaatcccaa gaatggatgt tctttgtgtg gtatgagagg
     5461 ttggtttgta tctcaaaagc aaaaatgtaa taaaggaaga caaaacaaaa
//
